Les vestiges fauniques de la rue Lecointre à Reims/Durocortorum : une carrière utilisée comme dépotoir by Frédéric Poupon

“…A majority of them are associated with food production, represented by an abundance of pig remains (at the expense of goat remains), and associated with secondary waste materials, represented by poultry and game remains. Though we cannot confirm their consumption, in terms of wild fauna, bear and fallow deer are represented by rare remains. …”
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A visual walkthrough of robotic partial mesorectal excision using the Versius surgical system by Amro Mureb

“…All these features help the colorectal surgeon complete the rectal surgery more safely and effectively, and like any surgical procedure, standardization of the technique can lead to a shorter learning curve and better outcomes. In this video, we demonstrated a step-by-step approach to tumour-specific mesorectal excision operation using the Versius robotic system platform, starting the mesorectal dissection posteriorly along the plane between the mesorectum and presacral fascia; this dissection should continue distally until reaching at least 5 cm beyond the lower edge of the tumour level which is localised intraoperatively using a rigid sigmoidoscope. …”
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HIV Drug Resistance Profile in Clients Experiencing Treatment Failure After the Transition to a Dolutegravir-Based First-Line Antiretroviral Treatment Regimen in Mozambique by Nalia Ismael, Cidia Hussein, Cacildo Magul, Humberto Inguane, Aleny Couto, Amancio Nhangave, Ana Muteerwa, Mahoudo Bonou, Artur Ramos, Peter Wesley Young, Sonia Chilundo, Rhoderick Machekano, Lauren Greenberg, Juliana da Silva, Nilesh Bhatt

“…Real-world data on HIV drug resistance (HIVDR) after transitioning to tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD) are limited. We assessed HIVDR rates and patterns in clients with virological failure (VF) after switching from an NNRTI-based regimen to TLD. …”
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Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells by Xu Zhou, Wen-Ming Liu, Han-Yong Sun, Yuan Peng, Ren-Jie Huang, Cai-Yang Chen, Hong-Dan Zhang, Shen-Ao Zhou, Hong-Ping Wu, Dan Tang, Wei-Jian Huang, Han Wu, Qi-Gen Li, Bo Zhai, Qiang Xia, Wei-Feng Yu, He-Xin Yan

“…Cell therapy demonstrates promising potential as a substitute therapeutic approach for liver cirrhosis. We have developed a strategy to effectively expand murine and human hepatocyte-derived liver progenitor-like cells (HepLPCs) in vitro. …”
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Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV by Giovanni Guaraldi, Jovana Milic, Elena Bacchi, Federica Carli, Marianna Menozzi, Iacopo Franconi, Alessandro Raimondi, Giacomo Ciusa, Valentina Masi, Michela Belli, Stefano Guaraldi, Emanuele Aprile, Maria Mancini, Cristina Mussini, Jordan E. Lake, Kristine M. Erlandson

“…Background: Integrase inhibitor (INSTI) use has been associated with greater weight gain (WG) among people living with HIV (PLWH), but it is unclear how this effect compares in magnitude to traditional risk factors for WG. We assessed the population attributable fractions (PAFs) of modifiable lifestyle factors and INSTI regimens in PLWH who experienced a ≥5% WG over follow-up. …”
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Molecular insight into reproductive toxicity and transgenerational effects of Cadmium exposure on Drosophila melanogaster by Yi Pan, Ke Fan, Linhao Zong, Yantao Luo, Xin Ni, Dong Chen, Jinjun Qian, Fei Ma, Jie Cheng, Miao Guan

“…Although the evidence for Cd-induced reproductive toxicity is well established, it remains elusive on the intricate dose-response relationship and underlying molecular mechanisms, especially for transgenerational toxicity in animals. Here, we employed fruit fly (Drosophila melanogaster) as a model organism to examine the reproductive performance across five generations by parental exposure to varying concentrations of Cd (5, 50, and 500 μM). …”
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Mamá Empoderada: study protocol for a pilot trial of a novel parenting and mental health prevention intervention for migrant mothers with young children at the Mexico-US border by Gudelia Rangel, Shira M Goldenberg, Eileen Pitpitan, Kaylee Ramage, Ietza Bojorquez-Chapela, Cecilia Martinez-Torteya, Katherine Rosenblum, Chelsie Hernandez, Monica Alvarez

