Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…After validation of the R47H variant, we predicted the molecular basis and effects on protein stability and ligand-binding affinity of the R62H and D87N variants that remain unknown in current literature. …”
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Genomic analysis of Enterobacter cloacae complex from Southern Thailand reveals insights into multidrug resistance genotypes and genetic diversity by Thunchanok Yaikhan, Kamonnut Singkhamanan, Pawarisa Luenglusontigit, Arnon Chukamnerd, Natakorn Nokchan, Nutwadee Chintakovid, Sarunyou Chusri, Rattanaruji Pomwised, Monwadee Wonglapsuwan, Kittinun Leetanaporn, Surasak Sangkhathat, Komwit Surachat

“…Abstract In this study, we conducted a comprehensive investigation into the Enterobacter cloacae complex (ECC), a group of notorious pathogens responsible for various hospital-acquired infections. …”
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Multimessenger Probes of Supermassive Black Hole Spin Evolution by Angelo Ricarte, Priyamvada Natarajan, Ramesh Narayan, Daniel C. M. Palumbo

“…Using the semianalytic model Serotina , we investigate the cosmic spin evolution of supermassive black holes (SMBHs) incorporating recent results from general-relativistic magnetohydrodynamics simulations of spin-down from relativistic jets. …”
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Prediction and verification of the influence of the rs367781716 SN P on the interaction of ТАТА -binding protein with the promoter of the human АВСА9 gene by O. V. Arkova, I. A. Drachkova, T. V. Arshinova, D. A. Rasskazov, V. V. Suslov, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, L. K. Savinkova

“…We found that the rate of formation (ka) of the TBP/TATA complex for the minor allele is 2.4-fold lower than that for the ancestral allele. …”
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Unveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis by Wei B, Wang S, Li S, Gu Q, Yue Q, Tang Z, Zhang J, Liu W

“…Finally, we selected the best-performing machine learning model to predict genes associated with AS. …”
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Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores by Timing Liu, Alagu Sankareswaran, Gordon Paterson, Genes & Health Research Team, Diane P. Fraser, Sam Hodgson, Qin Qin Huang, Teng Hiang Heng, Meera Ladwa, Nick Thomas, David A. van Heel, Michael N. Weedon, Chittaranjan S. Yajnik, Richard A. Oram, Giriraj R. Chandak, Hilary C. Martin, Sarah Finer

“…Combining these with 307 confirmed T1D cases and 307 controls from India, we calculated ancestry-corrected PRSs for T1D and T2D, with which we estimated the proportion of T1D cases within the ambiguous group at ~ 6%, dropping to ~ 4.5% within the subset who had T2D codes in their health records (and are thus most likely to have been misclassified). …”
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Analyzing Gait Dynamics and Recovery Trajectory in Lower Extremity Fractures Using Linear Mixed Models and Gait Analysis Variables by Mostafa Rezapour, Rachel B. Seymour, Suman Medda, Stephen H. Sims, Madhav A. Karunakar, Nahir Habet, Metin Nafi Gurcan

“…In a prospective study, we examined the recovery trajectory of patients with lower extremity fractures to better understand the healing process in the absence of complications. …”
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A structural analysis of ordered Cs3Sb films grown on single crystal graphene and silicon carbide substrates by C. A. Pennington, M. Gaowei, E. M. Echeverria, K. Evans-Lutterodt, A. Galdi, T. Juffmann, S. Karkare, J. Maxson, S. J. van der Molen, P. Saha, J. Smedley, W. G. Stam, R. M. Tromp

“…Moreover, we identify structural features such as Laue oscillations indicative of highly ordered films. …”
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ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice by Ninon Foussard, Célia Bourguignon, Virginie Grouthier, Caroline Caradu, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault

“…Results We used three different mouse models of diabetes and found that blood flow recovery in HFD STZ mice is altered only from day 14 post-surgery. …”
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Remote Mapping of Bedrock for Future Cosmogenic Nuclide Exposure Dating Studies in Unvisited Areas of Antarctica by Jonathan R. Adams, Philippa J. Mason, Stephen J. Roberts, Dylan H. Rood, John L. Smellie, Keir A. Nichols, John Woodward, Joanne S. Johnson

