Exosome‐derived long non‐coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β‐cat... by Shaojun Chu, Lingling Jia, Yulong Li, Jiachao Xiong, Yulin Sun, Qin Zhou, Dexiang Du, Zihan Li, Xin Huang, Hua Jiang, Baojin Wu, Yufei Li

“…The effects of Exosome‐loaded AC010789.1 prompted HFSCs proliferation and hair follicle regeneration were confirmed in hairless mice. Results We herein found that the mRNA levels of lncRNA AC010789.1 were decreased in AGA tissue samples but increased in HFSCs of surrounding normal tissue samples. …”
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Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong by Reena Rajasuriar, Syaza Hisham, John Son Lim, Jean Yi Cheong, Wen Ying Ho, Siew Hwei Yap, Nurul Syuhada Zulhaimi, Malinee Neelamegam, Catherine Cheung, Vivian Wong, Ruhana Che Yusof, Kejal Hasmukharay, Shahrul Bahyah Kamaruzzaman, Sharifah Faridah Syed Omar, Meng Li Chong, Pui Li Wong, Grace Chung‐Yan Lui

“…Abstract Introduction WHO's Integrated Care for Older People (ICOPE) proposes we measure the functional construct of intrinsic capacity (IC) to monitor and identify individuals with age‐associated vulnerabilities. …”
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Survey on the Status and Training Demands of Capabilities for Diagnosing and Treating Common Diseases of Primary Care General Practitioners in Hunan Province by LI Lingqi, GAO Yinyan, ZHANG Yuqin, SUN Dingkui, WU Xinyin, ZHANG Weiru

“…Additionally, 77.2% (260/337) of participants lacked sufficient knowledge of clinical practice guidelines; 90.8% (306/337) of participants rarely consulted guidelines when facing decision-making difficulties, mainly because they felt guidelines could not address complex cases[50.0% (153/306) ], were unclear on how to search for guidelines[43.1% (132/306) ]and the resources available for retrieving guidelines[34.3% (105 /306) ]; participants mainly obtain the guidelines through the WeChat official account[72.5% (237/327) ] and databases such as the China National Knowledge Infrastructure [50.2% (164/327) ]. 97.0% (327/337) of participants expressed a demand for training to improve their capabilities, suggesting that training should be tailored to the specific needs of primary care institutions[60.8% (205/337) ]; the preferred approaches are advanced training in higher-level hospitals[71.3% (233/327) ]and primary care institutions with high diagnostic and treatment capabilities[56.3% (184/327) ]; the preferred training programs are on standardized treatment of common diseases[78.0% (263/337) ]and multiple coexisting diseases[69.4% (234/337) ]. …”
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Full-thickness cervix reconstruction via collagen scaffolds in rabbits by Yaqian Li, Weijie Tian, Jianbin Guo, Yang Ye, Qianqian Gao, Yiwei Zhang, Xiaoyue Zhao, Jianwu Dai, Lan Zhu

“…However, full-thickness and large-scale cervical regeneration with complete structural and functional restoration have not been reported. In this study, we fabricated a double-layered collagen membrane (CM) scaffold based on decellularized extracellular matrix. …”
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A Pool of Bacterium-like Particles Displaying African Swine Fever Virus Antigens Induces Both Humoral and Cellular Immune Responses in Pigs by Jingshan Huang, Hongxia Wu, Tianqi Gao, Huanjie Zhai, Assad Moon, Xin Song, Shuwen Li, Zhanhao Lu, Jing Lan, Dailang Zhong, Xinyu Zhang, Hua-Ji Qiu, Yongfeng Li, Yuan Sun

