Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction by Lijiang Wei, Naifu Wan, Wentong Zhu, Chenchen Liu, Zeyu Chen, Wuwei Rong, Lujun Zhang, Meifeng Xie, Yueqi Qin, Ting Sun, Qing Jing, Ankang Lyu

“…In a mouse model of AMI, we observed MSN, which was absent in immunosuppressed mice. …”
Get full text

Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance by Henna Lehtonen, Heli Jokela, Julian Hofmann, Lauriina Tola, Arfa Mehmood, Florent Ginhoux, Burkhard Becher, Melanie Greter, Gennady G. Yegutkin, Marko Salmi, Heidi Gerke, Pia Rantakari

“…Using single-cell transcriptomics, fate mapping, and imaging, we characterize pituitary-resident macrophages (pitMØs), revealing their heterogeneity and spatial specialization. …”
Get full text

Hepatitis B Virus in Polish Blood Donors in the Period 2005–2019—Significant Changes in Epidemiology and Demographic Characteristics of Infected Donors by Aneta Kopacz, Dorota Kubicka-Russel, Grzegorz Liszewski, Ewa Sulkowska, Anna Chrzanowska, Paulina Zwolińska, Ewa Noceń, Anna Potępa, Magdalena Łętowska, Piotr Grabarczyk, the Group of Polish Blood Transfusion Centers for Blood Borne Pathogens

“…A spectacular decrease in the frequency of HBsAg(+) infections was observed in current study, indicating the effectiveness of the hepatitis prevention strategy applied in Poland. We expect that the improvement in the epidemiological situation among blood donors causes a reduction in the risk of TT-HBV. …”
Get full text

Minimally invasive determination of pancreatic ductal adenocarcinoma (PDAC) subtype by means of circulating cell‐free RNA by Martin Metzenmacher, Gregor Zaun, Marija Trajkovic‐Arsic, Phyllis Cheung, Timm M. Reissig, Hendrik Schürmann, Nils vonNeuhoff, Grainne O'Kane, Stephanie Ramotar, Anna Dodd, Steven Gallinger, Alexander Muckenhuber, Jennifer J. Knox, Volker Kunzmann, Peter A. Horn, Jörg D. Hoheisel, Jens T. Siveke, Smiths S. Lueong

“…Pancreatic ductal adenocarcinoma (PDAC) comprises two clinically relevant molecular subtypes that are currently determined using tissue biopsies, which are spatially biased and highly invasive. We used whole transcriptome sequencing of 10 plasma samples with tumor‐informed subtypes, complemented by proteomic analysis for minimally invasive identification of PDAC subtype markers. …”
Get full text

Preliminary effectiveness of social prescription and virtual patient information in increasing tertiary prevention among cancer patients (ESPRIT): protocol for a single-centre, ran... by Karen Steindorf, Michael Koller, Michael Leitzmann, Wolfgang Herr, Daniel Heudobler, Lisa Boyer, Anne Herrmann, Tobias Pukrop, Christine Bernardi, Sabine Einhell

“…However, more research is required on the effectiveness of strategies designed to increase the uptake of tertiary prevention programmes among cancer patients. Here, we present the protocol for a single-centre, randomised controlled pilot trial testing the preliminary effectiveness of social prescription and virtual patient information in increasing tertiary prevention among cancer patients and support persons (SPs) (ESPRIT “Effectiveness of a social prescription and virtual patient information in increasing tertiary prevention” pilot trial).Methods and analysis Cancer patients attending medical oncology units at a university hospital in southern Germany and their SPs will be randomly allocated as a dyad to group A (social prescription (n=36)), group B (virtual patient information (n=36)) or group C (usual care (n=36)). …”
Get full text

Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats by Jun Liu, Yonghua Cai, Khalil ur Rahman, Qixiong Zhou, Guangjie Liu, Huibin Kang, Mingzhou Li, Shichao Zhang, Gang Wang, Wenfeng Feng, Xi’an Zhang, Guozhong Zhang, Ye Song, Peng Li

“…Co-immunoprecipitation, immunofluorescence, TUNEL, Fluoro-Jade C, DHE staining, western blot, Nitrix Oxide (NO) quantification and side effect experiments were performed to evaluate post-GMH. We found endogenous relaxin-2 interacts with RXFP1 and both protein colocalized in neurons on the first day after GMH. …”
Get full text

Emergence and clonal dissemination of KPC-2- and NDM-1-coharboring Citrobacter freundii in China with an IncR plasmid by Juanjuan Zhou, Minghui Zhen, Kaijie Gao, Lu Xu, Dongyu Zhang, Junmei Yang

“…KPC-2-NDM-1-Citrobacter freundii is rarely reported in clinical settings. In this study, we report the largest cohort of eight KPC-2-NDM-1-C. freundii isolated from children with urinary tract infections. …”
Get full text

