Monozygotic twins with myocarditis and a novel likely pathogenic desmoplakin gene variant by Antheia Kissopoulou, Eva Fernlund, Christina Holmgren, Eira Isaksson, Jan‐Erik Karlsson, Henrik Green, Jon Jonasson, Rada Ellegård, Hanna Klang Årstrand, Anneli Svensson, Cecilia Gunnarsson

“…The clinical picture of myocarditis and ARVC may overlap during the early stages of cardiomyopathy, which may lead to misdiagnosis. In the literature, we found several cases that presented with episodes of myocarditis and ended up with a diagnosis of arrhythmogenic cardiomyopathy, mostly of the left predominant type. …”
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Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs) by Jeffrey J. Yu, Daniel B. Azzam, Marilyn Chwa, Kevin Schneider, Jang-Hyeon Cho, Chinhui Hsiang, Henry Klassen, M. Cristina Kenney, Jing Yang

“…Methods. In this study, we used a cell coculture system consisting of hRPCs and AMD or age-matched normal cybrid cells to characterize the effects of hRPCs in protecting AMD cybrids from cellular and mitochondrial damage and death. …”
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Association between chronic obstructive pulmonary disease and osteoporosis: Mendelian randomization combined with bibliometric analysis by Fangjun Yang, Huaming Wang, Miaomiao Liu, Shengtai Pei, Xiaoming Qiu

“…The results of the primary IVW MR Analysis were generally supported by our sensitivity MR Analysis. We performed MR Analysis for the validation of COPD and OP (IVW OR: 1.019; 95%CI: 0.898–1.564; p = 0.768) also did not support a causal relationship between COPD and BMD. …”
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Activation of Delta-Opioid Receptor Protects ARPE19 Cells against Oxygen-Glucose Deprivation/Reoxygenation-Induced Necroptosis and Apoptosis by Inhibiting the Release of TNF-α by Runjie Guo, Ping Chen, Tiantian Fu, Ren Zhang, Yuan Zhu, Nange Jin, Hong Xu, Yong Xia, Xuesong Tian

“…However, the role of TNF-α and DOR in necroptosis and apoptosis of retinal pigment epithelial (RPE) cells remains largely unknown. Here, we explored the mechanisms of TNF-α and DOR in necroptosis and apoptosis using an oxygen-glucose deprivation/reoxygenation (OGD/R) model of adult retinal pigment epithelial cell line-19 (ARPE19) cells. …”
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Prediction of Colorectal Cancer Risk Using a Genetic Risk Score: The Korean Cancer Prevention Study-II (KCPS-II) by Jaeseong Jo, Chung Mo Nam, Jae Woong Sull, Ji Eun Yun, Sang Yeun Kim, Sun Ju Lee, Yoon Nam Kim, Eun Jung Park, Heejin Kimm, Sun Ha Jee

“…Colorectal cancer (CRC) is among the leading causes of cancer deaths and can be caused by environmental factors as well as genetic factors. Therefore, we developed a prediction model of CRC using genetic risk scores (GRS) and evaluated the effects of conventional risk factors, including family history of CRC, in combination with GRS on the risk of CRC in Koreans. …”
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Exosomes and their distinct integrins transfer the characteristics of oxaliplatin- and 5-FU-resistant behaviors in colorectal cancer cells by Zeynab Vakili-Ghartavol, Hoda Deli, Amir Shadboorestan, Roxana Sahebnasagh, Elahe Motevaseli, Mohammad Hossein Ghahremani

“…Results Exosome integrins determine resistance behaviors in cells. We observed that exosomes from OXR cells or OXR cells treated with oxaliplatin increased ITGβ3 expression and decreased ITGβ4 expression in parental cells, resulting in distinct resistance behaviors. …”
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Investigating the psychology of eating after exercise — a scoping review by Alice Porter, Russell Jago, Luke A Robles, Elin Cawley, Peter J. Rogers, Danielle Ferriday, Jeffrey M. Brunstrom

