Simultaneous detection of human neutrophil elastase and cathepsin G on a single substrate using a fluorometric quantum dots probe and chemometric models by Fátima A.R. Mota, Rafael C. Castro, David S.M. Ribeiro, João L.M. Santos, Ricardo N.M.J. Páscoa, Marieta L.C. Passos, M. Lúcia M.F.S. Saraiva

“…High levels of these enzymes indicate prolonged inflammation and impaired healing processes, making their discrimination and quantification essential for effective wound management and treatment strategies. In this study, we propose a novel method combining distinctly sized CdTe quantum dots (QDs) as a fluorescent probe to implement a platform for simultaneous discrimination and quantification of HNE and CatG, applying chemometric analysis.The fluorometric response was acquired using two different methods: kinetic and excitation/emission matrices (EEM). …”
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Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease by Yanan Sun, Cao Ma, Hui Sun, Huan Wang, Wei Peng, Zibo Zhou, Hongwei Wang, Chenchen Pi, Yingai Shi, Xu He

“…Since AD has many characteristics in common with impaired insulin signaling pathways, AD can be regarded as a metabolic disease. We conclude from the published literature that the body’s diabetic status under certain circumstances such as metabolic abnormalities can increase the incidence of AD by affecting glucose transport to the brain and reducing glucose metabolism. …”
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Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications by Brix ATH, Petersen TG, Nymark T, Schmal H, Lindberg-Larsen M, Rubin KH

“…For pneumonia, it was 10.5% (CI 7.1– 13.9) in women and 14.9% (11.6– 18.2) in men.Conclusion: We observed an increased mortality in the month following MLEA, which remained elevated for years compared to the matched unamputated cohort. …”
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Comparison of efficacy and safety of thrombus prevention strategies after abdominal and pelvic cancer surgery: Bayesian network based meta-analysis by Shiran Qin, Shiran Qin, Sitong Guo, Yucheng Yao, Yucheng Yao, Ying He, Dandan Xu, Dandan Xu, Henghai Su, Xiaoyu Chen, Haoru Meng

“…However, there is insufficient evidence supporting the choice of anticoagulation strategies.MethodsWe searched PubMed, The Cochrane Library, Embase, and Web of Science for randomized controlled trials from inception to January 2024. …”
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Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction by Jingrun Lin, Xiaoqiu Zhu, Xuan Li, Yu Hong, Yaohui Liang, Siqi Chen, Chenzhuo Feng, Lin Cao

“…Doublecortin (DCX) immunofluorescence staining confirmed reduced hippocampal neurogenesis in aging mice, which was further decreased after surgery. We identified several key lncRNAs and miRNAs implicated in neurogenesis regulation. …”
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BenthicNet: A global compilation of seafloor images for deep learning applications by Scott C. Lowe, Benjamin Misiuk, Isaac Xu, Shakhboz Abdulazizov, Amit R. Baroi, Alex C. Bastos, Merlin Best, Vicki Ferrini, Ariell Friedman, Deborah Hart, Ove Hoegh-Guldberg, Daniel Ierodiaconou, Julia Mackin-McLaughlin, Kathryn Markey, Pedro S. Menandro, Jacquomo Monk, Shreya Nemani, John O’Brien, Elizabeth Oh, Luba Y. Reshitnyk, Katleen Robert, Chris M. Roelfsema, Jessica A. Sameoto, Alexandre C. G. Schimel, Jordan A. Thomson, Brittany R. Wilson, Melisa C. Wong, Craig J. Brown, Thomas Trappenberg

“…Machine learning approaches provide opportunities to increase the efficiency with which seafloor imagery is analyzed, yet large and consistent datasets to support development of such approaches are scarce. Here we present BenthicNet: a global compilation of seafloor imagery designed to support the training and evaluation of large-scale image recognition models. …”
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Systemic Overexpression of GDF5 in Adipocytes but Not Hepatocytes Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver in Mice by Yan Yang, Wenting Zhang, Xiaohui Wu, Jing Wu, Chengjun Sun, Feihong Luo, Zhou Pei

“…Our recent study demonstrated that growth differentiation factor 5 (GDF5) could promote white adipose tissue thermogenesis and alleviate high-fat diet- (HFD-) induced obesity in fatty acid-binding protein 4- (Fabp4-) GDF5 transgenic mice (TG). Here, we further investigated the effects of systemic overexpression of the GDF5 gene in adipocytes HFD-induced nonalcoholic fatty liver disease (NAFLD). …”
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Plasma-enhanced upcycling of mixed plastic waste over La0.6Ca0.4FeO3−δ nano spheres for co-producing hydrogen and high-value carbon by Guoxing Chen, Xiao Yu, Aasir Rashid, Chanchan Li, Marc Widenmeyer, Lina Liu, Bowen Liu, Yi Wang, Gert Homm, Emanuel Ionescu, Tao Shao, Anke Weidenkaff

