Prophylactic Subacute Administration of Zinc Increases CCL2, CCR2, FGF2, and IGF-1 Expression and Prevents the Long-Term Memory Loss in a Rat Model of Cerebral Hypoxia-Ischemia by Victor Manuel Blanco-Alvarez, Guadalupe Soto-Rodriguez, Juan Antonio Gonzalez-Barrios, Daniel Martinez-Fong, Eduardo Brambila, Maricela Torres-Soto, Ana Karina Aguilar-Peralta, Alejandro Gonzalez-Vazquez, Constantino Tomás-Sanchez, I. Daniel Limón, Jose R. Eguibar, Araceli Ugarte, Jeanett Hernandez-Castillo, Bertha Alicia Leon-Chavez

“…Chemokines and growth factors are also involved in the neuroprotective effect in hypoxia-ischemia. We explored whether zinc prevents the cerebral cortex-hippocampus injury through regulation of CCL2, CCR2, FGF2, and IGF-1 expression following a 10 min of common carotid artery occlusion (CCAO). …”
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Feasibility and Acceptability of a Real-Time Adherence Device among HIV-Positive IDU Patients in China by Mary Bachman DeSilva, Allen L. Gifford, Xu Keyi, Zhong Li, Cheng Feng, Mohamad Brooks, Mark Harrold, Hu Yueying, Christopher J. Gill, Xie Wubin, Taryn Vian, Jessica Haberer, David Bangsberg, Lora Sabin

“…We collected data on feasibility and acceptability of a real-time web-linked adherence monitoring container among HIV-positive injection drug users (IDU) in China. …”
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Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Stud... by Richard B. Warren, Lev Pavlovsky, Antonio Costanzo, Michael Bukhalo, Neil J. Korman, Yu-Huei Huang, Georgios Kokolakis, Andreas Pinter, Nadia Ibrahim, Yanbing Zheng, Leonidas Drogaris, Vassilis Stakias, Ahmed M. Soliman, Simone Rubant, Diamant Thaçi

“…Abstract Introduction Risankizumab has demonstrated superior efficacy compared to other psoriasis treatments, including secukinumab, adalimumab, and ustekinumab; switching to risankizumab from other psoriasis treatments has shown superior clinical and quality of life (QoL) outcomes. We evaluated the efficacy and safety of directly switching patients with moderate-to-severe plaque psoriasis and a suboptimal response to interleukin (IL)-17 inhibitors (secukinumab or ixekizumab) to risankizumab. …”
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Comparing cup placement, leg length, and offset discrepancy after total hip arthroplasty between CT-based robotic arm-assisted and navigation systems by Akira Shimizu, Satoshi Murakami, Takayuki Tamai, Yuuki Haga, Tatsuhiko Kutsuna, Tomofumi Kinoshita, Masaki Takao

“…This study aimed to determine whether a CT-based robotic arm-assisted system helps surgeons perform accurate cup placement, minimizes leg length, and offsets discrepancies more than a CT-based navigation system. Methods: We studied 60 hips from 54 patients who underwent rTHA between April 2021 and August 2023, and 45 hips from 44 patients who underwent nTHA between January 2020 and March 2021 with the same target cup orientation at the Department of Orthopedic Surgery at Ozu Memorial Hospital, Japan. …”
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Functional effect of adiponectin and body composition assessment in lung cancer subjects after video‐assisted thoracoscopic surgery (VATS) lobectomy by Gaetana Messina, Giovanni Natale, Alfonso Fiorelli, Maria Antonietta Puca, Fiorenzo Moscatelli, Vincenzo Monda, Marcellino Monda, Marina Di Domenico, Carminia Maria Della Corte, Gabriella Marsala, Giuseppe Vicario, Carmine Dalia, Paola Bassi, Beatrice Leonardi, Antonella De Maria, Antonietta Monda, Giovanni Messina, Antonietta Messina, Rita Polito

