Heterologous cAd3-Ebola and MVA-EbolaZ vaccines are safe and immunogenic in US and Uganda phase 1/1b trials by Myra Happe, Amelia R. Hofstetter, Jing Wang, Galina V. Yamshchikov, LaSonji A. Holman, Laura Novik, Larisa Strom, Francis Kiweewa, Salim Wakabi, Monica Millard, Colleen F. Kelley, Sarah Kabbani, Srilatha Edupuganti, Allison Beck, Florence Kaltovich, Tamar Murray, Susanna Tsukerman, Derick Carr, Carl Ashman, Daphne A. Stanley, Aurélie Ploquin, Robert T. Bailer, Richard Schwartz, Fatim Cham, Allan Tindikahwa, Zonghui Hu, Ingelise J. Gordon, Nadine Rouphael, Katherine V. Houser, Emily E. Coates, Barney S. Graham, Richard A. Koup, John R. Mascola, Nancy J. Sullivan, Merlin L. Robb, Julie A. Ake, Kirsten E. Lyke, Mark J. Mulligan, Julie E. Ledgerwood, Hannah Kibuuka, the VRC 208 and RV 422 study team

“…Abstract Ebola virus disease (EVD) is a filoviral infection caused by virus species of the Ebolavirus genus including Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV). We investigated the safety and immunogenicity of a heterologous prime-boost regimen involving a chimpanzee adenovirus 3 vectored Ebola vaccine [either monovalent (cAd3-EBOZ) or bivalent (cAd3-EBO)] prime followed by a recombinant modified vaccinia virus Ankara EBOV vaccine (MVA-EbolaZ) boost in two phase 1/1b randomized open-label clinical trials in healthy adults in the United States (US) and Uganda (UG). …”
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A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings by Steven P. Treon, Camille N. Kotton, David J. Park, Giorgia Moranzoni, Camilla K. Lemvigh, Joseph C. Gathe, Tilly A. Varughese, Christopher F. Barnett, Johnny M. Belenchia, Nina M. Clark, Charles M. Farber, Muhammad Bilal Abid, Gulrayz Ahmed, Christopher J. Patterson, Maria L. Guerrera, Jacob D. Soumerai, Vipheaviny A. Chea, Isabel P. Carulli, Jackson Southard, Shuqiang Li, Catherine J. Wu, Kenneth J. Livak, Eric Holmgren, Pil Kim, Carrie Shi, Holly Lin, Vanitha Ramakrishnan, Ying Ou, Scott Olszewski, Lars Rønn Olsen, Derin B. Keskin, Derin B. Keskin, Zachary R. Hunter, Christopher Tankersley, Todd Zimmerman, Binod Dhakal

“…Bruton tyrosine kinase (BTK) is involved in innate immunity, and BTK inhibitors block cytokine release. We assessed the next-generation BTK inhibitor zanubrutinib in SARS-CoV-2–infected patients with respiratory distress.MethodCohort 1 had a prospective, randomized, double-blind, placebo-controlled design; cohort 2 had a single-arm design. …”
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Anatomy In The Undergraduate Medical Curriculum; Blending The Old And New by Ayesha Yousaf

“…[iv] The specialty that benefits the most from this subject in clinical practice is surgery while the rest of the specialties rely on anatomy while during physical exams, symptom interpretation, patient education and interpretation of radiological images.[v]  If we talk specifically about the undergraduate medical curriculum, anatomy is a vital component of the basic sciences taught during the first one or two years of medical or dental school. …”
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Supercharged nanoadhesive through co-assembly of recombinant protein and tetrahedral DNA for corneal transplantation by Jing Zhao, Feng Zhang, Zhe Zhang, Zhenhua Li, Yanze Yu, Bingqing Sun, Binghong Yu, Yong Ma, Xuan Ding, Liyin Wang, Lifei Zheng, Wenguo Cui, Xingtao Zhou

“…A major challenge is achieving rapid adhesion without introducing polymer barriers or chemical toxicity from cross-linking. To address this, we developed a novel cornea-specific nanoadhesive constructed through protein-DNA co-assembly and applied it to corneal transplantation. …”
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Karel Janeček − a leading figure in Czech Music Theory and Pedagogy: his theoretical writings from the 1930s and 1940s by Miloš Hons

“…At this time, he also devoted himself to the analysis of Bedřich Smetana’s music. In these analyses we find the beginnings of his completely original concept of musical tectonics. …”
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Le sanctuaire romain du Vigneau à Pussigny (Indre-et-Loire) : un lieu de mémoire, de vie et d’accueil by Arnaud Coutelas, Sébastien Lepetz