Research on Land Surface Thermal-Hydrologic Exchange in Southern China under Future Climate and Land Cover Scenarios by Jianwu Yan, Baozhang Chen, Min Feng, John L. Innes, Guangyu Wang, Shifeng Fang, Guang Xu, Huifang Zhang, Dongjie Fu, Huimin Wang, Guirui Yu, Xiaomin Sun

“…(iv) The annual average H and ET would, respectively, increase and decrease by about 10% when woodland converts to the cultivated land. Through this study, we recognize that land surface water and heat exchanges are affected greatly by the future climate change as well as land cover change.…”
Get full text

Real-world effectiveness of azvudine versus nirmatrelvir-ritonavir in hospitalized patients with COVID-19 and pre-existing diabetes by Guanyue Su, Silin Li, Donghua Zhang, Yongjian Zhou, Ling Wang, Yiqiang Yuan, Guowu Qian, Guotao Li, Na Han, Ming Cheng, Guangming Li, Shixi Zhang, Hong Luo, Mengzhao Yang, Yanyang Zhang, Zhan Song, Jiyuan Xing, Zujiang Yu, Zhigang Ren

“…In this retrospective cohort study, we collected 32,864 hospitalized COVID-19 patients from nine hospitals, among which 636 azvudine recipients and 318 nirmatrelvir-ritonavir recipients were enrolled for final analysis after exclusion and propensity score matching. …”
Get full text

Polityka w dziedzinie edukacji i kształcenia zawodowego by Ryszard Jurkowski

“…W moim przekonaniu, wysoka jakość nauczania może zostać zapewniona przez komplementarne stosowanie obu filarów oceny jakości we wszystkich jednostkach systemu edukacji.…”
Get full text

Duration of Disease and Long‐Term Outcomes in Patients With Difficult‐To‐Treat Recurrent Pericarditis: A Chronic Condition Treated With Nonsteroidal Anti‐Inflammatory Drugs, Colchi... by Elisa Ceriani, Francesco Agozzino, Silvia Berra, Antonio Gidaro, Paolo Bindi, Alberto Pavarani, Silvia Macchi, Letizia Vena, Francesco Moda, Ludovico Luca Sicignano, Celeste Ambra Murace, Laura Gerardino, Elena Verrecchia, Caterina Chiara De Carlini, Silvia Maestroni, Gabriella Marinaro, Emanuele Bizzi, Antonio Brucato, Massimo Imazio

“…Objective We aimed to investigate the remission rate and disease duration in idiopathic or post–cardiac injury pericarditis and risk factors for disease duration and anti–interleukin‐1 (IL‐1) agent discontinuation. …”
Get full text

Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions by Chen-Yu Zou, Chen Han, Fei Xing, Yan-Lin Jiang, Ming Xiong, Jesse Li-Ling, Hui-Qi Xie

“…Additionally, sponges have been widely used in clinical and daily life because of their rapid blood absorption. Therefore, we provide the overview focusing on the latest advances and smart designs of biopolymer-based hemostatic sponge. …”
Get full text

Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells by Alexia Carré, Fatoumata Samassa, Zhicheng Zhou, Javier Perez-Hernandez, Christiana Lekka, Anthony Manganaro, Masaya Oshima, Hanqing Liao, Robert Parker, Annalisa Nicastri, Barbara Brandao, Maikel L. Colli, Decio L. Eizirik, Jahnavi Aluri, Deep Patel, Marcus Göransson, Orlando Burgos Morales, Amanda Anderson, Laurie Landry, Farah Kobaisi, Raphael Scharfmann, Lorella Marselli, Piero Marchetti, Sylvaine You, Maki Nakayama, Sine R. Hadrup, Sally C. Kent, Sarah J. Richardson, Nicola Ternette, Roberto Mallone

“…Abstract Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1 diabetes (T1D), but the effect of IFN-α on the antigen repertoire of HLA Class I (HLA-I) in pancreatic β-cells is unknown. Here we characterize the HLA-I antigen presentation in resting and IFN-α-exposed β-cells and find that IFN-α increases HLA-I expression and expands peptide repertoire to those derived from alternative mRNA splicing, protein cis-splicing and post-translational modifications. …”
Get full text

Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile by Luz María Medrano, Carlos Taxonera, Cristina González-Artacho, Virginia Pascual, María Gómez-García, Manuel Barreiro-de Acosta, José L. Pérez-Calle, Fernando Bermejo, Antonio López-Sanromán, Dolores Martín Arranz, Javier P. Gisbert, Juan Luis Mendoza, Javier Martín, Concepción Núñez, Elena Urcelay

“…The expression profile of five genes (S100A8-S100A9, G0S2, TNFAIP6, and IL11) reportedly predicted response to IFX and we aimed at investigating their etiologic role through genetic association analysis. …”
Get full text

