Molecular Phylogenetics and Estimation of Evolutionary Divergence and Biogeography of the Family Cordycipitaceae (Ascomycota, Hypocreales) by Huili Pu, Jiao Yang, Nemat O. Keyhani, Lixia Yang, Minhai Zheng, Chenghao Qiu, Yuchen Mao, Junya Shang, Yongsheng Lin, Chengjie Xiong, Longbing Lin, Pengyu Lai, Yanbin Huang, Xin Yuan, Huiling Liang, Longfei Fan, Xiaoli Ma, Chunjin Qiu, Junzhi Qiu

“…Based on Bayesian evolutionary analysis of five genomic loci(the small subunit of ribosomal RNA (SSU) gene, the large subunit of ribosomal RNA (LSU) gene, the translation elongation factor 1-α (<i>tef1-α</i>) gene, the largest subunit of RNA polymerase II (<i>rpb1</i>), and the second largest subunit of RNA polymerase II (<i>rpb2</i>), we inferred the divergence times for members of the Cordycipitaceae, improving the internal phylogeny of this fungal family. …”
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Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study by Hellen Livia Drumond Marra, Martin Luiz Myczkowski, Cláudia Maia Memória, Débora Arnaut, Philip Leite Ribeiro, Carlos Gustavo Sardinha Mansur, Rodrigo Lancelote Alberto, Bianca Boura Bellini, Adriano Alves Fernandes da Silva, Gabriel Tortella, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Orestes Vicente Forlenza, Marco Antonio Marcolin

“…This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). …”
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Risankizumab Versus Secukinumab: A Real-World Efficacy and Cost per Responder Comparison in Patients With Psoriasis in Italy by Federico Pirro, Giacomo Caldarola, Nicoletta Bernardini, Maria Grazia Celeste, Annunziata Dattola, Eleonora De Luca, Marco Galluzzo, Domenico Giordano, Chiara Izzi, Giulia Maretti, Lorenzo Marcelli, Roberto Ravasio, Antonio Giovanni Richetta, Nevena Skroza, Marina Talamonti, Arianna Zangrilli, Luca Bianchi, Giovanni Pellacani, Severino Persechino, Concetta Potenza, Ketty Peris, Clara De Simone

“… Introduction: Risankizumab and secukinumab are effective treatment options for patients with moderate to severe psoriasis. Objective: We sought to estimate the efficacy and the cost per responder of risankizumab and secukinumab by comparing these two drugs in a real-life setting. …”
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Effectiveness of acupuncture on glycolipid metabolism in patients with coronary heart disease: A systematic review and meta-analysis by Yuxin Sun, Yu Liu, Jian Xiong, Xiao Li, Ying Wei, Qianhua Zheng, Xiang Li, Wenchuan Qi, Fanrong Liang

“…To assess the effects of acupuncture on glycolipid metabolism in patients with coronary heart disease, we conducted a systematic review and meta-analysis. …”
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Understanding the potential impact of trimester-specific maternal immune activation due to SARS-CoV-2 on early human neurodevelopment and the role of cytokine balance by Alexandre Díaz-Pons, Sergio Castaño-Castaño, Víctor Ortiz-García de la Foz, Ángel Yorca-Ruiz, Carlos Martínez-Asensi, Eva Munarriz-Cuezva, Rosa Ayesa-Arriola

“…This study aims to examine the potential role of maternal immune activation (MIA), due to SARS-CoV-2 infection, on early neurodevelopment. Methods: We analysed 107 mother-infant dyads from the COGESTCOV-19 study in Cantabria, Spain, which included 59 SARS-CoV-2 exposed (cases) and 48 unexposed (controls) mothers, recruited between December 2020 and February 2022. …”
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Easy, fast and reproducible Stochastic Cellular Automata with chouca by Génin, Alexandre, Dupont, Guillaume, Valencia, Daniel, Zucconi, Mauro, Ávila-Thieme, M. Isidora, Navarrete, Sergio A., Wieters, Evie A.

