Comprehensive analysis of full genome sequence and Bd-milRNA/target mRNAs to discover the mechanism of hypovirulence in Botryosphaeria dothidea strains on pear infection with BdCV1... by Wangcheng Hu, Hui Luo, Yuekun Yang, Qiong Wang, Ni Hong, Guoping Wang, Aiming Wang, Liping Wang

“…To investigate the role of RNA-silencing in B. dothidea defense, we constructed four small RNA libraries and sequenced B. dothidea micro-like RNAs (Bd-milRNAs) produced in response to BdCV1 and BdPV1 infection. …”
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Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients by Van Phu Thang Nguyen, Hirokazu Kurohama, Yuko Akazawa, Thi Ngoc Anh Nguyen, Katsuya Matsuda, Yuki Matsuoka, Zhanna Mussazhanova, Kenichi Yokota, Shinya Satoh, Hiroyuki Yamashita, Thi Nhung Nguyen, Yerkerzhan Sailaubekova, Masahiro Nakashima

“…Adolescent and young adult (AYA, 15–39 years old) patients with papillary thyroid carcinoma (PTC) experience significant psychological distress and place great importance on obtaining information regarding the disease; however, their demands remain unmet. We aimed to investigate clinicopathological and molecular features of PTC in AYA patients and compare them to those of PTC in older patients (≥40 years). …”
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Habitat suitability modeling for Posidonia oceanica distribution along a Mediterranean region (NW Italy) by Rachele Bordoni, Chiara Paoli, Monica Montefalcone, Alice Oprandi, Ilaria Rigo, Francesca Ruggeri, Paolo Vassallo

“…Proper management and conservation of coastal marine habitats require the understanding of its distribution. To address this need, we developed habitat suitability models (HSMs), built up using the Random Forest algorithm in R software, that assess the suitability of the environment for the presence of P. oceanica in the Ligurian Sea (NW Italy).Model response variables included potential seabed areas characterized by P. oceanica habitats on soft and rocky bottoms, down to 50 m depth. …”
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Risk Factors and Outcome of Sepsis in Traumatic Patients and Pathogen Detection Using Metagenomic Next-Generation Sequencing by Yiqing Tong, Jianming Zhang, Yimu Fu, Xingxing He, Qiming Feng

“…Once diagnosed with sepsis, patients should be given an appropriate empiric antimicrobial treatment followed by the specific antibiotic therapy based on blood culture due to its rapid progression to tissue damage and organ failure. In this study, we aimed to analyze the risk factors and outcome of sepsis in traumatic patients and to investigate the performance of metagenomic next-generation sequencing (mNGS) compared with standard microbiological diagnostics in post-traumatic sepsis. …”
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Distinct Circle of Willis anatomical configurations in healthy preterm born adults: a 3D time-of-flight magnetic resonance angiography study by Julien Greggio, Christina Malamateniou, Kelly Pegoretti Baruteau, Constantino Carlos Reyes-Aldasoro, Odaro J. Huckstep, Jane M. Francis, Wilby Williamson, Paul Leeson, Adam J. Lewandowski, Winok Lapidaire

“…Statistical comparisons assessed the prevalence of each variant group between preterm and full-term populations, as well as the relationship between CoW variability, sex, and degree of prematurity. Results We identified 164 participants with variant CoW configurations. …”
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Sex differences in intracranial plaque burden in patients with type 2 diabetes mellitus with acute ischemic cerebrovascular disease: a pilot study based on high-resolution MRI by Xuejiao Yan, Ling Li, Jie Gao, Lihui Wang, Kai Ai, Xiaoyan Lei, Min Tang, Xiaoling Zhang, Dongsheng Zhang

“…This study attempts to explore possible associations between sex, treatment, and the burden of intracranial atherosclerosis (ICAS) in patients with T2DM who have experienced an acute ischemic cerebrovascular disease.MethodsWe focused on patients with T2DM with acute ischemic stroke or transient ischemic attack due to intracranial atherosclerotic stenosis. …”
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The anti-cancerous mechanism of licochalcone A on human hepatoma cell HepG2 based on the miRNA omics by Jun Wang, Xiuxiu Zhang, Zhijing Ni, Elnur Elam, Kiran Thakur, Kexin Li, Chuyan Wang, Jianguo Zhang, Zhaojun Wei

