Assessment framework to predict sensitivity of marine calcifiers to ocean alkalinity enhancement – identification of biological thresholds and importance of precautionary principle... by N. Bednaršek, H. van de Mortel, G. Pelletier, G. Pelletier, M. García-Reyes, R. A. Feely, A. G. Dickson, A. G. Dickson

“…For the negatively impacted species, biological thresholds, which were based on 50 % reduction of calcification rate, were in the range of 50 to 500 <span class="inline-formula">µ</span>mol kg<span class="inline-formula">⁻¹</span> NaOH addition. Thus, we emphasize the importance of including much lower additions of alkalinity in experimental trials to realistically evaluate in situ biological responses. …”
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Fálétí’s Philosophical Sensibility by Adeshina Afolayan

“…While Fágúnwà could not resist the influence of Christianity, and especially the allegorical motif of the journey in which humans encounter spiritual challenges (which John Bunyan’s Pilgrim Progress made popular), Fálétí is fundamentally a cultural connoisseur; a writer with a most intimate and dynamic understanding of the Yorùbá condition, especially in its conjunction with the political and sociocultural contexts of contemporary Nigeria. And we have Ọlátúndé Ọlátúnjí to thank for the deep exploration and interrogation of the fundamental poetic and literary nuances that Fálétí has left for us. …”
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WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis by Carolyn B. McNabb, Ian D. Driver, Vanessa Hyde, Garin Hughes, Hannah L. Chandler, Hannah Thomas, Christopher Allen, Eirini Messaritaki, Carl J. Hodgetts, Craig Hedge, Maria Engel, Sophie F. Standen, Emma L. Morgan, Elena Stylianopoulou, Svetla Manolova, Lucie Reed, Matthew Ploszajski, Mark Drakesmith, Michael Germuska, Alexander D. Shaw, Lars Mueller, Holly Rossiter, Christopher W. Davies-Jenkins, Tom Lancaster, C. John Evans, David Owen, Gavin Perry, Slawomir Kusmia, Emily Lambe, Adam M. Partridge, Allison Cooper, Peter Hobden, Hanzhang Lu, Kim S. Graham, Andrew D. Lawrence, Richard G. Wise, James T. R. Walters, Petroc Sumner, Krish D. Singh, Derek K. Jones

“…In addition to raw data, we provide brain-extracted T1-weighted images, and quality reports for diffusion, T1- and T2-weighted structural data, and blood-oxygen level dependent functional tasks. …”
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Neuroimaging features for cognitive fatigue and its recovery with VR intervention: An EEG microstates analysis by Jia-Cheng Han, Chi Zhang, Yan-Dong Cai, Yu-Ting Li, Yu-Xuan Shang, Zhu-Hong Chen, Guan Yang, Jia-Jie Song, Dan Su, Ke Bai, Jing-Ting Sun, Yu Liu, Na Liu, Ya Duan, Wen Wang

“…Natural scene exposure is a promising intervention for relieving cognitive fatigue, but the efficacy of virtual reality (VR) simulated natural scene exposure is unclear. We aimed to investigate the effect of VR natural scene on cognitive fatigue and further explored its underlying neurophysiological alterations with electroencephalogram (EEG) microstates analysis. …”
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Inequity and vulnerability in Latin American Indigenous and non-Indigenous populations with rheumatic diseases: a syndemic approach by Bernardo A Pons-Estel, Rosana Quintana, Ruben Burgos-Vargas, Everardo Álvarez-Hernández, John Londono, Ana M Santos, Adalberto Loyola-Sanchez, Mario H Cardiel, Maria Victoria Goycochea-Robles, Ingris Peláez-Ballestas, Ysabel Granados, Flor Julián-Santiago, Celenia Rosillo, Jose Alvarez-Nemegyei, Natalia Santana, Mario Goñi, Ligia Cedeño, Romina Nieto, Silvana Conti, María Elena Calvo, Eugenia Picco, Rosa Chacón, Jorge Delgado, Alfonso Gastelum Strozzi, Sergio Guevara-Pacheco, Vicente Juarez, Mario Alberto Garza-Elizondo, Juan Camilo Rueda, Amaranta Manrique de Lara, Nora Mathern, Marisa Jorfen, Alvaro Sanabria, Cristina Prigione, Adriana MR Silvestre, Vanina García, Julio Miljevic, Daniel Dhair, Matias Laithe, Fadua Midauar, Maria Celeste Martin, Maria Cecilia Barrios, María Elena Crespo, Mariana Aciar, Emilio Buschiazzo, Natalia L Cucchiaro, Mario Ruiz, José Adolfo Sánchez, Rodolfo Franco, Natalia Estrella, Silvia Jorge, Cinthya Retamozo, Sofia Fernandez, Martina Fay, Cecilia Camacho, Graciela Gomez, Jazmin Petrelli, Andrés Honeri, Viviana Arenas Solórzano, Ana Bensi, Marcela Valdata, Rodrigo Giraldo, Ignacio Angarita, Jesus G Ballesteros, Sofia Arias, Andres Vásquez, Lina Valero, Ani Cortes, Estafania Castañeda, Elias Forero, Astrid Feicán, Fernando Vintimilla, Jaime Vintimilla, Veronica Ochoa, Angelita Lliguisaca, Holger Dután, Jacqueline Rodríguez-Amado, Julio Casasola-Vargas, Conrado Garcia, Imelda García-Olivera, César Pacheco, Susana Aidee Gonzalez-Chávez, Hazel Garcia Morales, Arturo Velasco Gutierrez, JF Moctezuma-Rios, Eduardo Navarro-Zarza, Angelia Angulo, Rosana Flores, Janeth Galván Padrón, B Lorena Pérez, Janett Riega, Brenda Vaquez Fuentes, Miguel A Villarreal, Cassandra Skinner Taylor, Sara Marín, Dionicio Galarza Delgado, Diana Flores Alvarado, Jorge A Esquivel Varerio, Luz Helena Sanín, Marco Maradiaga Ceceño, Jorge Zamudio Lerm, Ivan Stekman, Yanira Martínez, Gloris Sánchez

