Pharmacokinetic Analysis of an Isoniazid Suspension Among Spanish Children Under 6 Years of Age by Antoni Noguera-Julian, Emma Wilhelmi, Maria Cussó, Rob Aarnoutse, Angela Colbers, Loreto Martorell, Maria Goretti López-Ramos, Joan Vinent, Rosa Farré, Dolors Soy, Sílvia Simó-Nebot, Clàudia Fortuny

“…Currently, there are no INH suspensions available in Europe. <b>Methods</b>: We aimed to characterize the pharmacokinetics of a licensed INH suspension (10 mg/mL, Pharmascience Inc., Montreal, QC, Canada) in children receiving INH daily at 10 mg/kg in a single-center, open-label, non-randomized, phase IIa clinical trial (EudraCT Number: 2016-002000-31) in Barcelona (Spain). …”
Get full text

CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment by Junfeng Xu, Na Li, Hui Xie, Changwei Duan, Xingchen Liao, Ruoran Li, Heng Zhang, Yuanming Pan, Xianzong Ma, Shuwen Du, Jianqiu Sheng, Xin Wang, Lang Yang, Peng Jin

“…Immunocoprecipitation was performed to verify the regulatory effects of CSF3 on IκBα ubiquitination. Results: We found that CSF3 was overexpressed in CRC tissues compared to adjacent normal tissues, which correlated with poor patient survival. …”
Get full text

Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment by Tatsuya Usui, Masashi Sakurai, Shuhei Enjoji, Hideyoshi Kawasaki, Koji Umata, Takashi Ohama, Nobuyuki Fujiwara, Ryotaro Yabe, Shunya Tsuji, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato

“…However, ALI organoid culture system from tissues of colorectal cancer patients has not been established. Here, we developed an ALI organoid model from normal and tumor colorectal tissues of human patients. …”
Get full text

Effect of Physical Activity on Physical and Mental Health in Young Cancer Patients and Survivors: A Systematic Review of RCTs and CCTs by Ann Christin Schneider, Sofia Anzeneder, Lars Rehbein, Eva Katharina Brack, Mirko Schmidt, Valentin Benzing

“…Methods A systematic search was conducted in APA PsycINFO, PubMed, SPORTDiscus, Web of Science, Embase, and Scopus. We examined RCTs and CCTs investigating PA interventions in children and adolescents with cancer, during or after treatment, that reported outcomes related to physical or mental health and/or quality of life. …”
Get full text

Therapeutic Potential of <i>Cajanus cajan</i> (L.) <i>Millsp</i>. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease by Mingzhang Lin, Linghua Piao, Zhendong Zhao, Li Liao, Dayong Wang, Haiwen Zhang, Xiande Liu

“…In addition, molecular docking analysis was performed to assess the interaction between the principal components of CCLE and the aryl hydrocarbon receptor (AHR). <b>Results:</b> We identified seven bioactive compounds in CCLE: catechin, cajachalcone, 2-hydroxy-4-methoxy-6-(2-phenylcinyl)-benzoic acid, longistylin A, longistylin C, pinostrobin, amorfrutin A, and cajaninstilbene acid. …”
Get full text

Development and validation of a machine learning model to predict the risk of lymph node metastasis in early-stage supraglottic laryngeal cancer by Hongyu Wang, Hongyu Wang, Hongyu Wang, Zhiqiang He, Zhiqiang He, Zhiqiang He, Jiayang Xu, Jiayang Xu, Ting Chen, Ting Chen, Ting Chen, Jingtian Huang, Jingtian Huang, Jingtian Huang, Lihong Chen, Lihong Chen, Lihong Chen, Xin Yue, Xin Yue, Xin Yue

“…Data from 78 early-stage SGLC patients were collected from Fujian Provincial Hospital for independent external validation. We identified four variables associated with cervical LNM and developed six ML models based on these variables to predict LNM in early-stage SGLC patients.ResultsIn the two cohorts, 167 (47.44%) and 26 (33.33%) patients experienced LNM, respectively. …”
Get full text

Quantitative attribution of 2016 extreme arctic warmth: comparison between late winter and early spring by Junjie Zhu, Ke Fan, Shengping He, Tuantuan Zhang, Yi Deng, Song Yang, Deliang Chen, Kaiqiang Deng, Wei Yu, Baoqiang Tian, Hoffman H N Cheung

“…A deep, large-scale warmth occurred in the Arctic from January to April 2016, but the roles of various physical processes in this period have not been quantified. Here, we utilize an updated version of the coupled atmosphere‒surface climate feedback response analysis method to quantitatively attribute the extreme warmth. …”
Get full text

