Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis by Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang

“…Nonetheless, the intricate details of intact glycopeptides in SSc remain elusive owing to challenges in their detection. In this study, we characterized plasma immunoglobulin G (IgG) intact N-glycopeptides from 30 SSc patients and 30 healthy controls (HCs) via our recently developed intact glycopeptide analysis method GlycoQuant. …”
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Energy and Macronutrients Intakes among Childbearing Age Women Living in the Urban Area of Morocco: A Cross-Sectional Study by Fatima Barich, Fatima Zahra Laamiri, Slimane Mehdad, Souad Benaich, Anass Rami, Mohamed Idrissi, Chaimae Serbouti, Houria Lahmame, Hasnae Benkirane, Manelle Rjimati, Amina Barkat, El Arbi Rjimati, Hassan Aguenaou

“…In Morocco, these changes have led to serious nutritional disorders and increased risk of morbidity and mortality particularly among vulnerable groups such as women of childbearing age. We aimed to assess the average daily energy and macronutrient intakes and to investigate their association with socioeconomic factors and weight status among women aged 19–49 years in urban areas. …”
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Strong-weak dual interface engineered electrocatalyst for large current density hydrogen evolution reaction by Shaorou Ke, Ruiyu Mi, Xin Min, Xinyu Zhu, Congyi Wu, Xin Li, Bozhi Yang, Xiaowen Wu, Yangai Liu, Zhaohui Huang, Minghao Fang

“…Abstract Supported nanocatalysts are crucial for hydrogen production, yet their activity and stability are challenging to manage due to complex metal-support interfaces. Herein, we design Pt@ anatase&rutile-TiO2 with a strong-weak dual interface by modifying TiO2 using high-energy ball milling and in-situ reduction to vary surface energies. …”
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Seaweed (Porphyra) cultivation enhances production of autochthonous refractory dissolved organic matter in coastal ecosystems by Ting Wang, Ting Wang, Jiajun Xu, Jiajun Xu, Randy A. Dahlgren, Qiang Liu, Yang Jia, Yang Jia, Binbin Chen, Binbin Chen, Hanqin Xu, Hanqin Xu, Zengling Ma, Zengling Ma, Liyin Qu, Liyin Qu

“…To fill this knowledge gap, we conducted investigations examining the quantity and optical properties of DOM and POM, microbial community structures and relevant environmental factors along a continuum from a subtropical river through its adjacent coastal Porphyra cultivation zone during the cultivation and non-cultivation periods. …”
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Reduction in <i>Aedes aegypti</i> Population After a Year-Long Application of Targeted Sterile Insect Releases in the West Valley Region of Southern California by Solomon Kibret Birhanie, Jacob Hans, Jennifer Thieme Castellon, Ale Macias, Rubi Casas, Huy Hoang, Deanna Mormile, Kecia Pitts-Love, Michelle Q. Brown

“…Over 99.6% eggs collected from female mosquitoes mated with irradiated males did not hatch, indicating a high level of sterility of the irradiated males utilized for our SIT application. Here, we demonstrated the potential of SIT when combined with IVM strategies such as In2Care^® Mosquito Stations, offering a holistic approach to reducing the public health risks associated with <i>Aedes</i>-borne diseases.…”
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Combination gemcitabine and PD-L1xCD3 bispecific T cell engager (BiTE) enhances T lymphocyte cytotoxicity against cholangiocarcinoma cells by Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya

“…To overcome this challenge and take advantage of PD-L1 upregulation upon gemcitabine treatment, we generated recombinant PD-L1xCD3 bispecific T cell engagers (BiTEs) to simultaneously block PD-1/PD-L1 signaling and recruit T lymphocytes to eliminate CCA cells. …”
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Immune-related adverse events with PD-1/PD-L1 inhibitors: insights from a real-world cohort of 2523 patients by Ting Yan, Minghui Long, Chaoyi Liu, Jiwen Zhang, Jiwen Zhang, Xingyu Wei, Xingyu Wei, Fei Li, Fei Li, Dehua Liao