“…This underscores the urgent need for safe and effective ASF vaccines. Methods: Here, we constructed five bacterium-like particles (BLPs) that each display one of the five ASFV antigens (F317L, H171R, D117L, B602L, and p54) based on the Gram-positive enhancer matrix-protein anchor (GEM-PA) system. …”
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Weight-based enoxaparin thromboprophylaxis in young trauma patients: analysis of the CLOTT-1 registry by Sarah Lombardo, Ram Nirula, Elliott R Haut, Scott Brakenridge, Brandon Bruns, Charles E Wade, M Margaret Knudson, Thomas Scalea, Todd W Costantini, Lisa Marie Knowlton, David Spain, Ernest E Moore, Michelle K McNutt, Matthew J Martin, Andrew J Kerwin, George C Velmahos, Bruce Crookes, Marta McCrum, Lucy Kornblith, Mark D Cipolle, Laszlo N Kiraly, David J Milia, Alicia Mohr, Frederick Rogers, Sherry Sixta, Jade Nunez

“…Weight-based (WB) dosing safely increases anti-factor Xa levels without the need for routine monitoring but it is unclear if it leads to lower VTE risk. We hypothesized that WB dosing would decrease VTE risk compared with standard fixed dosing (SFD).Methods Patients from the prospective, observational CLOTT-1 registry receiving prophylactic enoxaparin (n=5539) were categorized as WB (0.45–0.55 mg/kg two times per day) or SFD (30 mg two times per day, 40 mg once a day). …”
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Disability, comorbidities and risk determinants at end of TB treatment in Kenya, Uganda, Zambia and Zimbabwe by The Kenya, Uganda, Zambia, and Zimbabwe TB Disability Study Group (members listed here in alphabetical order):, S.A. Adakun, F.M. Banda, A. Bloom, M. Bochnowicz, J. Chakaya, A. Chansa, H. Chiguvare, R. Chimzizi, C. Colvin, J.P. Dongo, A. Durena, C. Duri, R. Edmund, A.D. Harries, I. Kathure, F.N. Kavenga, Y. Lin, H. Luzze, I. Mbithi, M. Mputu, A. Mubanga, D. Nair, M. Ngwenya, B. Okotu, P. Owiti, A. Owuor, P. Thekkur, C. Timire, S. Turyahabwe, E. Tweyongyere, M. YaDiul, R. Zachariah, K. Zimba

“…BACKGROUND: We examined the feasibility of assessing and referring adults successfully completing TB treatment for comorbidities, risk determinants and disability in health facilities in Kenya, Uganda, Zambia and Zimbabwe. …”
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Clinical Significance of Perioperative Minimal Residual Disease Detected by Circulating Tumor DNA in Patients With Lung Cancer With a Long Follow-up Data: An Exploratory Study by Shuta Ohara, MD, PhD, Kenichi Suda, MD, PhD, Sumedha Sudhaman, PhD, Akira Hamada, MD, PhD, Masato Chiba, MD, PhD, Masaki Shimoji, MD, PhD, Toshiki Takemoto, MD, PhD, Ekaterina Kalashnikova, PhD, Samantha K. Cheung, PhD, Michael Krainock, MD, PhD, Jordan Feeney, BS, Himanshu Sethi, MPH, Minetta C. Liu, MD, Junichi Soh, MD, PhD, Yasuhiro Tsutani, MD, PhD, Tetsuya Mitsudomi, MD, PhD

“…Nevertheless, additional detailed information regarding the association of longitudinal ctDNA detection with long-term follow-up in lung cancer is needed. Here, we report on a cohort of patients with NSCLC who underwent definitive surgery and ctDNA analysis in the pre-operative, adjuvant, and surveillance settings. …”
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TP53 germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate by Paula Rofes, Carmen Castillo-Manzano, Mireia Menéndez, Álex Teulé, Sílvia Iglesias, Elisabet Munté, Mireia Ramos-Muntada, Carolina Gómez, Eva Tornero, Esther Darder, Eva Montes, Laura Valle, Gabriel Capellá, Marta Pineda, Joan Brunet, Lidia Feliubadaló, Jesús del Valle, Conxi Lázaro

