Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis by Qiong-Yi Zhang, Hai-Biao Gong, Man-Ya Jiang, Fujun Jin, Guan Wang, Chang-Yu Yan, Xiang Luo, Wan-Yang Sun, Shu-Hua Ouyang, Yan-Ping Wu, Wen-Jun Duan, Lei Liang, Yun-Feng Cao, Xin-Xin Sun, Meijing Liu, Gen-Long Jiao, Hua-Jun Wang, Kurihara Hiroshi, Xiaogang Wang, Rong-Rong He, Yi-Fang Li

“…Mechanistically, 4-hydroxynonenal, an end-product of phospholipid peroxidation, binds to integrin-linked kinase and triggers its protein degradation, disrupting RUNX2 signaling and inhibiting osteoblastogenesis. Importantly, we identified two natural allosteric activators of GPX4, 6- and 8-Gingerols, which promote osteoblastogenesis and demonstrate anti-osteoporotic effects. …”
Get full text

QTL mapping and candidate gene analysis of element accumulation in rice grains via genome-wide association study and population genetic analysis by Min Li, Mengxue Gao, Jinmei Huang, Shaojuan Jin, Yamei Lv, Lin Wang, Tao Huang, Fengcai Wu, Zhijian Xu, Yinghua Pan, Zhixia Liu, Chaopu Zhang, Yuntao Liang, Lijun Meng, Jianlong Xu

“…The accumulation of heavy metals and essential elements in rice grains and their genetic mechanisms are still poorly understood. Results We conducted genetic dissection of four toxic heavy metal elements (lead, cadmium, mercury, and chromium), one quasi metallic element (arsenic), and one essential element (selenium) in grains of 290 Xian and 308 Geng rice accessions through a genome-wide association study (GWAS) based on three statistical models and assays of element concentrations from three environments. …”
Get full text

Biomass allocation and root topology alteration of an introduced amphibious plant in response to cultural eutrophication by Xiaolong Huang, Yu Zhao, Hai Xu, Chunyu Yin, Ruijie Shen, Baohua Guan, Zhigang Mao, Hu He, Jinlei Yu, Kuanyi Li

“…This morphological plasticity allows M. aquaticum to effectively absorb nutrients from different layers of the environment, making it a suitable model plant for exploring nutrient dynamics in both water and soil systems and investigating how wetland plants respond to cultural eutrophication. We designed an outdoor mesocosm experiment to assess plant growth traits and root topological indices in response to different nitrogen (N) and phosphorus (P) concentrations. …”
Get full text

Investigating the response mechanisms of the intertidal seagrass Zostera japonica to increased UVB radiation through physiological, transcriptomic, and metabolomic analyses by Jiayi Xin, Song Xue, Hongzhen Wang, Xinqi Li, Yu Zang, Lei Liu, Xuexi Tang, Jun Chen

“…However, the specific response mechanisms of Z. japonica to elevated levels of UVB radiation are not fully understood. Therefore, we investigated the response mechanism of Z. japonica to varying doses of increased UVB radiation by integrating the physiological responses with transcriptomic and metabolomic analyses. …”
Get full text

Annotated image dataset with different stages of European pear rust for UAV-based automated symptom detection in orchardsMendeley Data by Virginia Maß, Pendar Alirezazadeh, Johannes Seidl-Schulz, Matthias Leipnitz, Eric Fritzsche, Rasheed Ali Adam Ibraheem, Martin Geyer, Michael Pflanz, Stefanie Reim

“…Pear rust is widespread in orchards and causes conspicuous, clearly visible, yellow to orange-colored disease symptoms.In this paper, we provide a dataset with expert-annotated high-resolution RGB images with pear rust symptoms. …”
Get full text

Regenerative fibroblasts derived from autologous skin tissue for the treatment of Sjögren’s syndrome: a case report by Zhao-Xia Ma, Xing-Fei Wu, Li Cao, Cheng-Yan Jiao, Dai-Ping Ma, Yun-Hui Zhao, Zhi-Xing Yang, Min Hu, Min Hu

