SHoes for Adolescent PatEllofemoral pain: study protocol for the SHAPE Australian community-based, randomised clinical trial by Kim L Bennell, Kade L Paterson, Rana S Hinman, Jo-Anne Manski-Nankervis, Adam Bryant, Karen Elaine Lamb, Peixuan Li, Sam Shearer, Anurika P De Silva

“…This article outlines the protocol for a randomised clinical trial (RCT) that aims to determine if minimalist footwear improves pain, function and other symptoms compared with motion control shoes, in adolescents with patellofemoral pain.Methods and analysis This is a 3-month, pragmatic, two-arm parallel group, comparative effectiveness, superiority RCT conducted in Melbourne, Australia. We are recruiting 158 participants aged between 12 and 19 years with patellofemoral pain from the community. …”
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CAM/TMA-DPH as a promising alternative to SYTO9/PI for cell viability assessment in bacterial biofilms by Tinatini Tchatchiashvili, Tinatini Tchatchiashvili, Mateusz Jundzill, Mateusz Jundzill, Mike Marquet, Kamran A. Mirza, Kamran A. Mirza, Mathias W. Pletz, Mathias W. Pletz, Oliwia Makarewicz, Oliwia Makarewicz, Lara Thieme, Lara Thieme

“…To address this limitation, we investigated an alternative staining method employing calcein acetoxymethyl (CAM) to detect viable cells based on esterase activity, and 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene p-toluenesulfonate (TMA-DPH) to assess the remaining biofilm population.MethodsBiofilms of Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus faecium were matured and exposed to varying concentrations of antibiotics or sterile medium. …”
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Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure by Jing Ye, Zhen Wang, Di Ye, Yuan Wang, Menglong Wang, Qingwei Ji, Ying Huang, Ling Liu, Ying Shi, Lei Shi, Tao Zeng, Yao Xu, Jianfang Liu, Huimin Jiang, Yingzhong Lin, Jun Wan

“…The plasma concentrations of IL-11 were measured in 240 patients with chronic HF (CHF) and 80 control subjects without signs of significant heart disease. In addition, we prospectively followed these CHF patients to endpoints of cardiac events. …”
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PseudoCell: Hard Negative Mining as Pseudo Labeling for Deep Learning-Based Centroblast Cell Detection by Narongrid Seesawad, Piyalitt Ittichaiwong, Thapanun Sudhawiyangkul, Phattarapong Sawangjai, Peti Thuwajit, Paisarn Boonsakan, Supasan Sripodok, Kanyakorn Veerakanjana, Komgrid Charngkaew, Ananya Pongpaibul, Napat Angkathunyakul, Narit Hnoohom, Sumeth Yuenyong, Chanitra Thuwajit, Theerawit Wilaiprasitporn

“…<italic>Objective:</italic> To address this limitation, we propose <italic>PseudoCell</italic>, an object detection framework for automated centroblast detection in WSI, eliminating the need for extensive pathologist&#x0027;s refined labels. …”
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Outcome differences in acute vs. acute on chronic heart failure and cardiogenic shock by Tara L. Jones, Michael C. Tan, Vidang Nguyen, Kathleen E. Kearney, Charles C. Maynard, Emily Anderson, Claudius Mahr, James M. McCabe

“…Considerably less is understood about CS in the setting of acute decompensation in patients with chronic heart failure (HF). We sought to compare outcomes between patients with acute CS and patients with acute on chronic decompensated HF presenting with laboratory and haemodynamic features consistent with CS. …”
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Awareness of Sexual Partner’s HIV Status Among Men Who Have Sex With Men in China: Cross-Sec. tional Survey Study by Qian Ma, Tingting Jiang, Wanjun Chen, Shaoqiang Jiang, Jinlei Zheng, Hui Wang, Lin He

