Antimicrobial Residues in Poultry Litter: Assessing the Association of Antimicrobial Persistence with Resistant <i>Escherichia coli</i> Strains by Paula Cortés, Ekaterina Pokrant, Karina Yévenes, Aldo Maddaleno, Andrés Flores, María Belén Vargas, Lina Trincado, Matías Maturana, Lisette Lapierre, Javiera Cornejo

“…<b>Objective</b>: We set out to evaluate the persistence of sulfachloropyridazine, oxytetracycline, and enrofloxacin in broiler chicken litter following therapeutic oral treatment and its association with the isolation of <i>Escherichia coli</i> resistant to these antimicrobials. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…Nevertheless, in myeloma, the precise mechanisms underlying SEL-induced XPO1 degradation and its impact on drug responsiveness remain largely undefined. Methods We assessed XPO1 protein and mRNA levels using western blotting and RT-qPCR. …”
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A randomised controlled implementation trial of the feasibility and effectiveness of school staff delivery of a selective substance use and mental health program during the COVID-1... by Lucinda Grummitt, Kirsty Rowlinson, Joanne Cassar, Chloe Conroy, Louise Birrell, Lexine Stapinski, Emma Louise Barrett, Julia Macauley, Maree Teesson, Nicola C. Newton, Erin V. Kelly

“…In this first Australian randomised controlled trial of school staff implementation of Preventure, we aimed to examine i) acceptability, feasibility, and fidelity and ii) effectiveness of Preventure on student alcohol use, internalising, and externalising symptoms. …”
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Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever by Yizhen Yuan, Qian Chen, Zhe Li, Fangzhou Cai, Dan Li, Wei Wang

“…However, the features of adaptive immune responses associated with liver injury in severe dengue are not clear. Methods We used single‐cell sequencing to examine the liver tissues of mild or severe dengue mice model to analyze the changes in immune response of T cells in the liver after dengue virus infection, and the immune interaction between macrophages and T cells. …”
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The infiltration risk prediction models by logistic regression for ground-glass pulmonary nodules: a systematic review and meta-analysis by Mengqian Li, Mengqian Li, Xiaomei Zhang, Yuxin Lai, Yunlong Sun, Tianshu Yang, Xinlei Tan

“…The retrieval time was from the establishment of the database to January 31, 2024. We included all predictive models for the invasion of ground-glass pulmonary nodules established. …”
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Increased risk for alcohol- and other substance-exposed pregnancies among women who smoke tobacco: A secondary analysis of a primary care-based intervention by Thomas F. Northrup, Angela L. Stotts, Stephen M. Fischer, Kirk L. von Sternberg, Mary M. Velasquez

“…Material and Methods Eligible women (N=261) were recruited from 12 primary care clinics in a public healthcare system, not pregnant, aged 18–44 years, drinking >3 drinks/ day or >7 drinks/week, sexually active, and not using effective contraception. We compared women who did and did not smoke tobacco on alcohol and drug severity, and psychological distress (e.g. anxiety) at baseline. …”
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Dissemination of IncQ1 Plasmids Harboring NTE_KPC-IId in a Brazilian Hospital by Camila Maria dos Santos Boralli, Julian Andres Paganini, Rodrigo Silva Meneses, Camila Pacheco Silveira Martins da Mata, Edna Marilea Meireles Leite, Anita C. Schürch, Fernanda L. Paganelli, Rob J. L. Willems, Ilana L. B. C. Camargo

“…To fill the gap in the understanding of the stability and dissemination of NTE_KPC-carrying plasmids, we selected and characterized carbapenem-resistant bacteria isolated between 2009 and 2016 from a hospital for a retrospective study of their plasmids conjugation capacity, impact on fitness, and replication in different species. …”
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Effect of molybdenum supply on crop performance through rhizosphere soil microbial diversity and metabolite variation by Muhammad Shoaib Rana, Muhammad Shoaib Rana, Dikhnah Alshehri, Dikhnah Alshehri, Rui-Long Wang, Muhammad Imran, Yousif Abdelrahman Yousif Abdellah, Faiz Ur Rahman, Marfat Alatawy, Hanaa Ghabban, Hanaa Ghabban, Amany H. A. Abeed, Cheng-xiao Hu