“…In this study, we present a novel plasma-enabled method for efficiently decomposing mixed plastic waste into hydrogen and valuable carbon materials. …”
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Dataset of SARS-CoV-2 spike protein receptor binding domain variants in complex with antigen-binding fragments targeting COVID-19 vaccine-referenced variantsModel Archive by Ferdinando Spagnolo, Florigio Lista, Claudia Curcio

“…In this paper, we present a dataset of homology-modeled structures of SARS-CoV-2 Spike protein Receptor Binding Domain (RBD) variants complexed with antigen-binding fragments (Fab) derived from the PDB structures 8GPY (Omicron BA.4/5 RBD in complex with a neutralizing antibody scFv), 8H7Z (BA.2 RBD in complex with BA7535 Fab), and 8XE9 (XBB.1.5 RBD in complex with BD55–1205). …”
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Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? by Eduardo Mansilla, Vanina Díaz Aquino, Daniel Zambón, Gustavo Horacio Marin, Karina Mártire, Gustavo Roque, Thomas Ichim, Neil H. Riordan, Amit Patel, Flavio Sturla, Gustavo Larsen, Rubén Spretz, Luis Núñez, Carlos Soratti, Ricardo Ibar, Michiel van Leeuwen, José María Tau, Hugo Drago, Alberto Maceira

“…This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. …”
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Informal Caregivers Connecting on the Web: Content Analysis of Posts on Discussion Forums by Michelle L Foster, Chinenye Egwuonwu, Erin Vernon, Mohammad Alarifi, M Courtney Hughes

“…Researchers extracted the first 6 responses to the first 20 questions and comments to appear posted by the informal caregivers in each of the 5 forums, removing any individually identifying information. We used a codebook thematic analysis approach to examine the data with Dedoose (SocioCultural Research Consultants). …”
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Deep Lateral Wall Partial Rim-Sparing Orbital Decompression with Ultrasonic Bone Removal for Treatment of Thyroid-Related Orbitopathy by Álvaro Bengoa-González, Alicia Galindo-Ferreiro, Enrique Mencía-Gutiérrez, Hortensia Sánchez-Tocino, Agustín Martín-Clavijo, María-Dolores Lago-Llinás

“…All of these complications were resolved at the 6-month follow-up visit. We noted no surgical complications such as ocular or soft tissue damage, infection, inflammation, or visual loss. …”
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Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…Background/Objectives: Hyperlipidemia is a serious risk factor for cardiovascular diseases and liver steatosis. In this work, we explored the effect of an herbal formula (CBF) containing immature <i>Ceratonia siliqua</i> pods and <i>Ocimum basilicum</i> extracts on lipid metabolism disorders and lipoprotein-rich plasma (LRP) oxidation in mice. …”
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Analysis of mutations in CDC27, CTBP2, HYDIN and KMT5A genes in carotid paragangliomas by E. N. Lukyanova, A. V. Snezhkina, D. V. Kalinin, A. V. Pokrovsky, A. L. Golovyuk, O. A. Stepanov, E. A. Pudova, G. S. Razmakhaev, M. V. Orlova, A. P. Polyakov, M. V. Kiseleva, A. D. Kaprin, A. V. Kudryavtseva

“…The study of molecular pathogenesis of CPGLs will allow developing novel therapeutic approaches and revealing biomarkers. Previously, we performed the exome sequencing of 52 CPGLs and estimated mutational load (ML). …”
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Disparities in anxiety and related factors among Chinese older adults across different aged-care models: a comparison of two cross-sectional studies by Xin Zheng, Ziwen Xu, Jiajie Zhao, Sanyuan Hao, Fuqin Xu, Shuo Ding, Guoqing Liu, Shufan Yang, Benjamin Otsen, Wen Zhu, Zhongliang Bai, Jie Yang, Ren Chen

“…For the institutionalized older adults, gender, residence, source of income, and number of chronic diseases exhibited a significant association with anxiety. We noted the interactive effect, suggesting that community-dwelling female older adults with an income level of less than 6500 RMB per year and reported chronic disease comorbidities had the highest likelihood of anxiety, and institutionalized female older adults with income sources such as pension, subsidy, family providing, and resident in rural areas have the greatest risk of experiencing anxiety. …”
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miR-182 promoter hypermethylation predicts the better outcome of AML patients treated with AZA + VEN in a real-world setting by Yilan Xu, Danyang Li, Na Wang, Bei Ge, Chen Meng, Min Zhao, Zihan Lin, Min Li, Yigang Yuan, Yue Cai, Liuzhi Shi, Shenmeng Gao, Haige Ye