“…This is an evidence-based intervention that has been previously evaluated in the USA and has been recently adapted for Spanish-speaking mothers. We have recently adapted this intervention for MMC in Mexico and will conduct a pilot randomised controlled trial (RCT) of the intervention with MMC (n=100; Ntreatment=50; Ncontrol=50). …”
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Phenotypic effects of the dwarfing gene Rht-17 in spring durum wheat under two climatic conditions by A. G. Chernook, P. Yu. Kroupin, L. A. Bespalova, V. V. Panchenko, V. Ya. Kovtunenko, M. S. Bazhenov, L. A. Nazarova, G. I. Karlov, A. Yu. Kroupina, M. G. Divashuk

“…Durum wheat carries only two subgenomes (A and B), which limits the use of the D-subgenome genes and requires the expansion of the arsenal of dwarfing alleles and the study of their effects on height and agronomically important traits. We studied the effect of the gibberellin-insensitive allele Rht-B1p in the B2F2:3 families, developed by crossing Chris Mutant /#517//LD222 in a field experiment in Moscow and Krasnodar. …”
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Transcriptome signature in the blood of neuromyelitis optica spectrum disorder under steroid tapering by Ryohei Yamamura, Makoto Kinoshita, Yoshiaki Yasumizu, Yoshiaki Yasumizu, Yoshiaki Yasumizu, Tomohiro Yata, Keigo Kihara, Daisuke Motooka, Daisuke Motooka, Naoyuki Shiraishi, Yasuko Sugiyama, Shohei Beppu, Hisashi Murata, Naoshi Koizumi, Itsuki Sano, Toru Koda, Tatsusada Okuno, Hideki Mochizuki

“…However, there are no biomarkers that predict relapses associated with steroid tapering; therefore, it is critical to identify potential indicators of disease activity. In this study, we collected peripheral blood mononuclear cells (PBMCs) from NMOSD patients during steroid tapering and performed bulk RNA sequencing to analyze changes in immune dynamics caused by steroid reduction.MethodsPBMCs were collected at 3–5 timepoints from 10 NMOSD patients at our hospital (including one relapse case), and bulk RNA sequencing was performed. …”
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Evidences of the Low Implication of Mosquitoes in the Transmission of Mycobacterium ulcerans, the Causative Agent of Buruli Ulcer by Rousseau Djouaka, Francis Zeukeng, Jude Daiga Bigoga, David N’golo Coulibaly, Genevieve Tchigossou, Romaric Akoton, Sylla Aboubacar, Sodjinin Jean-Eudes Tchebe, Clavella Nantcho Nguepdjo, Razack Adeoti, Innocent Djegbe, Manuele Tamo, Wilfred Fon Mbacham, Solange E. Kakou-Ngazoa, Anthony Ablordey

“…Additional studies of artificially infected larvae of Anopheles kisumu with MU strains revealed that mosquitoes larvae are able to ingest and host MU during L1, L2, L3, and L4 developmental stages. However, we noticed an absence of these bacteria at both pupae and adult stages, certainly revealing the low ability of infected or colonized mosquitoes to vertically transmit MU to their offspring. …”
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In situ real-time measurement for electron spin polarization in atomic spin gyroscopes by Feng Li, Haoying Pang, Zhuo Wang, Wenfeng Fan, Min Zhang, Zehua Liu, Jiahang Li, Bodong Qin, Xinxiu Zhou, Xusheng Lei, Ruigang Wang

“…By utilizing artificial neural networks, we derive an output equation for electron spin polarization, using transmitted laser power and cell temperature as independent variables. …”
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Nomogram to predict 3 month prognosis of acute ischemic stroke among young adults by Qian He, Qian He, Miaoran Wang, Haoyue Zhu, Ying Xiao, Rui Wen, Xiaoqing Liu, Yangdi Shi, Linzhi Zhang, Bing Xu

“…Univariate logistic regression was used to select the independent factors of prognosis and multivariate logistic regression to establish a new nomogram model. We used the area under the receiver-operating characteristic curve (ROC) to evaluate the discriminative performance and used the calibration curve with Hosmer-Lemeshow goodness of fit test to assess the calibration performance of the risk prediction model. …”
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Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats by Liliany Souza de Brito Amaral, Cláudia Silva Souza, Rildo Aparecido Volpini, Maria Heloisa Massola Shimizu, Ana Carolina de Bragança, Daniele Canale, Antonio Carlos Seguro, Terezila Machado Coimbra, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares

“…At the end of the training protocol, we evaluated the following: glycosuria, body weight gain, plasma, renal and urinary levels of nitric oxide and thiobarbituric acid reactive substances, renal glutathione, and immunolocalization of lymphocytes, macrophages, and nuclear factor-kappa B (NF-κB/p65) in the renal cortex. …”
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Dynamic history of the Central Plain and Haidai region inferred from Late Neolithic to Iron Age ancient human genomes by Hui Fang, Fawei Liang, Hao Ma, Rui Wang, Haifeng He, Limin Qiu, Le Tao, Kongyang Zhu, Weihua Wu, Long Ma, Huazhen Zhang, Shuqing Chen, Chao Zhu, Haodong Chen, Yu Xu, Yongsheng Zhao, Haiwang Liu, Chuan-Chao Wang

