Giant and irregular pituitary neuroendocrine tumors surgery: comparison of simultaneous combined endoscopic endonasal and transcranial and purely endoscopic endonasal surgery at a... by Jun Fu, Wenwei Luo, Chunlin Zhang, Zhicheng Wang, Wenjian Fan, Yuanxiang Lin, Dezhi Kang, Jianping Song, Changzhen Jiang, Xiaorong Yan

“…While endoscopic endonasal surgery (EES) is a widely used approach for PitNETs, GIPitNETs with extensive intracranial extension pose challenges for purely EES. We use simultaneous combined endoscopic endonasal and transcranial surgery (CECS) for the treatment of this type of tumor. …”
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Evaluating the quality of care for heart failure hospitalizations in inflammatory arthritis – A population-based cohort study by Bindee Kuriya, Lihi Eder, Sahil Koppikar, Jessica Widdifield, Anna Chu, Jiming Fang, Irene Jeong, Douglas Lee, Jacob Udell

“…Patients were categorized into four groups: IA alone, DM alone, IA + DM, and a general population comparator. We assessed quality care measures within 30 days of hospitalization (echocardiogram, electrocardiogram, chest x-ray) and physician follow-up within 7 days. …”
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Accuracy of artificial intelligence algorithms in predicting acute respiratory distress syndrome: a systematic review and meta-analysis by Yaxin Xiong, Yuan Gao, Yucheng Qi, Yingfei Zhi, Jia Xu, Kuo Wang, Qiuyue Yang, Changsong Wang, Mingyan Zhao, Xianglin Meng

“…In an additional subgroup analysis, we evaluated the predictive performance of the AI models trained using different predictors. …”
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Development and validation of soil test crop response model for beetroot (Beta vulgaris) grown in ultisols of India by Ramasamy Arulmani, Ramasamy Arulmani, Kuppayevalasu Malayappagounder Sellamuthu, Kuppayevalasu Malayappagounder Sellamuthu, Subramaniam Maragatham, Subramaniam Maragatham, Alargarsamy Senthil, Alargarsamy Senthil, Seenapuram Palaniswami Thamaraiselvi, Seenapuram Palaniswami Thamaraiselvi, Palaniappan Malathi, Palaniappan Malathi, Govindaraja Sridevi, Govindaraja Sridevi

“…Using the basic parameters, fertilizer prescription equations were developed based on Integrated Plant Nutrition System and validated. We found that 0.38, 0.29, and 0.46 kg of N, P2O5, and K2O, respectively, were required for producing one quintal of beetroot tuber under the integrated approach. …”
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Stevioside mitigates metabolic dysregulation in offspring induced by maternal high-fat diet: the role of gut microbiota-driven thermogenesis by Jin Ye, Renjie Shi, Xiaoning Wu, Hua Fan, Yapei Zhao, Xinyun Hu, Lulu Wang, Xiaowei Bo, Dongning Li, Yunshu Ge, Danna Wang, Bing Xia, Zhenting Zhao, Chunxia Xiao, Beita Zhao, Yutang Wang, Xuebo Liu

“…Natural non-nutritive sweeteners, particularly stevioside (STV), play a crucial role in reducing obesity and affecting gut microbiota composition. Based on this, we hypothesized that maternal STV supplementation could improve the health of mothers and offspring by altering their gut microbiota. …”
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Analysis of the Heterogeneity of CD4+CD25+ T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALB/c Mice by Teng Zhang, Fangfang Duan, Danhua Su, Long Ma, Jiezuan Yang, Bin Shi, Xiaoyan He, Rui Ma, Suhong Sun, Xinsheng Yao

“…To study the homogeneity and heterogeneity of CD4+CD25+ T cells receptor β-chain complementarity determining region 3 (TCR β CDR3) repertoires in breast tumor tissues, lung metastatic tissues, and spleens from 4T1 tumor-bearing BALB/c mice. We used high-throughput sequencing to analyze the characteristics and changes of CD4+CD25+ TCR β CDR3 repertoires among tumor tissues, lung metastatic tissues, and spleens. …”
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Screening high-risk Veterans for cirrhosis: taking a stepwise population health approach by Jonathan Dounel, Carolyn Lamorte, Heather Patton, Ponni Perumalswami, Heather McCurdy, Nicole J. Kim, Lauren A. Beste, Dawn Scott, Jessimarie Casey, Patrick Spoutz, Linda Chia, Yiwen Yao, Elliott Lowy, Sandra Gibson, Timothy R. Morgan, Shari S. Rogal