“…Molybdenum (Mo) deficiency is a global problem in acidic soils, limiting plant growth, development, and nutrient availability. To address this, we carried out a field study with two treatments, i.e., Mo applied (+Mo) and without Mo (−Mo) treatment to explore the effects of Mo application on crop growth and development, microbial diversity, and metabolite variations in maize and soybean cropping systems. …”
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Investigating the effects of knee valgus orthosis on knee joint contact forces among subjects with knee osteoarthritis: A case series study by Mohammad Taghi KARIMI, Mahmood BAHRAMIZADEH, Hanieh KHALILIYAN, Majid ANSARI, Kavita BATRA, Aanuoluwapo AFOLABI, Olayinka ILESANMI, Lukasz SZARPAK, Hicham KHABBACHE, Gabriella NUCERA, Aldo SITIBONDO, Farhad GHAFFARI, Arash SHARAFATVAZIRI, Francesco CHIRICO

“…A motion analysis system with seven high-speed cameras and a Kistler force plate were used to record the motion of the subjects in walking and the forces applied on the leg. We used OpenSIM software to determine the knee joint contact force during walking, with and without the orthosis. …”
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Serum α1-AT Levels and <i>SERPINA1</i> Molecular Analysis in Breast Cancer: An Experimental and Computational Study by Guadalupe Ávalos-Navarro, Luis A. Bautista-Herrera, Asbiel Felipe Garibaldi-Ríos, Ramiro Ramírez-Patiño, Marisol Gutiérrez-García, Perla Briseño-Álvarez, Luis Felipe Jave-Suárez, Emmanuel Reyes-Uribe, Martha Patricia Gallegos-Arreola

“…Methods: For the experimental analysis, we evaluated 255 women with BC and 53 healthy women (HW) in a cross-sectional study. …”
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Ten simple rules for working with high resolution remote sensing data by Mahood, Adam L., Joseph, Maxwell B., Spiers, Anna I., Koontz, Michael J., Ilangakoon, Nayani, Solvik, Kylen K., Quarderer, Nathan, McGlinchy, Joe, Scholl, Victoria M., St. Denis, Lise A., Nagy, Chelsea, Braswell, Anna, Rossi, Matthew W., Herwehe, Lauren, Wasser, Leah, Cattau, Megan E., Iglesias, Virginia, Yao, Fangfang, Leyk, Stefan, Balch, Jennifer K.

“…In order to implement a consistent strategy, we outline ten rules with examples from Earth and environmental science to help academic researchers and professionals in industry work more effectively and competently with high-resolution data. …”
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High-Performance Carbon Nanotube Optoelectronic Transistor With Optimized Process for 3D Communication Circuit Applications by Shuang Liu, Heyi Huang, Yanqing Li, Yadong Zhang, Feixiong Wang, Zhaohao Zhang, Qingzhu Zhang, Jiali Huo, Jiaxin Yao, Jing Wen, Huaxiang Yin

“…Currently, CNT transistors need to further improve their performance with a more stable process and explore the most suitable circuit application scene. In this study, we successfully enhanced the performance of CNFETs through special Y2O3 film passivation and vacuum annealing processes. …”
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Effect of prenatal multiple micronutrient supplementation on birth weight in Ethiopia: protocol for a pragmatic cluster-randomised trial by Joanna Schellenberg, Charles Opondo, Tanya Marchant, Lars Åke Persson, Masresha Tessema, Atkure Defar, Alemneh Kabeta Daba, Girum Taye, Senait Alemayehu, Elias Asfaw, Anene Tesfa, Bedasa Tessema, Kalkidan Zenebe

“…During the study period, the birth weights of all eligible babies born in enrolled health facilities in these 42 districts are continuously recorded alongside data on maternal receipt and use of either multiple micronutrient or iron-folic acid supplementation. We hypothesise that newborns of women resident in the 21 multiple micronutrient supplementation districts will have higher mean birth weight than newborns of women resident in the 21 iron-folic acid supplementation districts. …”
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Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions by Yan Zhang, Dou Du, Chao Fang, Xin Yu, Yujia Fang, Xinyu Liu, Di Ou, Haohao Yin, Hui Liu, Taixia Wang, Lu Lu, Xiaolong Li, Kun Zhang