“…Germline TP53 variant interpretation is challenging due to the diverse nature of TP53 PVs, variable penetrance of the syndrome, possible occurrence of TP53 somatic mosaicism, and TP53 involvement in clonal hematopoiesis of indeterminate potential (CHIP). Here we aim to assess the relevance and impact of these issues on the diagnostic routine, and to evaluate the sensitivity of the different LFS clinical criteria to identify hTP53rc. …”
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Examining the therapeutic potential and side effects of calcium channel blockers in mortality and morbidity of patients with stroke: A systematic review of pre-clinical and clinica... by Sevak Hatamian, Asad Abdi, Fatemeh Sadat Seyedi Asl, Armin Tafazolimoghadam, Arian Tavasol, Seyed Ali Mousavi Nejad, Reza Madadi, Zohre Tajabadi, Mina Dehghani, Najmeh Ahmadpoor, Mobina Fathi, Mohammadreza Hajiesmaeili, Navid Nooraei

“…Objectives: This study's primary goal is to evaluate the effects of calcium channel blockers on reducing the risk, mortality, morbidity, and long-term outcomes of cerebrovascular events. Material and Methods: We conducted this systematic literature review by searching PubMed, Scopus, and Google Scholar databases. …”
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Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis by Samuel R. Moen, Jeffrey R. Misialek, Timothy M. Hughes, Craig W. Johnson, Mark J. Sarnak, Sarah N. Forrester, W.T. Longstreth, Jr., Mercedes R. Carnethon, James S. Pankow, Sanaz Sedaghat

“…Rationale & Objective: Equations for estimated glomerular filtration rate (eGFR) have previously included a coefficient for African American race. We evaluated and compared risk of incident stroke and dementia between old and new equations of eGFR for African American and non-African American participants. …”
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Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation by Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani

“…Immune checkpoints (ICPs) such as PD-1/PD-L1, CD40/CD40LG, and OX40/OX40L, regulate post-LTx T cell responses, and dysregulation of microRNAs (miRNAs) has been implicated in altering ICP expression, influencing the amplification of immune responses.In this preliminary study, we used the taqMan low-density array (TLDA) cards to investigate miRNA dysregulation's prognostic potential as a PGD marker in pre-transplant back-table lung biopsies. …”
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Intimate partner violence among women of reproductive age during the COVID-19 pandemic in Ethiopia: a systematic review and meta-analysis by Gizachew Yilak, Alemayehu Sayih Belay, Aychew Kassie, Befkad Derese Tilahun, Ambaw Abebaw Emrie, Mulat Ayele, Eyob Shitie Lake, Legese Fekede Abza

“…Moreover, the burden of IPV is increased not only during such a pandemic but also during different internal displacements, conflicts and unrest. Therefore, we recommend policymakers to frequently assess IPV-related burdens during such events and act accordingly.…”
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Reflecting on the impact of the COVID pandemic on patient management and its subsequent influence on long-term outcomes: a case–control study in the field of esophago-gastric cance... by Mohamed Alasmar, Nadia Matias, Norah Ali M. Alhamed, Omneya Alwani, Brogan Rudge, Terngu David Moti, Muhammad Ossama Yassin Abdelwahab, Jennifer Stockton, Charef Raslan, Jess Cairney-Hill, Mohammad Altarawni, Bilal Alkhaffaf, on behalf Greater Manchester Oesophago-Gastric Service

“…Results A consistent demographic profile across these periods was maintained, but with a significant decrease in patient referrals during P1 (35.25% reduction from PP to P1 and 9.5% reduction from PP to P2), quicker ‘time to treatment’ during P1 (130.8 days in P1 vs 162 in PP and 178.9 in P2), and notable changes in treatment modalities. Additionally, we found an increased deviation from initial curative to palliative intent in the P2 group (6.4% changed in P2 vs 2.2% in PP and 3.5% in P2) primarily driven by disease progression. …”
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Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer by Chengcong Yang, Musu Zha, Lu Li, Jiaqi Qiao, Lai-Yu Kwok, Dandan Wang, Yongfu Chen