“…Our analysis reveals the population structure in Shandong and the Central Plain in the Late Neolithic Longshan cultural period. We provide a genetic parallel to the observation of a significant increase in rice farming in the middle and lower YR in the Longshan period. …”
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Identification of EXPA4 as a key gene in cotton salt stress adaptation through transcriptomic and coexpression network analysis of root tip protoplasts by Qiankun Liu, Pengtao Li, Muhammad Jawad Umer, Mubashir Abbas, Yongqing Zhao, Yu Chen, Yanfang Li, Aiming Zhang, Yuling Liu, Yangyang Wei, Quanwei Lu, Mengying Yang, Yiman Liu, Xiaoyan Cai, Zhongli Zhou, Shuxun Yu, Fang Liu, Renhai Peng

“…Elucidating crop tolerance mechanisms that ameliorate these diverse salinity-induced stresses is key for improving agricultural productivity under saline conditions. Results Herein, we performed transcriptome profiling of Gossypium arboreum root tips and root tips-derived protoplasts to uncover salt tolerance genes and mechanisms. …”
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Lifetime history of concussion among children and adolescents with attention-deficit/hyperactivity disorder: examining differences stratified by age, medication status, and parent-... by Julia E. Maietta, Julia E. Maietta, Julia E. Maietta, Grant L. Iverson, Grant L. Iverson, Grant L. Iverson, Grant L. Iverson, Nathan E. Cook, Nathan E. Cook, Nathan E. Cook, Nathan E. Cook

“…It is unclear if ADHD severity or ADHD medication influences the association between ADHD and greater lifetime history of concussion. We investigated the association between parent-reported ADHD, ADHD severity, and medication status with parent-reported lifetime concussion history in children and adolescents ranging in age from 5 to 17, sampled from the United States general population.MethodsParent reported health data from 33,914 children and adolescents were selected from the 2021 National Survey of Children’s Health. …”
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Black carp RNF115 restricts IRF3/7-mediated antiviral signaling in innate immunity by Yixuan He, Qun Wang, Lili Xiao, Hui Wu, Jun Xiao, Jun Zou, Hao Feng

“…RING finger protein 115 (RNF115), also known as BCA2, Rabring7, or ZNF364, is a novel RING domain protein. In this paper, we cloned the RNF115 homologue from black carp (Mylopharyngodon piceus) and characterized it. …”
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Noninvasive imaging biomarker reveals invisible microscopic variation in acute ischaemic stroke (≤ 24 h): a multicentre retrospective study by Kui Sun, Rongchao Shi, Xinxin Yu, Ying Wang, Wei Zhang, Xiaoxia Yang, Mei Zhang, Jian Wang, Shu Jiang, Haiou Li, Bing Kang, Tong Li, Shuying Zhao, Yu Ai, Jianfeng Qiu, Haiyan Wang, Ximing Wang

“…Abstract To develop and validate non-contrast computed tomography (NCCT)-based radiomics method combines machine learning (ML) to investigate invisible microscopic acute ischaemic stroke (AIS) lesions. We retrospectively analyzed 1122 patients from August 2015 to July 2022, whose were later confirmed AIS by diffusion-weighted imaging (DWI). …”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…This study aimed to evaluate the inflammatory status and clinical outcomes of patients hospitalized with COVID-19, with and without <i>C. difficile</i> co-infection, and to identify the inflammatory markers most predictive of severe disease. Methods: We conducted a retrospective cohort study of 200 hospitalized adults with confirmed COVID-19, of whom 92 had laboratory-confirmed <i>C. difficile</i> infection. …”
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A harmonized dataset relating alternative farmer management practices to crop yield, soil organic carbon stock, nitrous oxide emissions, and nitrate leaching generated using IPCC m... by Roberta Calone, Angela Fiore, Guido Pellis, Maria Luz Cayuela, Gabriele Mongiano, Alessandra Lagomarsino, Simone Bregaglio

“…However, these methods often do not explicitly account for the combined effects of management practices on carbon and nitrogen cycles or productivity, as this is not required for national GHG inventories. Here we present a new dataset featuring 1.8 Mln of agronomic case scenarios, i.e., unique combinations of farming practices and pedoclimatic conditions, which have been associated with values of SOC changes, nitrous oxide emissions, nitrate-nitrogen leaching, and crop yield. …”
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