Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study. by Aleksandra Turkiewicz, Karin Magnusson, Simon Timpka, Ali Kiadaliri, Andrea Dell'Isola, Martin Englund

“…<h4>Methods and findings</h4>We included approximately 40,000 18-year-old Swedish males, who completed their conscription examination in 1969 to 1970, followed up until age of 60 years. …”
Get full text

Direct anterior approach (DAA) vs. conventional approaches in total hip arthroplasty: A RCT meta-analysis with an overview of related meta-analyses. by Philip Lazaru, Simon Bueschges, Nikolai Ramadanov

“…We compared our findings with 7 related meta-analyses.…”
Get full text

Computing the time-dependent activity rate using non-declustered and declustered catalogues – a first step towards time-dependent seismic hazard calculations for operational earthq... by D. Montiel-López, S. Molina, S. Molina, J. J. Galiana-Merino, J. J. Galiana-Merino, I. Gómez, I. Gómez, A. Kharazian, J. L. Soler-Llorens, J. A. Huesca-Tortosa, A. Guardiola-Villora, G. Ortuño-Sáez

“…To illustrate this methodology, we selected two scenarios as representatives of the high-seismicity region and low-to-moderate-seismicity region. …”
Get full text

Antimicrobial Stewardship in the Pediatric Emergency Department: An Observational Pre-Post Study by Erika Silvestro, Ilaria Mussinatto, Antonia Versace, Marco Denina, Giulia Pruccoli, Raffaella Marino, Giulia Mazzetti, Lorenzo Scaglione, Federico Vigna, Alessandra Macciotta, Silvia Garazzino, Claudia Bondone

“…<b>Methods</b>: We conducted a pre-post observational study with an audit, intervention, and feedback given to prescribers. …”
Get full text

Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii group in Taiwan by Tran Lam Tu Quyen, Yu-Chia Hsieh, Shiao-Wen Li, Lii-Tzu Wu, Ya-Zhu Liu, Yi-Jiun Pan

“…We confirmed their identity by rpoB gene sequencing of 239 randomly selected A. baumannii strains and all 27 NAB strains. …”
Get full text

Psychosocial factors are associated with community mobility and participation in persons with dizziness by Pamela M. Dunlap, Jeffrey P. Staab, Patrick J. Sparto, Patrick J. Sparto, Joseph M. Furman, Susan L. Whitney, Susan L. Whitney

“…We measured community mobility and participation at baseline and 3-month follow-up using the Life Space Assessment (LSA) and Vestibular Activities and Participation Measure (VAP). …”
Get full text

Co-occurring climate events and environmental justice in California, 2018–2019 by Brittany Shea, Gabriella Y Meltzer, Benjamin B Steiger, Robbie M Parks, Vivian Do, Heather McBrien, Nina Flores, Milo Gordon, Elizabeth M Blake, Joan A Casey

“…We defined county-day anomalously warm temperatures when daily average temperatures exceeded 24 °C and the 85th percentile of the long-term county average. …”
Get full text

LRP1 involvement in FHIT-regulated HER2 signaling in non-small cell lung cancer by Théophile Ponchel, Emma Loeffler, Julien Ancel, Audrey Brisebarre, Nathalie Lalun, Véronique Dalstein, Anne Durlach, Gaëtan Deslée, Stéphane Dedieu, Myriam Polette, Béatrice Nawrocki-Raby

“…Here, we sought to decipher the FHIT-regulated HER2 signaling pathway in NSCLC. …”
Get full text

Endothelial calcium firing mediates the extravasation of metastatic tumor cells by Marina Peralta, Amandine Dupas, Annabel Larnicol, Olivier Lefebvre, Ruchi Goswami, Tristan Stemmelen, Anne Molitor, Raphael Carapito, Salvatore Girardo, Naël Osmani, Jacky G. Goetz

“…In this work, we dissect the cellular and molecular mechanisms driving endothelial remodeling. …”
Get full text

Preservation of cellular structure via immersion fixation in brain banking by Macy Garrood, Emma L. Thorn, Adam Goldstein, Allison Sowa, William Janssen, Alyssa Wilson, Claudia S. López, Raakhee Shankar, Erin S. Stempinski, Kurt Farrell, John F. Crary, Andrew T. McKenzie

“…Using serial section transmission electron microscopy, we found that identified synapses could be traced from one section to the next. …”
Get full text

Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in... by Imran Khan, Stephanie J. C. Taylor, Clare Robinson, Elisavet Moschopoulou, Paul McCrone, Liam Bourke, Mohamed Thaha, Kamaldeep Bhui, Derek Rosario, Damien Ridge, Sheila Donovan, Ania Korszun, Paul Little, Adrienne Morgan, Olivier Quentin, Rebecca Roylance, Peter White, Trudie Chalder