“…ConclusionsOverall, 45.2% of MSM who were HIV-negative or had an unknown status were aware of their sexual partners’ HIV status in China. We suggest strengthening targeted interventions through web-based platforms and gay apps to promote the disclosure of HIV serostatus and reduce HIV transmission among MSM.…”
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Protocol for an intervention development and pilot implementation evaluation study of an e-health solution to improve newborn care quality and survival in two low-resource settings... by Hassan Haghparast-Bidgoli, Michelle Heys, Caroline Crehan, Erin Kesler, Monica Lakhanpaul, Emma Wilson, Fabiana Lorencatto, Felicity Fitzgerald, Mario Cortina Borja, Msandeni Chiume, Hannah Gannon, Simbarashe Chimhuya, Gwendoline Chimhini, Tim Hull-Bailey, Tarisai Chiyaka, Yali Sassoon, Deliwe Nkhoma, Nushrat Khan, Alexander G. Stevenson, Kristina Curtis

“…Digital health technologies may offer an implementation solution. Since 2014, we have worked in Bangladesh, Malawi, Zimbabwe and the UK to develop and pilot Neotree: an android app with accompanying data visualisation, linkage and export. …”
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Tracking acute flaccid paralysis in Niger: a half-decade epidemiological portrait (2016–2021) by El Khalef Ishagh, Marc Talatou Ouédraogo, Batouré Oumarou, Mutenda Sheria Kaya, Gbaguidi Aichatou Diawara, Abdoulaye Macire Camara, Seyni Moussa, Kuyangisa Bienvenu, Joseph Toko, Hamidou Harouna, Haladou Moussa, N.’Zue Kofi, Jacques L. Tamuzi, Patrick D. M. C. Katoto, Charles S. Wiysonge, Blanche-Philomene Melanga Anya, Manengu Casimir Tshikolasoni

“…This analysis aims to comprehensively assess AFP surveillance trends, patterns, and challenges in Niger, offering insights for public health initiatives in conflict-affected contexts. Methods We analyzed nationwide AFP surveillance data from 2016 to 2021. …”
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Unveiling causal immune cell–gene associations in multiple myeloma: insights from systematic reviews and Mendelian randomization analyses by Hui Zhang, Hui Zhang, Ling Zhang, Jing-Xuan Lian, Zhi-Fu Kou, Yu Zhu, Yu Zhu, Li-Tian Ma, Li-Tian Ma, Jin Zheng, Jin Zheng, Can-Jun Zhao, Can-Jun Zhao

“…This study utilized meta-analysis to evaluate CAR-T-cell therapy efficacy and safety and employed two-sample Mendelian randomization (MR) analysis to investigate the causal links between immune cells and Multiple Myeloma (MM).MethodOur literature review, conducted from January 1, 2019, to August 30, 2024, across Medline/PubMed, Scopus, and Web of Science, identified 2,709 articles, 34 of which met our inclusion criteria. We utilized MR analysis of GWAS data to identify immune cells causally related to multiple myeloma, followed by SMR analysis to highlight associated pathogenic genes and colocalisation analysis for validation.ResultsThe meta-analysis revealed an 82.2% overall response rate to CAR-T-cell therapy, characterized by a safe profile with a grade 3 or higher CRS of 6.3% and neurotoxicity of 0.9%. …”
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Innovations in Medical Education in Gastrointestinal Surgery Using Interactive Anatomical Tables by A. D. Kashtanov, E. O. Stetsyk, S. S. Dydykin, O. V. Kytko, E. M. Trunin, O. Yu. Aleshkina, A. N. Lavrentieva, A. N. Andreeva, D. S. Alekseeva, A. A. Muratova, A. Yu. Kharina, V. V. Tatarkin, A. S. Sokolova, V. N. Filatov, I. L. Samodova, E. A. Makeeva, E. S. Pekeldina, M. Yu. Kapitonova, T. S. Bikbaeva, I. A. Polkovova, B. A. Volel, T. M. Litvinova, E. N. Dudnik, N. V. Kireeva, K. V. Ivashkin, Yu. L. Vasil’ev

“…This indicates that students’ subjective experience of the learning process has improved due to their increased involvement in the class and their interest in innovative teaching methods.Conclusion. We plan to study learning outcomes in more detail to identify any differences in the formation of general and professional competencies among students. …”
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Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study by Atsushi Nakajima, Yasushi Honda, Kento Imajo, Masato Yoneda, Yuji Ogawa, Takaomi Kessoku, Takashi Kobayashi, Anna Ozaki, Asako Nogami, Satoru Saito, Michihiro Iwaki, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Noritoshi Kobayashi

