The development of winter wheat lines with several genes for resistance to Puccinia graminis Pers. f. sp. tritici for use in breeding programs in Russia by I. F. Lapochkina, O. A. Baranova, N. R. Gainullin, G. V.  Volkova, E. V. Gladkova, E. O. Kovaleva, A. V.  Osipova

“…The spectrum of the stem rust gene combinations in the created lines differs from the gene combinations in the parental accessions involved in the crossing and is associated with the direction of the selections conducted by the marker assisted selection method. We discovered more than 20 different combinations of the Sr2, Sr22, Sr31, Sr32, Sr36, Sr39, Sr40 and Sr47 genes in winter wheat lines. …”
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Medication underuse in real-life practice: the impact of galcanezumab towards achieving very low frequency episodic migraine in a southeast Asian middle-income nation by Wanakorn Rattanawong, Prakit Anukoolwittaya, Akarin Hiransuthikul, Thanakit Pongpitakmetha, Auranee Trisataya, Sekh Thanprasertsuk, Alan Rapoport

“…Galcanezumab given early in the course of the disease, may prevent migraine chronification and have a robust response, moreso than when initiated in later stages of migraine. We aimed to determine the efficacy of galcanezumab in achieving very low-frequency episodic migraine (VLFEM) among patients with high-frequency episodic migraine (HFEM) and CM in a real world-setting in Thailand. …”
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Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence by Keyu Kong, Baixing Li, Yongyun Chang, Chen Zhao, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Liao Wang, Yansong Qi, Yongsheng Xu, Zanjing Zhai, Peixiang Ma, Huiwu Li

“…However, traditional protein delivery methods have limited efficacy due to the short lifetime and shallow infiltration. Results In this work, we discovered that lipid nanoparticle (LNP) can infiltrate and deliver FGF18 mRNA deeper in the cartilage than proteins. …”
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Analisis Kinerja Intrusion Detection System Berbasis Algoritma Random Forest Menggunakan Dataset Unbalanced Honeynet BSSN by Kuni Inayah, Kalamullah Ramli

“…One way to improve IDS performance is by using machine learning. In this research, we propose an IDS design based on a random forest algorithm with the CIC-ToN-IoT dataset as a whitelist dataset and the Honeynet BSSN dataset as a blacklist dataset. …”
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The co-occurrence patterns and assembly mechanisms of microeukaryotic communities in geothermal ecosystems of the Qinghai-Tibet Plateau by Bingjie Yan, Bingjie Yan, Xiaodong Li, Xiaodong Li, Nanqian Qiao, Nanqian Qiao, Zhen Da, Zhen Da, Jiajie Xu, Jiajie Xu, Chuanqi Jiang, Sang Ba, Sang Ba

“…However, existing studies on the stability of microeukaryotic communities in geothermal ecosystems across different habitats and temperature gradients are still limited. In this study, we used high-throughput 18S rDNA sequencing in combination with environmental factor analysis to investigate the co-occurrence patterns, assembly mechanisms, and responses to environmental changes of microeukaryotic communities in sediment and water samples from 36 geothermal springs across different temperature gradients in southern Tibet. …”
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Mollusk Diversity in Percut Sei Tuan Silvofishery Ponds, North Sumatra, Indonesia by Ipanna Enggar Susetya, Mohammad Basyuni, Muhammad Rakezza Rifzy Rifzy, Rizka Amelia, Yuntha Bimantara, Rusdi Leidonald, Amanatul Fadhilah

“…Highlight Research • We found 16 species of mollusks with a total of 15 species from the gastropod class and 1 species from the Bivalvia class bivalves in the silvofishery ponds, recording a total of 369 individuals…”
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Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population by Dione Aguilar, María Lourdes Garza-Rodríguez, Carolina Elizabeth Muñiz-Garza, Fernando Alcorta Nuñez, Cynthia Mayte Villarreal-Garza, Oscar Vidal-Gutiérrez, Diana Cristina Pérez-Ibave, Carlos Horacio Burciaga-Flores

“…For the data analysis of qualitative and quantitative variants, JASP statistical software (version 0.18.1) was used, taking p < 0.05 as a significant result. Results We found that 32.7% of the patients had at least one GPV in non-BRCA genes. …”
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Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers by Florica Sandru, Elena Poenaru, Smaranda Stoleru, Andreea-Maria Radu, Alexandra-Maria Roman, Corina Ionescu, Aurelian Zugravu, Jafal Mugurel Nader, Livia-Cristiana Băicoianu-Nițescu

