Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid–Liquid Phase Separation and Ferroptosis-Related Genes by Wenchao Chen, Ting Zhu, Xiaofan Pu, Linlin Zhao, Senhao Zhou, Xin Zhong, Suihan Wang, Tianyu Lin

“…Then the effects of NRAS on the development of HCC and ferroptosis were also detected. Results: We identified 24 DEGs overlapping among HCC-specific, LLPS, and ferroptosis-related genes. …”
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Omics-Based Comparison of Fungal Virulence Genes, Biosynthetic Gene Clusters, and Small Molecules in <i>Penicillium expansum</i> and <i>Penicillium chrysogenum</i> by Holly P. Bartholomew, Christopher Gottschalk, Bret Cooper, Michael R. Bukowski, Ronghui Yang, Verneta L. Gaskins, Dianiris Luciano-Rosario, Jorge M. Fonseca, Wayne M. Jurick

“…To shed light on this observation, we conducted a comparative genomic, transcriptomic, and metabolomic study of two <i>P. chrysogenum</i> (404 and 413) and two <i>P. expansum</i> (Pe21 and R19) isolates. …”
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Clinical Profile and Outcome in Patients with Coronary Slow Flow Phenomenon by Xiaogang Zhu, Hua Shen, Fei Gao, Sijing Wu, Qian Ma, Shuo Jia, Ziwei Zhao, Shan Tong, Zhihao Zhang, Yujie Zhou

“…The coronary slow flow phenomenon (CSFP) is a poorly recognized clinical entity characterized by delayed distal vessel opacification in the absence of epicardial coronary stenosis and presently lack of specific data on the clinical profile and outcome. We investigated a cohort of 429 patients who fulfilled the criteria for CSFP to explore the clinical feature, outcome, and risk factor of prognosis. …”
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Effects of Ciprofol and Propofol General Anesthesia on Postoperative Recovery Quality in Patients Undergoing Ureteroscopy: A Randomized, Controlled, Double-Blind Clinical Trial by Shi S, Wu J, Wu Y, Han X, Dai H, Chen X, Sun Z, Wang F

“…Shuqi Shi,1,2,&ast; Jimin Wu,1,&ast; Yini Wu,1 Xin Han,1 Hong Dai,1 Xuedong Chen,3 Zhangnan Sun,4 Faxing Wang1,2 1Department of Anesthesiology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, Lishui, People’s Republic of China; 2Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Urology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, Lishui, People’s Republic of China; 4Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Faxing Wang, Department of Anesthesiology, Lishui People’s Hospital, Wenzhou Medical University Lishui Hospital, The First Affiliated Hospital of Lishui University, No. 15, Dazhong Street, Lishui, Zhejiang Province, 323000, People’s Republic of China, Email wfx2023@wmu.edu.cn Zhangnan Sun, Department of Anesthesiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China, Email 28703077@hebmu.edu.cnObjective: This study compares postoperative recovery quality between Ciprofol and Propofol, providing a reference for the clinical application of anesthetics.Methods: We randomized 112 patients undergoing ureteroscopic surgery into two groups: the Ciprofol group (Group C), with an induction dose of 0.4 mg/kg and a maintenance dose of 0.8– 1.5 mg/(kg·h), and the Propofol group (Group P), with an induction dose of 2 mg/kg and a maintenance dose of 4– 10 mg/(kg·h). …”
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Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue season by Htin Lin, Mya Myat Ngwe Tun, Yin Mon Wint Zin, Khin Theingi Myint, Win Kay Khine, Khine Mya Nwe, Aye Aye Thant, Thin Thin Shwe, Win Mar, Khin Sandar Aye, Khaing Moe Aung, Yuki Takamatsu, Wah Wah Aung, Yi Yi Kyaw, Takeshi Urano, Kouichi Morita, Hlaing Myat Thu

“…Methods This cross-sectional study was conducted at Insein General Hospital in Yangon, Myanmar, from June to September 2022. We recruited 221 suspected dengue patients (134 children and 87 adults), with or without other diseases, and tested their dengue serological markers using a serological method and their dengue virus (DENV) serotypes using conventional RT-PCR. …”
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Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province by Zichen Feng, Long Sun, Shu Niu, Bin Liu, Ruijie Ba, Guoqing Wang, Qing Sun, Chunxiang Li, Yan Wang, Fangfang Yu, Guoyu Zhou, Yue Ba