“…In this randomised, open label, parallel-group, phase IIa study, we made attempts to conduct a proof-of-concept assessment by evaluating the efficacy and safety of guanabenz acetate treatment in patients with NAFLD/NASH.Methods and analysis A total of 28 adult patients with NAFLD or NASH and hypertension complications meeting the inclusion/exclusion criteria will be enrolled. …”
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An interactive course program on nutrition for medical students: interdisciplinary development and mixed-methods evaluation by Gonza B. Ngoumou, Daniela A. Koppold, Laetitia Wenzel, Anne Schirmaier, Carolin Breinlinger, Lisa M. Pörtner, Stefan Jordan, Julia K. Schiele, Etienne Hanslian, Annika Koppold, Beate Stock-Schröer, Dimitra M. Varvarezou, Michael Jeitler, Miriam Ortiz, Andreas Michalsen, Wiebke Stritter, Georg Seifert, Christian S. Kessler

“…The relevance of nutrition for individual and planetary health is insufficiently addressed in German medical schools. Here, we present a two-week course for medical students in the 8th semester at Charité - Universitätsmedizin Berlin on nutrition and fasting in the context of human and planetary health. …”
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Vascular Access Device Infections: Current Management Practices and the Role of Multidisciplinary Teams at a Large Hospital in Northern Italy by Marta Colaneri, Lucia Galli, Martina Offer, Fabio Borgonovo, Giovanni Scaglione, Camilla Genovese, Rebecca Fattore, Monica Schiavini, Giovanni De Capitani, Maria Calloni, Arianna Bartoli, Antonio Gidaro, Chiara Cogliati, Spinello Antinori, Andrea Gori, Antonella Foschi

“…This study aims to evaluate the alignment between actual VAD infection management practices and VAT-recommended protocols. <b>Methods</b>: We conducted a retrospective, single-center study at Luigi Sacco Hospital (May 2021–October 2023) involving non-ICU adult patients with diagnosed CRBSI or CABSI. …”
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Healthy lifestyle before and during pregnancy to prevent childhood obesity: study protocol for a parallel group randomised trial — the PRE-STORK trial by Tina Vilsbøll, Signe S Torekov, Julie Lyng Forman, Romain Barrès, Andreas Andersen, Filip K Knop, Signe Foghsgaard, Klaus Bønnelykke, Thomas Bergholt, Karoline Kragelund Nielsen, Christina Anne Vinter, Majken Lillholm Pico, Louise Groth Grunnet, Nina Kornerup, Julie Hagstrøm Danielsen, Ronni Eg Sahl, Mette Yun Johansen, Louise Kelstrup, Nida Ghauri, Emilie Grønlund, Lærke Lund

“…The ‘healthy lifestyle before and during pregnancy to prevent childhood obesity — the PRE-STORK trial’ aims to provide insights into the effect of a lifestyle intervention initiated before conception and continued during pregnancy in women with overweight or obesity, on neonatal adiposity in their children.Methods and analysis In this randomised, two-arm, parallel-group, controlled trial, we will include 360 women with overweight or obesity (aged 18–40; body mass index 25–44 kg/m2) and their partners. …”
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Biogeochemical cycling of sedimentary organic carbon and benthic nutrient fluxes in the semi-enclosed Jinhae Bay, Korea: insights into benthic-pelagic coupling by Sung-Uk An, Sung-Uk An, Kyung-Tae Kim, Sung-Han Kim, Sung-Han Kim, Ju-Wook Baek, Ju-Wook Baek, Hyun-Jeong Jeong, Hyun-Jeong Jeong, Chul-In Sun, Jin Young Choi, Jin Young Choi, Sokjin Hong, Dae In Lee, Jae Seong Lee, Jae Seong Lee