“…This study aimed to investigate the microbial populations and antibiotic resistance profiles in HS and VU patients, comparing the prevalence of common pathogens and their antimicrobial resistance profiles. <b>Methods</b>: We conducted a cross-sectional analysis that included a total of 112 individuals (24 with the diagnosis of hidradenitis suppurativa and 88 diagnosed with venous ulcer). …”
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Association of burnout and working environment conditions in respiratory care professionals in Saudi Arabia: a cross-sectional study by Saad Al-Anazi, Saad Al-Anazi, Syed Shahid Habib, Thamir Al-khlaiwi, Abdulaziz Alhomaidi Alodhayani, Abdulmueen Alotaibi, Abdulmueen Alotaibi, Saja Aldulejan, Sufana Al Safadi, Fahad Saad Alshammari, Aqeelah Marar, Afaf Alrashdi, Alhanouf G. Almutairi, Mohammed Alshahrani

“…This study examines factors associated with burnout and working environment among respiratory therapists in Saudi Arabia.MethodsA structured questionnaire was used to collect data from respiratory therapists. We collected 315 questionnaires including burnout assessment. …”
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Prevalence and incidence of sarcopenia in Swiss postmenopausal women: findings from the OsteoLaus Cohort by Colin Vendrami, Elena Gonzalez Rodriguez, Guillaume Gatineau, Peter Vollenweider, Pedro Marques-Vidal, Olivier Lamy, Didier Hans, Enisa Shevroja

“…METHODS: Postmenopausal women from the last 5 years of the CoLaus/OsteoLaus prospective population-based cohort were included based on complete case analysis (April 2015 to October 2022; Lausanne, Switzerland). We assessed appendicular lean mass via Dual X-ray Absorptiometry (GE Lunar iDXA), handgrip strength using a Jamar Dynamometer and 6-metre gait speed at multiple visits. …”
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Health system costs of a breast cancer early diagnosis programme in a rural district of Rwanda: a retrospective, cross-sectional economic analysis by Lydia E Pace, Lawrence N Shulman, Jean Claude Mugunga, Parsa Erfani, Kayleigh Pavitra Bhangdia, Rashidah Nambaziira, Lysa Carolle Niteka, Jean Marie Vianney Dusengimana, John Ruhumuriza, Marie Louise Uwineza, Vestine Rugema, Cyprien Shyirambere, Melany Rabideau

“…Objectives This study aimed to quantify the health system cost of the first 2 years of a Breast Cancer Early Detection (BCED) programme in a rural district in Rwanda. We also aimed to estimate the cost of implementing the programme in other districts with different referral pathways and identify opportunities for enhanced cost efficiency.Design Retrospective, cross-sectional analysis using time-driven activity-based costing, based on timed patient clinical encounters, retrospective patient data and unit costs of resources abstracted from administrative and finance records.Setting The BCED programme focused on timely evaluation of individuals with breast symptoms. …”
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Clinical Characteristics and Management of Functional Pancreatic Neuroendocrine Neoplasms: A Single Institution 20-Year Experience with 286 Patients by Yuqing Qu, Haoming Li, Xianling Wang, Yulong Chen, Qinghua Guo, Yu Pei, Jin Du, Jingtao Dou, Jianming Ba, Zhaohui Lv, Yiming Mu

“…It has always been challenging in dealing with such rare but complicated disorders. In this report, we analyzed the clinical characteristics of functional PanNENs in a large cohort of Chinese patients and summarized our clinical experience in diagnosis and treatment. …”
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The Peptide Vaccine Combined with Prior Immunization of a Conventional Diphtheria-Tetanus Toxoid Vaccine Induced Amyloid β Binding Antibodies on Cynomolgus Monkeys and Guinea Pigs by Akira Yano, Kaori Ito, Yoshikatsu Miwa, Yoshito Kanazawa, Akiko Chiba, Yutaka Iigo, Yoshinori Kashimoto, Akira Kanda, Shinji Murata, Mitsuhiro Makino

