Efficacy & safety of brolucizumab 6.0 mg versus 3.6 mg in diabetic macular edema by Sanjay Kumar Mishra, Pradeep Kumar, Amrita Joshi, Aman Saraf, Abhijeet Awasthi, Supriya Dhar, Khaleel M, Atul Kumar, Vipin Rana, Ravi D

“…Therefore newer Anti-VEGFs like Brolucizumab with longer durability have been introduced. We compared two different dosages of Brolucizumab, 6.0 mg and 3.6 mg, for their safety & efficacy in treatment of DME, in treatment naïve patients over 52 weeks. …”
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Iron deposition is associated with motor and non-motor network breakdown in parkinsonism by Fangda Leng, Yue Gao, Fan Li, Luhua Wei, Yunchuang Sun, Fang Liu, Ying Zhu, Jianxing Qiu, Zhaoxia Wang, Yiwei Zhang

“…However, how iron deposition influences brain network remains to be elucidated.MethodsWe recruited 16 Parkinson’s disease (PD), 8 multiple system atrophy (MSA) and 7 progressive supranuclear palsy (PSP) patients. …”
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The Art and life of Alàgbà Fálétí – A Pic torial, Art and Artifacts Exhibition in Honor of Alàgbà Adébáyọ̀ Fálétí (1921- 2017) curated by Akinsola Adejuwon and Seyi Ogunjobi... by Akinsola Adejuwon

“…In spite of introduction of foreign culture and customs into Nigeria by the Europeans, Yorùbá culture remained resilient. Hence, we could imagine that the childhood of Alàgbà Fálétí was not radically different from Samuel Johnson’s description of features of Yorùbá childhood as characterised by ‘freedom’ (Johnson: 2009, pp.98-100). …”
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MSCPNet: A Multi-Scale Convolutional Pooling Network for Maize Disease Classification by Mehdhar S. A. M. Al-Gaashani, Reem Alkanhel, Muthana Ali Salem Ali, Mohammed Saleh Ali Muthanna, Ahmed Aziz, Ammar Muthanna

“…To overcome these challenges, we propose MSCPNet, a novel architecture that combines a truncated MobileNetV2 backbone with a Multi-Scale Convolutional PoolFormer block. …”
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Virtual reality support during systemic cancer therapy to improve anxiety/depressive symptoms and reduce toxicity in patients with gastrointestinal cancers—OncoVR by S. Kasper, S. Liszio, K. Schorrmann, M. Gerigk, S. Jovic, O. Basu, K. Kostbade, B. Goraus, A. Elsakka, B. Puladi, J. Kleesiek, M. Schuler, G. Luijten, J. Egger

“…Relaxation techniques can help alleviate toxicities but their implementation in clinical practice is challenging. We hypothesize that virtual reality (VR) systems which project a relaxing nature environment may help to reduce psychological stress and toxicities of cancer therapies. …”
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<i>Artemia</i> Nauplii Enriched with Soybean Lecithin Enhances Growth Performance, Intestine Morphology, and Desiccation Stress Resistance in Yellow Drum (<i>Nibea albiflora</i>) L... by Zhenya Zhou, Pian Zhang, Peng Tan, Ruiyi Chen, Weihua Hu, Ligai Wang, Yuming Zhang, Dongdong Xu

“…In our previous study, we optimized a phospholipid enrichment method by incubating <i>Artemia</i> nauplii with 10 g of soybean lecithin per m³ of seawater for 12 h, significantly enhancing their phospholipid content. …”
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Dichlormid protect wheat from fomesafen residual injury by increasing PPO expression and the photosynthesis characterize by Dongzhi Li, Yilin Liu, Li Xu, Hao Yu, Yunchao Kan, Runqiang Liu, Guangling Li

“…Dichlormid is a widely used safener protecting maize from chloroacetanilide and thiocarbamate injury. We found that dichlormid treatment could restore the growth of wheat seedlings exposed to fomesafen stress. …”
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Scoping review of Neglected Tropical Disease Interventions and Health Promotion: A framework for successful NTD interventions as evidenced by the literature. by Caroline Ackley, Mohamed Elsheikh, Shahaduz Zaman