“…Abstract Background Because cirrhosis is often unrecognized, we aimed to develop a stepwise screening algorithm for cirrhosis in the Veterans Health Administration (VHA) and assess this approach’s feasibility and acceptability. …”
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A U-shaped non-linear association between serum uric acid levels and the risk of Hashimoto’s thyroiditis: a cross-sectional study by Manli Yan, Wenhua Shi, Ping Gong, Yunsi Xie, Kaiyuan Zhang, Xiang Li, Hua Wei, Hua Wei

“…To further investigate the relationship between metabolic indicators and HT, we conducted a restricted cubic spline (RCS) analysis. …”
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Mesenchymal Stem Cells Carrying Viral Fusogenic Protein p14 to Treat Solid Tumors by Inducing Cell–Cell Fusion and Immune Activation by Yao Wang, Xunlei Pang, Ruirui Li, Jiuzhou Chen, Chen Wen, Huihuang Zhu, Tingyu Long, Jianjie Li, Lijun Zheng, Youcai Deng, Junnian Zheng, Bo Xu

“…Therefore, cell–cell fusion as a cell-killing mechanism might develop a novel cytotherapy aimed at improving the efficacy against solid tumors. Methods: We constructed a fusogenic protein, fusion-associated small transmembrane (FAST) p14 of reptilian reovirus, into cancer cells and mesenchymal stem cells (MSCs), which cocultured with various colon cancer cells and melenoma cells to validate its ability to induce cell fusion and syncytia formation. …”
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Oxidative stress in critically ill neonatal foals by David Wong, Dipak Kumar Sahoo, Cosette Faivre, Jamie Kopper, Katie Dersh, Theresa Beachler, Melissa Esser

“…Objectives/Hypothesis To measure reactive oxygen species (ROS), biomarkers of oxidative injury, and antioxidants in neonatal foals. We hypothesized that ill foals would have higher blood concentrations of ROS and biomarkers of oxidative injury and lower concentrations of antioxidants compared to healthy foals. …”
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Efficacy and safety of filgotinib in patients with rheumatoid arthritis: week 156 interim results from a long-term extension study by Hendrik Schulze-Koops, Tsutomu Takeuchi, Daniel Aletaha, Maya H Buch, Yoshiya Tanaka, Ricardo Blanco, Paul Emery, Jacques-Eric Gottenberg, Bernard G Combe, Roberto Caporali, Patrick Verschueren, Vijay Rajendran, Anna Zubrzycka-Sienkiewicz, Edmund V Ekoka Omoruyi, Francesco De Leonardis

“…Filgotinib is a Janus kinase 1–preferential inhibitor available in two doses for moderate-to-severe RA. We report the long-term efficacy and safety of filgotinib.Methods In the ongoing long-term extension study FINCH 4 (NCT03025308), patients continue filgotinib 200 mg or 100 mg from FINCH 1, 2 or 3 or receive filgotinib 200 mg or 100 mg de novo. …”
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The Fabrication and Evaluation of a Potential Biomaterial Produced with Stem Cell Sheet Technology for Future Regenerative Medicine by Shukui Zhou, Ying Wang, Kaile Zhang, Nailong Cao, Ranxing Yang, Jianwen Huang, Weixin Zhao, Mahbubur Rahman, Hong Liao, Qiang Fu

“…However, the acellular matrix derived from natural tissues and organs has a lot of defects, including the limited amount of autogenous tissue and surgical complication such as risk of blood loss, wound infection, pain, shock, and functional damage in the donor part of the body. In this study, we prepared acellular matrix using adipose-derived stem cell (ADSC) sheets and evaluate the cellular compatibility and immunoreactivity. …”
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Ultrasonographic Assessment of Intima-Media Thickness (IMT), as a Surrogate of Future Atherosclerosis and Cardiac Diseases in Patients with Hashimoto’s Thyroiditis and Concomitant... by Maryam Alaei, Mohamad Ghazanfari Hashemi, Seyedeh Nooshin Miratashi Yazdi, Mohammad Ali Kaviani, Ali Asadifar, Sahand Adib Moradi, Khazar Adibmoradi Langaroudi, Helia Helali, Mina Mahboudi, Aynaz Gerami