“…The reduction of brain amyloid beta (Aβ) peptides by anti-Aβ antibodies is one of the possible therapies for Alzheimer’s disease. We previously reported that the Aβ peptide vaccine including the T-cell epitope of diphtheria-tetanus combined toxoid (DT) induced anti-Aβ antibodies, and the prior immunization with conventional DT vaccine enhanced the immunogenicity of the peptide. …”
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Baicalin Mitigates Cardiac Hypertrophy and Fibrosis by Inhibiting the p85a Subunit of PI3K by Lu He, Min Zhu, Rui Yin, Liangli Dai, Juan Chen, Jie Zhou

“…Molecular docking was carried out to reveal the effect of baicalin on p85a. <b>Results:</b> We observed significant antihypertrophic and antifibrotic effects of baicalin both in vivo and in vitro. …”
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Ion bridging enables high-voltage polyether electrolytes for quasi-solid-state batteries by Tianyi Hou, Donghai Wang, Bowen Jiang, Yi Liu, Jia Kong, Yanbing He, Yunhui Huang, Henghui Xu

“…Abstract Polyether electrolytes have been widely recognized for their favorable compatibility with lithium-metal, yet they are hampered by intrinsically low oxidation thresholds, limiting their potential for realizing high-energy Li-metal batteries. Here, we report a general approach involving the bridge joints between non-lithium metal ions and ethereal oxygen, which significantly enhances the oxidation stability of various polyether electrolyte systems. …”
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High CXCR3 on Leukemic Cells Distinguishes IgHVmut from IgHVunmut in Chronic Lymphocytic Leukemia: Evidence from CD5high and CD5low Clones by Gayane Manukyan, Tomas Papajik, Zuzana Mikulkova, Renata Urbanova, Veronika Smotkova Kraiczova, Jakub Savara, Milos Kudelka, Peter Turcsanyi, Eva Kriegova

“…To further characterize CD5high and CD5low neoplastic cells, we assessed the chemokine receptors (CCR5, CCR7, CCR10, CXCR3, CXCR4, CXCR5) and adhesion molecules (CD54, CD62L, CD49d) on the CD5high and CD5low subpopulations, defined by CD5/CD19 coexpression, in peripheral blood of CLL patients (n=60) subgrouped according to the IgHV mutational status (IgHVmut, n=24; IgHVunmut, n=36). …”
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Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease by L. M. O. Caram, R. A. F. Amaral, R. Ferrari, S. E. Tanni, C. R. Correa, S. A. R. Paiva, I. Godoy

“…Evaluating vitamin A in the serum and sputum and testing its correlation with inflammatory markers in individuals with or without COPD. Methods. We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7). …”
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Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis by Ming Yuan, Zhiwei Zhang, Gary Tse, Xiaojin Feng, Panagiotis Korantzopoulos, Konstantinos P. Letsas, Bryan P. Yan, William K. K. Wu, Huilai Zhang, Guangping Li, Tong Liu, Yunlong Xia

“…The risk of AF was highest within 90 days of cancer diagnosis. We should take into account the increased risk of atrial fibrillation development and, after this, study the embolic risk and potential indication of oral anticoagulation.…”
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Combining several indicators to assess the effectiveness of tailor-made health plans in pig farms by Levallois, Pierre, Leblanc-Maridor, Mily, Scollo, Annalisa, Ferrari, Paolo, Belloc, Catherine, Fourichon, Christine

“…Changes in health, performances and antimicrobial use were monitored. We defined two categories of plans: i) 14 plans targeting a given health disorder present in a farm; ii) 17 plans to improve prevention, not targeting a specific health disorder (a farm could have both types of plans). …”
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N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth by Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D’Angelo, Larry J. Seidman, Sarah Gumlak, April Kim, Kristen A. Woodberry, Ashley Rober, Sahil Tembulkar, Kyle O’Donnell, Hesham M. Hamoda, Kara Kimball, Alexander Rotenberg, Lindsay M. Oberman, Alvaro Pascual-Leone, Matcheri S. Keshavan, Frank H. Duffy

“…This adaptation may index the health of plasticity mechanisms required for normal development. We exposed participants aged 5 to 17 years with psychosis n=22, at clinical high risk (CHR) for psychosis n=29, and healthy controls n=17 to an auditory tone repeated 450 times and measured N100 adaptation (mean amplitude during first 150 tones − mean amplitude during last 150 tones). …”
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