Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings by Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux, Abdijapar Shamshiev

“…The emergence of Repulsive Guidance Molecule b (RGMb), a ligand for PD-L2, as a novel co-inhibitory pathway in T cells, together with its regulation by the gut microbiome, encouraged the discovery and development of fully human anti-RGMb antibodies. Here, we describe phage display-derived monoclonal antibodies (mAbs) 2C11 and 5C10 that bind human RGMb with high affinities of 1.4 nM and 0.72 nM, respectively. …”
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Spatial and seasonal determinants of arthropod community composition across an agro-ecosystem landscape by P. Burgess, G.S. Betini, A. Cholewka, J.R. deWaard, S. deWaard, C. Griswold, P.D.N. Hebert, A. MacDougall, K.S. McCann, J. McGroarty, E. Miller, K. Perez, S. Ratnasingham, C. Reisiger, D. Steinke, E. Wright, E. Zakharov, J.M. Fryxell

“…We used Malaise traps to sample arthropod community composition at biweekly intervals across an agroecosystem landscape in southern Ontario, Canada, to evaluate the relative impact of site spacing, seasonal timing, weather conditions, local plant community attributes, and agricultural extent across the local landscape on spatial and temporal variation in arthropod community composition. …”
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Evaluasi Kualitas Layanan E-Government Pada Aplikasi Pendaftaran Seleksi Calon Aparatur Sipil Negara Menggunakan Model E-GovQual Berdasarkan Perspektif Pengguna by Puja Putri Abdullah, Rina Rahmawati, Dana Indra Sensuse, Sofian Lusa, Assaf Arief, Prasetyo Adi

“…The recommendation that we provide is that BKN as the responsible institution for developing SSCASN must prioritize all indicators in the Efficiency and Reliability variabels because they get the highest score and have the most influence on the quality of SSCASN services. …”
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One-Year Review Of Reduced Fetal Movements In Izzat Ali Shah MCH Center: A Predictor Of Poor Perinatal Outcome by Humera Rani, Gulwish Salahuddin, Ayesha Naz, Noreen Majeed, Faiza Safdar, Shazia Rafique

“…It signifies the need for more vigilance in this area of practice. But we can’t neglect the perception of a mother. Mother’s feelings are more important than any other test. …”
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Comparative Analysis of Automated and Handheld Breast Ultrasound Findings for Small (≤1 cm) Breast Cancers Based on BI-RADS Category by Han Song Mun, Eun Young Ko, Boo-Kyung Han, Eun Sook Ko, Ji Soo Choi, Haejung Kim, Myoung Kyoung Kim, Jieun Kim

“…<b>Objectives</b>: This study aimed to compare ultrasound (US) findings between automated and handheld breast ultrasound (ABUS and HHUS, respectively) in small breast cancers, based on the breast imaging reporting and data system (BI-RADS) category. <b>Methods</b>: We included 51 women (mean age: 52 years; range: 39–66 years) with breast cancer (invasive or DCIS), all of whom underwent both ABUS and HHUS. …”
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Environmental, socioeconomic, and sociocultural drivers of monkeypox transmission in the Democratic Republic of the Congo: a One Health perspective by Guangyu Lu, Zeyin Chong, Enyu Xu, Ce Na, Kaixuan Liu, Liying Chai, Pengpeng Xia, Kai Yang, Guoqiang Zhu, Jinkou Zhao, Olaf Müller

“…Methods Epidemiological, environmental, socioeconomic, and sociocultural data from the DRC from 2000 to 2015 were obtained from publicly available dataset. Using these data, we applied negative binomial regression model, least absolute shrinkage and selection operator regression model, and principal component analysis (PCA) to identify key environmental, socioeconomic, and sociocultural factors contributing to mpox transmission. …”
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Associated adverse outcomes with tumor treating fields when combined to temozolomide versus temozolomide alone for the treatment of glioblastoma: a meta-analysis of randomized tria... by Yuanyuan Chen, Yan Chen, Hong Zhen, Danhua Lou

“…Recently, the Food and Drug Administration (FDA) has approved tumor treating fields (TTF) for the treatment of glioblastoma. In this analysis, we aimed to systematically assess the adverse outcomes associated with TTF when combined to temozolamide versus temozolamide alone for the treatment of glioblastoma. …”
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Investigation of the Performance of a Sb2S3-Based Solar Cell with a Hybrid Electron Transport Layer (h-ETL): A Simulation Approach Using SCAPS-1D Software by Pierre Gérard Darel Kond Ngue, Ariel Teyou Ngoupo, Aimé Magloire Ntouga Abena, François Xavier Abomo Abega, Jean-Marie Bienvenu Ndjaka