“…<h4>Conclusions</h4>Based on the literature we have identified the four core components of best practices including programmatic interventions, multi sectoral and multi-level interventions, adopting a social and ecological model and clearly defining 'community.' …”
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TNF-α Enhances the Therapeutic Effects of MenSC-Derived Small Extracellular Vesicles on Inflammatory Bowel Disease through Macrophage Polarization by miR-24-3p by Huikang Xu, Jiamin Fu, Lijun Chen, Sining Zhou, Yangxin Fang, Qi Zhang, Xin Chen, Li Yuan, Yifei Li, Zhenyu Xu, Charlie Xiang

“…At present, the existing therapeutic methods are ineffective for many patients and have obvious side effects. Hence, we explored the role of tumor necrosis factor α- (TNF-α-) pretreated MenSC-derived small EV (MenSCs-sEVTNF-α) in a mouse model of dextran sulfate sodium- (DSS-) induced colitis, expecting to find better therapeutic alterations. …”
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PER3 suppresses tumor metastasis of oral squamous cell carcinoma by promoting HIF-1α degradation by Yaoxu Li, Bing Li, Kai Yang, Lihua Zhu, Hong Tang, Yinpei Huang, Jinhai Deng, Jun Duan

“…Hypoxia-inducible factor 1 subunit alpha (HIF-1α) regulates epithelial-mesenchymal transition (EMT) transcription factors, activates EMT, and promotes tumor metastasis. Here, we investigated the role and molecular mechanism of PER3 in regulating HIF-1α and metastasis in oral squamous cell carcinoma (OSCC) by using bioinformatics analyses and in vitro and in vivo experiments. …”
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Estimation and Analysis of Caspian Region\'s Future Rainfalls by Using General Atmospheric Circulation Models. by alimohammad khorshiddoust, behrooz sarraf, bagher ghermez cheshmeh, fatemeh jafarzadeh

“…On the southern coasts of the Caspian Sea, precipitation as one of the important climatic parameters has undergone changes due to global climate change. In the present study, we tried to evaluate the effect of climate change on rainfall in this region by applying a suitable model. …”
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Strengthening research preparedness for crises: lessons from Norwegian government agencies in using randomized trials and quasi-experimental methods to evaluate public policy inter... by Unni Gopinathan, Ingeborg Elgersma, Therese Dalsbø, Mona Bjørbæk, Atle Fretheim

“…It raised a crucial question: how can governments in non-crisis times develop capabilities to generate evidence on the effects of public policy interventions, thus enabling a rapid and effective research response during public health crises? We conducted a mapping to explore how government agencies in Norway use RCTs and quasi-experimental methods to strengthen the evidence base for public policy interventions and to identify barriers and facilitators to their use. …”
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Validation of a data-driven motion-compensated PET brain image reconstruction algorithm in clinical patients using four radiotracers by Ole L. Munk, Anders B. Rodell, Patricia B. Danielsen, Josefine R. Madsen, Mie T. Sørensen, Niels Okkels, Jacob Horsager, Katrine B. Andersen, Per Borghammer, Joel Aanerud, Judson Jones, Inki Hong, Sven Zuehlsdorff

“…Validation was conducted using phantom scans, healthy volunteers, and clinical patients using four radiotracers with distinct tracer activity distributions. Methods We conducted technical validation experiments of the algorithm using Hoffman brain phantom scans during a series of controlled movements, followed by two blinded reader studies assessing image quality between standard images and MoCo images in 38 clinical patients receiving dementia scans with [18F]Fluorodeoxyglucose, [18F]N-(3-iodopro-2E-enyl)-2beta-carbomethoxy-3beta-(4’-methylphenyl)-nortropane, [18F]flutemetamol, and a research group comprising 25 elderly subjects scanned with [18F]fluoroethoxybenzovesamicol. …”
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Safety and Effectiveness of BPaL-Based Regimens to Treat Multidrug-Resistant TB: First Experience of an Italian Tuberculosis Referral Hospital by Gina Gualano, Maria Musso, Paola Mencarini, Silvia Mosti, Carlotta Cerva, Pietro Vittozzi, Antonio Mazzarelli, Angela Cannas, Assunta Navarra, Stefania Ianniello, Paolo Faccendini, Fabrizio Palmieri

