LPS from P. gingivalis and Hypoxia Increases Oxidative Stress in Periodontal Ligament Fibroblasts and Contributes to Periodontitis by L. Gölz, S. Memmert, B. Rath-Deschner, A. Jäger, T. Appel, G. Baumgarten, W. Götz, S. Frede

“…By quantitative PCR, immunoblot, immunostaining, and a specific ROS assay we determined the amount of NOX4, ROS, and several redox systems. …”
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Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway by Quanxin Ma, Kai Wang, Qinqin Yang, Shun Ping, Weichun Zhao, Qiyang Shou, Weimin Zhou, Minli Chen

“…However, the detailed mechanism underlying this action is not clear. Here, we studied the protective effects of V. axillare against acute lung injury (ALI), and we further explored the pharmacological mechanisms of this action. …”
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Mechanistic insight into human milk extracellular vesicle‐intestinal barrier interactions by Xiang Luo, Yunyue Zhang, Ning Ding, Jana Javorovic, Bahijja Tolulope Raimi‐Abraham, Steven Lynham, Xiaoping Yang, Natalie Shenker, Driton Vllasaliu

“…Additionally, we probed the endocytic mechanisms mediating the EV intestinal uptake. …”
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Scar Healing after Breast Reconstruction: A 5-year Follow-up in Asian Patients by Risa Murakami, Tomohiro Shiraishi, Mikiko Imamura, Akihiko Takushima, Hirotaka Suga

“…In this study, we followed these patients for as long as 5 years postoperatively. …”
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Towards a new spatial representation of bone remodeling by Jason M. Graham, Bruce P. Ayati, Prem S. Ramakrishnan, James A. Martin

“…Based on these observations we employ the use of a level-set function to represent the spatial behavior of remodeling. …”
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The influences of social support expressed from doctors and disclosed from peers on patient decision-making: an analysis from the online health community by Beibei Yang, Wei Lu, Yan Xuan, Chongqi Hao, Xiaojun Huang

“…Based on social support theory, this study aims to reveal the role of informational support and emotional support of doctors in infertile patient decision-making. We select Haodf.com as our data source and we collected information for all new patients of 2,989 doctors. we use Jieba word segmentation tool and TF-IDF algorithm to segment word and find keywords. …”
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APBIO: bioactive profiling of air pollutants through inferred bioactivity signatures and prediction of novel target interactions by Eva Viesi, Ugo Perricone, Patrick Aloy, Rosalba Giugno

“…Scientific contribution We derived ex novo bioactivity signatures for air pollutant molecules to capture their biological behaviour and associations with protein targets. …”
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Compliance with face mask use during the COVID-19 pandemic: a community observational study in Singapore by Sean Wei Xiang Ong, Ying Wei Tang, Kyaw Zaw Linn, Xiao Wei Huan, Allie Lim, Chu Ying Poon, Danielle Hui Ru Tan, Nur Hafizah Binte Hamed, Sharifah Farhanah Binte Syed Husen, Clara Chong Hui Ong, Monica Chan, Shawn Vasoo, Yee-Sin Leo, Oon-Tek Ng, Kalisvar Marimuthu

“…In this observational study, we evaluated the proportion of and factors influencing face mask use and related hygiene practices. …”
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Unveiling polyoxometalate redox properties at the nanoscale by Volatron, Florence, Izzet, Guillaume, Vuillaume, Dominique,  Proust, Anna

“…Additionally, we have demonstrated that we can commute the redox state of a POM layer by exposure to light or by applying an electric field, opening up new opportunities to stimuli-responsive devices.…”
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Modelling the immunopathogenesis of HIV-1 infection and the effect of multidrug therapy: The role of fusion inhibitors in HAART by Gesham Magombedze, Winston Garira, Eddie Mwenje