The near-optimal adjustment of carbon and nitrogen allocations into different organs in early-season rice cultivars with drastically different yield components under nitrogen appli... by Wen Ning, Wen Ning, Lin Su, Lin Su, Dandan Shi, Dandan Shi, Meina Ji, Meina Ji, Xiang Ouyang, Qingfeng Song, Caihong Shao, Xin-Guang Zhu, Shuoqi Chang, Shuoqi Chang

“…IntroductionOptimized photosynthesis and transport of photosynthate from the upper three leaves in a rice plant is critical for yield formation in rice.MethodsIn this study, we selected two high-yielding early-season rice cultivars, i.e. a large-panicle inbred rice Zhongzao39 (ZZ39) and a plural-panicle hybrid rice Lingliangyou268 (LLY268) with high effective panicle number, to study the translocation of photosynthate from the flag and the basipetal 2nd leaves to the other organs under different nitrogen application scenarios. 13CO2 labeling was study the proportion of newly assimilated carbon partitioned into different organs.ResultsResults demonstrate that the ratio that 13C assimilated in the flag leaves and the basipetal 2nd leaves, and the distribution ratio 13C in the organs of ZZ39 and LLY268 cultivars were not affected by nitrogen application. …”
Get full text

NF-κB/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton by Van Thai Ha, Heung Soo Beak, Eunji Kim, Kwang-Soo Baek, Muhammad Jahangir Hossen, Woo Seok Yang, Yong Kim, Jun Ho Kim, Sungjae Yang, Jeong-Hwan Kim, Yung Hyup Joo, Chang Seok Lee, Joonho Choi, Hong-Ju Shin, Sungyoul Hong, Song Seok Shin, Jae Youl Cho

“…Since macrophage-mediated inflammatory responses are critical for skin health, here we investigated the potential anti-inflammatory activity of AP736. …”
Get full text

Rapid antigen testing by community health workers for detection of SARS-CoV-2 in Dhaka, Bangladesh: a cross-sectional study by Mahbubur Rahman, Ayesha Sania, Seonjoo Lee, Tahmina Shirin, A S M Alamgir, Yael K Rayport, Ahmed Nawsher Alam, Joanna Andrecka, Eric Brum, Fergus Chadwick, Tasnuva Chowdhury, Zakiul Hasan, Davina L Hill, Farzana Khan, Mikolaj Kundegorski, Motahara Tasneem, Katie Hampson

“…Objective To evaluate the diagnostic performance and feasibility of rapid antigen testing for SARS-CoV-2 detection in low-income communities.Design We conducted a cross-sectional community-based diagnostic accuracy study. …”
Get full text

AN INTEGRATED INFORMATION SYSTEM ON BIORESOURCE COLLECTIONS OF THE FASO OF RUSSIA by S. A. Lashin, D. A. Afonnikov, M. A. Genaev, F. V. Kazantsev, E. G. Komyshev, E. A. Oschepkova, А. V. Petrov, D. A. Rasskazov, A. A. Smirnova, N. A. Kolchanov

“…Architecturally, the portal is concerned as a central node with a series of modules communicating through the unified interfaces. In this way, we solve the problem of connecting new data sources (collection databases) implemented in different DBMS. …”
Get full text

Quantifying the Turbulent Entrainment‐Mixing Processes Based on Z‐LWC Relationships of Cloud Droplets by Shi Luo, Chunsong Lu, Yangang Liu, Haoran Li, Fengwei Zhang, Jingjing Lv, Lei Zhu, Xiaoqi Xu, Junjun Li, Xin He, Ying He, Sinan Gao, Xinlin Yang, Juan Gu, Xuemin Chen, Haining Sun

“…To address this gap, 12,218 entrainment‐mixing cases are simulated using the Explicit Mixing Parcel Model. We examine the variations of the parameters in the power‐law relationship Z = aLWCb, and the relationship between parameter b and homogeneous mixing degree (ψ), a measure quantifying entrainment‐mixing processes. …”
Get full text

Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer by Federica Sabia, MSc, Camilla Valsecchi, MSc, Roberta Eufrasia Ledda, MD, Giorgio Bogani, MD, Riccardo Orlandi, MD, Luigi Rolli, MD, Michele Ferrari, MD, Maurizio Balbi, MD, Alfonso Marchianò, MD, Ugo Pastorino, MD

“…The 5-year survival was 80.3% overall, 84.7% in CAC less than 100, 77.5% in CAC 100 to 399, and 73.5% in CAC greater than or equal to 400 (p = 0.0047). Conclusions: We observed that the CAC score predicted the 5-year overall survival in patients with resected stage I LC, both alone and combined with the modified routine blood test score. …”
Get full text