“…Outcomes varied and included energy intake (kcal/kJ), portion size, food intake, food choice, food preference, dietary lapse, and self-reported compensatory eating. We found that increased consumption of energy-dense foods occurred after exercise when exercise was perceived as less enjoyable, less autonomous, or hard work. …”
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Genotype 3 is linked to worse liver disease progression in hepatitis C patients even after SVR following DAA therapy by Xiping Ran, Xiping Ran, Yang Xu, Ying Wang, Cheng Zeng, Chen Gong, Ni Wang, Dachuan Cai, Dachuan Cai

“…However, the liver disease progression and its risk factors in patients with HCV GT 3 infection after sustained virological response (SVR) following direct-acting antivirals (DAAs) remain unclear. Therefore, we aimed to investigate the liver disease progression of patients with GT 3 after SVR.MethodsThis was a retrospective cohort study of patients with HCV infection who achieved SVR by DAAs. …”
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Glucagon: a potential protective factor against peripheral nerve compromise in patients with type 2 diabetes and obesity by Hao Hua, Rui Wang, Yu-xian Xu, Feng Xu, Chun-hua Wang, Li-hua Zhao, Li-hua Wang, Cheng-wei Duan, Jian-bin Su

“…This study aimed to elucidate the role of glucagon in peripheral nerve function in patients with T2D with different body mass indices (BMIs). Methods We consecutively enrolled 174 individuals with T2D and obesity (T2D/OB, BMI ≥ 28 kg/m2), and 480 individuals with T2D and nonobesity (T2D/non-OB, BMI < 28 kg/m2), all of whom underwent oral glucose tolerance tests to determine the area under the curve for glucagon (AUCgla). …”
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Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH by Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero

“…Notably, substituting FHR-B Tyr162 (a key residue homologous to the disease-associated Tyr402 in human FH) for His reduces dimerization. We also found that a recombinant FHR-B with a duplicated dimerization domain formed stable dimers but lacked functional activity. …”
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Vision Improvement after Osimertinib Treatment in Paraneoplastic Optic Neuropathy Associated with Lung Adenocarcinoma by Masaomi Kubota, Nobumasa Tamura, Takaaki Hayashi, Euido Nishijima, Haruhiko Yanagisawa, Akira Kojima, Tadashi Nakano

“…Treatments for paraneoplastic optic neuropathy (PON), a tumor-related autoimmune disease, include immunosuppression, plasma exchange, and immunoglobulin therapies, as well as treatment of the underlying disease. Herein, we describe the clinical course of an older adult patient with PON whose loss of vision improved after switching between epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatments for cancer. …”
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The Petrogenesis of the Permian Podong Ultramafic Intrusion in the Tarim Craton, Western China: Constraints from C-He-Ne-Ar Isotopes by Mingjie Zhang, Pengyu Feng, Tong Li, Liwu Li, Juerong Fu, Peng Wang, Yuekun Wang, Zhongping Li, Xiaodong Wang

“…The type and addition mechanism of the confirmed crustal contaminations and possible mantle plume involved in the intrusion formation require evidences from carbon and noble gas isotopic compositions. In the present study, we have measured C, He, Ne, and Ar isotopic compositions of volatiles from magmatic minerals in the Podong ultramafic intrusion. …”
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Optimizing lipopeptide bioactivity: The impact of non-ionic surfactant dressing by Ágnes Ábrahám, Gergő Gyulai, Judith Mihály, Andrea Horváth, Orsolya Dobay, Zoltán Varga, Éva Kiss, Kata Horváti

“…The physico-chemical properties of poloxamers vary depending on the length of the blocks. In our study, we experimented with different types and systematically investigated the variation of the critical micelle concentration (CMC) of poloxamers at 25 and 37 °C in different media. …”
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Assessing Physician and Patient Agreement on Whether Patient Outcomes Captured in Clinical Progress Notes Reflect Treatment Success: Cross-Sectional Study by Sarah B Floyd, Jordyn C Sutton, Marvin Okon, Mary McCarthy, Liza Fisher, Benjamin Judkins, Zachary Cole Reynolds, Ann Blair Kennedy