“…To determine whether miR-182 promoter methylation is a predictive marker of clinical outcomes in AZA + VEN-treated AML patients in a real-world setting, we analyzed and compared the complete remission (CR)/CR with incomplete hematologic recovery (CRi) rate, overall survival (OS), and leukemia free-survival (LFS) across different methylation groups: miR-182 promoter hypomethylation (median value < 20.21%) and hypermethylation (> 20.21%) in a retrospective study. …”
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Elevated resting heart rate in adolescent men and risk of heart failure and cardiomyopathy by Martin Lindgren, Josefina Robertson, Martin Adiels, Maria Schaufelberger, Maria Åberg, Kjell Torén, Margda Waern, N. David Åberg, Annika Rosengren

“…Abstract Aims This study aims to investigate the association of resting heart rate (RHR) measured in late adolescence with long‐term risk of cause‐specific heart failure (HF) and subtypes of cardiomyopathy (CM), with special attention to cardiorespiratory fitness. Methods and results We performed a nation‐wide, register‐based cohort study of all Swedish men enrolled for conscription in 1968–2005 (n = 1 008 363; mean age = 18.3 years). …”
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Breeding Performances of the European Blackbird (Turdus merula) in Morocco: Habitat Selection, Breeding Phenology, and Breeding Success by Abderahim El Hassani, Ismail Mansouri, Wafae Squalli, Abdelbari El Agy, Amine Assouguem, Kenza Bouayad, Abdellah Markou, Mohamed Mounir, Hamid Achiban, Mohamed Dakki, Lahsen El Ghadraoui

“…This study investigates breeding biology, nesting habitats, breeding chronology, and reproductive success of the European Blackbird in both apple orchards and surrounding woody vegetation at Ait Ayach (Morocco) between March and August 2016. We monitored weekly nest status, nesting sites, breeding dates, and failure factors. …”
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Impact of the Late Miocene Cooling on the loss of coral reefs in the Central Indo-Pacific by B. F. Petrick, L. Reuning, M. Pfeiffer, G. Auer, L. Schwark

“…However, a lack of proxy data prevents an understanding of climatic changes during this time. Here, we present a TEX<span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M1" display="inline" overflow="scroll" dspmath="mathml"><mrow><msubsup><mi/><mn mathvariant="normal">86</mn><mi mathvariant="normal">H</mi></msubsup></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="11pt" height="17pt" class="svg-formula" dspmath="mathimg" md5hash="2a07f66c340e5ca419639b2784f7d244"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="cp-21-405-2025-ie00001.svg" width="11pt" height="17pt" src="cp-21-405-2025-ie00001.png"/></svg:svg></span></span>-based sea surface temperature (SST) record for the Coral Sea, suggesting that the LMC is present across the Central Indo-Pacific. …”
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Non-Pharmaceutical Interventions May Attenuate Acute Exacerbations of Asthma: Experience During the COVID-19 Pandemic in Taiwan by Lin CY, Lin CH, Lo YL, Lo CY, Huang HY, Hsieh MH, Fang YF, Li TC, Lin SM, Huang YT, Chang PJ, Lin HC

“…Chun-Yu Lin,1,2 Chiung-Hung Lin,1,2 Yu-Lun Lo,1,2 Chun-Yu Lo,1,2 Hung-Yu Huang,1,2 Meng-Heng Hsieh,1,2 Yueh-Fu Fang,1,2 Tsu-Chuan Li,1,2 Shu-Min Lin,1,2 Yu-Tung Huang,3 Po-Jui Chang,1,2 Horng-Chyuan Lin1,2,4 1Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; 2College of Medicine Chang Gung University, Taoyuan, Taiwan; 3Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Department of Respiratory Therapy, Chang Gung Memorial Hospital at Linkou, Taoyuan, TaiwanCorrespondence: Horng-Chyuan Lin, Department of Thoracic Medicine, Chang Gung Memorial Hospital, 5 Fu-Hsing Street, Kweishan, Taoyuan, 33305, Taiwan, Tel +886-3-3281200 ext. 8470, Fax +886-3-3282474, Email lin53424@gmail.comBackground: Non-pharmaceutical interventions (NPIs) were widely used during the coronavirus disease 2019 (COVID-19) pandemic, however their impact on acute asthma exacerbations (AEs) is not well studied.Methods: We had retrospectively collected patients with asthma AEs between 2019 and 2020 and retrieved data from the Chang Gung Research Database, including clinical manifestations, medications, pulmonary function, clinic and emergency department visits and hospitalizations.Results: A total of 39,108 adult patients with asthma were enrolled, of whom 1502 were eligible for analysis. …”
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