“…Twenty clusters were identified in the Indigenous population and 17 in the non-Indigenous population.Results The variables associated with RMD among Indigenous populations were rurality, public health system, high joint biomechanical stress, greater pain, disability and alcoholism; and among non-Indigenous people they were being a woman, urban origin, older age, private health system, joint biomechanical stress, greater pain and disability. We identified different health inequities among patients with RMD (ie, lower educational attainment, more comorbidities), associated with factors such as Indigenous self-identification and rural residence.Conclusions A syndemic approach enables us to identify health inequities in RMD, as shown by higher prevalence of comorbidities, disability and socioeconomic factors like lower educational attainment. …”
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Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation studyResearch in context by Shruti Agrawal, Claudia Smith, Stefan Y. Bogli, Michal M. Placek, Manuel Cabeleira, Deborah White, Esther Daubney, Adam Young, Erta Beqiri, Riaz Kayani, Diarmuid O'Donnell, Nazima Pathan, Suzanna Watson, Anna Maw, Matthew Ganrett, Hari Krishan Kanthimathianathan, Harish Bangalore, Santosh Sundararajan, Gayathri Subramanian, Dusan Raffaj, Avishay Sarfatti, Simona Lampareillo, Anton Mayer, Oliver Ross, Marek Czosnyka, Peter J. Hutchinson, Peter Smielewski, Carly Tooke, Caroline Payne, Holly Belfield, Amisha Mistry, Collette Spencer, Claire Jennings, Lara Bunni, Laura Anderson, Emily Morgan, Melanie James, Rebecca Beckley, Tahnima Khatun, Hafiza Khatun, Olivia Nugent, Richard Aldridge, Ruth Morgan, Julie Morcombe, Martin Quinton, Catherine Postlethwaite, Jenny Pond, Jessica Cutler, Caitlin Oxford

“…Interpretation: With STARSHIP, we validate the outcome association of CA derangements as assessed by PRx in pTBI in the first prospective observational multicentre study. …”
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IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3 by Huiyue Dong, Huiyue Dong, Ling Zhu, Ling Zhu, Jingjing Sun, Jingjing Sun, Qiuyan Chen, Qiuyan Chen, Pengyang Liu, Pengyang Liu, Wei Zhang, Huajing Zeng, Rong Lin, Rong Lin, Zongyang Yu, Zongyang Yu, Jun Lu, Jun Lu, Jun Lu, Jun Lu

“…HT1080 cells, three-dimensional (3D) spheroids, and the xenograft mouse models were treated with IFNβ, RSL3, or IFNβ combination with RSL3 to analyze whether IFNβ enhances RSL3-induced ferroptosis.ResultsHere, we found that IFNβ could promote intracellular Fe2+ and lipid peroxidation levels, and decrease GSH levels in tumor cells. …”
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Sleeve gastrectomy reveals the plasticity of the human gastric epithelium by Amit Elad, Botros Moalem, Dana Sender, Aya Bardugo, Ki-Suk Kim, Yhara Arad, Haya Benhayon, Ayelet Gal Etzyoni, Nehemia Greenstein, Aviv Halfon, Sarah Knapp, Michelle Malis, Bailey Peck, Itia Samuel, Amram Kupietzky, Saleh Daher, Esther Forkosh, David Hakimian, Tiberiu Hershcovici, Nadav Ilani, Lior Katz, Moshe Rottenstreich, Elez Vainer, Yuval Ishay, Eitan Zlotnick, Abed Nasereddin, Idid Shiff, Ariel Benson, Ronit Grinbaum, Siddhartha Mishra, Shlomi Kotler, Linda C. Samuelson, Darleen A. Sandoval, Rachel Ben-Haroush Schyr, Danny Ben-Zvi

