Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8+ T cells by Madison R. Mix, Stephanie van de Wall, Mohammad Heidarian, Elizabeth A. Escue, Cori E. Fain, Lecia L. Pewe, Lisa S. Hancox, Sahaana A. Arumugam, Cassie M. Sievers, Vladimir P. Badovinac, John T. Harty

“…Here, utilizing two murine models of peripheral viral infection, we demonstrate that circulating memory CD8+ T cells with previous antigen exposure exhibit a markedly reduced capacity to form brain TRM compared to naive CD8+ T cells. …”
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Reproductive Efficiency of Nelore Cows in Fixed-Time Artificial Insemination Programs with Early Resynchronization by Larissa de Paiva Nunes Gonçalves, Alisson Jordão Prado, Aline Pacheco, Yana Eliza Feitosa de Almeida, Pietro Sampaio Baruselli, Welligton Conceição da Silva, Antônio Humberto Hamad Minervino, Jucelane Salvino de Lima, Kedson Alessandri Lobo Neves

“…We aimed to evaluate the reproductive efficiency of Nelore cows in fixed-time artificial insemination (FTAI) programs with early resynchronization. …”
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KMS (Knowledge Management System) Obat Ibu Hamil Berbasis Android by Halimah Tus Sadiah, Muhamad Saad Nurul Ishlah, Nyayu Siti Aminah Lily Elfrieda, Mauladani Adi Gasbara

“…This can occur due to a lack of knowledge about medicines that can be consumed during pregnancy. Therefore, we need a system that collects knowledge about medicines that are safe for consumption by pregnant women. …”
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Lipopolymers as the Basis of Non-Viral Delivery of Therapeutic siRNA Nanoparticles in a Leukemia (MOLM-13) Model by Panadda Yotsomnuk, Amarnath Praphakar Rajendran, Daniel Nisakar Meenakshi Sundaram, Luis Carlos Morales, Cezary Kucharski, Mohammad Nasrullah, Wanwisa Skolpap, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Hasan Uludağ

“…The development of a clinically applicable method for delivering siRNA molecules is imperative due to the challenges involved in effectively delivering the siRNA into cells. We investigated the delivery of siRNA to AML MOLM-13 cells with the use of two lipid-substituted polyethyleneimines (PEIs), a commercially available reagent (Prime-Fect) and a recently reported reagent with improved lipid substitution (PEI1.2k-PHPA-Lin9). …”
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Association Between Surgeon Sex and Days Alive at Home Following Surgery: A Population-Based Cohort Study by Kiyan Heybati, BHSc, Raj Satkunasivam, MD, MS, Khatereh Aminoltejari, MD, MSc, FRCSC, Hannah S. Thomas, MBChB, MS, Arghavan Salles, MD, PhD, Natalie Coburn, MD, MPH, Frances C. Wright, MD, Med, FRCSC, Lesley Gotlib Conn, PhD, Amy N. Luckenbaugh, MD, Sanjana Ranganathan, MD, Carlos Riveros, MD, Colin McCartney, MBChB, PhD, FRCA, FFARCSI, FRCPC, Kathleen Armstrong, MD, MSc, FRCSC, Barbara Bass, MD, Allan S. Detsky, MD, PhD, CM, Angela Jerath, MD, MSc, Christopher J. D. Wallis, MD, PhD

“…DAH is a validated measure, shown to better capture the patient experience of postoperative recovery. Methods:. We conducted a retrospective study of adults (≥18 years of age) undergoing common surgeries between January 01, 2007 and December 31, 2019 in Ontario, Canada. …”
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β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury by Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li, Jinchao Wang, Xu Zhang, Jianye Xu, Yajuan Wang, Xin Xu, Tuo Li, Jianning Zhang, Shu Zhang

“…Using the fluid percussion injury (FPI) mouse model, we investigated the therapeutic efficacy of Rovelizumab, an agent that blocks ITGB2. …”
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Therapeutic Effect and Location of GFP-Labeled Placental Mesenchymal Stem Cells on Hepatic Fibrosis in Rats by Jiong Yu, Guangshu Hao, Dan Wang, Jingqi Liu, Xiaotian Dong, Yanni Sun, Qiaoling Pan, Yang Li, Xiaowei Shi, Lanjuan Li, Hongcui Cao