“…Methods In this study, we analyzed body composition through bioelectrical impedance analysis (BIA) and biochemical parameters such as glycemic and lipidic profile, inflammation profile and adiponectin serum levels in 30 patients (19 male; 11 women) undergoing video‐assisted thoracoscopic surgery (VATS) lobectomy for lung cancer from September 2021 to May 2022 at the Thoracic Unit of Luigi Vanvitelli University of Naples. …”
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Molecular and cellular aspects of the impact of secondary metabolites from common barberry and hybrid goat’s rue on the HeLa cell line by E. Yu. Zlatnik, Ya. S. Enin, O. N. Burov, E. S. Bondarenko, A. B. Sagakyants, D. S. Kutilin, Yu. V. Dzigunova, O. G. Ishonina, E. V. Shalashnaya, N. D. Ushakova

“…In the first stage of the study, we isolated and verified the berberine alkaloid extracted from the roots of B. vulgaris (L.), as well as 2,4-dihydroxy-2,5-dimethylfuran-3(2H)-one and 2,2,8-trimethyldecahydroazulene-5,6-dicarbaldehyde from P. hibridus (L.). …”
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Effect of drug interactions with apixaban on clinical outcomes in cancer patients with venous thromboembolism by Marte Svalastoga, Trine-Lise Larsen, Trine-Lise Larsen, Jorunn Brekke, Tone Enden, Hege Frøen, Herish Garresori, Eva Marie Jacobsen, Alina Carmen Porojnicu, Anne Hansen Ree, Anne Hansen Ree, Dag Torfoss, Elin Osvik Velle, Hilde Skuterud Wik, Waleed Ghanima, Waleed Ghanima, Per Morten Sandset, Per Morten Sandset, Anders Erik Astrup Dahm, Anders Erik Astrup Dahm

“…There were no major bleedings in 23 patients using aprepitant nor in the 10 patients taking macrolides. We found no association between drugs and recurrent VTE, except that there were no recurrent VTE in 19 patients using bevacizumab.ConclusionsDespite the high number of drugs taken that could potentially interact with apixaban, none were found to clearly influence clinical outcomes, except that fluconazole may increase the risk of CRNMB.…”
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Development and validation a methodology model for traditional Chinese medicine good practice recommendation: an exploratory sequential mixed methods study by Su Li, Su Li, Su Li, Luan Zhang, Yangyang Wang, Yangyang Wang, Runsheng Xie, Runsheng Xie, Wenjia Chen, Wenjia Chen, Myeong Soo Lee, Yasser Sami Amer, Yasser Sami Amer, Yasser Sami Amer, Amin Sharifan, Heba Hussein, Hui Li, Hui Li, Hui Li

“…BackgroundTo develop a rational and standardized traditional Chinese medicine (TCM) good practice recommendation (GPR) methodology model that guides the formulation of recommendations grounded in clinical experience.MethodsWe adopted an exploratory sequential mixed-method to develop a methodology model by coding systematically collected literature on methodology and TCM guidelines related to TCM GPR using a best-fit framework synthesis. …”
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Assessing the Future ODYSEA Satellite Mission for the Estimation of Ocean Surface Currents, Wind Stress, Energy Fluxes, and the Mechanical Coupling Between the Ocean and the Atmosp... by Marco Larrañaga, Lionel Renault, Alexander Wineteer, Marcela Contreras, Brian K. Arbic, Mark A. Bourassa, Ernesto Rodriguez

“…This study evaluates the potential of ODYSEA to measure surface winds, currents, energy fluxes, and ocean–atmosphere coupling coefficients. To this end, we generated synthetic ODYSEA data from a high-resolution coupled ocean–wave–atmosphere simulation of the Gulf Stream using ODYSIM, the Doppler scatterometer simulator for ODYSEA. …”
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The history of childbirth: Women and doctors in the lying-in hospital of Göttingen University, eighteenth – nineteenth century by Jürgen Schlumbohm