“…Using histology, and single-cell RNA sequencing of the gastric epithelium in 12 women, we observed that SG is associated with an increase in a sub-population of acid-secreting parietal cells that overexpress respiratory enzymes and an increase in histamine-secreting enterochromaffin-like cells (ECLs). …”
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STAGER checklist: Standardized testing and assessment guidelines for evaluating generative artificial intelligence reliability by Jinghong Chen, Lingxuan Zhu, Weiming Mou, Anqi Lin, Dongqiang Zeng, Chang Qi, Zaoqu Liu, Aimin Jiang, Bufu Tang, Wenjie Shi, Ulf D. Kahlert, Jianguo Zhou, Shipeng Guo, Xiaofan Lu, Xu Sun, Trunghieu Ngo, Zhongji Pu, Baolei Jia, Che Ok Jeon, Yongbin He, Haiyang Wu, Shuqin Gu, Wisit Cheungpasitporn, Haojie Huang, Weipu Mao, Shixiang Wang, Xin Chen, Loïc Cabannes, Gerald Sng Gui Ren, Iain S. Whitaker, Stephen Ali, Quan Cheng, Kai Miao, Shuofeng Yuan, Peng Luo

“…Through a rigorous literature review utilizing the Web of Sciences, Cochrane Library, PubMed, and Google Scholar, we focused on research testing generative AI capabilities in medicine. …”
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Comparison of autism domains across thirty rare variant genotypesResearch in context by Nabila M.H. Ali, Samuel J.R.A. Chawner, Leila Kushan-Wells, Carrie E. Bearden, Jennifer Gladys Mulle, Rebecca M. Pollak, Raquel E. Gur, Wendy K. Chung, Michael J. Owen, Marianne B.M. van den Bree, Harriet Housby, Irene Lee, David Skuse, Jeanne Wolstencroft, William Mandy, Spiros Denaxas, Kate Baker, Lucy Raymond, Marianne van den Bree, Samuel Chawner, Jeremy Hall, Peter Holmans, Josh Hope-Bell, Danielle Le Roux, Sally Morrin, Michael Owen, Shreeya Sivakumar

“…SJRAC is funded by a Medical Research Foundation Fellowship (MRF-058-0015-F-CHAW). We would also like to acknowledge NIH 1R01MH110701-01A1 (PI Mulle), U01MH119736 (CEB), R21MH116473 (CEB), and R01MH085953 (CEB), and the Simons Foundation (SFARI Explorer Award to CEB).…”
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Single Dose of Attenuated Vaccinia Viruses Expressing H5 Hemagglutinin Affords Rapid and Long-Term Protection Against Lethal Infection with Highly Pathogenic Avian Influenza A H5N1... by Fumihiko Yasui, Keisuke Munekata, Tomoko Fujiyuki, Takeshi Kuraishi, Kenzaburo Yamaji, Tomoko Honda, Sumiko Gomi, Misako Yoneda, Takahiro Sanada, Koji Ishii, Yoshihiro Sakoda, Hiroshi Kida, Shosaku Hattori, Chieko Kai, Michinori Kohara

“…Methods: To address this aspect, we generated recombinant influenza vaccines against H5-subtype viruses using two different strains of highly attenuated vaccinia virus (VACV) vectors. …”
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The high-resolution global shipping emission inventory by the Shipping Emission Inventory Model (SEIM) by W. Yi, X. Wang, T. He, H. Liu, Z. Luo, Z. Lv, K. He

“…<p>The high-resolution ship emission inventory serves as a crucial dataset for various disciplines including atmospheric science, marine science, and environmental management. Here, we present a global high-spatiotemporal-resolution ship emission inventory at a resolution of 0.1° <span class="inline-formula">×</span> 0.1° for the years 2013 and 2016–2021, generated by the state-of-the-art Shipping Emission Inventory Model (SEIMv2.2). …”
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Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery by Kaichao Hu, Junrui Ye, Pinglong Fan, Ruifang Zheng, Shasha Wang, Ye Peng, Yuan Ruan, Xu Yan, Zhao Zhang, Shifeng Chu, Naihong Chen

“…Ginsenoside Rg1, derived from Panax ginseng, exhibits neuroprotective properties and regulates cellular metabolism in vitro but its therapeutic application is limited by poor brain penetration. Here, we present a targeted delivery system utilizing neutrophil-like cell membrane vesicles (NCM), prepared via nitrogen cavitation, to enhance Rg1 delivery to the brain. …”
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The responses of vegetation water use efficiency to biomass density and CO2 balance in dryland of Central Asia during 21st century by Alphonse Kayiranga, Xi Chen, Xuexi Ma, Dative Ingabire, Tie Liu, Yaoming Li, Emeka Edwin Igboeli, Eldiiar Duulatov, Hubert Hirwa, Clement Nzabanita, Ping Hu