“…This study aims to investigate the prevalence and associated risk factors of irAEs in a real-world setting, as well as to assess their effects on optimal therapeutic outcomes.MethodsA retrospective analysis involved 2523 patients with cancer who received inpatient PD-1/PD-L1 inhibitors treatment between January 2018 and December 2022. We documented patients’ demographic and clinical characteristics, PD-1 or PD-L1 inhibitors, treatment modalities, incidences, timing, and severity of irAEs, and efficacy outcomes by reviewing inpatient records. …”
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Body composition and physical performance of mountain bike athletes by Rayane Carvalho de Moura, Crislane de Moura Costa, Cirley Pinheiro Ferreira, Bruna Lorena Soares Cavalcante Sousa, Leandra Caline dos Santos, Michelly da Silva Pinheiro, Sérgio Luís Galan Ribeiro, Sandro Soares Almeida, Joseline Lima e Silva Pinho, Naíza Monge Lages, Maria Flávia de Sousa, Iago Alves Costa, Glêbia Alexa Cardoso, Acácio Salvador Veras Silva, Alisson Alves Silva, Jefferson Cruz dos Santos Leite, Felipe Machado Brito, Lailson Henrique Oliveira dos Santos, Rubens Lima Rodrigues, Jairo da Costa Souza, Marcos Antonio Pereira dos Santos

“…Participants performed the standing long jump and handgrip strength tests, to assess their strength of the lower and upper limbs, respectively. Finally, we measured the completion time of a Mountain Bike Marathon, with the distance of 75 km). …”
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Rare renal proximal tubular dysfunctions in primary biliary cholangitis by Xiaoxiao Shi, Tianchen Guo, Yubing Wen, Wei Ye, Wenling Ye, Ke Zheng, Yan Qin, Xuemei Li, Fengchun Zhang, Limeng Chen

“…Proximal tubular (PT) dysfunctions in PBC were rarely reported with unclear clinicopathological characteristics and renal prognosis.Methods We identified 11 cases of PBC with PT dysfunctions (PBC-PT). …”
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Characterization of cellular immune system at different ages in water buffalo (Bubalus bubalis) by Maria C. Scata’, Giovanna De Matteis, Francesco Grandoni, Gabriele Di Vuolo, Giovanna Cappelli, Domenico Vecchio

“…In this study, to characterize the myeloid and lymphoid cells in peripheral blood of buffalo, we assessed three flow cytometric multicolor panels of antibodies: panel 1, with anti CD3, CD4, CD8α and TCR-δ mAbs; panel 2, with anti CD79a and CD21 mAbs; panel 3 with anti CD172a, CD14, CD16, CD335 mAbs. …”
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

“…However, the precise molecular steps that regulate RANKL signaling remain largely unknown. Here, we revealed the indispensable role of a class III histone deacetylase (SIRT5) in the processes of RANKL-induced osteoclast differentiation and activation. …”
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Association between insulin resistance indices and outcomes in patients with heart failure with preserved ejection fraction by Weicheng Ni, Ruihao Jiang, Di Xu, Jianhan Zhu, Jing Chen, Yuanzhen Lin, Hao Zhou

“…Furthermore, to assess the incremental prognostic value of the TyG index, we conducted comprehensive analyses using area under the curve (AUC), the continuous net reclassification index (cNRI), and the integrated discrimination index (IDI). …”
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Giant energy storage density with ultrahigh efficiency in multilayer ceramic capacitors via interlaminar strain engineering by Ying Yang, Ke Xu, Bin Yang, Xu Hou, Zhanming Dou, Yuhong Li, Zihao Zheng, Gengguang Luo, Nengneng Luo, Guanglong Ge, Jiwei Zhai, Yuanyuan Fan, Jing Wang, Haoming Yang, Yao Zhang, Jing Wang, Changyuan Wang, Shenglin Jiang, Kanghua Li, Jinming Guo, Houbing Huang, Guangzu Zhang

“…Herein, for the purpose of decoupling the inherent conflicts between high polarization and low electric hysteresis (loss), and achieving high energy storage density and efficiency simultaneously in multilayer ceramic capacitors (MLCCs), we propose an interlaminar strain engineering strategy to modulate the domain structure and manipulate the polarization behavior of the dielectric mediums. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…Leveraging the radiosensitizing ability of Deruxtecan (DXd) and the internal radiation therapy of 131I for tumors, we aimed to develop the first radio-antibody-drug conjugates (RADCs) for the treatment of gastric cancer.Methods: The CLDN18.2-specific antibody HLX58 was conjugated with the payload DXd through a cleavable maleimide glycynglycyn-phenylalanyn-glycyn (GGFG) peptide linker. …”
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Estimation of the incidence of invasive meningococcal disease using a capture–recapture model based on two independent surveillance systems in Catalonia, Spain by Pilar Ciruela, Carmen Munoz-Almagro, Cristina Rius, Tomas Pumarola, Frederic Gomez-Bertomeu, Núria Soldevila, Ángela Domínguez, LAURA RUIZ, Ana Calderon, Ana Martinez, M Ángeles Domínguez, Mercé Garcia, Dionisia Fontanals, Gloria Carmona, Pere Godoy, Goretti Sauca, Jordi Vila, Marta Vilaró, Mireia Jané, Tomás Garcia, Sergi Hernández, Maria Teresa Bastida, Frederic Ballester, Isabel Pujol, Miguel Angel Benítez, Alba Cebollero, Jordi Bosch, Margarida Curriu, Fe Tubau Quintano, Jose Manuel Ramirez, Ma Jose Fusté, Carme Gallés, Pilar Hernandez Pérez, ElisendaCapdevila GildeBernabe, Paula Gassiot, Araceli González-Cuevas, Marius Juanpere, Amaresch Perez Arguello, Carmina Martí, Nuria Margall, Lurdes Matas, Montserrat Giménez, Montserrat Morta, Gloria Trujillo, Silvia Noguer, Montserrat Olsina, Amaia Oteiza Ubanell, Pepa Perez, Mar Olga Pérez-Moreno, Juanjo Gonzales, Xavier Raga, Mercè Ribelles, Esther Sanfeliu, Isabel Sanfeliu, Anna Vilamala, César Arias, Irene Barrabeig, Neus Camps, Mònica Carol, Núria Follia, Sofia Minguell, Ignasi Parron, Ma Rosa Sala-Farré, Ariadna Rovira