“…To understand the biogeochemical processes associated with organic matter mineralization and nutrient regeneration, we estimated total and diffusive sediment oxygen uptake rates, benthic nutrient fluxes, and organic carbon (OC) budgets at four sites in the semi-enclosed Jinhae Bay (JB). …”
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Ten pressure points in primary care during COVID-19: findings from an international narrative review by Sally Hall Dykgraaf, Anne Parkinson, Michael Wright, William C. W. Wong, Jane Desborough, Lauren Ball, Elizabeth Sturgiss, Garang M. Dut, Katelyn Barnes, Danielle Butler, Steph Davis, Kirsty Douglas, Candan Kendir, Danielle Martin, Robert Marten, Katherine Rouleau, Shannon Barkley, Lucas de Toca, Michael Kidd

“…This secondary analysis of data from an integrative systematic review across international PC settings aimed to identify and describe burdens and challenges experienced by PCPs and PC services in the context of their contributions to COVID-19 pandemic responses. Methods We conducted an integrative systematic review and narrative analysis, searching PubMed/Medline, Scopus, Proquest Central and Cochrane Database of Systematic Reviews, plus reference lists of key publications. …”
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Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children by Camille M. Moore, Jonathan Thornburg, Elizabeth A. Secor, Katharine L. Hamlington, Allison M. Schiltz, Kristy L. Freeman, Jamie L. Everman, Tasha E. Fingerlin, Andrew H. Liu, Max A. Seibold

“…Few studies evaluate breathing zone exposures, which may be more consequential for asthma outcomes. Methods We measured personal exposures to NO2, O3, PM10 and PM10 constituents, including black carbon (BC), brown carbon (BrC), environmental tobacco smoke (ETS), endotoxins, and 𝛽-glucan, in a cohort of children with exacerbation-prone asthma for 72 h using wearable monitors. …”
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Value of triglyceride glucose-body mass index in predicting nonalcoholic fatty liver disease in individuals with type 2 diabetes mellitus by Xiaoyi Qian, Wenwen Wu, Boyang Chen, Simin Zhang, Chunmei Xiao, Long Chen, Jun Chen, Jun Chen, Lingli Ke, Meian He, Xiulou Li, Xiulou Li, Xiulou Li

“…The magnitude of risk prediction and predictive efficacy of TyG-BMI for T2DM with NAFLD remains unclear.ObjectiveTo examine the association of TyG-BMI with NAFLD in T2DM patients and assess the effectiveness of screening using the TyG-BMI index.MethodsWe conducted a retrospective analysis of clinical data from 602 T2DM patients at an enterprise health lodge from September 2021 to November 2022. …”
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Typical and extreme weather datasets for studying the resilience of buildings to climate change and heatwaves by Anaïs Machard, Agnese Salvati, Mamak P. Tootkaboni, Abhishek Gaur, Jiwei Zou, Liangzhu Leon Wang, Fuad Baba, Hua Ge, Facundo Bre, Emmanuel Bozonnet, Vincenzo Corrado, Xuan Luo, Ronnen Levinson, Sang Hoon Lee, Tianzhen Hong, Marcelo Salles Olinger, Rayner Maurício e Silva Machado, Emeli Lalesca Aparecida da Guarda, Rodolfo Kirch Veiga, Roberto Lamberts, Afshin Afshari, Delphine Ramon, Hoang Ngoc Dung Ngo, Abantika Sengupta, Hilde Breesch, Nicolas Heijmans, Jade Deltour, Xavier Kuborn, Sana Sayadi, Bin Qian, Chen Zhang, Ramin Rahif, Shady Attia, Philipp Stern, Peter Holzer

“…Abstract We present unprecedented datasets of current and future projected weather files for building simulations in 15 major cities distributed across 10 climate zones worldwide. …”
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A 4-Week Mobile App–Based Telerehabilitation Program vs Conventional In-Person Rehabilitation in Older Adults With Sarcopenia: Randomized Controlled Trial by Lu Zhang, Ying Ge, Wowa Zhao, Xuan Shu, Lin Kang, Qiumei Wang, Ying Liu

“…However, they often face challenges when receiving traditional rehabilitation treatments at hospitals. ObjectiveWe aimed to compare the effects of a digital rehabilitation program with those of traditional therapist-supervised rehabilitation training on older adults with sarcopenia. …”
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