“…The main objectives of the present work are to propose a h-ETL with good band alignment with the Sb2S3 absorber, high transparency, and Cd free; to mitigate the instability and cost issues associated with using Spiro-OMeTAD HTL; and to optimize the solar cell. Thus, we calibrated the J-V characteristics and electrical parameters of the FTO/(ZnO/TiO2)/Sb2S3/Spiro-OMeTAD/Au solar cell by numerical simulation and compared them with those of the experiment. …”
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Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies by Rui Gao, Rui Gao, Rui Gao, Meilin Liu, Meilin Liu, Meilin Liu, Haoyi Yang, Haoyi Yang, Haoyi Yang, Yuhan Shen, Yuhan Shen, Yuhan Shen, Ni Xia, Ni Xia, Ni Xia

“…This review synthesizes novel epigenetic insights into CAD, addressing the pathological processes, key molecular mechanisms, and potential biomarkers. Furthermore, we discuss emerging therapeutic strategies targeting epigenetic pathways. …”
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A Subgroup of Latently Mycobacterium tuberculosis Infected Individuals Is Characterized by Consistently Elevated IgA Responses to Several Mycobacterial Antigens by Ralf Baumann, Susanne Kaempfer, Novel N. Chegou, Wulf Oehlmann, Ralf Spallek, André G. Loxton, Paul D. van Helden, Gillian F. Black, Mahavir Singh, Gerhard Walzl

“…In the present study, IgA and/or IgG responses to the mycobacterial protein antigens AlaDH, NarL, 19 kDa, PstS3, and MPT83 were determined in a blinded fashion in sera from 53 LTBI controls, 14 healthy controls, and 42 active TB subjects. Among controls, we found that elevated IgA levels against all investigated antigens were not randomly distributed but concentrated on a subgroup of <30%—with particular high levels in a small subgroup of ~5% comprising one progressor to active TB. …”
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Clinical features and genetic analysis of 15 Chinese children with dent disease by Qian Li, Zhenle Yang, Ruixian Zang, Suwen Liu, Lichun Yu, Jing Wang, Cong Wang, Xiaoyuan Wang, Shuzhen Sun

“…Objective  The clinical characteristics, genetic mutation spectrum, treatment strategies and prognoses of 15 children with Dent disease were retrospectively analyzed to improve pediatricians’ awareness of and attention to this disease.Methods  We analyzed the clinical and laboratory data of 15 Chinese children with Dent disease who were diagnosed and treated at our hospital between January 2017 and May 2023 and evaluated the expression of the CLCN5 and OCRL1 genes.Results  All 15 patients were male and complained of proteinuria, and the incidence of low-molecular-weight proteinuria (LMWP) was 100.0% in both Dent disease 1 (DD1) and Dent disease 2 (DD2) patients. …”
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Renewed Global Partnerships and Redesigned Roadmaps for Rabies Prevention and Control by Tiziana Lembo, Michaël Attlan, Hervé Bourhy, Sarah Cleaveland, Peter Costa, Katinka de Balogh, Betty Dodet, Anthony R. Fooks, Elly Hiby, Fernando Leanes, François-Xavier Meslin, Mary Elizabeth Miranda, Thomas Müller, Louis H. Nel, Charles E. Rupprecht, Noël Tordo, Abbigail Tumpey, Alexander Wandeler, Deborah J. Briggs

“…Although preventing human deaths through canine rabies elimination is feasible, dog rabies control is often neglected, because dogs are not considered typical economic commodities by the animal health sector. Here, we demonstrate that the responsibility of managing rabies falls upon multiple sectors, that a truly integrated approach is the key to rabies elimination, and that considerable progress has been made to this effect. …”
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Pengaruh Kompres Panas dan Dingin terhadap Penurunan Nyeri Kala I Fase Aktif Persalinan Fisiologis Ibu Primipara by Mutia Felina, Masrul ., Detty Iryani

“…There is differences of the pain deviation in hot compress and cold compress p=0.001. We conclude that there is the difference of the effect of hot and cold compress on pain relief during labor.…”
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Pre-sowing treatment of acorns with gibberellic acid and N-hexanoyl-L-homoserine lactone induced changes in growth and hormonal balance of Quercus robur L. seedlings by Voytenko Lesya, Vasyuk Valentyna, Babenko Lidia, Shcherbatiuk Mykola, Romanenko Kateryna, Kosakivska Iryna V.

