Poly (ADP-ribose) (PAR) levels in Peripheral Blood Mononuclear Cells (PBMC) during peri-implantation and early pregnancy in buffalo cows by Giovanna De Matteis, Anna Reale, Michele Zampieri, Emanuela Rossi, Federica Signorelli, Olimpia Barbato, Vittoria Lucia Barile

“…Since its involvement in the blastocyst implantation has been hypothesized and considered the importance of markers for predicting pregnancy success, with this study, we wanted to evaluate dynamic changes in PAR levels during peri-implantation and early pregnancy in peripheral blood mononuclear cells (PBMCs) in buffalo species. …”
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Early release of circulating tumor cells after transarterial chemoembolization hinders therapeutic response in patients with hepatocellular carcinoma by María L. Espejo-Cruz, Sandra González-Rubio, Juan J. Espejo, Javier M. Zamora-Olaya, María Prieto-Torre, Clara I. Linares, Álvaro Ruiz-Ramas, Álvaro Jiménez-Arranz, Marta Guerrero-Misas, Pilar Barrera-Baena, Antonio Poyato-González, José L. Montero, Marina Sánchez-Frías, María D. Ayllón, Manuel L. Rodríguez-Perálvarez, Manuel de la Mata, Gustavo Ferrín

“…Tumor neovascularization allows tumor growth and may facilitate the release of circulating tumor cells (CTCs) to the bloodstream after TACE. We investigated the relationship between early release of CTCs and radiological response after TACE. …”
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Green Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Diet by Cláudio A. Cunha, Fábio S. Lira, José C. Rosa Neto, Gustavo D. Pimentel, Gabriel I. H. Souza, Camila Morais Gonçalves da Silva, Cláudio T. de Souza, Eliane B. Ribeiro, Alexandra Christine Helena Frankland Sawaya, Cláudia M. Oller do Nascimento, Bruno Rodrigues, Patrícia de Oliveira Carvalho, Lila M. Oyama

“…Green tea administered concomitantly with a high-fat diet increased HSL, ABHD5, and perilipin in mesenteric adipose tissue, and this was associated with reduced body weight and adipose tissue gain. Further, we observed that green tea supplementation reduced inflammatory cytokine TNFα levels, as well as TLR4, MYD88, and TRAF6 proinflammatory signalling. …”
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Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions by Jun Song, Meiqi Li, Yuan Tao, Yumeng Li, Canrong Mai, Jingting Zhang, Lan Yao, Shaoquan Shi, Jianyong Xu

“…Conclusions In conclusion, we have demonstrated here that the scar tissues in IUA biopsy are characterized with enhanced differentiation of pro-fibrotic fibroblast and myofibroblast. …”
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Altered zygotic gene expression caused by sperm with Tdrd6 variants disrupts early embryonic development by Zhijie Hu, Yuqi Zhang, Renfei Cai, Qiuju Chen, Haiyan Guo, Danjun Li, Weidong Lin, Hongxi He, Haibo Wu, Yali Liu, Bin Li, Qianwen Xi, Hongyuan Gao, Jian Zhang, Qifeng Lyu, Yanping Kuang, Xuefeng Lu

“…Abstract The precise mechanisms behind early embryonic arrest due to sperm‐related factors and the most effective strategies are not yet fully understood. Here, we present two cases of male infertility linked to novel TDRD6 variants, associated with oligoasthenoteratozoospermia (OAT) and early embryonic arrest. …”
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A head-to-head comparison of the adult EQ-5D-5L and youth EQ-5D-Y-5L in adolescents with idiopathic scoliosis by Joshua M. Bonsel, Charles M. M. Peeters, Max Reijman, Tim Dings, Joost P. H. J. Rutges, Diederik H. R. Kempen, Jan A. N. Verhaar, Gouke J. Bonsel

“…While they were similar in terms of validity and test-retest reliability, differences in score distribution were present. Taken together, we advise using the EQ-5D-5L to monitor the QoL in adolescent patients with AIS, as it avoids switching instruments and thus data discontinuities. …”
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Vertical distribution of ice nucleating particles over the boreal forest of Hyytiälä, Finland by Z. Brasseur, J. Schneider, J. Lampilahti, V. Vakkari, V. Vakkari, V. A. Sinclair, C. J. Williamson, C. J. Williamson, C. Xavier, C. Xavier, D. Moisseev, D. Moisseev, M. Hartmann, P. Poutanen, M. Lampimäki, M. Kulmala, T. Petäjä, K. Lehtipalo, K. Lehtipalo, E. S. Thomson, K. Höhler, O. Möhler, J. Duplissy