“…This ambivalent attitude to midwives becomes visible even in the Göttingen maternity hospital, if we carefully analyse its educational policy. Around 1800, in 78 per cent of the cases, the birth attendants were male (medical students and professor Osiander), and only in 22 per cent, the attendants were female (midwife apprentices and the hospital midwife). …”
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A Vitamin Pattern Diet Is Associated with Decreased Risk of Gestational Diabetes Mellitus in Chinese Women: Results from a Case Control Study in Taiyuan, China by Qiong Chen, Yongliang Feng, Hailan Yang, Weiwei Wu, Ping Zhang, Keke Wang, Ying Wang, Jamie Ko, Jiaxin Shen, Lingling Guo, Feng Zhao, Wenqiong Du, Shouhang Ru, Suping Wang, Yawei Zhang

“…Identification of modifiable dietary factors, which are involved in the development of gestational diabetes mellitus (GDM), could inform strategies to prevent GDM. Therefore, we examined the dietary nutrient patterns and evaluated their relationship with GDM risk in a Chinese population using a case control study design. …”
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Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study by Yan Huang, Qiuxia Zhong, Junzhi Chen, Xianhui Qin, Yaya Yang, Yanhuan He, Zizhen Lin, Yumin Li, Shenglin Yang, Yongxin Lu, Yanhong Zhao, Yaozhong Kong, Qijun Wan, Qi Wang, Sheng Huang, Yan Liu, Aiqun Liu, Fanna Liu, Fanfan Hou, Min Liang

“…Objective The relationship between serum total cholesterol (TC) and triglyceride (TG) levels and mortality in maintenance hemodialysis (MHD) patients remains inconsistent. We aimed to explore the individual and combined association of TC and TG levels with the risk of mortality in Chinese MHD patients.Methods 1036 MHD patients were enrolled in this multicenter, prospective cohort study. …”
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Long-term cardiovascular outcomes after percutaneous coronary intervention in patients with systemic sclerosis by Kazutoshi Hirose, Hiroyuki Kiriyama, Shun Minatsuki, Yugo Nagae, Tatsuki Furusawa, Takashi Hiruma, Atsushi Kobayashi, Masataka Sato, Shinnosuke Sawano, Tatsuya Kamon, Hiroki Shinohara, Mizuki Miura, Akihito Saito, Satoshi Kodera, Junichi Ishida, Norifumi Takeda, Hiroyuki Morita, Issei Komuro, Norihiko Takeda

“…However, the morphological characteristics of CAD and the long-term cardiovascular outcomes in patients with concurrent SSc and CAD remain unclear. Methods: We retrospectively investigated 3,300 patients with CAD who underwent percutaneous coronary intervention (PCI) without prior myocardial infarction or coronary artery revascularization. …”
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Impact Assessment of Energy Transition Policy on Air Quality over a Typical District of the Pearl River Delta Region, China by Weidong Chen, Haixian Li, Yun Zhu, Jicheng Jang, Che-Jen Lin, Pen-Chi Chiang, Shuxiao Wang, Jia Xing, Tingting Fang, Jie Li, Qingshan Yang, Kaiming Zheng

“…Using Shunde District as a case study, we developed the emission inventories of CO2 and air pollutants, projected the trend of CO2 emissions, and estimated the air quality under three energy transition scenarios using the Long-range Energy Alternatives Planning (LEAP) model and the Weather Research and Forecasting-Community Multiscale Air Quality Modeling (WRF-CMAQ) system. …”
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Health and Experiences During the COVID-19 Pandemic Among Children and Young People: Analysis of Free-Text Responses From the Children and Young People With Long COVID Study by Natalia K Rojas, Sam Martin, Mario Cortina-Borja, Roz Shafran, Lana Fox-Smith, Terence Stephenson, Brian C F Ching, Anaïs d'Oelsnitz, Tom Norris, Yue Xu, Kelsey McOwat, Emma Dalrymple, Isobel Heyman, Tamsin Ford, Trudie Chalder, Ruth Simmons, Snehal M Pinto Pereira