“…In front of the double portico, a pit (FS1252) contained a large slab, likely from a megalithic building and hollowed out of a cupula, which we have interpreted as a possible altar buried on the ground, in the image of certain Chthonian cults.Although the data is incomplete for the eastern portion of the sanctuary, all evidence points to it facing west: interruption in the gallery walls, presence of the double portico, absence of structures in the axis of the cella, and installation of the slab in the FS1252 pit. …”
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Identification of a novel SPTB gene splicing mutation in hereditary spherocytosis: a case report and diagnostic insights by Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Xuemei Li, Li Wang, Li Wang, Li Wang, Li Wang, Qian Li, Qian Li, Qian Li, Qian Li, Qianqian Liu, Qianqian Liu, Qianqian Liu, Qianqian Liu, Chengyin He, Li Zhang, Li Zhang, Li Zhang, Li Zhang, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Junling Tang, Junling Tang, Junling Tang, Junling Tang

“…Mutations in key genes, including SPTB, ANK1, SLC4A1, SPTA1, and EPB42, are commonly implicated in HS.Case PresentationWe report the case of a 22-year-old female presenting with anemia, jaundice, and a family history of splenectomy. …”
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Bug off or bug out: mapping flight secrets of Triatoma garciabesi (Hemiptera: Reduviidae) through climate, geography, and greenery by Thaiane Verly, Thaiane Verly, Federico G. Fiad, Ana Laura Carbajal-de-la-Fuente, Ana Laura Carbajal-de-la-Fuente, Sebastián Pita, Romina V. Piccinali, Romina V. Piccinali, Patricia A. Lobbia, Paz Sánchez-Casaccia, Paz Sánchez-Casaccia, Paz Sánchez-Casaccia, Antonieta Rojas de Arias, María José Cavallo, Gisel V. Gigena, Claudia S. Rodríguez, María C. Vega-Gómez, Miriam Rolón, Julieta Nattero, Julieta Nattero, Julieta Nattero

“…These lineages occur across the species distribution range and coincide with different ecological regions. Here, we aim to examine how phenotypic variation in flight-related traits is structured, determine the association between these traits and geographic distance, and identify the climatic, geographic, and/or vegetation cover variables that best explain the morphometric variation in flight-related traits.MethodsA total of 198 males of T. garciabesi from 24 populations in Argentina and Paraguay were included in this study, covering almost the entire T. garciabesi distribution range. …”
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…The biological evaluation of compound 8 was performed by transwell, flow cytometry, laser scanning confocal microscopy, Western blot, CTESA and immunohistochemistry. Results: Here, we employed molecular hybridization methods to construct a series of quinazoline-2-indolinone derivatives as PI3Kα selective inhibitors. …”
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Characterisation of pregnancy-induced alterations in apolipoproteins and their associations with maternal metabolic risk factors and offspring birth outcomes: a preconception and l... by Li Chen, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry Kok Yen Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D. Gluckman, Johan G. Eriksson, Markus R. Wenk, Sartaj Ahmad Mir

“…Higher maternal ApoC-I and ApoC-III concentrations at preconception were significantly associated with shorter gestational age of the offspring. Interpretation: We describe the longitudinal landscape of maternal circulating apolipoproteins from preconception to postpartum and their associations with maternal metabolic risk factors and offspring birth outcomes. …”
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A Conversation with Toyin Falola on the future of Yoruba Language by Oyesina Fadare

“…Wọn gbagb ́ ọ pe ti ọmọ bá ti mọ e ̀dè Gẹẹ̀ si, o ́ ́ ti kogo ja; ko ́ ̀ sí ipò ti ́ kò le ̀ dé ni aye ́ . Ile ́ í we to n ko ̀ ọmọ ni ede Gẹẹ̀ si ni ́ ̀kan ni won ma n fẹ ra ́ n a ́ ẁ ọn ọmọ wọn lo. …”
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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

“…Each new or modified checklist item is accompanied by a detailed description, its rationale with supportive evidence, and examples of good reporting curated from EPDF trial protocols covering a range of therapeutic areas and interventions. We recommend utilising this paper alongside the SPIRIT statement, and any relevant extensions, to enhance the development and review of EPDF trial protocols.By facilitating adoption of the SPIRIT-DEFINE statement for EPDF trials, this E&E document can promote enhancement of methodological rigour, patient safety, transparency, and facilitate the generation of high-quality, reproducible evidence that will strengthen the foundation of early phase research and ultimately improve patient outcomes. …”
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A randomized trial of blended first aid education for the public

“…The effectiveness of learning was measured through pre- and post-learning evaluation forms using 0-10 Likert scales and questions on first aid knowledge for both face-to-face and blended groups, and additionally, post-online (blended learners only).Results: We found comparable results between face-to-face and blended learning for improving learner knowledge of first aid. …”
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Steady-state mixing state of black carbon aerosols from a particle-resolved model by Z. Zhang, Z. Zhang, J. Wang, J. Wang, J. Wang, J. Wang, N. Riemer, C. Liu, C. Liu, Y. Jin, Y. Jin, Z. Tian, Z. Tian, J. Cai, J. Cai, Y. Cheng, Y. Cheng, G. Chen, G. Chen, B. Wang, B. Wang, S. Wang, A. Ding, A. Ding