“…Most of the INP concentrations and activated fractions observed in the free troposphere are notably lower than in the boundary layer, and the distinct particle size distributions suggest that different aerosol populations, likely resulting from long-range transport, are present in the free troposphere. However, we show one case where higher INP concentrations are observed in the free troposphere and where a homogeneous particle population exists from the surface to the free troposphere. …”
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Evaluation of the recombinant protein Sh-TSP-2 for the serological diagnosis of imported urogenital schistosomiasis and comparison with commercially available tests by María Pilar Luzón-García, Laura Navarro, Esther Rodríguez, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, María Isabel Cabeza-Barrera, Alex Loukas, Nerea Castillo-Fernández, María Jesús Perteguer, Javier Sotillo, Joaquín Salas-Coronas

“…However, there is still a lack of evidence regarding the most appropriate methods for this purpose. Here we assessed the diagnostic efficacy of a newly developed serological technique that utilizes the recombinant protein Sh-TSP-2, applied to the urine and serum of migrants suspected of having urogenital schistosomiasis. …”
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Usability and Usefulness of a Symptom Management Coaching System for Patients With Cancer Treated With Immune Checkpoint Inhibitors: Comparative Mixed Methods Study by Savannah Lucia Caterina Glaser, Itske Fraterman, Noah van Brummelen, Valentina Tibollo, Laura Maria Del Campo, Henk Mallo, Sofie Wilgenhof, Szymon Wilk, Vitali Gisko, Vadzim Khadakou, Ronald Cornet, Manuel Ottaviano, Stephanie Medlock

“…Usability problems were extracted from the interview data by independent coding and mapped to an eHealth Usability Problem Framework. ResultsWe included 21 participants in the study, aged 29 to 73 years; 13 participants who had received immunotherapy and 8 participants who had not received immunotherapy. …”
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The association of energy or macronutrient intake in three meals with depression in adults with cardiovascular disease: the United States National Health and Nutrition Examination... by Hongquan Xie, Yueying Chen, Jijiao Tang, Yuteng Ma, Ying Liu, Xiyun Ren

“…Conclusions High energy intake at breakfast may be associated with a lower risk of depression in those with CVD. We should focus on the potential role of breakfast energy intake in preventing the onset of depression.…”
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Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy by Hanyu Zhu, Moyan Liu, Hanjie Yu, Xiawei Liu, Yaogang Zhong, Jian Shu, Xinle Fu, Guangyan Cai, Xiangmei Chen, Wenjia Geng, Xiaoli Yang, Minghui Wu, Zheng Li, Dong Zhang

“…However, so little is known about alterations of the glycopatterns in urine with the development of diabetic nephropathy. Presently, we interrogated glycopatterns in urine specimens using a lectin microarray. …”
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The Effects of MyChoices and LYNX Mobile Apps on HIV Testing and Pre-Exposure Prophylaxis Use by Young US Sexual Minority Men: Results From a National Randomized Controlled Trial by Katie B Biello, Kenneth H Mayer, Hyman Scott, Pablo K Valente, Jonathan Hill-Rorie, Susan Buchbinder, Lucinda Ackah-Toffey, Patrick S Sullivan, Lisa Hightow-Weidman, Albert Y Liu

“…MethodsBetween October 2019 and May 2022, we implemented a 3-arm, parallel randomized controlled trial in 9 US cities to test the efficacy of the LYNX and MyChoices apps against standard of care (SOC) among young sexual minority men (aged 15-29 years) reporting anal sex with cisgender male or transgender female in the last 12 months. …”
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TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin by Olfa Khalifa, Nathalie Balandraud, Nathalie Lambert, Isabelle Auger, Jean Roudier, Audrey Sénéchal, David Geneviève, Christophe Picard, Gérard Lefranc, Isabelle Touitou, Bakridine M’Madi Mrenda, Cécilia Benedito, Etienne Pardoux, Anne-Laure Gagez, Yves-Marie Pers, Christian Jorgensen, Touhami Mahjoub, Florence Apparailly

“…Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. …”
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Metabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya by Isaiah Debrah, Daibin Zhong, Maxwell G. Machani, Godfrey Nattoh, Kevin O. Ochwedo, Collins M. Morang’a, Ming-Chieh Lee, Linda E. Amoah, Andrew K. Githeko, Yaw A. Afrane, Guiyun Yan