“…The results were broadly similar when reweighted to the general population of children and young people in England: 78.52% (negative), 13.23% (positive), and 8.24% (neutral). ConclusionsWe used InfraNodus to analyze free-text responses from a large sample of children and young people. …”
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Effects of non-pharmacological interventions on biochemical hyperandrogenism in women with polycystic ovary syndrome: a systematic review and network meta-analysis by Qi Jin, Ge Xu, Yuchen Ying, Lumin Liu, Huimin Zheng, Shifen Xu, Ping Yin, Yuelai Chen

“…Network meta-analysis (NMA) was used to synthesize data, with network diagrams illustrating comparisons between NPIs. We assessed the consistency of the results, performed sensitivity analyses, and examined publication bias to evaluate the influence of individual studies. …”
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Effects of dietary l-carnosine supplementation on the growth, intestinal microbiota, and serum metabolome of fattening lambs by Yaxuan Meng, Yaxuan Meng, Yaxuan Meng, Tingting Xian, Tingting Xian, Guolei Kang, Hongna Wang, Tao Feng, Tao Feng, Tao Feng

“…However, the mechanisms underlying the effects of l-carnosine on the physiological functions of animals have not been fully elucidated. We investigated the effects of dietary l-carnosine supplementation on growth performance, intestinal microbiota diversity, and the serum metabolome in fattening lambs to reveal the molecular mechanism underlying the effect of l-carnosine on the growth performance of sheep. …”
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Chemoimmunotherapy as induction treatment in concurrent chemoradiotherapy for patients with nasopharyngeal carcinoma stage IVa by Kun-Peng Wu, Qing-Qing Li, Xu-Qiang Luo, Xiao-Xi Wang, Yan-Zhen Lai, Dan Tian, Hong-cheng Yang, Xue-Ling Wei, Lan-Ying Wang, Qiu-Ming Li, Dao Zhu, Si-Jie Chen, Yang-Si Li

“…All patients underwent standard platinum-based concurrent intensity-modulated radiation therapy. We compared tumor response and toxicity during induction treatment and concurrent chemoradiotherapy (CCRT) between the two groups.Results The objective and complete response rates were significantly higher in the induction chemoimmunotherapy group compared to the induction chemotherapy group (95.7% vs 77.8%, and 39.1% vs 22.2%, respectively). …”
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Predictive Validity of Hospital-Associated Complications of Older People Identified Using Diagnosis Procedure Combination Data From an Acute Care Hospital in Japan: Observational S... by Seigo Mitsutake, Tatsuro Ishizaki, Shohei Yano, Takumi Hirata, Kae Ito, Ko Furuta, Yoshitomo Shimazaki, Hideki Ito, Alison Mudge, Kenji Toba

“…MethodsThis retrospective cohort study acquired DPC data (routinely collected administrative data) from a general acute care hospital in Tokyo, Japan. We included data from index hospitalizations for patients aged ≥65 years hospitalized for ≥3 days and discharged between July 2016 and March 2021. …”
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Switch of phosphorylation to O-GlcNAcylation of AhR contributes to vascular oxidative stress induced by benzo[a]pyrene by Rong Wang, Yun Huang, Xiaoruo Gan, Chenghao Fu, Yuemin Li, Ning Chen, Hao Xi, Huishan Guo, Wei Zhang, Yuhong Lü, Yan Zhang, Pin Lü

“…The nuclear translocation of Arylhydrocarbon receptor (AhR) plays an important role in B[a]P-induced oxidative stress and vascular diseases. We confirmed that B[a]P promoted ROS production in vascular smooth muscle cells (VSMCs) in vitro and in vivo, associated with the nuclear translocation of AhR. …”
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