The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway by Yalan Jiang, Pingping He, Ke Sheng, Yongmiao Peng, Huilan Wu, Songwei Qian, Weiping Ji, Xiaoling Guo, Xiaoou Shan

“…However, the potential effects of EUG on T1DM had not been investigated. In this study, we established the streptozotocin (STZ)-induced T1DM mouse model in vivo and STZ-induced pancreatic β cell MIN6 cell model in vitro to investigate the protective effects of EUG on T1DM, and tried to elucidate its potential mechanism. …”
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Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…Therefore, combining ibrutinib and pembrolizumab could potentially induce an increase in Th1 immune polarity in melanoma patients. We hypothesize that the combination would be well-tolerated and might result in clinical benefit for patients with metastatic melanoma. …”
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Microbial community variations in adult Hyalomma dromedarii ticks from single locations in Saudi Arabia and Tunisia by Myriam Kratou, Apolline Maitre, Apolline Maitre, Apolline Maitre, Lianet Abuin-Denis, Lianet Abuin-Denis, Rachid Selmi, Hanène Belkahia, Abdullah D. Alanazi, Hattan Gattan, Hattan Gattan, Bassam M. Al-Ahmadi, Abdullah F. Shater, Lourdes Mateos-Hernández, Dasiel Obregón, Lilia Messadi, Alejandro Cabezas-Cruz, Mourad Ben Said, Mourad Ben Said

“…Despite prior studies on its microbiota, the effects of geographic origin and sex on microbial community structure and functional stability remain poorly understood.MethodsTo address this, we characterized the bacterial microbiota of H. dromedarii ticks collected from camels in Tunisia (TUN) and Saudi Arabia (SA) using 16S rRNA gene sequencing, microbial network analysis, and metabolic pathway prediction.ResultsOur findings indicate a dominant presence of Francisella endosymbionts in Tunisian ticks, suggesting adaptive roles of H. dromedarii ticks in arid ecosystems. …”
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Model-Based Variation-Aware Optimization for Offset Calibration and Pre-Sensing in DRAM Sense Amplifiers by Dongyeong Kim, Geon Kim, Suyeon Kim, Jewon Park, Sinwook Kim, Hyeona Seo, Chaehyuk Lim, Sowon Kim, Juwon Lee, Jeonghyeon Yun, Hyerin Lee, Jinseok Park, Yongbok Lee, Seungchan Lee, Myoungjin Lee

“…While various BLSAs incorporating OC and PS techniques have been proposed to address these challenges, and studies have been conducted on models predicting statistical offset, previous research has not adequately considered OC timing (<inline-formula> <tex-math notation="LaTeX">$t_{OC}$ </tex-math></inline-formula>) and transistor size effects. We independently model the OC, charge sharing (CS), and PS operations of DRAM BLSAs to accurately predict both deterministic and stochastic offsets resulting from various operation combinations. …”
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Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phas... by Jorge E. Cortes, Gail J. Roboz, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, P. Brent Ferrell, Jay Yang, Eunice S. Wang, William G. Blum, Alice Mims, Hua Tian, Aaron Sheppard, Stéphane de Botton, Pau Montesinos, Antonio Curti, Justin M. Watts, the Olutasidenib Combination Therapy Study Group

“…Abstract Background Olutasidenib is a potent, selective, oral, small molecule inhibitor of mutant IDH1 (mIDH1) which induced durable remissions in high-risk, relapsed/refractory (R/R) mIDH1 AML patients in a phase 1/2 trial. We present a pooled analysis from multiple cohorts of the phase 1/2 trial of patients with R/R AML who received combination olutasidenib and azacitidine therapy. …”
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Chemical Composition and Larvicidal Activity of Flower Extracts from Clitoria ternatea against Aedes (Diptera: Culicidae) by Darvin R. Ravindran, Madhuri Bharathithasan, Patmani Ramaiah, Mohd Sukhairi Mat Rasat, Dinesh Rajendran, Shakila Srikumar, Intan H. Ishak, Abd Rahman Said, Rajiv Ravi, Mohamad Faiz Mohd Amin

“…Moreover, the results for nontarget organism test on guppy fish, Poecilia reticulata, showed no mortalities with flower extracts at 2500 mg/L, hence posing no toxic effects on fish. In this study, we have found a total of 16 chemical compounds and 6 chemical compounds have been reported to possess direct insecticidal, larvicidal, and pupicidal effects. …”
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The pattem of the conquest of the Polabian Slavs and Western Baltic lands from the point of view of Christianization of the Baltic tribes by Marius Ščavinskas