“…No treatment interruption was necessary due to AEs. <b>Methods</b>: Here, we report the real-world experience of a tertiary referral hospital for TB in Italy, from 2022 to 2024, in the management, outcomes, and adverse drug reactions of a cohort of twenty-two MDR/RR patients treated with BPaL and BPaLM regimens. …”
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Medicarpin suppresses lung cancer cell growth in vitro and in vivo by inducing cell apoptosis by Shen Zongyi, Yin Liqi, Chang Manxia, Wang Haifeng, Hao Mingxuan, Liang Youfeng, Guo Rui, Bi Ying, Wang Jiansong, Yu Changyuan, Li Jinmei, Zhai Qiongli, Cheng Runfen, Zhang Jinku, Sun Jirui, Yang Zhao

“…This study was de sig ned to evaluate the anti-LC effect and reveal the underlying mechanisms of MED in vivo and in vitro. We found that MED could significantly inhibit proliferation, induce apoptosis, and cell cycle arrest of A549 and H157 cell lines. …”
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Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism by Jiefeng Huang, Wuyan Lu, Shenli Zhao, Zixin Cai, Linxiao Li, Zihao Hu, Yu Jiang, Jinyi Deng, Yiming Tang, Chenzhang Shi, Chen Wang, Guangpeng Liu, Shuaijun Li

“…However, it remains unclear whether Hcy accumulation plays a pathogenic role in skin fibrosis. Here, we report that Hcy metabolism in fibroblasts plays a crucial role in regulating the pathogenesis of skin fibrosis. …”
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Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein by Yanxiao Han, John R.D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Surl-Hee Ahn, Igor Vorobyov

“…Using advanced computer modeling and simulation, we identified atomistic-level structural, dynamic, and energetic mechanisms of norepinephrine (NE) and stimulatory G protein (Gs) interactions with β-adrenergic receptors (βARs), crucial GPCRs for heart function regulation and major drug targets. …”
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Intravenous esketamine in pediatric Rett syndrome: An open-label, early phase 1 pilot study by Huiping Li, Shu Liu, Caimei Lin, Yuchao Wu, Xiuping Wu, Yukun Huang, Yajun Wu, Xiubin Tong, Xiu Xu

“…N-Methyl-d-aspartate receptor (NMDAR) antagonism has shown therapeutic potential in preclinical RTT models. We performed a pilot study to explore whether intravenous esketamine, an NMDAR antagonist, alleviates the symptoms of pediatric RTT. …”
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Effects of different microplastics on the physicochemical properties and microbial diversity of rice rhizosphere soil by Sheng Lai, Sheng Lai, Sheng Lai, Cunzhong Fan, Ping Yang, Ping Yang, Yuanyuan Fang, Yuanyuan Fang, Lanting Zhang, Lanting Zhang, Minfei Jian, Guofei Dai, Guofei Dai, Jutao Liu, Jutao Liu, Huilin Yang, Liqin Shen, Liqin Shen

“…The ecological risks brought by the aging of microplastics have also been scarcely studied. In this study, we selected conventional microplastics (PE-MPs), biodegradable microplastics (PLA-MPs), and aged biodegradable microplastics (aging-PLA-MPs) to explore their effects on the rhizosphere soil environment of rice. …”
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Prevalence and impact of pelvic floor dysfunctions on quality of life in women 5–10 years after their first vaginal or caesarian delivery by Alba González-Timoneda, Nerea Valles-Murcia, Paula Muñoz Esteban, María Sol Torres López, Elisa Turrión Martínez, Patxi Errandonea Garcia, Lola Serrano Raya, Francisco Nohales Alfonso

“…Objective: Our aim was to investigate late prevalence, risk factors, and the impact on quality of life of PFD in women after their first vaginal or caesarian birth. Methods: We conducted an ambispective cohort observational study. …”
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