“…Inthe ongoing search for powerful antiretroviral agents that can affect sustainedcontrol for HIV infection, mathematical models can help in assessing both thecorrelates of protective immunity and the clinical role of a given drug regimen aswell as in understanding the efficacy of drug therapies administered at differentstages of the disease. In this study, we develop a new mathematical model ofthe immuno-pathogenesis of HIV-1 infection, which we use to assess virologicalresponses to both intracellular and extracellular antiretroviral drugs. …”
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Ensemble modeling of the climate-energy nexus for renewable energy generation across multiple US states by Joy Adul, Rohini Kumar, Renee Obringer

“…To determine the optimal model, we test six primary machine learning techniques, as well as an ensemble and a mean-only baseline. …”
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Revealing excitation-inhibition imbalance in Alzheimer’s disease using multiscale neural model inversion of resting-state functional MRI by Guoshi Li, Li-Ming Hsu, Ye Wu, Andrea C. Bozoki, Yen-Yu Ian Shih, Pew-Thian Yap

“…Moreover, we reveal a core AD network comprised mainly of limbic and cingulate regions. …”
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Hybrid Method of Modal Analysis and Laser Shock Scanning to Visualize the Pyroshock Propagation in a Tension Joint by Yong-Woon Kim, Jae-Kyeong Jang, Jung-Ryul Lee, Hak-Seong Gim

“…In addition, we were able to visualize the simulation results in the temporal and spectral domains to compare the pyroshock induced by each pyrodevice. …”
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Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women by Lyla Blake-Gumbs, Zhengyi Chen, Cheryl L. Thompson, Nathan A. Berger, Thomas C. Tucker, Li Li

“…Purpose. We recently reported an association of adult BMI change with colon cancer risk. …”
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Combined delivery of IL12 and an IL18 mutant without IL18BP-binding activity by an adenoviral vector enhances tumor specific immunity by Yan Cheng, Renjie Luo, Erguang Li

“…To minimize adverse effects associated with systemic delivery, we constructed oncolytic adenoviruses (oAd) harboring DR18 and IL12 (oAd.DR18/IL12). …”
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Antecedents and service contact in an observational study of 242 suicide deaths in middle-aged men in England, Scotland and Wales, 2017 by Nav Kapur, Saied Ibrahim, Jane Graney

“…Of the 288 suicide deaths in middle-aged men randomly selected for review, we obtained data about antecedents on 242 (84%). …”
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An Analytical Approach Differentiates Between Individual and Collective Cancer Invasion by Elad Katz, Wim Verleyen, Colin G. Blackmore, Michael Edward, V. Anne Smith, David J. Harrison

“…Previous studies have suggested a range of invasion modes from single cells to large clusters. Here, we use a novel image analysis method to quantify and categorise invasion. …”
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Defining pediatric polypharmacy: A scoping review. by Paul M Bakaki, Alexis Horace, Neal Dawson, Almut Winterstein, Jennifer Waldron, Jennifer Staley, Elia M Pestana Knight, Sharon B Meropol, Rujia Liu, Hannah Johnson, Negar Golchin, James A Feinstein, Shari D Bolen, Lawrence C Kleinman

“…<h4>Objectives</h4>Lack of consensus regarding the semantics and definitions of pediatric polypharmacy challenges researchers and clinicians alike. We conducted a scoping review to describe definitions and terminology of pediatric polypharmacy.…”
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Improvement of Mouth Functional Disability in Systemic Sclerosis Patients over One Year in a Trial of Fat Transplantation versus Adipose-Derived Stromal Cells by Maria Giuseppina Onesti, Paolo Fioramonti, Sara Carella, Pasquale Fino, Cinzia Marchese, Nicolò Scuderi

“…To value mouth opening, we use the Italian version of Mouth Handicap in Systemic Sclerosis Scale (IvMHISS). …”
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Designing and evaluating a patient decision aid for patients with locally advanced or locally recurrent rectal cancer: a national multicentre mixed methods study protocol by Martyn Evans, Hayley Anne Hutchings, Dean Anthony Harris, Deena Harji, Anwen Williams

“…In stage 3, we will assess the feasibility and efficacy of the PtDA. …”
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