The fate of recessive deleterious or overdominant mutations near mating-type loci under partial selfing by Tezenas, Emilie, Giraud, Tatiana, Véber, Amandine, Billiard, Sylvain

“…We obtained analytical and numerical results on the probability and purging time of the new mutation. …”
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Visfatin Induces Inflammation and Insulin Resistance via the NF-κB and STAT3 Signaling Pathways in Hepatocytes by Yu Jung Heo, Sung-E Choi, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim

“…We treated HepG2 cells with both visfatin and either AG490 (a JAK2 inhibitor) or Bay 7082 (an NF-κB inhibitor); we examined proinflammatory cytokine mRNA levels using RT-PCR and insulin signaling using western blotting. …”
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Greenness and averted mortality in 390 cities in China (2000–2020)Research in context by John S. Ji, Zheng Tao, Hui Miao, Tom Cole-Hunter, Xuecao Li, David Rojas-Rueda, Wenjia Cai

“…We tracked changes in greenness in the urban area over time and created a spatial–temporal map. …”
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The Bullseye: HST, Keck/KCWI, and Dragonfly Characterization of a Giant Nine-ringed Galaxy by Imad Pasha, Pieter G. van Dokkum, Qing Liu, William P. Bowman, Steven R. Janssens, Michael A. Keim, Chloe Neufeld, Roberto Abraham

“…We report the discovery and multiwavelength follow-up of LEDA 1313424 (“Bullseye”), a collisional ring galaxy (CRG) with nine readily identified rings—the most so far reported for a CRG. …”
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Sparse Convolution FPGA Accelerator Based on Multi-Bank Hash Selection by Jia Xu, Han Pu, Dong Wang

“…To address this issue, we propose a shared feature map cache design for asynchronous convolution in the accelerators presented in this paper. …”
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Effect of custom-designed transfection buffer on delivery of genome modification components into primary cells of buffalo, cattle, goats, and sheep by Shreya Malhotra, Priyanka Singh, Aseem Tara, Bosco Jose, Devika Gautam, Ram Prasad, Gaurav Tripathi, Sacchinandan De, Naresh L. Selokar

“…In the present study, we examined the effect of the developed buffer on transfection rates and cell viability of primary somatic cells from buffalo, cattle, goats, and sheep. …”
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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…Therapeutic strategies to target MRD may benefit these children. We developed a new chimeric antigen receptor (CAR) targeting glypican-2 (GPC2) and conducted iterative preclinical engineering of the CAR structure to maximize its anti-tumor efficacy before clinical translation.Methods We evaluated different GPC2-CAR constructs by measuring the CAR activity in vitro. …”
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HANNAH ARENDT E A QUESTÃO NEGRA NA DESSEGREGAÇÃO DA ESCOLA DE LITTLE ROCK, 1957 by Danilo Arnaldo Briskievicz, Amauri Carlos Ferreira

“…We briefly recount the struggle of the American social movements linked to the black issue until the Little Rock case. …”
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Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States by Andrea Bilger, Eion Plenn, Frances K. Barg, Katharine A. Rendle, William B. Carter, Andrea Lamour-Harrington, Nora Jones, Beth Peterson, John A. Sauceda, Pablo Tebas, Karam Mounzer, David Metzger, Luis J. Montaner, Karine Dubé

“…We used conventional content analysis to code the data. …”
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Identification and Analysis of Potential Immune-Related Biomarkers in Endometriosis by Yanan He, Jixin Li, Yanjun Qu, Liyuan Sun, Xibo Zhao, Han Wu, Guangmei Zhang

“…Then, DETFs and DEIRGs were further validated in the external datasets of GSE51981 and GSE1230103. Then, we used quantitative real-time polymerase chain reaction (qRT-PCR) to verify the hub genes. …”
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Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1 by Coco Duizer, Moniek Salomons, Merel van Gogh, Sanne Gräve, Freke A. Schaafsma, Maaike J. Stok, Merel Sijbranda, Raghuvandhanan Kumarasamy Sivasamy, Rob J. L. Willems, Marcel R. de Zoete