“…Regenerative fibroblast (rFib) is a type of new MSC obtained through chemical reprogramming technology from skin fibroblasts. In this study, we report the safety and efficacy of intravenous infusion of autologous rFib in a volunteer with SS.Case reportIn March 2021, the volunteer was diagnosed with SS due to positive anti-SSB antibodies, lymphocyte infiltration in the lip gland, dry eyes, and a large area of purpura in both lower limbs. …”
Get full text

Factors associated with having a steady homosexual partner among men who have sex with men, based on internet recruitment by Peng Zhang, Weiyong Chen, Jing Li, Yun Fu, Fang Wang, Xing Wang, Zhongrong Yang

“…Univariate and multivariate logistic regression analyses were used to evaluate the factors influencing whether the participants had a steady HP.ResultsWe surveyed 604 participants;211 (34.93%) had a current steady HP. …”
Get full text

The Protective Effects of Maresin 1 in the OVA-Induced Asthma Mouse Model by Guochun Ou, Qin Liu, Chengxiu Yu, Xiaoju Chen, Wenbo Zhang, Yong Chen, Tao Wang, Yongqiang Luo, Guolu Jiang, Mingmei Zhu, Hongmei Li, Mei Zeng

“…Quantitative real-time polymerase chain reactions (qRT-PCRs) were used to evaluate the expression levels of COX-2 and ICAM-1 in lung tissues. We found that high doses of MaR1 were most effective in preventing OVA-induced inflammatory cell infiltration and excessive mucus production in lung tissue, reducing the number of inflammatory cells in the BALF and inhibiting the expression of serum or BALF-associated inflammatory factors. …”
Get full text

Understanding stakeholder views of the use of digital therapeutic interventions within children and young people’s mental health services by Brioney Gee, Brioney Gee, Tim Clarke, Tim Clarke, Jess Garner, Bonnie Teague, Bonnie Teague, Georgianna Coote, Aoife Dunne, Rachel McGuire, Andrew Laphan, Manjul Rathee, Jon Wilson, Jon Wilson

“…Increased use of digital technology in the delivery of children and young people’s mental health services has been proposed as a means of increasing access to treatment.MethodsWe conducted three interrelated studies to provide multi-perspective insights into the use of digital therapeutic interventions within children and young people’s mental health services in the UK. …”
Get full text

Trends and distribution patterns of infant mortality and maternal HIV positivity in South Africa: A decade review (2007 - 2016) by M Makhele, N Ledibane, H Ramatsoma, A Musekiwa

“…There is a correlation evident between maternal HIV prevalence and IMR in SA. We recommend the use of disability-adjusted life expectancy in SA to measure population health and introduce robust data sets that can better inform policy. …”
Get full text

Pregnant Women, a Potential Reservoir for Onchocerca volvulus? A Cross Sectional Study in Maridi County, South Sudan by Chiara Trevisan, Amber Hadermann, Stephen Raimon Jada, Raphael A. Abong, Yak Yak Bol, Joseph N. Siewe Fodjo, Katja Polman, Robert Colebunders

“…Pregnant women may be a parasite reservoir as they are not included in routine ivermectin (IVM) treatments due to unassessed drug safety. In our study we determined the proportion of pregnant women infected with Onchocerca volvulus and assessed the knowledge and practices on IVM use during pregnancy. …”
Get full text

Methodological aspects in gastroenteric methane evaluation trial in water buffalo by Maria Chiara La Mantia, Emanuela Rossi, Francesco Cenci, David Meo Zilio, Roberto Steri, Miriam Iacurto, Antonella Chiariotti

“…As for the CH4 measure, there was a significant correlation between the rumen’s highest pick value of emission at the cannula and the intensity and duration of breath emission, calculated as breath + eructation. Moreover, we found a highly significant difference in emissions patterns when animals were subjected to distress (confinement, manipulation). …”
Get full text

Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy by Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang

“…In addition, melanoma mouse tumor immunotherapy models were performed to explore the synergistical efficacy of antitumor immunity via prevention of tumor-specific T cell senescence combined with anti-programmed death-ligand 1 (anti-PD-L1) checkpoint blockade therapy.Results We report that both mouse malignant tumor cells and Treg cells can induce responder T cell senescence, similar as shown in human Treg and tumor cells. …”
Get full text