“…This study aimed to assess and compare the impact of priming with gibberellic acid (GA3) and N-hexanoyl-L-homoserine lactone (C6-HSL) on acorn germination, seedling growth, and the balance of endogenous phytohormones in 47-day-old seedlings of pedunculated oak (Quercus robur L.). We hypothesized that exogenous GA3 and C6-HSL induce changes in hormonal homeostasis, which activate the germination of acorns and growth of seedlings. …”
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Knowledge of prevention and treatment of infectious diarrhea among parents of children under five with diarrhea in Anhui province: an outpatient-clinic-based questionnaire survey by Yuanfang SUN, Yongkang XIAO, Lei GONG, Hongyuan WEI, Wanwan MA, Shuo FENG, Qiang ZHANG, Linlin LI, Qile WU, Jiabing WU

“…ObjectiveTo assess the status and determinants of knowledge of prevention and treatment of infectious diarrhea among parents of children aged ≤5 years with diarrhea to provide evidence for the development of targeted health intervention strategies. MethodsWe conducted face-to-face interviews with 1 325 parents of children aged ≤ 5 years diagnosed with infectious diarrhea at outpatient clinics of 8 grade II medical institutions selected by cluster sampling in 4 cities across geographic regions of Anhui province between May 2021 and October 2022. …”
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Clinical confocal laser endomicroscopy for imaging of autofluorescence signals of human brain tumors and non-tumor brain by Marlen Reichenbach, Sven Richter, Roberta Galli, Matthias Meinhardt, Katrin Kirsche, Achim Temme, Dimitrios Emmanouilidis, Witold Polanski, Insa Prilop, Dietmar Krex, Stephan B. Sobottka, Tareq A. Juratli, Ilker Y. Eyüpoglu, Ortrud Uckermann

“…Abstract Purpose Analysis of autofluorescence holds promise for brain tumor delineation and diagnosis. Therefore, we investigated the potential of a commercial confocal laser scanning endomicroscopy (CLE) system for clinical imaging of brain tumors. …”
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Necrosis in Preoperative Cross-Sectional Imaging and Postoperative Histology Is a Diagnostic Marker for Malignancy of Adrenocortical Tumors by Agata Dukaczewska, Stephan R. Marticorena Garcia, Simon Ponsel, Alexandra Webster, Frederike Butz, Eva M. Dobrindt, Johann Pratschke, David Horst, Martina T. Mogl, Catarina A. Kunze

“…Necrosis in postoperative histology has been reported as being specific for adrenocortical carcinoma (ACC) compared to adenoma. We therefore retrospectively analyzed the diagnostic accuracy of the finding of necrosis in preoperative cross-sectional imaging and postoperative histology as a marker for ACC in our patient cohort. …”
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Co-creation and application of a framework for the de-prioritization of urban communities during insecticide-treated bed net mass campaigns for malaria prevention and control in Kw... by Ifeoma D. Ozodiegwu, Laurette Mhlanga, Eniola A. Bamgboye, Adeniyi F. Fagbamigbe, Cyril Ademu, Chukwu Okoronkwo, Joshua O. Akinyemi, Akintayo O. Ogunwale, IkeOluwapo O. Ajayi, Beatriz Galatas

“…In response to funding constraints in the Global Fund Grant Cycle 7, Nigeria’s National Malaria Elimination Programme (NMEP) aimed to develop an approach that maximizes the impact of limited malaria interventions by focusing on areas with the greatest need. We developed an urban LLINs distribution framework and a novel strategy, which was piloted in Ilorin, the capital of Kwara State. …”
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Methylammonium-free, high-efficiency, and stable all-perovskite tandem solar cells enabled by multifunctional rubidium acetate by Xufeng Liao, Xuefei Jia, Weisheng Li, Xiting Lang, Jianhua Zhang, Xinyu Zhao, Yitong Ji, Qingguo Du, Chun-Hsiao Kuan, Zhiwei Ren, Wenchao Huang, Yang Bai, Kaicheng Zhang, Chuanxiao Xiao, Qianqian Lin, Yi-Bing Cheng, Jinhui Tong

“…Here, a multifunctional additive rubidium acetate (RbAC) is proposed to passivate Sn-Pb perovskite. We find that RbAC can suppress Sn2+ oxidation, alleviate microstrain, and improve the crystallinity of the MA-free Sn-Pb perovskite. …”
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Analisis Sentimen untuk Evaluasi Reputasi Merek Motor XYZ Berkaitan dengan Isu Rangka Motor di Twitter Menggunakan Pendekatan Machine Learning by Ferdian Maulana Akbar, Robby Hermansyah, Sofian Lusa, Dana Indra Sensuse, Nadya Safitri, Damayanti Elisabeth

“…Data was collected using crawling techniques from tweets posted between August and November 2023. We used sentiment analysis with word clouds, trend and distribution analysis, and compared five machine learning algorithms: Naïve Bayes, Decision Tree, Support Vector Machine, Logistic Regression, and Random Forest. …”
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