CD14loCD301b+ macrophages gathering as a proangiogenic marker in adipose tissues by Yibing Lv, Yidan Zheng, Shanshan Su, Junyi Xiao, Jie Yang, Lingyun Xiong, Yanyan Guo, Xiaoqi Zhou, Nengqiang Guo, Ping Lei

“…Because Igf1 expression has been suggested to be associated with Cd301b expression through pseudotime analysis, we found it was insulin-like growth factor 1 secreted from Cd14−/− macrophages that mediated the angiogenesis enhancement. …”
Get full text

Curcumin dietary supplementation enhances serum carbohydrate-degrading enzyme activities in buffaloes by Maima Matin, Natalia Ksepka, Kamil Wysocki, Michel-Edwar Mickael, Alpana Pande, Jarosław Olav Horbańczuk, Artur Jóźwik, Olga Adamska, Artur Stolarczyk, Laszlo Barna Iantovics, Yordanka Ilieva, Pencho Penchev, Atanas G. Atanasov

“…Previous studies have investigated metabolic effects of curcumin in humans or established animal research models such as mice, but studies with farm animals have been scarce. In this work, we aimed to study the effects of curcumin supplementation in Bulgarian Murrah buffaloes (Bubalus bubalis), on the serum activities of seven important carbohydrate-metabolizing enzymes, β-glucuronidase, α-galactosidase, α-glucosidase, β-glucosidase, β-galactosidase, N-acetyl-hexosaminidase, and mannosidase. …”
Get full text

The Magnetic Origin of the Mystery of Rare Hα Moreton Waves by Ze Zhong, Yao Chen, Y. W. Ni, P. F. Chen, Ruisheng Zheng, Xiangliang Kong, Chuan Li

“…Here, to shed light on this problem, we investigate the photospheric vector magnetograms of the Moreton-wave events associated with M- and X-class solar flares during 2010–2023. …”
Get full text

Exponential distribution of wave-driven near-bed water speeds under short-crested waves: a case study in the eastern Gulf of Riga, the Baltic Sea by Maris Eelsalu, Laura Piho, Juris Aigars, Loreta Kelpšaitė-Rimkienė, Vitalijus Kondrat, Maarja Kruusmaa, Kevin E. Parnell, Asko Ristolainen, Ilona Šakurova, Māris Skudra, Maija Viška, Tarmo Soomere

“…Loads exerted to the seabed by short-crested wind-seas with a wide directional spread have extensive spatio-temporal variability. We quantify this variability in terms of near-bed water speed using an array of nine high-resolution hydromast devices for recording pressure and water velocity in the range of 0.12â1 m/s mounted at a distance of 10 m from each other on a rigid rectangular frame of 20 Ã 20 m in approximately 4 m deep water and 700 m from the eastern shore of the Gulf of Riga near Skulte (Latvia) in AugustâSeptember 2022. …”
Get full text

Women Are More Susceptible to Caries but Individuals Born with Clefts Are Not by Aditi Jindal, Michelle McMeans, Somnya Narayanan, Erin K. Rose, Shilpa Jain, Mary L. Marazita, Renato Menezes, Ariadne Letra, Flavia M. Carvalho, Carla A. Brandon, Judith M. Resick, Juan C. Mereb, Fernando A. Poletta, Jorge S. Lopez-Camelo, Eduardo E. Castilla, Iêda M. Orioli, Alexandre R. Vieira

“…The identification of individuals of higher susceptibility to caries is of great interest. In this paper, we assessed caries experience of 1,593 individuals from three distinct populations. …”
Get full text

Mutation in the COL2A1 gene is associated with acetabular dysplasia by Miaomiao Xin, Xin Guan, Xin Guan, Jiangfei Yang, Yi Li, Zhentao Man, Hongsheng Sun, Min Fu

“…BackgroundDevelopmental dysplasia of the hip (DDH) is one of the most common developmental disorders worldwide, caused by a combination of genetic and environmental factors.MethodsTo investigate the genetic etiology of DDH in a proband (a 27-year-old male), we reviewed the patient’s clinical data and collected peripheral blood samples from the proband and his parents. …”
Get full text

Percutaneous Mitral Valve Repair versus Optimal Medical Therapy in Patients with Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis by Muhammad Uzair Lodhi, Muhammad Shariq Usman, Tariq Jamal Siddiqi, Muhammad Shahzeb Khan, Muhammad Arbaz Arshad Khan, Safi U. Khan, Intekhab Askari Syed, Mustafa Rahim, Srihari S. Naidu, Rami Doukky, Mohamad Alkhouli