“…The expression levels of fibrotic markers, transforming growth factor β1 (TGF-β1) and α-smooth muscle actin (α-SMA), were assessed using real-time polymerase chain reaction. Results. We demonstrated that liver fibrosis was significantly dampened in the hPMSC transplantation group according to the Laennec fibrosis scoring system and histological data. …”
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Narratives of swiss football players about talent - and positive youth development: The role of social agents and agency. by Philipp Koch, Bryan Charbonnet, Noora Ronkainen

“…., & Den Hartigh, R. J. R. (2023). What do we currently know about the development of talent? …”
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Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α by Jie Yu, Haibin Liu, Shuli He, Pingping Li, Chunxiao Ma, Minglei Ma, Yiwen Liu, Lu Lv, Fan Ping, Huabing Zhang, Wei Li, Qi Sun, Lingling Xu, Yuxiu Li

“…Objectives. In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). …”
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Bridging Land and Sea: Geophysical insights into coastal karstic groundwater dynamics, freshwater plumes and saltwater intrusions in the urban regions of Antalya (Türkiye) by Jasper J.L. Hoffmann, Ercan Erkul, Simon Fischer, Irfan Yolcubal, Pritam Yogeshwar, Wolfgang Rabbel, Amir Haroon, Şerif Bariş, Ahmet Şener, Jens Schneider von Deimling, Ismail Kaplanvural, Bülent Tezkan, Elif Şen, Felix Gross, Ertan Pekşen, Elnur Gasimov, Aaron Micallef

“…With an increasing population along coastlines, understanding coastal groundwater interactions is essential. In this study we utilize on- and offshore hydrogeophysical techniques to image variations in subsurface porewater salinities. …”
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Clinical Response and Transfusion Reactions of Sheep Subjected to Single Homologous Blood Transfusion by Rejane Santos Sousa, Antonio Humberto Hamad Minervino, Carolina Akiko Sato Cabral Araújo, Frederico Augusto Mazzocca Lopes Rodrigues, Francisco Leonardo Costa Oliveira, Clara Satsuki Mori, Janaina Larissa Rodrigues Zaminhan, Thiago Rocha Moreira, Isadora Karolina Freitas Sousa, Enrico Lippi Ortolani, Raimundo Alves Barrêto Júnior

“…Studies in relation to blood conservation and responses to transfusion are scarce for ruminants. We evaluated the clinical manifestations of sheep that received a single homologous transfusion of whole blood, focusing on transfusion reactions. …”
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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

“…Abstract Background Combining the programmed death-1 inhibitor toripalimab and the angio-immuno kinase inhibitor surufatinib showed preliminary antitumor activity in patients with advanced solid tumors in a phase I study. Here, we report the efficacy and safety of this combination regimen in treatment-naive advanced or metastatic non-small-cell lung cancer (NSCLC) patients with a programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) of 1% or greater (PD-L1-positive) and patients with previously treated small-cell lung cancer (SCLC). …”
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Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer by Wang L, Deng X, Tang J, Gong Y, Bu S, Li Z, Liao B, Ding Y, Dai T, Liao Y, Li Y

“…Following the knockdown of EARS2, we assessed cell proliferation, migration capabilities, and apoptosis. …”
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Should Echocardiographic Evaluation Be Performed Routinely in the First 72 Hours in Extremely Low Birth Weight Babies? by Ruya Colak, Senem Alkan Ozdemir, Ezgi Yangin Ergon, Ferit Kulali, Oguz Han Kalkanli, Tulin Gokmen Yildirim, Murat Muhtar Yilmazer, Cuneyt Zihni, Sebnem Calkavur

“… Objective: Hemodynamically significant patent ductus arteriosus(hsPDA) is resulting in severe mortality and morbidity in infants with extremely low birth weight(ELBW). In our study, we aimed to evaluate the necessity of performing routine echocardiography(ECHO) in the first 72hours in ELBW infants. …”
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Sepiolite immobilizes soil Cd to optimize microbial community structure thereby promoting wheat growth and reducing Cd accumulation by Ziqi Li, Xiaoxun Xu, Xin Qi, Changlian Xu, Guiyin Wang, Shirong Zhang, Zhanbiao Yang, Zhang Cheng, Junzhuo Cai, Guochun Lv, Ting Li, Yulin Pu, Yongxia Jia