“…Our findings indicate that intragastric administration of BX245-fermented milk effectively modulated the intratumor microbiota, as well as the gut microbiota and its metabolism. We also observed a decreased relative abundance of intratumor Akkermansia in the CRC mice, while the intratumor Parabacteroides exhibited a significant positive correlation with tumor number and weight. …”
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Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging by Maggie K. Pecsok, Heather Robinson, Ally Atkins, Monica E. Calkins, Monica E. Calkins, Mark A. Elliott, Arianna Mordy, Jacquelyn Stifelman, Ruben C. Gur, Ruben C. Gur, Paul J. Moberg, Ravi Prakash Reddy Nanga, Kosha Ruparel, Kosha Ruparel, Russell T. Shinohara, David A. Wolk, Ravinder Reddy, David R. Roalf, David R. Roalf

“…IntroductionHippocampal glutamate (Glu) dysfunction is a pertinent indicator of neurodegeneration, yet mapping typical age-related changes in Glu has been challenging. Here, we use a 7T MRI approach, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to measure bilateral hippocampal Glu in healthy old (HOA) and young (HYA) adults.MethodsBilateral hippocampal GluCEST data was acquired from 27 HOA and 22 HYA using 7T MRI. …”
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Immunogenicity and safety of a COVID-19 DNA vaccine in healthy adults and elderly: A randomized, observer-blind, placebo-controlled phase 2 trial by Siyue Jia, Chengwei Shao, Xin Cheng, Hongxing Pan, Zhijian Wang, Yu Xia, Jianfang Xu, Xuefen Huai, Danjing Leng, Jiarong Wang, Gan Zhao, Bin Wang, Jingxin Li, Fengcai Zhu

“…This phase 2 trial evaluated the immunogenicity and safety of INO-4800 as a primary vaccination series in adults. We conducted a randomized, observer-blind, placebo-controlled phase 2 trial of intradermal injection of INO-4800 in both healthy adults and elderly individuals. …”
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Relationship between triglyceride glucose-body mass index baselines and variation with future cardiovascular diseases risk in the middle-aged and elderly individuals by Junpeng Qiao, Xueyu Chen, Jinhong Pang, Haicheng Fei, Zhang Liu, Fang Cheng, Qiaoqiao Chen, Yingying Zhao, Fengxue Shi, Hongying Jia, Hongying Jia, Weiwei Chi, Weiwei Chi

“…The change of TyG-BMI was categorized using K-means clustering and baseline TyG-BMI was grouped based on quartiles. We used Cox proportional hazards models to evaluate the relationship between baseline quartiles of the TyG-BMI index and its variability with CVDs and their subtypes.ResultsAmong the 7,072 participants (mean age of 59.1 ± 9.3 years), 3330 (47%) were male. …”
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Exploring the genomic and antimicrobial resistance tapestry: comparative insights into Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama in Latin American surfa... by Zhao Chen, Enrique J. Delgado Suárez, Raquel R. Bonelli, Celso J. B. Oliveira, Andrea I. Moreno-Switt, Aiko D. Adell, Angélica Reyes-Jara, Christopher J. Grim, Marc W. Allard, Sandra M. Tallent, Eric W. Brown, Rebecca L. Bell, Magaly Toro, Jianghong Meng

“…ABSTRACT Surface waters function as ecological niches where Salmonella enterica can persist and disseminate to fresh produce production systems. We examined the genomic characteristics of S. enterica serotypes Agona (n = 86), Braenderup (n = 47), Muenchen (n = 53), and Panama (n = 69) isolates from surface waters in Chile, Mexico, and Brazil between 2019 and 2022. …”
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Evaluation of Ecological Resilience of Agricultural Ecosystems in Razavi Khorasan Province: Comparison of Integrated and Non-Integrated Ecosystems by Pegah Naghipour, Alireza Koocheki, Mahdi Nasiri mahalati, Soroor Khorramdel

“…The main findings indicated that the integrated farmlands with other activities particularly with animal husbandry is much more resilient than pure and monotype farm production systems.AcknowledgementsWe are grateful to the Honorable Vice Chancellor of Research and Technology of Ferdowsi University of Mashhad for providing the costs of this research.…”
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