“…Using this approach, we identified four dominant rock types which we used as a basis for felsic–mafic differentiation: felsic granites and gneisses, and mafic basalts and fragmental hydrovolcanic rocks. …”
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Pulmonary aspiration during pregnancy or immediately postpartum in the UK: A population-based case-control study [version 1; peer review: 2 approved] by Ruth Tunn, Marian Knight, Alison Gooda, Nuala Lucas

“…Methods We conducted a population-based surveillance and case-control study. …”
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Problem of pain in the USA: evaluating the generalisability of high-impact chronic pain models over time using National Health Interview Survey (NHIS) data by Sean Mackey, Titilola Falasinnu, Md Belal Hossain, Mohammad Ehsanul Karim, Kenneth Arnold Weber

“…We used logistic regression with Least Absolute Shrinkage and Selection Operator (LASSO) and random forest techniques. …”
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Cardiovascular risk and mortality in men receiving testosterone replacement therapy for Klinefelter syndrome in Denmark: a retrospective cohort studyResearch in context by Simon Chang, Lars Pedersen, Anne Skakkebæk, Agnethe Berglund, Claus H. Gravholt

“…Methods: We performed a nationwide registry based matched cohort study. …”
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Antihypertensive drug-related problems in Vietnamese ambulatory care by Hoang Hai Nguyen, Le Anh Thu Vu, Minh-Hoang Tran, Hong Tham Pham

“…We analyzed 221 cases (patient age of 64.1 ± 9.0 years, 51.1% being female). …”
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Prevalence of Depression and Sleep Disorders in Patients on Dialysis: A Cross-Sectional Study in Qatar by Fadwa Al-Ali, Mostafa Elshirbeny, Abdullah Hamad, Ahmad Kaddourah, Tarek Ghonimi, Rania Ibrahim, Tarek Fouda

“…We randomly studied 253 patients (62% on HD and 38% on PD). …”
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Positive energy density in topologically charged exponential wormholes and Regge–Wheeler potential by Faizuddin Ahmed, Jaydeep Goswami, Abdelmalek Bouzenada

“…For each model, we evaluate key properties such as the wormhole throat radius, geometric stability, and energy conditions. …”
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Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis by Qi Xu, Xiaoyu Feng, Siyuan Qin, Yu Hong, Rui Cui, Jia Liang, Zhuya Xiao, Yuan Li

“…We then conducted a bibliometric analysis using Bibliometrix in R and VOSviewer to illustrate the prospects, highlights, and trends of TNBC treatment options. …”
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Multidimension Analysis of the Prognostic Value, Immune Regulatory Function, and ceRNA Network of LY6E in Individuals with Colorectal Cancer by Ting Li, Weidong Liu, Chun Wang, Man Wang, Wenjia Hui, Jiajie Lu, Feng Gao

“…Methods. We analyzed the expression pattern of LY6E in various cancers. …”
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Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails by Yiyue Zhang, Hong-Zhe Li, Martin Breed, Zhonghui Tang, Li Cui, Yong-Guan Zhu, Xin Sun

“…Furthermore, we identified elevated biosynthetic gene clusters (BGCs) within these ARG-carrying MAGs, with a third encoding at least one BGC. …”
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A Case of Torsion in an Otherwise-Normal Ovary with a Giant Hematosalpinx Larger than Enlarged Ovary: Utilization of Diagnostic Laparoscopy for the Accurate Diagnosis by Sae Yu, Koji Yamanoi, Masumi Sunada, Sachiko Kitamura, Naoki Horikawa, Yoshitsugu Chigusa, Ken Yamaguchi, Akihito Horie, Junzo Hamanishi, Eiji Kondoh, Masaki Mandai

“…We report a case of torsion in an otherwise-normal ovary with a giant hematosalpinx. …”
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