“…Thus, this study explored the relationships among fluoride exposure, genetic factors, physiological characteristics, lifestyle, and OAD risk, as well as the potential interactions among contributors in 593 adults from a cross-sectional study conducted in 2017. We observed that the OAD (n = 175) risk was increased with increasing urinary fluoride (UF) levels (OR=1.484; 95 %CI: 1.043, 2.111), age (OR=1.065; 95 %CI: 1.033, 1.098), and hip circumference (OR=1.069; 95 %CI: 1.014, 1.127), as well as a poor night sleep quality (OR=1.818; 95 %CI: 1.072, 3.084). …”
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Comparative transcriptomic analysis and identification of candidate genes related to Verticillium wilt resistance in Gossypium barbadense and Gossypium hirsutum by Jieyin Zhao, Xingui Hu, Yuxiang Wang, Jiaxin Lu, Wenju Gao, Xuening Su, Quanjia Chen, Yanying Qu

“…The resistance to Verticillium wilt in Gossypium barbadense is generally greater than that in Gossypium hirsutum, and analyzing the differences in the mechanism and regulatory genes involved in Verticillium wilt resistance between G. barbadense and G. hirsutum is particularly important. Here, we report a transcriptomic study for phenotypic evaluation of Verticillium wilt resistance in G. hirsutum (TM-1) and G. barbadense (Hai7124) and a comparison of the transcriptomes at 7 time points after Verticillium dahliae inoculation. …”
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Analysis of influencing factors of washed microbiota transplantation in treating patients with metabolic syndrome by De-Jiang Lin, Dong-Xia Hu, Qing-Ting Wu, Lin-Gui Huang, Zi-Han Lin, Jia-Ting Xu, Xing-Xiang He, Lei Wu, Lei Wu

“…The therapeutic effect of WMT on MS patients is closely related to their age, smoking index, infection, chronic disease status, donor type, and WMT courses. Therefore, we can improve the efficacy of WMT by reducing independent influencing factors that affect gut microbiota homeostasis.…”
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Oxidative potential determines the oxidative stress and ferroptotic toxicity of airborne particulate matter on pulmonary epithelial cells by Bingxue Nie, Daoqiang Zhang, Xin Liu, Chengying Lei, Zhiruo Li, Nan Zhang, Shuping Zhang, Yiju Wei, Jie Zhang

“…PM is a complex mixture with physiochemical properties that can vary over time and space, presenting a challenge when attempting to analyze their health risks. In this study, we compared two kinds of commercial PM with real PM to explore an index which takes account of both the diverse physicochemical properties of PM and accurate prediction of their toxicities. …”
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Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study by Yong Zhou, Jiayue Duan, Jiayi Zhu, Yunying Huang, Tao Tu, Keke Wu, Qiuzhen Lin, Yingxu Ma, Qiming Liu

“…Aims To assess the bidirectional causal relationship between frailty and nine mental disorders. Method We conducted a bidirectional two-sample Mendelian randomisation on genome-wide association study summary data, to investigate causality between frailty and nine mental disorders. …”
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HaCaT Cells as a Reliable In Vitro Differentiation Model to Dissect the Inflammatory/Repair Response of Human Keratinocytes by Irma Colombo, Enrico Sangiovanni, Roberta Maggio, Carlo Mattozzi, Stefania Zava, Yolanda Corbett, Marco Fumagalli, Claudia Carlino, Paola Antonia Corsetto, Diletta Scaccabarozzi, Stefano Calvieri, Angela Gismondi, Donatella Taramelli, Mario Dell’Agli

“…To standardize the in vitro studies on keratinocytes, we investigated the use of HaCaT cells, a long-lived, spontaneously immortalized human keratinocyte line which is able to differentiate in vitro, as a suitable model to follow the release of inflammatory and repair mediators in response to TNFα or IL-1β. …”
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Gut microbial dysbiosis, IgA, and Enterococcus in common variable immunodeficiency with immune dysregulation by Roos-Marijn Berbers, Fernanda L. Paganelli, Joris M. van Montfrans, Pauline M. Ellerbroek, Marco C. Viveen, Malbert R. C. Rogers, Moniek Salomons, Jaap Schuurmans, Martine van Stigt Thans, Remi M. M. Vanmaris, Lodewijk A. A. Brosens, Maria Marlot van der Wal, Virgil A. S. H. Dalm, P. Martin van Hagen, Annick A. J. M. van de Ven, Hae-Won Uh, Femke van Wijk, Rob J. L. Willems, Helen L. Leavis

“…Significant morbidity and mortality are caused by immune dysregulation complications (CVIDid), which affect around one-third of CVID patients and have a poorly understood etiology. Here, we investigate the hypothesis that gut microbial dysbiosis contributes to the inflammation underlying CVIDid. …”
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Serum Pharmacochemistry and Network Pharmacology Reveal Active Compounds and Mechanisms of the Huaxian Formula in Alleviating Radiation-Induced Pulmonary Fibrosis by Gong C, Chen J, Zou P, Fang Z, Quan L, Wang J, Yin J, Lin B, Lang J, Chen M