“…Methods We will conduct a multi-centre, pragmatic, theory driven, randomised controlled trial. …”
Get full text

Harnessing Human-Centered Design for Evidence-Based Psychosocial Interventions and Implementation Strategies in Community Settings: Protocol for Redesign to Improve Usability, Enga... by Aaron R Lyon, Sean A Munson, Michael D Pullmann, Brittany Mosser, Tricia Aung, John Fortney, Alex Dopp, Katie P Osterhage, Helen G Haile, Kathryn E Bruzios, Brittany E Blanchard, Ryan Allred, Macey R Fuller, Patrick J Raue, Ian Bennett, Jill Locke, Karen Bearss, Denise Walker, Elizabeth Connors, Eric Bruns, Jenna Van Draanen, Doyanne Darnell, Patricia A Areán

“…ConclusionsDuring the first round of the center, we established that DDBT is a useful approach to systematically identify and address chronic challenges of implementing clinical interventions and implementation strategies. …”
Get full text

Cathepsin G promotes arteriovenous fistula maturation by positively regulating the MMP2/MMP9 pathway by Lemei Hu, Changqing Zheng, Ying Kong, Zhiqing Luo, Fengzhang Huang, Zhigang Zhu, Quhuan Li, Ming Liang

“…We screened 84 differentially expressed genes (DEGs) and performed the functional enrichment analysis. …”
Get full text

Changes in the Expression of Mitochondrial Morphology-Related Genes during the Differentiation of Murine Embryonic Stem Cells by Jeong Eon Lee, Bong Jong Seo, Min Ji Han, Yean Ju Hong, Kwonho Hong, Hyuk Song, Jeong Woong Lee, Jeong Tae Do

“…We hypothesized that mitochondrial fusion genes would be overexpressed while the fission genes would be downregulated during the differentiation of ESCs. …”
Get full text

Adolescent Youth Survey on HIV Prevention and Sexual Health Education in Alabama: Protocol for a Web-Based Survey With Fraud Protection Study by Henna Budhwani, Ibrahim Yigit, Josh Bruce, Christyenne Lily Bond, Andrea Johnson

“…In the survey, we also evaluated young sexual and gender minority individuals’ preferences related to prevention modalities and trusted sources of health information. …”
Get full text

Treatment Options for Psychotic Depression in Adolescents: A Comprehensive Review by Perez-Rodriguez V, Aymerich C, Catalan A, Jauhar S, Salazar de Pablo G

“…Based on the findings, we recommend a stepped approach to the treatment of psychotic depression in adolescents. …”
Get full text

Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models by Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins

“…<b>Methods:</b> We leveraged unique mouse models of IL6 trans-signaling that we developed that recapitulate the production of active sIL6R in a genotypic and quantitative fashion observed in humans. …”
Get full text

Individual mobility prediction by considering current traveling features and historical activity chain by Xiaotong Zhang, Zhipeng Gui, Yuhang Liu, Dehua Peng, Qianxi Lan, Zhangxiao Shen, Huan Chen, Yuhui Zuo, Yao Yao, Huayi Wu, Kai Li, Kun Qin

“…Specifically, (1) we construct current traveling features by extracting real-time moving states, and represent spatiotemporal correlations between traversed road intersections using word embedding; (2) we learn travel intentions as a probability vector for each historical trip, and combine it with spatiotemporal features to construct historical activity chain; (3) we construct an individual mobility prediction model using Long Short-Term Memory (LSTM) network and spatiotemporal scoring mechanism, to capture short-term and long-term dependencies in current trip and historical activity chain, respectively. …”
Get full text

Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastases by Longyu Zhu, Miaomiao Liu, Yuguang Shang, Jingge Cheng, Hongye Zhao, Jun Zhang, Dongxing Shen

“…Notably. pCAFs dominated breast cancer with lymphatic node, bone, and brain metastasis. Furthermore, we identified four malignant epithelial cell subpopulations: G0, G1, G2, and G3. …”
Get full text

Probing aspects of extracellular vesicle associated AAV allows increased vector yield and insight into its transduction and immune-evasive properties by Ming Cheng, Demitri de la Cruz, Adam V. Crain, Paula Espinoza, Carrie Ng, Zachary C. Elmore, Aravind Asokan, Casey A. Maguire

“…We found that the fraction of EV-AAV to conventional AAV in culture media from six AAV serotypes ranged from 0.5% to 12%. …”
Get full text