“…In the relationship to the Baltic tribes we can observe similar but yet different processes). …”
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Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis by Beatriz Cicuéndez, Alfonso Mora, Juan Antonio López, Andrea Curtabbi, Javier Pérez-García, Begoña Porteiro, Daniel Jimenez-Blasco, Pedro Latorre-Muro, Paula Vo, Madison Jerome, Beatriz Gómez-Santos, Rafael Romero-Becerra, Magdalena Leiva, Elena Rodríguez, Marta León, Luis Leiva-Vega, Noemi Gómez-Lado, Jorge L. Torres, Lourdes Hernández-Cosido, Pablo Aguiar, Miguel Marcos, Martin Jastroch, Andreas Daiber, Patricia Aspichueta, Juan Pedro Bolaños, Jessica B. Spinelli, Pere Puigserver, José Antonio Enriquez, Jesús Vázquez, Cintia Folgueira, Guadalupe Sabio

“…This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples. …”
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Development of a Predictive Model of Occult Cancer After a Venous Thromboembolism Event Using Machine Learning: The CLOVER Study by Anabel Franco-Moreno, Elena Madroñal-Cerezo, Cristina Lucía de Ancos-Aracil, Ana Isabel Farfán-Sedano, Nuria Muñoz-Rivas, José Bascuñana Morejón-Girón, José Manuel Ruiz-Giardín, Federico Álvarez-Rodríguez, Jesús Prada-Alonso, Yvonne Gala-García, Miguel Ángel Casado-Suela, Ana Bustamante-Fermosel, Nuria Alfaro-Fernández, Juan Torres-Macho

“…<i>Materials and Methods</i>: We designed a case–control study nested in a cohort of patients with VTE included in a prospective registry from two Spanish hospitals between 2005 and 2021. …”
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Impacts of irrigation expansion on moist-heat stress based on IRRMIP results by Yi Yao, Agnès Ducharne, Benjamin I. Cook, Steven J. De Hertog, Kjetil Schanke Aas, Pedro F. Arboleda-Obando, Jonathan Buzan, Jeanne Colin, Maya Costantini, Bertrand Decharme, David M. Lawrence, Peter Lawrence, L. Ruby Leung, Min-Hui Lo, Narayanappa Devaraju, William R. Wieder, Ren-Jie Wu, Tian Zhou, Jonas Jägermeyr, Sonali McDermid, Yadu Pokhrel, Maxwell Elling, Naota Hanasaki, Paul Muñoz, Larissa S. Nazarenko, Kedar Otta, Yusuke Satoh, Tokuta Yokohata, Lei Jin, Xuhui Wang, Vimal Mishra, Subimal Ghosh, Wim Thiery

“…Previous assessments of these effects predominantly relied on a single Earth System Model, and therefore suffered from structural model uncertainties. Here we quantify the impacts of historical irrigation expansion on climate by analysing simulation results from six Earth system models participating in the Irrigation Model Intercomparison Project (IRRMIP). …”
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Whole-genome sequencing and phylogenetic analysis of Salmonella isolated from pullets through final raw product in the processing plant of a conventional broiler complex: a longitu... by Yagya Adhikari, Matthew A. Bailey, Steven Kitchens, Pankaj Gaonkar, Luis R. Munoz, Stuart B. Price, Dianna V. Bourassa, Laura Huber, Richard J. Buhr, Kenneth S. Macklin

“…From the above results, we can conclude that Salmonella from chicken houses/facilities’ environment can enter the broiler complex and can potentially contaminate the final raw product in the processing plant. …”
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Overexpression of OsDUF868.12 enhances salt tolerance in rice by Hao Chen, Jiale Wan, Jiali Zhu, Ziyi Wang, Caiyao Mao, Wanjing Xu, Juan Yang, Yijuan Kong, Xiaofei Zan, Rongjun Chen, Jianqing Zhu, Zhengjun Xu, Lihua Li, Lihua Li

“…The Domain of Unknown Function 868 (DUF868) family, comprising 15 members in rice, has been identified in the protein family database. In this study, we cloned and functionally characterized OsDUF868.12, a member of the OsDUF868 family, to elucidate its role in rice response to salt stress. …”
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Hubungan Pertambahan Berat Badan Ibu Hamil terhadap Berat Bayi Lahir di Kota Pariaman by Akbar Shiddiq, Nur Indrawaty Lipoeto, Yusrawati .