“…The Huaxian formula (HXF), a traditional Chinese herbal remedy, shows promise in alleviating RIPF; however, its active ingredients and underlying mechanisms remain poorly understood.Methods: Through serum pharmacochemistry, network pharmacology, molecular docking, and experimental validation, we investigate the potential mechanisms of HXF in the prevention and treatment of radiation-induced pulmonary fibrosis (RIPF).Results: Histological examination and non-invasive computed tomography (CT) scans in animal experiments revealed that HXF improved extracellular matrix collagen deposition in the lung tissue of irradiated mice and reduced fibrosis manifestations on CT images. …”
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L’emploi antique des géomatériaux à Reims/Durocortorum by Gilles Fronteau, Sébastien Laratte, Alain Devos, Claire Pichard

“…Thus, the supply of building materials highlights the implementation of multiple strategies, including specific “regional” or extra-regional supplies, but also the optimization of the use of local resources. In this article, we propose to review the geomaterial resources identified in the ancient town of Durocortorum, according to their uses and availability in growing areas, starting from the city center and spreading to areas where investment in material supply was important. …”
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Geochronology and geochemistry of the Neoproterozoic–Mesozoic intrusive rocks in the Xinlin area, northeastern China: new constraints on the tectonic evolution of the Erguna block... by Sheng Lu, Sheng Lu, Sheng Lu, Sheng Lu, Chenglu Li, Masroor Alam, Zhichao Song, Xiannan Zhu, Anzong Fu, Wenpeng Yang

“…The occurrence of intrusive rocks within the Xinlin area, northeastern China, provides insights into the Neoproterozoic–Mesozoic geodynamic setting of the Erguna block. In this study, we present petrographic, geochemical, and geochronological data on intrusive rocks from the Xinlin area. …”
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The Middle to Late Triassic of Central Saudi Arabia with emphasis on the Jilh Formation. Part I: lithostratigraphy, facies and paleoenvironments, palaeontology and biostratigraphic... by Le Nindre, Yves-Michel, Vaslet, Denis, Vrielynck, Bruno, Krystyn, Leopold, Manivit, Jacques, Memesh, Abdullah, Davies, Roger Brett

“…Marine flooding events are indicated by tidal flat sediments during the Anisian, and thin carbonate beds during the Ladinian, late Julian (Early Carnian), associated with Fe-oolite beds, and Tuvalian (Late Carnian). We recognise a regional Carnian–Norian hiatus and an early Middle Norian transgression, as well as marine and continental erosional discontinuities affecting the stacking pattern of the T–R wedges. …”
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Employee retention through effective human resource management practices in Maldives: Mediation effects of compensation and rewards system by Zubair Hassan

“…This means, indirectly PA and T&D can increase ER in the retail sector of Maldives. Similarly, we conclude that there is no moderating effect of PA and T&D in the relationship between HRM practices and ER. …”
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Temporal changes in plasma and milk lipids in response to an esophageal bolus of rumen-protected fish oil in lactating Holstein dairy cows by J.E. Rico, V. Sáinz de la Maza-Escolà, N.D. Senevirathne, P. Deme, N.J. Haughey, R. Gervais, J.W. McFadden

“…Total milk n-3 increased over time in treated cows compared to control. We conclude that triglyceride- or starch-encapsulated fish oil increases the plasma and milk concentrations of VLC n-3 FA and phospholipids containing these acyl chains in lactating cows.…”
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Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling by Raquel Arantes Megid, Guilherme Gomes Ribeiro, Izabela Natalia Faria Gomes, Ana Carolina Laus, Letícia Ferro Leal, Letícia Ferro Leal, Luciane Sussuchi da Silva, Abu-Bakr Adetayo Ariwoola, Josiane Mourão Dias, Rui Manuel Reis, Rui Manuel Reis, Renato Jose da Silva-Oliveira, Renato Jose da Silva-Oliveira

“…To identify potential therapeutic strategies for overcoming sotorasib resistance, we investigated the combination of AKT and p38 inhibitors. …”
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Neutrophil Gelatinase-Associated Lipocalin in Kidney Transplantation Is an Early Marker of Graft Dysfunction and Is Associated with One-Year Renal Function by Isabel Fonseca, José Carlos Oliveira, Manuela Almeida, Madalena Cruz, Anabela Malho, La Salete Martins, Leonídio Dias, Sofia Pedroso, Josefina Santos, Luísa Lobato, António Castro Henriques, Denisa Mendonça

“…Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been suggested as potential early marker of delayed graft function (DGF) following kidney transplantation (KTx). We conducted a prospective study in 40 consecutive KTx recipients to evaluate serial changes of uNGAL within the first week after KTx and assess its performance in predicting DGF (dialysis requirement during initial posttransplant week) and graft function throughout first year. …”
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