“…The objective of the study was to assess the sensitivity of two independent surveillance systems and to estimate the incidence of IMD.Design We used capture–recapture model based on two independent surveillance systems, the statutory disease reporting (SDR) system and the microbiological reporting system (MRS) of the Public Health Agency of Catalonia, between 2011 and 2015. …”
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Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous c... by Ting-Yu Lin, Hsin-Bang Leu, Yen-Wen Wu, Wei-Kung Tseng, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Wei-Hsian Yin, Chau-Chung Wu, Chun-Yao Huang, Shing-Jong Lin, Chien-Yi Hsu, Jaw-Wen Chen

“…Furthermore, no significant prognostic predictive value between NGAL levels and stable CAD has been established. Hypothesis We aimed to investigate the prognostic role of NGAL levels in a prospective cohort study of patients with stable CAD treated with percutaneous coronary intervention (PCI). …”
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Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis by Xiaotong Yu, Xiaotong Yu, Chen Huang, Chen Huang, Yan Song, Yan Song, Chun Zhang, Chun Zhang, Debo You, Debo You, XuRan Dong, XuRan Dong, DeFu Wu, DeFu Wu, Alan Keith Meeker, Hao Feng, Yuqing Wang, Yuqing Wang

“…This article aims to provide a bibliometric analysis of the research progress and perspectives on the application of TSA-based mIHC/IF.MethodsWe collected all the TSA-based mIHC/IF documents published between 2007 and 2023 from the Web of Science Core Collection (WoSCC) database. …”
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Learning with Digital Tools vs. Learning Through Digital Tools in Physical Education: Impacts on Student Perceptions by André Klostermann, Till Etterlin

“…Therefore, this study investigates the effects of two intervention types on PEU and PU: (1) learning with digital tools (LWD), aimed at skill acquisition, and (2) learning with and through digital tools (LWTD), targeting skill acquisition and digital competency development. We hypothesized that LWTD would result in higher PEU and PU post-intervention. …”
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Mid-Infrared High-Power InGaAsSb/AlGaInAsSb Multiple-Quantum-Well Laser Diodes Around 2.9 μm by Hongguang Yu, Chengao Yang, Yihang Chen, Jianmei Shi, Juntian Cao, Zhengqi Geng, Zhiyuan Wang, Haoran Wen, Enquan Zhang, Yu Zhang, Hao Tan, Donghai Wu, Yingqiang Xu, Haiqiao Ni, Zhichuan Niu

“…However, the laser’s performance significantly degrades as the emission wavelength increases, primarily due to severe quantum-well hole leakage and significant non-radiative recombination. In this paper, we put up an active region with a high valence band offset and excellent crystalline quality with high luminescence to improve the laser’s performance. …”
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Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against <i>Aspergillus</i> Species by Tatevik Sargsyan, Lala Stepanyan, Henrik Panosyan, Heghine Hakobyan, Monika Israyelyan, Avetis Tsaturyan, Nelli Hovhannisyan, Caterina Vicidomini, Anna Mkrtchyan, Ashot Saghyan, Giovanni N. Roviello

“…This study focuses on the synthesis and antifungal evaluation of novel 9-fluorenylmethoxycarbonyl (Fmoc)-protected 1,2,4-triazolyl-α-amino acids and their dipeptides, designed to combat fungal pathogens. More in detail, we evaluated their antifungal activity against various species, including <i>Aspergillus versicolor</i> (ATCC 12134) and <i>Aspergillus flavus</i> (ATCC 10567). …”
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