“…However, the variations of plant CO2 in response to water use efficiency (WUE) across temperate dryland ecosystems remains inadequately understood. In this study, we examined the patterns and magnitude of WUE effects on desert vegetation aboveground biomass (AGB) and carbon stocks (C. stocks) and related fluxes by utilizing multiple streams of state-of-the-art multispectral satellite imagery and polynomial model across the temperate drylands of Central Asia (CA) from 2000 to 2023. …”
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Modulation effects of folic acid and vitamin D on the relationships between prenatal cumulative phthalate exposure and preschoolers’ emotional and behavioral problems by Li-wen Chen, Xin Chen, Chen Han, Bei-bei Zhu, Yi-fan Wang, Yuan Liu, Min-min Jiang, Ya-fei Wang, Chun-han Shan, Hua-yan Mo, Kun Huang, Hui Gao, Fang-biao Tao

“…To assess children’s behavior, we used the Strengths and Difficulties Questionnaire (SDQ). …”
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Aberrant functional connectome gradient and its neurotransmitter basis in Parkinson's disease by Tao Guo, Cheng Zhou, Jiaqi Wen, Jingjing Wu, Yaping Yan, Jianmei Qin, Min Xuan, Haoting Wu, Chenqing Wu, Jingwen Chen, Sijia Tan, Xiaojie Duanmu, Baorong Zhang, Xiaojun Xu, Minming Zhang, Xiaojun Guan

“…By constructing functional network and calculating its gradient in 134 PD patients and 172 normal controls, we compared functional connectivity gradients between groups and performed spearman correlation to explore the association between neurotransmitter expression and functional network gradient-based alternations in PD. …”
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Characterisation of <i>Staphylococcus aureus</i> Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes <i>lukP/Q</i> by Stefan Monecke, Sindy Burgold-Voigt, Andrea T. Feßler, Martina Krapf, Igor Loncaric, Elisabeth M. Liebler-Tenorio, Sascha D. Braun, Celia Diezel, Elke Müller, Martin Reinicke, Annett Reissig, Adriana Cabal Rosel, Werner Ruppitsch, Helmut Hotzel, Dennis Hanke, Christiane Cuny, Wolfgang Witte, Stefan Schwarz, Ralf Ehricht

“…The genes <i>lukP/Q</i> have been described from equine <i>S. aureus</i> isolates. We examined the genomes, including the <i>lukP/Q</i> prophages, of <i>S. aureus</i> strains belonging to clonal complexes CC1, CC350, CC816, and CC8115. …”
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NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression by Wenchao Xu, Jianzhou Liu, Qiaofei Liu, Jia Xu, Li Zhou, Zhiyong Liang, Haoran Huang, Bowen Huang, Gary Guishan Xiao, Junchao Guo

“…Here, combined single-cell sequencing with spatial transcriptomics results revealed that liver metastases exhibit more aggressive transcriptional characteristics and higher levels of immunosuppression compared with the primary tumor. We identified neutrophils_S100A12 (S100 calcium binding protein A12) cells as the pivotal pro-metastatic cluster, specifically distributed at the invasive front of the metastatic lesions. …”
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Superior Mesenteric Artery Syndrome: Clinical, Endoscopic, and Radiological Findings by Emanuele Sinagra, Dario Raimondo, Domenico Albano, Valentina Guarnotta, Melania Blasco, Sergio Testai, Marta Marasà, Vincenzo Mastrella, Valerio Alaimo, Valentina Bova, Giovanni Albano, Dario Sorrentino, Giovanni Tomasello, Francesco Cappello, Angelo Leone, Francesca Rossi, Massimo Galia, Roberto Lagalla, Federico Midiri, Gaetano Cristian Morreale, Georgios Amvrosiadis, Guido Martorana, Marcello Giuseppe Spampinato, Vittorio Virgilio, Massimo Midiri

“…After, a gastroenterologist and a nutritionist personalized the therapy. Furthermore, we compared the demographical, clinical, endoscopic, and radiological parameters of these cases with a control group consisting of 10 cases out of 2380 EGDS of initially suspected (but not radiologically confirmed) SMA over a follow-up 2-year period (2015-2016). …”
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Psychological discomfort in carriers and non-carriers of the Huntington disease mutation and its relationship with disease burden by Y. Rodríguez-Agudelo, M. Chávez-Oliveros, A. Ochoa-Morales, L. Martínez-Ruano, A. Camacho-Molina, F. Paz-Rodríguez

“…Conclusions: In general, we found that the PEH group obtained a higher score in the dimensions evaluated with the SCL-90-R, showing a relationship with the burden and differences due to the proximity of the disease. …”
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