“…To provide a unifying, well-tested technical basis to this class of models and facilitate their implementation, we built chouca, an R package that translates definitions of SCA models into compiled code, and runs simulations in an efficient way. chouca supports SCA based on rectangular grids where transition probabilities are defined for each cell, with performance typically two to three orders of magnitude above typical implementations in interpreted languages (e.g. …”
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Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in strokeResearch in context by Wenqian Liu, Mo Yang, Nanxing Wang, Xiangrong Liu, Chaoyu Wang, Kaibin Shi, Fu-Dong Shi, Yuesong Pan, Mingjun Zhang, Zhiwei Sun, Yongjun Wang, Yilong Wang

“…However, there has been no research on the feasibility, safety, and efficacy of this delivery method for drug treatment of stroke. Methods: We used a microporous method for intracalvariosseous (ICO) injection to deliver drugs directly into brain parenchyma through skull bone marrow. …”
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Inflammation biomarkers and neurobehavioral performance in rural adolescentsKey PointsRelevance by Beemnet Amdemicael, Kun Yang, Briana N.C. Chronister, Caroline Mackey, Xin Tu, Sheila Gahagan, Danilo Martinez, Harvey Checkoway, David R. Jacobs, Jr., Jose Suarez-Torres, Suzi Hong, Jose R. Suarez-Lopez

“…This work seeks to investigate the association between inflammation and neurobehavior in adolescents living in a rural region of Ecuador. Methods: We examined 535 adolescents in rural communities of Ecuador (ESPINA study), 508 of which had neurobehavioral assessments (NEPSY-II) and circulating plasma levels of inflammatory markers (CRP, IL-6, TNF-⍺, sICAM-1, sVCAM-1, SAA, and sCD14). …”
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Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel by Yanhong Xing, Meng-meng Wang, Feifei Zhang, Tianli Xin, Xinyan Wang, Rong Chen, Zhongheng Sui, Yawei Dong, Dongxue Xu, Xingyu Qian, Qixia Lu, Qingqing Li, Weijie Cai, Meiqin Hu, Yuqing Wang, Jun-li Cao, Derong Cui, Jiansong Qi, Wuyang Wang

“…Abstract Lysosomes are best known for their roles in inflammatory responses by engaging in autophagy to remove inflammasomes. Here, we describe an unrecognized role for the lysosome, showing that it finely controls macrophage inflammatory function by manipulating the lysosomal Fe2+—prolyl hydroxylase domain enzymes (PHDs)—NF-κB—interleukin 1 beta (IL1B) transcription pathway that directly links lysosomes with inflammatory responses. …”
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Gestational weight gain and increased risk of cesarean delivery across body mass index categoriesAJOG Global Reports at a Glance by Pearl A. McElfish, PhD, Britni L. Ayers, PhD, Nicola L. Hawley, PhD, Aaron Caldwell, PhD, Austin Porter, DrPh, Michael D. Macechko, MD, Donya Watson, MD, Jennifer A. Callaghan-Koru, PhD, James P. Selig, PhD, Jennifer A. Andersen, PhD, Nirvana Manning, MD, Lanita White, PharmD, Enrique Gomez-Pomar, MD, Clare C. Brown, PhD

“…Only low-risk births were included (singleton, term-gestation [≥37 weeks], cephalic presentation, and first birth to exclude women who had a prior cesarean delivery). We used the rate of gestational weight gain (lb/wk) measured as both a categorical and continuous variable. …”
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Identification of positive selection signatures associated with milk and composition traits in Murciano-Granadina and Barki by Hossein Mohammadi, amir hossien khaltabadi farahani, Mohammad Hossein Moradi

“…GeneCards (http://www.genecards.org) and UniProtKB (http://www.uniprot.org) databases were also used to interpret the function of the obtained genes.Results and Discussion Using FST approach, we identified seven genomic regions on chromosomes 4, 6, 14, 15 (two regions per chromosome), 17, and 23 chromosomes. …”
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

“…To identify novel, better-tolerated anticancer combinations, we screened a collection of plant extracts and found two natural compounds from the plant, Psoralea corylifolia, that synergistically inhibit cancer cell proliferation. …”
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A new multi-grid bathymetric dataset of the Gulf of Naples (Italy) from complementary multi-beam echo sounders by F. Foglini, M. Rovere, R. Tonielli, G. Castellan, G. Castellan, M. Prampolini, M. Prampolini, F. Budillon, M. Cuffaro, G. Di Martino, V. Grande, S. Innangi, M. F. Loreto, L. Langone, F. Madricardo, A. Mercorella, P. Montagna, C. Palmiotto, C. Pellegrini, A. Petrizzo, L. Petracchini, A. Remia, M. Sacchi, D. Sanchez Galvez, A. N. Tassetti, F. Trincardi