“…PMVR has recently emerged as an alternative solution. Methods. We performed a systematic review and a meta-analysis to address this question. …”
Get full text

The Diagnosis Value of a Novel Model with 5 Circulating miRNAs for Liver Fibrosis in Patients with Chronic Hepatitis B by Qingqing Zhang, Qidi Zhang, Binghang Li, Ying Qu, Zhenghong Li, Lungen Lu, Rongzhou Li, Xiaobo Cai

“…However, miRNA expression profiles during different stages of chronic hepatitis B (CHB) are not well defined. In this study, we aimed to further validate the features of 5 miRNA candidates from our previous study during different fibrotic stages and the value of diagnosis for liver fibrosis. …”
Get full text

Systematic Review with Network Meta-Analysis: Comparative Efficacy and Safety of Combination Therapy with Angiotensin II Receptor Blockers and Amlodipine in Asian Hypertensive Pati... by Dae Wook Lee, Mira Jung, Hye Won Wang, Zainah Khan, Philippe Pinton

“…A systematic literature review sourced Asian randomized controlled trials (RCTs) from PubMed and Cochrane Libraries to inform a network meta-analysis (NMA). We considered the ARB-AML CT. The primary efficacy and safety endpoints were short-term (8–12 weeks) treatment response and treatment-emergent adverse events (TEAEs), respectively. …”
Get full text

miR-223 and Chromogranin A Affect Inflammatory Immune Cell Activation in Liver Metastasis of Neuroendocrine Neoplasms by Lukas Geisler, Katharina Detjen, Teresa Hellberg, Marlene Kohlhepp, Carsten Grötzinger, Jana Knorr, Ines Eichhorn, Raphael Mohr, Theresa Holtmann, Bertram Wiedenmann, Frank Tacke, Christoph Roderburg, Alexander Wree

“…Secretion/posttranslational proteolytic cleavage of CgA results in multiple bioactive fragments, which are essential regulators of the cardiovascular and immune system. miR-223, regulator of Nrlp3 inflammasome and neutrophil activation, was recently found to have decreased in patients with NEN. We performed flow cytometry of circulating neutrophils in a patient cohort (n = 10) with NEN, microdissection and histology of tumor tissue. …”
Get full text

Adipose-Derived Mesenchymal Stem Cells Migrate and Rescue RPE in the Setting of Oxidative Stress by Aya Barzelay, Shira Weisthal Algor, Anat Niztan, Sebastian Katz, Moshe Benhamou, Itay Nakdimon, Noam Azmon, Sandy Gozlan, Daphna Mezad-Koursh, Meira Neudorfer, Michaella Goldstein, Benjamin Meilik, Anat Loewenstein, Adiel Barak

“…Oxidative stress leads to the degeneration of retinal pigment epithelial (RPE) and photoreceptor cells. We evaluated the potential of adipose-derived mesenchymal stem cells (ASCs) as a therapeutic tool by studying the migration capacity of ASCs in vitro and their protective effect against RPE cell death under oxidative stress in vitro and in vivo. …”
Get full text

Soil organic carbon and related properties under conservation agriculture and contrasting conventional fields in Northern Malawi by Muneta G. Manzeke-Kangara, Ivy S. Ligowe, Austin Tibu, Timothy N. Gondwe, Henry M. R. Greathead, Marcelo V. Galdos, Marcelo V. Galdos

“…Several studies have focused on effects of CA on crop yields and soil moisture dynamics in sub-Saharan Africa, with limited focus on effects of CA on soil organic carbon (SOC) and associated fractions. We collected representative soil samples from 30 paired farms under CA and conventional tillage in Mzimba district, north of Malawi to determine effects of tillage and soil depth on soil physico-chemical properties, total SOC, and organic carbon fractions. …”
Get full text

Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway by Qiuer Liang, Minghao Chen, Guangtian Chen, Pengli Xu, Lai Kwan Lam, Pengcheng Xie, Ting Xie, Wanqing Tu, Tianhao Liu, Xiaopeng Peng, Haoyao Yuan, Liguo Chen, Ya Xiao

“…Using an 8 % high-salt diet model, we evaluated the effects of Kae (200 mg/kg/day) in wild-type (WT) and activating transcription factor 4 (ATF4+/−) knockout mice. …”
Get full text