“…However, evidence on the molecular basis of pyrethroid resistance in western Kenya is limited. Here, we reported metabolic resistance mechanisms and demonstrated that multiple non-coding Ribonucleic Acids (ncRNAs) could play a potential role in An. funestus resistance to pyrethroid in western Kenya. …”
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Sexual Practices and HIV Prevention Strategies Used by Female Sex Workers in Lagos, Nigeria: An Assessment of the Willingness to Use a Microbicide by Ekama SO, Sheth AN, Ilomuanya MO, Okwuzu JO, Musa AZ, Idigbe I, Ezeobi PM, Oladele DA, Ezechi OC, Salako BL

“…This research aimed to evaluate the sexual practices, existing HIV prevention methods, and willingness to use a microbicide for HIV prevention among female sex workers in Nigeria. We also explored factors that might influence their willingness to use a new microbicide product.Methods: A cross-sectional study was conducted among female sex workers recruited from brothels within Lagos-Nigeria, in which participants were selected via purposive sampling over a period of five-months. …”
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An “initial-engineering-end use” quasi-market pricing mechanism under cascading risk for cross-regional water rights trading by Xuxia Li, Huimin Wang, Gang Liu, Liu Yang, Zhou Fang, Yi Xiao, Xiaoying Lai, Li Gao, Ying Teng

“…To support these stages, data from field studies is used to calibrate three unique pricing models: the stochastic differential game, incomplete contract theory, and the Nash-bargaining model. We analyze the interactions among equilibrium water prices across these stages to explore the cascade effects. …”
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Understanding Community Health Care Through Problem-Based Learning With Real-Patient Videos: Single-Arm Pre-Post Mixed Methods Study by Kiyoshi Shikino, Kazuyo Yamauchi, Nobuyuki Araki, Ikuo Shimizu, Hajime Kasai, Tomoko Tsukamoto, Hiroshi Tajima, Yu Li, Misaki Onodera, Shoichi Ito

“…Educational interventions targeting students’ career decision-making can potentially address this problem by promoting interest in rural medicine. We hypothesized that community-based problem-based learning (PBL) using real-patient videos could foster students’ understanding of community health care and encourage positive attitudes toward rural health care. …”
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The polarity of high-definition transcranial direct current stimulation affects the planning and execution of movement sequences by Jake J. Son, Tara D. Erker, Thomas W. Ward, Yasra Arif, Peihan J. Huang, Jason A. John, Kellen M. McDonald, Nathan M. Petro, Grant M. Garrison, Hannah J. Okelberry, Kennedy A. Kress, Giorgia Picci, Elizabeth Heinrichs-Graham, Tony W. Wilson

“…Determining the impact of such neurostimulation on the neural processing supporting motor control is a critical step toward further harnessing its therapeutic potential in multiple neurological conditions affecting the motor system. Herein, we leverage the excellent spatio-temporal precision of magnetoencephalographic (MEG) imaging to identify the spectral, spatial, and temporal effects of high-definition transcranial direct current stimulation (HD-tDCS) on the neural responses supporting motor control. …”
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A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier by Alok Sharma, Hemangi Sane, Nandini Gokulchandran, Pooja Kulkarni, Sushant Gandhi, Jyothi Sundaram, Amruta Paranjape, Akshata Shetty, Khushboo Bhagwanani, Hema Biju, Prerna Badhe

“…The various mechanisms by which cellular therapy works include neuroprotection, immunomodulation, neurorestoration, and neurogenesis. We conducted an open label, nonrandomized study on 40 cases of cerebral palsy with an aim of evaluating the benefit of cellular therapy in combination with rehabilitation. …”
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Fluid Inclusions and H-O-C-S Isotopes of the Wushan Copper Polymetallic Deposit in the Suizao Area, Hubei Province: Implications for Ore Genesis by Pan-Pan Niu, Shao-Yong Jiang, Suo-Fei Xiong, Qi-Sheng Hu, Tian-liang Xu

“…By comparing with the typical characteristics of magmatic hydrothermal vein deposit and orogenic deposit related to shear zones, we suggest that the Wushan copper polymetallic deposit is most likely a magmatic hydrothermal vein deposit, which is of great significance for the further exploration work in the Wushan and surrounding areas. …”
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