“…However, due to computational constraints, the mixing state is challenging to accurately represent in large-scale models. In this study, we employ a particle-resolved model to simulate the evolution of BC mixing state based on field observation. …”
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Clinical, genomic, and histopathologic diversity in cerebral cavernous malformations by Jian Ren, Daochao Wang, Leiming Wang, Chendan Jiang, An Tian, Ziwei Cui, Yeqing Ren, Lisong Bian, Gao Zeng, Guolu Meng, Yongzhi Shan, Jiantao Liang, Xinru Xiao, Jie Tang, Yukui Wei, Chuan He, Liyong Sun, Yongjie Ma, Jiaxing Yu, Guilin Li, Ming Ye, Peng Hu, Jingwei Li, Ye Li, Lijian Niu, Qianwen Li, Feng Ling, Jan-Karl Burkhardt, Hongqi Zhang, Tao Hong

“…This study aimed to clarify the clinical, genetic, and pathological features of CCMs using a multicenter cohort across three Chinese centers. We analyzed 290 surgical specimens from symptomatic CCM patients, utilizing whole-exome sequencing, droplet digital PCR, and targeted panel sequencing, alongside immunohistology to examine genotypic and phenotypic differences. …”
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Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding by Yinghao Li, Dongling Xiao, Weixi Yan, Meilin Jiang, Ju Tan, Zhongliang Qin, Jingting Zhou, Yue Sun, Mingcan Yang, Guanyuan Yang, Yawei Gu, Yong Liu, Chuhong Zhu

“…Here, inspired by the principle of chromatin assembly, we present a tissue-conformable tough matrix for robust sealing of severe bleeding. …”
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Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study by Sandra Dos Santos, Anne-Sophie Valentin, Mathilde Farizon, Manon Charbonneau, Mohamed Riadh Boukhris, Roselyne Brat, Fabiana Cazzorla, Jennifer Chauvel, Fabrice Cneude, Pauline Coutable, Maryvonne Demasure, Emeline Duminil, Vénonique Faraut-Derouin, Maud Gits Muselli, Valérie Gorin, Rosemary Goujon, Melinda Guillouche-Puissant, Nadine Hacinlioglu, Caroline Landelle, Annick Lefebvre, Elise Leroy-Terquem, Aurore Martinet, Camille Massebeuf, Nadia Mazille Orfanos, Guillaume Menard, Laure Menvielle, Vanessa Monin, Virginie Morange, Juliana Patkai, Nathalie Perrault, Emilie Prat, Nathalie van der Mee-Marquet

“…The incidence of S. haemolyticus-associated CLABSIs in French neonates is increasing, but the mechanisms underlying this trend remain unclear.MethodsWe examined microorganisms in 108 central line infusion sets used in preterm infants across 12 neonatal intensive care units, and collected at the time of removal.ResultsThe infusion sets varied widely in type (28 types; 1-6 parts) and length (10-180 cm, mean 52.9 cm). …”
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Association of exposure to second-hand smoke during childhood with blood DNA methylation by Marta Cosin-Tomas, Thanh Hoang, Cancan Qi, Giulietta S. Monasso, Ryan Langdon, Simon Kebede Merid, Lucinda Calas, Paula de Prado-Bert, Rebecca Richmond, Vincent VW Jaddoe, Liesbeth Duijts, John Wright, Isabella Annesi-Maesano, Regina Grazuleviciene, Marianna Karachaliou, Gerard H. Koppelman, Erik Melén, Olena Gruzieva, Martine Vrijheid, Paul Yousefi, Janine F. Felix, Stephanie J. London, Mariona Bustamante

“…While numerous studies have linked maternal smoking during pregnancy (MSDP) to widespread differences in child blood DNA methylation (DNAm), research specifically examining postnatal SHS exposure remains sparse. To address this gap, we conducted epigenome-wide meta-analyses to identify associations of postnatal SHS and child blood DNAm. …”
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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

“…For each new or modified checklist item, we provide a detailed description and its rationale with supporting evidence, and present examples from EPDF trial reports published in peer-reviewed scientific journals. …”
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Coronary plaque characteristics quantified by artificial intelligence-enabled plaque analysis: Insights from a multi-ethnic asymptomatic US population by Guadalupe Flores Tomasino, Caroline Park, Kajetan Grodecki, Jolien Geers, Donghee Han, Andrew Lin, Keiichiro Kuronuma, Nipun Manral, Emily Xing, Heidi Gransar, Sebastien Cadet, Alan Rozanski, Piotr J. Slomka, Michelle Williams, Daniel S. Berman, Damini Dey

“…Background: Ethnic differences in coronary atherosclerosis remain to be fully elucidated. We aimed to assess quantitative plaque characteristics from coronary CT Angiography (CCTA) in relation to ethnicity and cardiovascular risk factors in a multi-ethnic asymptomatic US population. …”
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