“…Sonographic changes of intima-media thickness of carotid artery in Hashimoto’s thyroiditis and Celiac disease have been investigated separately. In this study we aimed to evaluate the changes in sonographic appearance of the carotid artery and its mural thickness in patients with Hashimoto’s thyroiditis and concomitant Celiac disease, as a surrogate marker of atherosclerosis and a predictor of cardiovascular diseases. …”
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Association of C1q/TNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease by Zexuan Li, Yunhui Du, Lixin Jia, Jingyao Fan, Ruifeng Guo, Xinliang Ma, Xiao Wang, Shaoping Nie, Yongxiang Wei

“…C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling. We aimed to ascertain the clinical relevance of CTRP9 with OSA prevalence in patients with CAD. …”
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Deep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii by Aleksandra Maria Kocot, Tomasz Swebocki, Karolina Ciemińska, Adrianna Łupkowska, Małgorzata Kapusta, Dennis Grimon, Ewa Laskowska, Anna-Karina Kaczorowska, Tadeusz Kaczorowski, Rabah Boukherroub, Yves Briers, Magdalena Plotka

“…Abstract In this study, we evaluated the combined effect between MLE-15, a modular lytic enzyme composed of four building blocks, and reline, a natural deep eutectic solvent. …”
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Sigma1 inhibitor suppression of adaptive immune resistance mechanisms mediated by cancer cell derived extracellular vesicles by Paola A. Castagnino, Derick A. Haas, Luca Musante, Nathalia A. Tancler, Bach V. Tran, Rhonda Kean, Alexandra R. Steck, Luis A. Martinez, Elahe A. Mostaghel, D. Craig Hooper, Felix J. Kim

“…PD-L1 can also be incorporated into cancer cell-derived extracellular vesicles (EVs), and EV-associated PD-L1 can inactivate T-cells within the tumor microenvironment. Here, we demonstrate that a selective small molecule inhibitor of Sigma1 can block IFN-γ mediated adaptive immune resistance in part by altering the incorporation of PD-L1 into cancer cell-derived EVs. …”
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Autistic and transgender/gender diverse people’s experiences of health and healthcare by Kate Green, Elizabeth Weir, Lily Wright, Carrie Allison, Simon Baron-Cohen

“…Despite this, there is a paucity of studies on the healthcare experiences and health outcomes of transgender/gender diverse autistic individuals. Methods We compared the healthcare experiences and health outcomes of cisgender autistic (n = 1094), transgender/gender diverse autistic (n = 174), and cisgender non-autistic adults (n = 1295) via an anonymous, self-report survey. …”
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Advancing arabic dialect detection with hybrid stacked transformer models by Hager Saleh, Hager Saleh, Hager Saleh, Abdulaziz AlMohimeed, Rasha Hassan, Mandour M. Ibrahim, Saeed Hamood Alsamhi, Moatamad Refaat Hassan, Sherif Mostafa

“…Recent advances in deep learning (DL) models have shown promise in overcoming potential challenges in identifying Arabic dialects. In this paper, we propose a novel stacking model based on two transformer models, i.e., Bert-Base-Arabertv02 and Dialectal-Arabic-XLM-R-Base, to enhance the classification of dialectal Arabic. …”
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The Association between Type-2 Diabetes Duration and Major Adverse Cardiac Events after Percutaneous Coronary Intervention by Botey Katamu Benjamin, Chunguang Qiu, Zhanying Han, Wenjie Lu, Guoju Sun, Xiaofei Qin, Xule Wang, Xi Wang, Ran Li, Liang Pan

“…A total of 302 cases of diabetic patients undergoing an elective PCI with drug-eluting stent (DES) deployment and or percutaneous transluminal coronary angioplasty (PTCA) using a drug-coated balloon (DCB) were prospectively studied. We divided patients into three groups based on diabetes duration: <5 years group (n=165), 5–10 years’ group (n=72), and ≥10 years’ group (n=65). …”
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Impact of enhanced chest CT with three-dimensional reconstruction combined with preoperative olive oil administration on the incidence of postoperative chylothorax: a retrospective... by Xindong Luo, Di Lu, Ziqiang Wang, Jingyi Wang, Ruozhu Dong, Yaping Wang, Wei Cao, Dacheng Jin, Zhaohao Lin, Haochi Li, Pengcheng Du, Yunjiu Gou, Pengcheng Dong, Yayuan Yang

“…This study aims to investigate the impact of a strategy combining preoperative three-dimensional (3D) reconstruction of contrast-enhanced chest CT with olive oil ingestion on the incidence of chylothorax following esophageal cancer resection. Methods We retrospectively analyzed the clinical data of 357 patients who underwent esophageal cancer resection in the Department of Thoracic Surgery at Gansu Provincial People’s Hospital from January 2019 to June 2024. …”
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