A Program for Master of Science in Environment and Natural Resources (MENR) by Kabale University

“…According to UN Sustainable Development Goals (SDG), the Goals and targets will stimulate action over the next 15 years in areas of critical importance for humanity and the planet. It states, “We are determined to end poverty and hunger, in all their forms and dimensions, and to ensure that all human beings can fulfil their potential in dignity and equality and in a healthy environment and determined to protect the planet from degradation, including through sustainable consumption and production, sustainably managing its natural resources and taking urgent action on climate change, so that it can support the need of the present and future generations” Goal 15 is to protect, restore and promote sustainable use of terrestrial ecosystems, sustainably manage forests, combat desertification, and halt and reverse land degradation and halt biodiversity loss. …”
Get full text

Presenting the model of antecedents affecting moral-emotional acting in education by arefeh kazemi malekmahmoudi, negin jabbari, kiomars niaz azari

“…Considering the factors affecting moral-emotional acting, we can observe the growth of positive organizational behaviors and the institutionalization of ethics in the organization. …”
Get full text

Comprehensive analysis of lncRNAs and mRNAs revealed potential participants in the process of avian reovirus infection by Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Jinkang Li, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Ying Wu, Ying Wu, Ying Wu, Ying Wu, Qiao Yang, Qiao Yang, Qiao Yang, Qiao Yang, Juan Huang, Juan Huang, Juan Huang, Juan Huang, Xumin Ou, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Bin Tian, Yu He, Yu He, Yu He, Yu He, Zhen Wu, Zhen Wu, Zhen Wu, Zhen Wu, Anchun Cheng, Anchun Cheng, Anchun Cheng, Anchun Cheng

“…The analysis revealed that 3,818 mRNA expressions were up-regulated, 4,573 mRNA expressions were down-regulated, 472 long noncoding RNAs (LncRNAs) were up-regulated, and 345 lncRNAs were down-regulated. We employed qRT-PCR to validate the sequencing results, confirming their accuracy. …”
Get full text

Presenting a model for the establishment and maintenance of expert human resources in the government organizations of Sistan and Baluchestan province by Majid Reza Dahmardeh, Vahid pourshahabi, Amin Reza Kamalian, Habibollah Salaerzehi

“…The results show that in this research, the dimensions of maintaining expert human resources include: behavioral, structural, contextual, and normative/attitudinal factors; and 31 components, based on the output of structural equation analysis and path analysis technique, the path coefficient of behavioral factors is 0.901, structural factors 0.886, contextual 0.821, and normative/attitudinal 0.840, in which the behavioral factors have the greatest impact and the job satisfaction component with a significant number obtained from the T-test equals 24.004 and the path coefficient 0.901 has played the greatest role in maintaining expert human resources in the government organizations of Sistan and Baluchistan provinceExtended abstractIntroductionHuman capital is considered the most complex and valuable capital in any organization, which plays the main role in realizing the organization's goals. If we carefully study the national wealth of a society, we come across two types of capital resources: material capital and human capital, meanwhile, it is the existence of trained and expert human capital that uses material capital, and its lack and deficiency is the reason for the loss and stagnation of the national capital and the decline of production and reproduction (Armestrang, 2018). …”
Get full text

Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury by Ali Khadim, Georgios Kiliaris, Ana Ivonne Vazquez-Armendariz, Tara Procida-Kowalski, David Glaser, Marek Bartkuhn, Tanya Malik, Xuran Chu, Alena Moiseenko, Irina Kuznetsova, Negah Ahmadvand, Arun Lingampally, Stefan Hadzic, Ioannis Alexopoulos, Yuexin Chen, Andreas Günther, Jürgen Behr, Jens Neumann, Herbert B. Schiller, Xiaokun Li, Norbert Weissmann, Thomas Braun, Werner Seeger, Malgorzata Wygrecka, Rory E. Morty, Susanne Herold, Elie El Agha

“…We show that myofibroblasts that are reminiscent of developmental alveolar myofibroblasts (AMFs), termed AMF-like cells, are activated during alveolar regeneration following influenza-virus-induced lung injury. …”
Get full text

Analyzing the discourse of tourism development with a justice-oriented and moderate approach by Mostafa Ghodrati, Mehraban Hadipeykani, Reza Ebrahimzadeh