“…The digital bathymetric data previously available are restricted to the shallow highly dynamic area of the Gulf of Naples and appear fragmented as they were acquired in successive years, with different goals thereby using a variety of devices, with markedly different spatial resolutions. In this paper, we present bathymetric maps of the Gulf of Naples and adjacent slope basins at unprecedented resolution using three state-of-the-art multi-beam echo sounders. …”
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Case Report: Combination of focal vibration therapy and botulinum toxin injections to treat equinus gait in a child with unilateral spastic cerebral palsy by Christophe Boulay, Christophe Boulay, Christophe Boulay, Jacques-Olivier Coq, Morgan Sangeux, Morgan Sangeux, Guillaume Authier, Guillaume Authier, Alexis Ulian, Alexis Ulian, Maud Pradines, Maud Pradines, Marjolaine Baude, Marjolaine Baude, Béatrice Desnous, Jean-Luc Jouve, Jean-Luc Jouve, Bernard Parratte, Emilie Peltier, Sébastien Pesenti, Jean-Michel Gracies, Jean-Michel Gracies

“…In children with spastic cerebral palsy (CP), FVT has also been suggested to reduce spasticity, increase torque production and improve gait function, but evidence is limited.MethodsWe report the case of a child with unilateral spastic CP (USCP) and equinus gait (GFMCS II level) with (i) ankle dorsiflexor paresis, (ii) ankle plantar flexor overactivity, especially in gastrosoleus complex and peroneus longus, (iii) spastic myopathy, affecting gastrosoleus complex in particular, and (iv) calf pain seemingly related to muscle overactivity. …”
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Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges by Weigao Zhang, Hu Liu, Danyang Zhang, Yuguo Yi, Liang Tao, Yunfeng Zhu, Shuxian Huang, Xunan Zhao, Qianchao Shao, Peiqi Li, Yiwen Weng, Wei Lu, Jianfa Zhang, Haibing Zhang, Yuxin Chen, Dan Weng

“…However, the mechanisms governing this resilience remain incompletely understood. In this study, we identified Receptor interacting protein kinase 1 (RIPK1) in hepatocytes as a critical regulator in preserving hepatic homeostasis during metabolic challenges, such as short-term fasting or high-fat dieting. …”
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Prospective Single-Arm Study of Remifentanil-Propofol Anesthesia with Manual Right Hypochondrial Compression for Painless Gastroscopy in Obese Patients by Wang M, Tang J, Pan Z, Jiang H, Hu D, Zhu B, Liang Z, Zhao X, Li Y

“…Furthermore, our findings contribute to the understanding of the lowest SpO2 values that obese patients can tolerate during such procedures, establishing Nadir SpO2 as the cut-off point. We also identified severe OSA and diabetes as independent predictive risk factors for hypoxemia. …”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…However, the mechanism how VSIG4+ TAMs mediate immune evasion in aggressive cancers have not been fully elucidated. In our study, we found targeting VSIG4+ TAMs by VSIG4 deficiency or blockade remarkably limited tumor growth and metastasis, especially those derived from anaplastic thyroid cancer (ATC) and pancreatic cancer, two extremely aggressive types. …”
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An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…This study aimed to explore potential biomarkers associated with gemcitabine chemoresistance in pancreatic cancer by utilizing gemcitabine-resistant cell lines and pathological pancreatic cancer tissues, in conjunction with data from online databases. Additionally, we analyzed follow-up data from pancreatic cancer patients to assess the impact of relevant targets on patient prognosis. …”
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Relationship Between Adenoma Detection Rate and Respective Withdrawal Time in Different Colon Segments: A Retrospective, Single‐Center Study by Xujin Chen, Bingxin Xu, Bingni Wei, Lin Ji, Cheng Yang, Qiang Zhan

“…The adenomas in the rectosigmoid colon are more likely to be detected and do not take longer withdrawal times. We need to choose the appropriate time according to different colon segments.…”
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Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC by Domenico Lo Tartaro, Beatrice Aramini, Valentina Masciale, Nikolaos Paschalidis, Francesco Demetrio Lofaro, Anita Neroni, Rebecca Borella, Elena Santacroce, Alin Liviu Ciobanu, Anna Valeria Samarelli, Federica Boraldi, Daniela Quaglino, Alessandra Dubini, Michele Gaudio, Gloria Manzotti, Francesca Reggiani, Federica Torricelli, Alessia Ciarrocchi, Antonino Neri, Federica Bertolini, Massimo Dominici, Pier Luigi Filosso, Franco Stella, Lara Gibellini, Sara De Biasi, Andrea Cossarizza

“…In this study, using polychromatic flow cytometry, mass cytometry, and spatial transcriptomics we explored the intricate landscape of B cell phenotypes, bioenergetics, and their interaction with T cells in NSCLC. …”
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