“…Pregnant women’s data taken from January until June 2011.There were 95 samples used in this study.Obtained the highest number of maternal weight gain, we found that the average of birth weight, range &lt; 10 kg, as many as 39 samples with an average 7.46 kg (± 1.274 SD), whereas sample with a weight gain of more than 12.53 kg as many as 27 samples with an average 17.39 kg (± 5.792 SD). …”
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Natural variation of CTB5 confers cold adaptation in plateau japonica rice by Haifeng Guo, Shilei Gao, Huahui Li, Jiazhen Yang, Jin Li, Yunsong Gu, Qijin Lou, Runbin Su, Wei Ye, Andong Zou, Yulong Wang, Xingming Sun, Zhanying Zhang, Hongliang Zhang, Yawen Zeng, Pingrong Yuan, Youliang Peng, Zichao Li, Jinjie Li

“…Abstract During cold acclimation in high-latitude and high-altitude regions, japonica rice develops enhanced cold tolerance, but the underlying genetic basis remains unclear. Here, we identify CTB5, a homeodomain-leucine zipper (HD-Zip) transcription factor that confers cold tolerance at the booting stage in japonica rice. …”
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Long-Term Clinical Outcomes for Non-ST Elevation Acute Coronary Syndrome Patients with High-Risk Angiographic Findings Undergoing Percutaneous Coronary Intervention by Sida Jia, Ce Zhang, Yue Liu, Deshan Yuan, Xueyan Zhao, Runlin Gao, Yuejin Yang, Bo Xu, Zhan Gao, Jinqing Yuan

“…Objective. We aim to evaluate the long-term prognosis of non-ST elevation acute coronary syndrome (NSTE-ACS) patients with high-risk coronary anatomy (HRCA). …”
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Breast cancers with neuroendocrine differentiation: Retrospective case studies series from a single institution based on the 2019 WHO classification by Youngkyung Jeon, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Kyuehee Choi, Sun Young Jeong, Yeji Jung, Jaeyeon Jang, Dae-Ho Choi, Joohyun Hong, Hyo Jung Kim, Soo Youn Cho, Yeon Hee Park

“…Based on the updated classification of the NEN, we conducted a case series using the Clinical Data Warehouse platform of SMC. …”
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Synthesis, Characterization, and Cytotoxic Activity of New Lanthanum(III) Complexes of Bis-Coumarins

“…On the basis of the <mml:math alttext="$ u({C}={O})$"> <mml:mi>&#x03BD;</mml:mi><mml:mrow><mml:mo>(</mml:mo> <mml:mrow> <mml:mtext>C</mml:mtext><mml:mo>=</mml:mo><mml:mtext>O</mml:mtext> </mml:mrow> <mml:mo>)</mml:mo></mml:mrow> </mml:math> red shift observed, participation of the carbonyl groups in the coordination with the metal ion was also suggested. In the present study, we performed a cytotoxic-effects screening of the lanthanum complexes with <mml:math alttext="$chem{H_{2}}$"> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> </mml:math>L1 and <mml:math alttext="$chem{H_{2}}$"> <mml:msub> <mml:mtext>H</mml:mtext> <mml:mn>2</mml:mn> </mml:msub> </mml:math>L2 in a panel of human tumor cell lines, using the standard MTT-dye reduction assay for cell viability. …”
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Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI by Hyeong-Geol Shin, Woojun Kim, Jung Hwan Lee, Hyun-soo Lee, Yoonho Nam, Jiwoong Kim, Xu Li, Peter C.M. van Zijl, Peter A. Calabresi, Jongho Lee, Jinhee Jang

“…To monitor lesions from their early stage (lesion age < 1 year), we identified newly-noted lesions (NNLs) and contrast-enhancing lesions (CELs), and tracked their longitudinal changes in χpara and χdia signals. …”
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PSR J1947−1120: A New Huntsman Millisecond Pulsar Binary by Jay Strader, Paul S. Ray, Ryan Urquhart, Samuel J. Swihart, Laura Chomiuk, Elias Aydi, Eric C. Bellm, Kristen C. Dage, Megan E. DeCesar, Julia S. Deneva, Maura A. McLaughlin, Isabella Molina, Teresa Panurach, Kirill V. Sokolovsky

“…We present the discovery of PSR J1947–1120, a new huntsman millisecond pulsar with a red giant companion star in a 10.3 day orbit. …”
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Pregabalin for Refractory Radicular Leg Pain due to Lumbar Spinal Stenosis: A Preliminary Prospective Study by Sumihisa Orita, Masaomi Yamashita, Yawara Eguchi, Miyako Suzuki, Gen Inoue, Masayuki Miyagi, Tomoko Watanabe, Tomoyuki Ozawa, Hiroto Kamoda, Tetsuhiro Ishikawa, Yasuchika Aoki, Toshinori Ito, Go Kubota, Munetaka Suzuki, Kazuyo Yamauchi, Eiji Hanaoka, Yoshihiro Sakuma, Jun Shimbo, Yasuhiro Oikawa, Takane Suzuki, Kazuhisa Takahashi, Seiji Ohtori

“…We investigated the efficacy of pregabalin (PGB) for neuropathic leg pain in lumbar spinal stenosis (LSS) patients with disturbed activities of daily living (ADL)/quality of life (QOL) in a prospective observational study. …”
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