“…Since Iran has been experiencing climate change and drought in the last few years, agriculture is not in a very favorable situation, and this is where the tourism industry becomes an important issue for employment. When we pay attention to the priority of the tourism sector, we see Iran at the 117th rank, a position that shows that even though everyone knows the colorful role of the tourism industry in economic prosperity and employment, little effort is being made to grow this industry in Iran. …”
Get full text

Global outcomes and prognosis for relapsed/refractory mature T-cell and NK-cell lymphomas: results from the PETAL consortium by Jessy Xinyi Han, Min Jung Koh, Leora Boussi, Mark Sorial, Sean M. McCabe, Luke Peng, Shambhavi Singh, Ijeoma Julie Eche-Ugwu, Judith Gabler, Maria J. Fernandez Turizo, Caroline T. MacVicar, Aditya Garg, Alexander Disciullo, Kusha Chopra, Alexandra Lenart, Emmanuel Nwodo, Jeffrey Barnes, Min Ji Koh, Eliana Miranda, Carlos Chiattone, Robert Stuver, Steven M. Horwitz, Mwanasha Merrill, Eric Jacobsen, Martina Manni, Monica Civallero, Tetiana Skrypets, Athina Lymboussaki, Massimo Federico, Yuri Kim, Jin Seok Kim, Jae Yong Cho, Thomas Eipe, Tanuja Shet, Epari Sridhar, Alok Shetty, Saswata Saha, Hasmukh Jain, Manju Sengar, Carrie Van Der Weyden, Henry Miles Prince, Ramzi Hamouche, Tinatin Murdashvili, Francine Foss, Marianna Gentilini, Beatrice Casadei, Pier Luigi Zinzani, Takeshi Okatani, Noriaki Yoshida, Sang Eun Yoon, Won-Seog Kim, Girisha Panchoo, Zainab Mohamed, Estelle Verburgh, Jackielyn Cuenca Alturas, Mubarak Al-Mansour, Josie Ford, Maria Elena Cabrera, Amy Ku, Govind Bhagat, Helen Ma, Ahmed Sawas, Khyati Maulik Kariya, Makoto Iwasaki, Forum Bhanushali, Owen A. O’Connor, Enrica Marchi, Changyu Shen, Devavrat Shah, Salvia Jain

“…Abstract: Variances in global access to drugs and treatment practices make it challenging to understand the benefit of contemporary therapies in patients with relapsed and refractory (R/R) mature T-cell and natural killer–cell lymphomas (MTCL and MNKCL). We conducted an international retrospective cohort study of 925 patients with R/R MTCL and MNKCL. …”
Get full text

Level-8 Ph.D. Programs In Medical Sciences: High Time For The Higher Education Commission (HEC) Of Pakistan To Establish A Medical Wing by Wafa Omer

“…Knowledge and skill in any form if planned according to a proper framework will always be beneficial for the community at large and in a country like Pakistan where we have a dire shortage of resources and manpower we should aim towards producing multifaceted doctors rather than restricting their field of expertise and limiting the available options for them to excel in their respective Medical Sciences fields.  …”
Get full text

Overview: quasi-Lagrangian observations of Arctic air mass transformations – introduction and initial results of the HALO–(𝒜 𝒞)³ aircraft campaign by M. Wendisch, S. Crewell, A. Ehrlich, A. Herber, B. Kirbus, C. Lüpkes, M. Mech, S. J. Abel, E. F. Akansu, F. Ament, C. Aubry, C. Aubry, S. Becker, S. Borrmann, S. Borrmann, H. Bozem, M. Brückner, H.-C. Clemen, S. Dahlke, G. Dekoutsidis, J. Delanoë, E. De La Torre Castro, E. De La Torre Castro, E. De La Torre Castro, H. Dorff, R. Dupuy, O. Eppers, F. Ewald, G. George, G. George, I. V. Gorodetskaya, S. Grawe, S. Groß, J. Hartmann, S. Henning, L. Hirsch, E. Jäkel, P. Joppe, P. Joppe, O. Jourdan, Z. Jurányi, M. Karalis, M. Kellermann, M. Klingebiel, M. Lonardi, M. Lonardi, J. Lucke, J. Lucke, A. E. Luebke, M. Maahn, N. Maherndl, M. Maturilli, B. Mayer, J. Mayer, S. Mertes, J. Michaelis, J. Michaelis, M. Michalkov, G. Mioche, M. Moser, M. Moser, H. Müller, R. Neggers, D. Ori, D. Paul, F. M. Paulus, C. Pilz, F. Pithan, M. Pöhlker, M. Pöhlker, V. Pörtge, M. Ringel, N. Risse, G. C. Roberts, S. Rosenburg, J. Röttenbacher, J. Rückert, M. Schäfer, J. Schaefer, V. Schemann, I. Schirmacher, J. Schmidt, S. Schmidt, J. Schneider, S. Schnitt, A. Schwarz, H. Siebert, H. Sodemann, H. Sodemann, T. Sperzel, T. Sperzel, G. Spreen, B. Stevens, F. Stratmann, G. Svensson, C. Tatzelt, T. Tuch, T. Vihma, C. Voigt, C. Voigt, L. Volkmer, A. Walbröl, A. Weber, B. Wehner, B. Wetzel, M. Wirth, T. Zinner