RespiroDynamics: A Multifaceted Dataset for Enhanced Lung Health Assessment Using Deep Learning by Ahmed Sharshar, Muhammad Sharshar, Hosam Elhady, Ahmed Aboeitta, Youssef Nafea, Yasser Ashraf, Mohammad Yaqub, Mohsen Guizani

“…This dataset incorporates various data types, including Red-Green-Blue (RGB) and Thermal videos, Heart Rate (HR), ECG readings and metadata, all synchronized with observed respiratory activities. We elaborate on the data collection methodology, post-processing techniques employed, and the analytical approach to extract meaningful patterns and insights. …”
Get full text

Wild pink bayberry free phenolic extract induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest through p38/MAPK and PI3K/Akt pathway in MDA-MB-231 cancer cells by Wen Xia, Er-sheng Gong, Yanyun Lin, Bisheng Zheng, Wenhan Yang, Tong Li, Sheng Zhang, Peng Li, Rui-hai Liu

“…Further study of the upstream protein, we found that WPBFE down-regulated TRAF2, while upregulated p-ASK1, p-p38 and p-p53. …”
Get full text

The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population by Guoda Ma, Haiyang Wang, Guixi Mo, Lili Cui, You Li, Yiming Shao, Xin Liu, Yuliu Xie, Jia Li, Jiawu Fu, Hua Tao, Bin Zhao, Liangqing Zhang, Keshen Li

“…Therefore, PPAR-γ has been suggested as a candidate gene for sepsis. In the present study, we investigated the association between the Pro12Ala polymorphism of PPAR-γ and sepsis in a Han Chinese population. …”
Get full text

Single Exposure to Low-Intensity Focused Ultrasound Causes Biphasic Opening of the Blood-Brain Barrier Through Secondary Mechanisms by Tasneem A. Arsiwala, Kathryn E. Blethen, Cullen P. Wolford, Geoffrey L. Pecar, Dhruvi M. Panchal, Brooke N. Kielkowski, Peng Wang, Manish Ranjan, Jeffrey S. Carpenter, Victor Finomore, Ali Rezai, Paul R. Lockman

“…This study aimed to characterize the time-dependent changes in BBB permeability, transporter function, and inflammatory responses in both sonicated and non-sonicated brain tissues following LiFUS treatment. <b>Methods:</b> We employed in situ brain perfusion to assess alterations in BBB integrity and transporter function, as well as multiplex cytokine analysis to quantify the inflammatory response. …”
Get full text

Sport innovation structure landscape in Switzerland and abroad by Christelle Ganné-Chedeville, Solange Emmenegger, Hippolyt Kempf, Cornel Gübeli

“…For example, the Dutch initiative "Sport Innovator" bring together Stakeholders from sport, public administration, business and research. Similar structures we find in Australia or in France. The analyses of institutions in other sectors shows that they help to follow ideas continuously. …”
Get full text

Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria by Michael Gilligan, Smathorn Thakolwiboon, Emma Orozco, Samantha Banks, Eoin P. Flanagan, Sebastian Lopez‐Chiriboga, Jan‐Mendelt Tillema, John R. Mills, Sean J. Pittock, Cristina Valencia Sanchez, Anastasia Zekeridou, Divyanshu Dubey, Andrew McKeon

“…Abstract Objective We describe neurologic phenotype, clinical associations, and outcomes in autoimmune brainstem encephalitis. …”
Get full text

Role of transforming growth factor-β1 in regulating adipocyte progenitors by Nguyen Quynh Phuong, Muhammad Bilal, Allah Nawaz, Le Duc Anh, Memoona, Muhammad Rahil Aslam, Sana Khalid, Tomonobu Kado, Yoshiyuki Watanabe, Ayumi Nishimura, Yoshiko Igarashi, Keisuke Okabe, Kenichi Hirabayashi, Seiji Yamamoto, Takashi Nakagawa, Hisashi Mori, Isao Usui, Shiho Fujisaka, Ryuji Hayashi, Kazuyuki Tobe

“…Among cytokines, the role of transforming growth factor-β1 (Tgf-β1), a cytokine abundantly expressed in CD206+ M2-like macrophage and correlated with the expansion of AT and fibrosis, in AT metabolism, remains unknown. We used CD206CreERT2; Tgf-β1f/f mouse model in which the Tgf-β1 gene was conditionally deleted in CD206+ M2-like macrophages followed by tamoxifen administration, to investigate the role of the Tgf-β1 gene in glucose and insulin metabolism. …”
Get full text