Mortality of elder financial and psychological abuse victims in rural Malaysia: a prospective cohort study by Raudah Mohd Yunus, Farizah Hairi, Noran N Hairi, Wan Yuen Choo, Sajaratulnisah Othman, Rajini Sooryanarayana, Norliana Ismail, Sharifah Nor Ahmad, Inayah Abdul Razak, Devi Peramalah, Awang Bulgiba Awang Mahmud, Halima B Awang, Siti Zaharah Jamaludin, Jamali Samsuddin, Mohammad Mafrukhin Mokhtar, Syed Mohd Fauzi, Zainudin Mohd Ali

“…Among all the variables studied, only cognitive impairment led to higher mortality risk (HR 1.32, 95% CI 1.03 to 1.69).Conclusion Our findings contradict prior empirical studies that supported the link between elder abuse and neglect (EAN) and mortality, even though we focused on two abuse subtypes. Results in this study are more in line with the recently emerging evidence that showed no association between EAN and mortality.…”
Get full text

Clinical comparison and genetic analysis in pheochromocytoma with primary aldosteronism by Xurong Mai, Mitsuhiro Kometani, Toshiaki Kato, Ko Aiga, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Koshiro Nishimoto, Kazuyoshi Hosomichi, Atsushi Watanabe, Yuko Noda, Yoshiyu Takeda, Takashi Yoneda

“…This study aimed to investigate the clinical characteristics and associated genetic mutations in patients with pheochromocytoma and primary aldosteronism. We retrospectively analyzed data from 23 patients with pheochromocytoma diagnosed and treated between 2011 and 2022. …”
Get full text

MTMR6 downregulation contributes to cisplatin resistance in oral squamous cell carcinoma by Kah Young Lee, Su Young Oh, Heon-Jin Lee, Tae-Geon Kwon, Jin-Wook Kim, Chang-Geol Shin, Su-Hyung Hong, So-Young Choi

“…The role of myotubularin and myotubularin-related (MTMR) genes in cisplatin resistance remains unclear. We aimed to elucidate the molecular mechanisms underlying MTMR6 with cisplatin resistance in OSCC. …”
Get full text

Gestational Weight Gain and Small for Gestational Age in Obese Women: A Systematic Review and Meta-Analysis by Wen Chen, Beiyi Li, Kexin Gan, Jing Liu, Yajing Yang, Xiuqin Lv, Huijuan Ma

“…Our findings indicated that obese pregnant women who had weight loss or inadequate weight (0–4.9 kg) according to the IOM guideline had increased risks for SGA. Moreover, we also evaluated that gestational weight loss (<0 kg) in these pregnancies was associated with an increased risk for SGA compared with inadequate weight (0–4.9 kg) in these pregnancies. …”
Get full text

Sexual Dimorphism for the Association between Vitamin D and Insulin Resistance in Chinese People by Bing Han, Qin Li, Ningjian Wang, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Zhen Cang, Meng Lu, Ying Meng, Chi Chen, Yingli Lu

“…In regression analysis, serum 25(OH)D concentration was significantly associated with HOMA-IR only in overweight males. Conclusion. We found an inverse association between 25(OH)D and HOMA-IR in Chinese overweight males. …”
Get full text

Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study by Qian Ge, Zhongyan Li, Weijing Meng, Chen Cai, Mengdi Qiu, Yafei Liu, Haibo Zhu

“…To evaluate the dependability of the results, we conducted sensitivity analysis (heterogeneity and pleiotropy) and employed supplementary MR techniques, such as the inverse variance weighted (IVW) and MR‐Egger. …”
Get full text

Prevalence and determinants of persistent symptoms after infection with SARS-CoV-2: protocol for an observational cohort study (LongCOVID-study) by Lotte Haverman, Eelco Franz, Ka Yin Leung, Albert Jan Van Hoek, Hans Knoop, Cees C van den Wijngaard, Elizabeth N Mutubuki, Tessa van der Maaden, Albert Wong, Anna D Tulen, Siméon de Bruijn

“…However, knowledge regarding the nature and risk factors for developing persisting symptoms is still limited. Hence, in this study, we aim to determine the prevalence, severity, risk factors and impact on quality of life of persisting symptoms in the first year following acute SARS-CoV-2 infection.Methods and analysis The LongCOVID-study is both a prospective and retrospective cohort study being conducted in the Netherlands, with a one year follow-up. …”
Get full text