“…Post-transcriptional epigenetic modifications provide numerous implications for tumor progression, metastasis and recurrence, which also pose resistances to reactive oxygen species (ROS)-based anti-tumor. Herein, we proposed an epigenetic deubiquitination disruption strategy to disarm the ubiquitination-deubiquitination balance-induced resistances to ROS production and ROS-based anti-tumor action for potentiating sonodynamic treatment (SDT) efficiency. …”
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Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease by John McFadden, Julian Matthews, Lauren Scott, Karl Herholz, Ben Dickie, Hamied Haroon, Oliver Sparasci, Saadat Ahmed, Natalia Kyrtata, Geoffrey J.M. Parker, Hedley C.A. Emsley, Joel Handley, Maélène Lohezic, Laura M. Parkes

“…In early stages, reduced CBF may be associated with a compensatory increase in oxygen extraction fraction (OEF) to maintain the cerebral metabolic rate of oxygen consumption (CMRO2). We used a simultaneous PET-MRI protocol to measure OEF, CBF, CMRO2, and arterial transit time (ATT) in elderly people (n = 24, age 69.6 ± 5.3 years) with a range of vascular disease risk (QRisk 18.7 ± 10.8 %) and cognitive abilities (MoCA scores 26.7 ± 3.4) to determine if a) vascular disease risk (parameterised with QRisk2 score) is associated with altered CBF, ATT, OEF and CMRO2, b) if impaired blood supply and increasing transit times are associated with elevated OEF and c) if these physiological measures are associated with impaired cognition. …”
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Good-Quality mHealth Apps for Endometriosis Care: Systematic Search by Diksha Sirohi, Cecilia HM Ng, Niranjan Bidargaddi, Helen Slater, Melissa Parker, M Louise Hull, Rebecca O'Hara

“…ConclusionsAlthough time and geographical location can influence the search results, we identified 6 “good-quality” endometriosis mHealth apps that can be recommended to the endometriosis community. mHealth apps designed for community use should evaluate their effectiveness on user’s endometriosis knowledge, self-recommended management strategies, pain self-efficacy, user satisfaction, and user quality of life. …”
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Metabolomics and Transcriptomics Reveal the Effects of Different Fermentation Times on Antioxidant Activities of <i>Ophiocordyceps sinensis</i> by Min He, Tao Wang, Chuyu Tang, Mengjun Xiao, Xiaojian Pu, Jianzhao Qi, Yuling Li, Xiuzhang Li

“…Using LC-MS/MS to measure the metabolites on D24, D30, and D36, we found that the majority of the differential accumulated metabolites (DAMs) primarily accumulate in lipids, organoheterocyclic compounds, and organic acids and their derivatives. …”
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Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005–2018 by WenYi Xu, Li Zhang, Li Zhang, QianKun Yang, Ying Cao, Rui Rao, Li Lv, Qin Cen, Qiong Wei, LuLing Yang

“…Mortality outcomes and causes of death were obtained from National Death Index (NDI) records. We used restricted cubic spline (RCS) and maximally selected rank statistics method (MSRSM) to assess the nonlinearity of the PNI-mortality association and determine the optimal PNI cutoff for survival outcomes. …”
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Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes by Claudia Omarini, Virginia Catani, Ilenia Mastrolia, Angela Toss, Federico Banchelli, Chrystel Isca, Daniele Medici, Ornella Ponzoni, Marco Brucale, Francesco Valle, Maria Cristina Baschieri, Roberto D’Amico, Valentina Masciale, Chiara Chiavelli, Federica Caggia, Carlo Augusto Bortolotti, Federico Piacentini, Massimo Dominici

“…However, limited knowledge exists on the levels and clinical meaning of miR-21 in extracellular vesicles (EVs) of patients with breast cancer (BC). We assessed EV-derived miR-21 levels in one hundred women: 30 with early BC (EBC), 30 with metastatic BC on treatment progression (MBC), 30 cancer survivors on follow-up (FU) and 10 healthy donors (HD) as age- and body mass index (BMI)-matched controls. …”
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Dynamic Tracking Human Mesenchymal Stem Cells Tropism following Smoke Inhalation Injury in NOD/SCID Mice by MeiJuan Song, Qi Lv, XiuWei Zhang, Juan Cao, ShuLi Sun, PeiXin Xiao, ShiKe Hou, Hui Ding, ZiQuan Liu, WenLong Dong, JinQiang Wang, Xue Wang, ZhiGuang Sun, Man Tian, HaoJun Fan

“…However, few studies focus on the dynamic tropism of MSCs in animals with acute lung injury. In this study, we track systemically transplanted human bone marrow-derived mesenchymal stem cells (hBMSCs) in NOD/SCID mice with smoke inhalation injury (SII) through bioluminescence imaging (BLI). …”
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