“…To explore the function of licochalcone A as an anticancer phytochemical on HepG2 cells and investigate its potential mechanisms, we analyzed the microRNAs (miRNAs) expression profile of HepG2 cells in response to licochalcone A (70 μmol/L) in vitro. 102 dysregulated miRNAs were detected, and SP1 was expected as the transcription factor that regulates the functions of most screened miRNAs. …”
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Small extracellular vesicles derived from sequential stimulation of canine adipose-derived mesenchymal stem cells enhance anti-inflammatory activity by Saranyou Oontawee, Parkpoom Siriarchavatana, Watchareewan Rodprasert, Irma Padeta, Yudith Violetta Pamulang, Poorichaya Somparn, Trairak Pisitkun, Boondarika Nambooppha, Nattawooti Sthitmatee, Daneeya Na Nan, Thanaphum Osathanon, Hiroshi Egusa, Chenphop Sawangmake

“…To validate the efficacy of IVES for sEV production, various analyses were conducted, including microscopic examination, surface marker assessment, zeta-potential measurement, protein quantification, nanoparticle tracking analysis, and determination of anti-inflammatory activity. Results We found that IVES demonstrated non-cytotoxicity and induced crucial genotypic changes associated with sEV production in cAD-MSCs. …”
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Prevalence of Diabetes and Associated Risk Factors among a Group of Prisoners in the Yaoundé Central Prison by Sylvain Raoul Simeni Njonnou, Jérôme Boombhi, Martine Claude Etoa Etoga, Aimée Tiodoung Timnou, Ahmadou Musa Jingi, Kevin Nkem Efon, Esther Astrid Mbono Samba Eloumba, Marie-Josiane Ntsama Essomba, Odette Kengni Kebiwo, Alice Ninon Tsitsol Meke, Stéphane Talbit Ndjonya, Mesmin Dehayem Yefou, Eugène Sobngwi

“…Analyzed variables included phenotypic characteristics, lifestyle, the reason for detention, the sentence severity, and the length of detention. Results. We recruited 437 inmates (344 men) with an average age of 37.0 (95% CI: 35.9-38.3) years. …”
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Adalimumab Treatment in Biologically Naïve Crohn’s Disease: Relationship with Ectopic MUC5AC Expression and Endoscopic Improvement by Tsutomu Mizoshita, Satoshi Tanida, Hironobu Tsukamoto, Keiji Ozeki, Takahito Katano, Hirotaka Nishiwaki, Masahide Ebi, Yoshinori Mori, Eiji Kubota, Hiromi Kataoka, Takeshi Kamiya, Takashi Joh

“…Fifteen patients with active biologically naïve CD were treated with ADA. We examined them clinically and pathologically with ectopic MUC5AC expression in the lesions before and after 12 and 52 weeks of ADA therapy, retrospectively. …”
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Clinical Characteristics of COVID-19 in Neonates and Infants Younger Than 3 Months by Fatemeh Varshoei, Mohammad Sadegh Rezai, Roya Farhadi, Azin Hajialibeig, Saeid Mohammadi, Masoud Moradi, Fatemeh Hosseinzadeh

“…Objectives: To better understand COVID-19 in young children, we evaluated the epidemiological, clinical, and outcomes of SARS-CoV-2 infection in neonates and 1-3 months old infants and compared the differences between the two groups. …”
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METTL16 is Required for Meiotic Sex Chromosome Inactivation and DSB Formation and Recombination during Male Meiosis by Lisha Yin, Nan Jiang, Wenjing Xiong, Shiyu Yang, Jin Zhang, Mengneng Xiong, Kuan Liu, Yuting Zhang, Xinxin Xiong, Yiqian Gui, Huihui Gao, Tao Li, Yi Li, Xiaoli Wang, Youzhi Zhang, Fengli Wang, Shuiqiao Yuan

“…However, the key regulators involved in this process and the underlying molecular mechanisms remain unclear. Here, we report an essential role of the m6A methyltransferase METTL16 in meiotic sex chromosome inactivation (MSCI), double‐strand break (DSB) formation, homologous recombination and SYCP1 deposition during male meiosis. …”
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CAD-Q (COPD-Asthma Differentiation Questionnaire): Performance of a new diagnostic score to differentiate between COPD and asthma in adults by Alejandra Lozano-Forero, Eduardo Tuta-Quintero, Alirio R. Bastidas, Blanka Pacheco, Juan Cordero, Kamil Faizal, Miguel Molina, Irma Méndez, Andrés Cardona, Nicoll Navarro, Gabriela Bonilla, Manuela Franco, Juan Samboní, Julio de La Hoz, Georgina Doumat, David Portilla, Hannah Eljach