“…However, further investigation is needed to understand the impact of sepiolite on soil environmental quality and microbial communities. If we add sepiolite to the soil, the soil microbial community structure will be improved, and the abundance of bacteria associated with Cd-fixing and plant growth-promoting will be enhanced, which will significantly immobilize soil Cd thereby enhancing Cd tolerance and reducing Cd uptake in wheat. …”
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Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer by Yaojun Ren, Min Xue, Xinhui Hui, Xiuyu Liu, Muhammad Asad Farooq, Yiran Chen, Yuzhou Ji, Yixin Duan, Iqra Ajmal, Jie Yao, Wenzheng Jiang

“…This study aims to tackle the challenge of TGF-β-mediated tumor immune evasion within the immunosuppressive tumor microenvironment by designing a novel chimeric cytokine receptor TRII/21 R, which consists of extracellular domains of TGF-β receptor II (TRII) and transmembrane and intracellular domains of IL-21 receptor (21 R) and can convert the immunosuppressive signal from TGF-β in the tumor microenvironment (TME) into an NK cell activation signal through the IL-21R-STAT3 pathway. We successfully constructed NKG2D-CAR-NK cells expressing TRII/21 R and demonstrated strong anti-tumor activity against cancer cells both in vitro and in vivo. …”
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A Navier–Stokes-Informed Neural Network for Simulating the Flow Behavior of Flowable Cement Paste in 3D Concrete Printing by Tianjie Zhang, Donglei Wang, Yang Lu

“…In this work, we propose a Navier–Stokes-Informed Neural Network (NSINN) as a surrogate approach to predict the localized flow behavior of cementitious materials for advancing 3D additive construction technology to gain fundamental insights into multiscale mechanisms of cement paste rheology. …”
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YOLOv8-CBAM: a study of sheep head identification in Ujumqin sheep by Qing Qin, Qing Qin, Qing Qin, Xingyu Zhou, Xingyu Zhou, Xingyu Zhou, Jiale Gao, Jiale Gao, Jiale Gao, Zhixin Wang, A. Naer, Long Hai, Suhe Alatan, Haijun Zhang, Zhihong Liu, Zhihong Liu, Zhihong Liu

“…IntroductionThe facial coloration of sheep is not only a critical characteristic for breed and individual identification but also serves as a significant indicator for assessing genetic diversity and guiding selective breeding efforts.MethodsIn this study, 201 Ujumqin sheep were used as research objects and 1713 head image data were collected. We delineated feature points related to the facial coloration of Ujumqin sheep and successfully developed a head color recognition model (YOLOv8-CBAM) utilizing the YOLOv8 architecture in conjunction with the CBAM attention mechanism.ResultsThe model demonstrated impressive performance in recognizing four head color categories, achieving an average precision (mAP) of 97.7% and an F1 score of 0.94. …”
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Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease by Weigang Shu, Yongheng Wang, Mengfan Chen, Xiaoli Zhu, Fangtao Wang, Chunqiu Chen, Peng Du, Alexandra Bartolomucci, Xin Su, Xiaolei Wang

“…Using high‐throughput sequencing, we demonstrated that CrF‐EVs significantly increased HLEC proliferation, migration, tube formation and CCL‐21 production in a miR‐132‐3p/RASA1/ERK1/2 axis‐dependent manner. …”
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Tracheostomy Practice in the Italian Intensive Care Units: A Point-Prevalence Survey by Raffaele Merola, Maria Vargas, Filippo Sanfilippo, Marco Vergano, Giovanni Mistraletti, Luigi Vetrugno, Gennaro De Pascale, Elena Giovanna Bignami, Giuseppe Servillo, Denise Battaglini

“…<i>Materials and Methods</i>: We conducted an observational, cross-sectional, point-prevalence survey across eight ICUs in Italy. …”
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