“…From the quasi-Lagrangian measurements, we have quantified the diabatic heating/cooling and moistening/drying of the transported air masses. …”
Get full text

The Great Lakes Winter Grab: Limnological data from a multi‐institutional winter sampling campaign on the Laurentian Great Lakes by Ge Pu, Kirill Shchapov, Nolan J. T. Pearce, Kelly Bowen, Andrew Bramburger, Andrew Camilleri, Hunter Carrick, Justin D. Chaffin, William Cody, Maureen L. Coleman, Warren J. S. Currie, David C. Depew, Jonathan P. Doubek, Rachel Eveleth, Mark Fitzpatrick, Paul W. Glyshaw, Casey M. Godwin, R. Michael McKay, Mohiuddin Munawar, Heather Niblock, Maci Quintanilla, Michael Rennie, Matthew W. Sand, Kimberly J. Schraitle, Michael R. Twiss, Donald G. Uzarski, Henry A. Vanderploeg, Trista J. Vick‐Majors, Judy A. Westrick, Bridget A. Wheelock, Marguerite A. Xenopoulos, Arthur Zastepa, Ted Ozersky

“…Addressing the winter data gap will enhance our understanding of winter ecosystem function and of lake response to environmental change. Here, we describe a dataset generated by a multi‐institutional winter sampling campaign across all five Laurentian Great Lakes and some of their connecting waters (the Great Lakes Winter Grab). …”
Get full text

Risk Communication and Community Engagement (RCCE) implementations to control cholera outbreak in Oromia region, Ethiopia by Dabesa Gobena, Esayas Kebede Gudina, Getahun Fetensa, Tizta Tilahun Degfie, Tessema Debela, Afework Tamiru, Zenebu Begna Bayissa, Dereje Diriba, Tarekegn Sarbessa, Daniel Bekele, Natinel Teferi, Achalu Layesa, Abate Zewdie, Dawit Worku Ayele, Meron Debebe Mersha, Chala Bafikadu, Senahara Korsa Wake, Lemi Abebe, Tesfaye Kebebew, Tefera Goshu, Birhanu Kenate, Yadeta Dessie, Zeleke Mekonnen

“…This study aimed to examine the implementation of Risk Communication and Community Engagement (RCCE) activities for cholera outbreak control in the region. Methods We conducted a quantitative and qualitative mixed-method study. …”
Get full text

Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Irene F. Marques, Carola Domènech-Panicello, Madelon L. Geurtsen, Thanh T. Hoang, Rebecca Richmond, Kristen Polinski, Lea Sirignano, Christian M. Page, Anne-Claire Binter, Todd Everson, Amber Burt, Michael Deuschle, Maria Gilles, Fabian Streit, Sunni L. Mumford, Per Magnus, Irwin K. M. Reiss, Marijn J. Vermeulen, Stephanie H. Witt, Inês Chaves, Edwina Yeung, Stephanie J. London, Mònica Guxens, Janine F. Felix

“…Abstract Background Night shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studies have explored this association in cord blood. We aimed to examine associations of maternal night shift work with cord blood DNA methylation. …”
Get full text

Reduction of intestinal RIPK1 ameliorates HFD-induced metabolic disorders in female mice by Ye Yuan, Xiaomin Hu, Chunguang Guo, Yihua Xu, Shihan Li, Wei Wen, Xinli Hu, Fanxin Zeng, Weiyi Cui, Wenli Chen, Xueting Sun, Ning Hou, Jue Wang, Rui-Ping Xiao, Xiuqin Zhang

“…In this study, using receptor-interacting protein kinase 1 (Ripk1) intestine-specific heterozygous knockout mice (Ripk1IEC+/−) and high-fat diet (HFD)-feeding mouse model, we report that HFD-induced shift in the transcriptional profile of the ileum toward that of the jejunum, characterized by increased expression of jejunal feature genes in the ileum, are attenuated in Ripk1IEC+/− female mice, but not in males. …”
Get full text