“…Finally, we show that stimulation of HT-29 cells with F. nucleatum resulted in an ALPK1-dependent upregulation of PD-L1. …”
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Outdoor Massive MIMO Testbed With Directional Beams: Design, Implementation, and Validation by Spandan Bisoyi, Pasupuleti Muralimohan, Harish Kumar Dureppagari, Pavan Reddy Manne, Kiran Kuchi

“…By leveraging this two-dimensional structure, we explore the two dimensions to identify spatially uncorrelated users for pairing. …”
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Candidate SNP markers of social dominance, which may affect the affinity of the TATAbinding protein for human gene promoters by I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko

“…We took them from the database dbSNP, v.147 As a result, we found 45 and 47 candidate SNP markers of dominance and submission, respectively (e. g., rs373600960 and rs747572588). …”
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CDK4/6 inhibitors promote PARP1 degradation and synergize with PARP inhibitors in non-small cell lung cancer by Carlos M Roggero, Anwesha B Ghosh, Anvita Devineni, Shihong Ma, Eliot Blatt, Ganesh V. Raj, Yi Yin

“…Furthermore, we showed that PARP trapping is engaged in this synergy. …”
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Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution. by Nicolas Tessandier, Baptiste Elie, Vanina Boué, Christian Selinger, Massilva Rahmoun, Claire Bernat, Sophie Grasset, Soraya Groc, Anne-Sophie Bedin, Thomas Beneteau, Marine Bonneau, Christelle Graf, Nathalie Jacobs, Tsukushi Kamiya, Marion Kerioui, Julie Lajoie, Imène Melki, Jean-Luc Prétet, Bastien Reyné, Géraldine Schlecht-Louf, Mircea T Sofonea, Olivier Supplisson, Chris Wymant, Vincent Foulongne, Jérémie Guedj, Christophe Hirtz, Marie-Christine Picot, Jacques Reynes, Vincent Tribout, Édouard Tuaillon, Tim Waterboer, Michel Segondy, Ignacio G Bravo, Nathalie Boulle, Carmen Lía Murall, Samuel Alizon

“…We performed 974 on-site visits for a total of 1,619 months of follow-up. …”
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Impact of pathogenic mutations of the GLUT1 glucose transporter on solute carrier dynamics using ComDYN enhanced sampling [version 2; peer review: 2 approved, 1 approved with reser... by K. Anton Feenstra, Akiko Higuchi, Kei Yura, Sanne Abeln, Halima Mouhib

“…Conclusions: Using our approach, we can explain the pathogenicity of the mutation G91D and some of the effects of other known pathogenic mutations, when we observe the configurations of the transmembrane helices, suggesting that their relative position is crucial for the correct functioning of the GLUT1 protein. …”
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Association of Depression with Age at Natural Menopause: A Cross-Sectional Analysis with NHANES Data by An S, Ren S, Ma J, Zhang Y

“…We obtained ANM information from the Reproductive Health questionnaire. …”
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Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function by Gustavo Della-Flora Nunes, Lindsay A. Osso, Johana A. Haynes, Lauren Conant, Michael A. Thornton, Michael E. Stockton, Katherine A. Brassell, Amanda Morris, Yessenia I. Mancha Corchado, John A. Gaynes, Anthony R. Chavez, Michaelanne B. Woerner, Deidre A. MacKenna, Aryan Alavi, Anne Danks, Alon Poleg-Polsky, Rohan Gandhi, Jeffrey A. Vivian, Daniel J. Denman, Ethan G. Hughes

“…We focus on the visual pathway, which is uniquely positioned to provide insights into structure-function relationships during de/remyelination. …”
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Transendothelial migration of the Lyme disease spirochete involves spirochete internalization as an intermediate step through a transcellular pathway that involves Cdc42 and Rac1 by Daiana Alvarez-Olmedo, Claire Kamaliddin, Theodore B. Verhey, May Ho, Rebekah De Vinney, George Chaconas

“…In B. burgdorferi-infected monolayers, we observed ~55% of wild-type spirochetes crossing the monolayer. …”
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Mathematical modelling and phylodynamics for the study of dog rabies dynamics and control: A scoping review. by Maylis Layan, Simon Dellicour, Guy Baele, Simon Cauchemez, Hervé Bourhy

“…We also addressed the methodological limitations of both approaches and the remaining issues related to studying rabies spread and how this could be applied to rabies control.…”
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