“…ObjectiveThis study aims to assess if physicians and patients agree on whether patient outcomes captured in clinical progress notes reflect a successful treatment outcome following orthopedic care. MethodsWe performed a cross-sectional analysis of a subset of clinical notes for patients presenting to a Level-1 Trauma Center and Regional Health System for follow-up for an acute proximal humerus fracture (PHF). …”
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Manipulation of seed coat content for increasing oil content via modulating BnaMYB52 in Brassica napus by Jiang Ye, Xiaowei Wu, Xiang Li, Yuting Zhang, Yuqing Li, Hui Zhang, Jie Chen, Yuyan Xiang, Yefan Xia, Hu Zhao, Zengdong Tan, Liang Guo, Xuan Yao

“…Through genome-wide association studies in Brassica napus accessions, we identify BnaA09.MYB52 transcription factor as a candidate gene underlying ZS11_qSCC.A09. …”
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AlScN/GaN HEMTs with 4 A/mm on-current and maximum oscillation frequency >130 GHz by Kazuki Nomoto, Joseph Casamento, Thai-Son Nguyen, Lei Li, Hyunjea Lee, Chandrashekhar Savant, Austin Lee Hickman, Takuya Maeda, Jimy Encomendero, Ved Gund, Timothy Vasen, Shamima Afroz, Daniel Hannan, James C. M. Hwang, Debdeep Jena, Huili Grace Xing

“…Aluminum Scandium Nitride (AlScN) is an attractive material for use as a lattice-matched epitaxial barrier layer in GaN high-electron mobility transistors (HEMTs). Here we report the device fabrication, direct current (DC) and radio frequency (RF) characteristics of epitaxial AlScN/AlN/GaN HEMTs on SiC substrates with regrown ohmic contacts. …”
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Functional and Structural Investigation of Myenteric Neurons in the Human Colon by Kristin Elfers, Alina Sophia Sehnert, Alexander Wagner, Ulrich Zwirner, Helena Linge, Ulf Kulik, Daniel Poehnert, Markus Winny, Benjamin Gundert, Heiko Aselmann, Gemma Mazzuoli-Weber

“…Using the neuroimaging technique, we are able to record human colonic myenteric neuronal activity and investigate their functional properties in a large cohort of patients. …”
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Climate response to stratospheric aerosol injection during the Harmattan season in West Africa by Francis Nkrumah, Gandome Mayeul Leger Davy Quenum, Kwesi A Quagraine, Simone Tilmes, Nana Ama Browne Klutse, Atanas Dommo, Hubert A Koffi, Patrick Essien, Rebecca Bediako

“…During the Harmattan season (December–February) in West Africa (WA), a natural meteorological phenomenon injects dust and sand particles into the atmosphere, leading to a cooling effect. In this study, we investigate the influence of SAI on West African surface temperature, dust, and other meteorological variables using the Whole Atmosphere Community Climate Model under the Shared Socioeconomic Pathway 2-4.5 scenario and the Assessing Responses and Impacts of Solar Climate Intervention on the Earth system with SAI (ARISE-SAI) dataset. …”
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Effects of dietary Bacillus subtilis 14823 on growth performance, gut barrier integrity and inflammatory response of broilers raised in a stressful tropical environment by Sunisa Khongthong, Pipat Piewngam, Natthrit Roekngam, Prapot Maliwan, Sonsawan Kongpuckdee, Juthatip Jeenkeawpleam, Prawit Rodjan

“…HS impacts gut health by causing damaged mucosal microstructures, increased oxidative stress, weakened immunity, and heightened permeability to toxins and poultry pathogens. We investigated the potential benefits to broiler chickens subjected to HS of dietary supplementation with Bacillus subtilis 14823. …”
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Heterogeneity in Seed Samples from Vineyards and Natural Habitats Along the Eurasian <i>Vitis vinifera</i> Range: Implications for Domestication and Hybridization by Diego Rivera, Javier Valera, David Maghradze, Maia Kikvadze, Anna Nebish, Rafael Ocete, Carlos Álvar Ocete, Claire Arnold, Emilio Laguna, Francisco Alcaraz, Diego José Rivera-Obón, Gianni Lovicu, Massimino Farci, Concepción Obón

“…Through the analysis of domestication index values, probabilities, and entropy, we assessed seed diversity. Samples with high domestication probability values—predominantly from vineyards—exhibited low heterogeneity and entropy, with similar patterns observed in natural habitats, suggesting the presence of feral vines. …”
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