“…Utilizing clinical questionnaires to identify and differentiate patients with COPD and asthma for further diagnostic procedures has emerged as an effective strategy to address this issue. We developed a new diagnostic tool, the COPD-Asthma Differentiation Questionnaire (CAD-Q), to differentiate between COPD and asthma in adults. …”
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Mechanical and Pharmacological Revascularization Strategies for Prevention of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction: Analysis from Index of Microc... by Ji-Hun Jang, Man-Jong Lee, Kyu-Yong Ko, Jin-Hee Park, Yong-Soo Baek, Kwon Sung-Woo, Sung-Hee Shin, Seong-Ill Woo, Dae-Hyeok Kim, Young Ju Suh, Jun Kwan, Sang-Don Park

“…Objectives. We aimed to identify mechanical and pharmacological revascularization strategies correlated with the index of microcirculatory resistance (IMR) in ST-elevation myocardial infarction (STEMI) patients. …”
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Clinical spectrum, treatment and outcomes of the m.10197G>A mutation in MT-ND3: a case report, systematic review and meta-analysis by YuZhi Shi, Bin Chen, SongTao Niu, XinGao Wang, ZaiQiang Zhang

“…Results A total of 84 participants (78 patients and 6 asymptomatic carriers) with the m.10197G>A mutation retrieved from 33 articles and the patient whose case we reported were included in the review and meta-analysis. …”
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Comparison of IMO vifa24plus(1-2) and Humphrey Field Analyzer 24-2 by Takagi Y, Asano R, Yamashita K, Sakai Y, Yokoyama S, Ichikawa K, Ichikawa K

“…Yuki Takagi,1,2 Ryo Asano,1,3 Kanna Yamashita,2 Yukihiro Sakai,2 Sho Yokoyama,1 Kei Ichikawa,2 Kazuo Ichikawa2 1Department of Ophthalmology, Japan Community Healthcare Organization Chukyo Hospital, Nagoya, Aichi, Japan; 2Chukyo Eye Clinic, Nagoya, Aichi, Japan; 3Asano Eye Clinic, Nagoya, Aichi, JapanCorrespondence: Yuki Takagi, Department of Ophthalmology, Japan Community Healthcare Organization Chukyo Hospital, 1-1-10 Sanjo Minami-ku, Nagoya, Aichi, Japan, Tel +81-52-691-7151, Fax +81-52-692-5220, Email ytakagi@sanjogroup.jpPurpose: This study aimed to compare the results of the IMO vifa 24plus(1– 2) and HFA 24– 2 visual field tests.Patients and Methods: We included 52 patients (104 eyes) with glaucoma who visited Chukyo Eye Clinic between June 2023 and March 2024. …”
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Transcriptomic responses of sponge holobionts to in situ, seasonal anoxia and hypoxia by Strehlow, Brian W., Schuster, Astrid, Francis, Warren R., Eckford-Soper, Lisa, Kraft, Beate, McAllen, Rob, Nielsen, Ronni, Mandrup, Susanne, Canfield, Donald E.

“…To understand their tolerance mechanisms, we performed differential gene expression analyses on the sponges, their mitochondria and their microbial symbionts under in situ conditions of normoxia, hypoxia and anoxia. …”
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Influence of water masses and environmental variables on fish community in the south bank of Yangtze River Estuary, China by Dongrong Zhang, Dongrong Zhang, Hengtao Xu, Hengtao Xu, Xin Fang, Xin Fang, Wei Huang, Wei Huang, Youzheng Zhang, Youzheng Zhang, Jian Qian, Jian Qian

“…Consequently, it is essential to study the characteristics of fish communities and their impacts within the estuary. In this study, we employed a single-boat bottom trawl to conduct four fishery resource surveys in April (spring), August (summer), October (autumn), and December (winter) of 2020 at ten sampling sites along the south bank of the Yangtze River Estuary (SBYRE). …”
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Codicology in Lithuania in 1918-1990: Between Book History and Palaeography by Rima Cicėnienė

“…The end of the Second World War saw the reactivation of academic institutions, the training of a new generation of historians and librarians, the accumulation of manuscript books, and the appearance of individual works on the history of the book. However, we can only speak of codicological research and attention to the manuscript book as a research object since the 1980s. …”
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Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway by Orlei Ribeiro de Araujo, Reinaldo Salomão, Milena Karina Coló Brunialti, Dafne Cardoso Bourguignon da Silva, Andreza Almeida Senerchia, Fabianne Altruda de Moraes Costa Carlesse, Antonio Sergio Petrilli

“…Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis.…”
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