Comprehensive Sepsis Risk Prediction in Leukemia Using a Random Forest Model and Restricted Cubic Spline Analysis by Kou Y, Tian Y, Ha Y, Wang S, Sun X, Lv S, Luo B, Yang Y, Qin L

“…Shapley additive explanations (SHAP) were applied to interpret the results, and restricted cubic spline (RCS) regression explored the nonlinear relationships between variables and sepsis risk. Furthermore, we examined the interactions among predictors to better understand their potential interrelationships.Results: The random forest (RF) model outperformed all others, achieving an AUC of 0.765 in the training cohort and 0.700 in the validation cohort. …”
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Development of a Recombinant Omicron BA.1 Subunit Vaccine Candidate in Pichia pastoris by Sibel Kalyoncu, Dogu Sayili, Ayca Zeybek Kuyucu, Hakan Soyturk, Seyda Gullu, Busra Ersayan, Ibrahim Oguzhan Tarman, Mehmet Ender Avci, Olcay Mert, Umut Haskok, Ege Tekin, Huseyin Akinturk, Ridvan Orkut, Aysegul Demirtas, Idil Tilmensagir, Ceren Ulker, Bilgi Gungor, Mehmet Inan

“…Pichia pastoris is an ideal expression system for recombinant protein production due to its cost‐effective and easy‐to‐scale‐up process. Here, we developed a next‐generation SARS‐CoV2 Omicron BA.1‐based recombinant vaccine candidate expressed in P. pastoris. …”
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Clinical and imaging features of co-existent pulmonary tuberculosis and lung cancer: a population-based matching study in China by Fan Zhang, Fei Qi, Yi Han, Hongjie Yang, Yishuo Wang, Guirong Wang, Yujie Dong, Hongxia Li, Yuan Gao, Hongmei Zhang, Tongmei Zhang, Liang Li

“…Based on our findings, we recommend conducting TB-related tests for LC patients who exhibit relevant risk factors or are identified as high-risk cases according to the pre-diagnostic model.…”
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The availability of drugs for stable COPD treatment in China: a cross-sectional survey by Dongru Du, Xueru Hu, Qiunan Zuo, Dan Xu, Tao Zhu, Tao Fan, Jiao Yang, Weiguo Xu, Hailong Wei, Kangzhuo Baima, Ying Zhang, Yanhui Gu, Lei Chen, Fengming Luo, Yongchun Shen, Fuqiang Wen

“…Doctors from different hospitals completed the survey via WeChat. The availability of each category and kind of drug was analyzed based on final valid responses. …”
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Beyond support: exploring the dynamic and static biomechanical changes induced by preventive ankle taping: a novel cross-sectional study by María Bravo-Aguilar, Vanesa Abuín-Porras, María Blanco-Morales, Carlos Romero Morales, Jaime Almazán-Polo, Jorge Hugo Villafañe, Lorena Canosa-Carro

“…Conclusions In conclusion, we observed that ankle taping led to increased peak pressures in the midfoot and decreased maximum pressures in the forefoot, indicating a shift in load distribution within the plantar surface. …”
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E-cigarettes on Instagram: Exploring vape content via an Australian vaping influencer by Jonine Jancey, Renee N. Carey, Becky Freeman, Tama Leaver, Katharina Wolf, Marilyn Bromberg, Kevin Chai, Stella Bialous, Phoebe Adams, Meghan Mcleod, Kahlia McCausland

“…This study explores how e-cigarettes are being promoted on Instagram, using a case-study approach, and the extent to which Meta’s Restricted Goods and Services Policy (Meta’s policy) is being applied and enforced. Methods We identified the accounts followed by an Australian Instagram influencer who primarily posts e-cigarette-related content. …”
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Metrics for Evaluating Telemedicine in Randomized Controlled Trials: Scoping Review by Yuka Sugawara, Yosuke Hirakawa, Masao Iwagami, Ryota Inokuchi, Rie Wakimizu, Masaomi Nangaku

“…ObjectiveThis review aimed to provide an overview of the general and cross-disciplinarity metrics used to compare telemedicine with in-person care in randomized controlled trials. In addition, we identified previously unevaluated indicators and suggested those that should be prioritized in future clinical trials. …”
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Combined Color-Doppler Flow and Angio Planewave UltraSensitive™ Imaging for Analysis of Hemodynamic Characteristics of Normal Upper Limb Arteries by Yanzhou Liu, Xiyue Zhang, Hang Yang, Xueyan Tan, Duo Huang, Hongmei Yuan, Lili Yu, Fang Yang, Yuan Zou, Xiuli He, Yuqun Luo, Fangzhao Cui, Ping Wang, Zukun Li, Qing Zhang, Ning Zhang, Binglei Jiang, Wensheng Yue

“…Abstract Background To evaluate the hemodynamic characteristics of normal upper extremity arteries from the brachial artery to the fingertip arterioles. Methods We analyzed the characteristics and changes in the regularities of ultrasonic parameters in the upper extremity arteries of 104 healthy volunteers using color Doppler flow imaging and Angio Planewave UltraSensitive™ imaging. …”
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Additively manufactured biodegradable Zn metamaterials with tunable Poisson’s ratio and enhanced mechanical properties by Yixuan Shi, Jiaqi Gao, Xuan Li, Zui Tao, Chengcong Huang, Shangyan Zhao, Yuzhi Wu, Youwen Yang, Yabin Yang, Yageng Li, Lu-Ning Wang

“…Using laser powder bed fusion (LPBF), we fabricated these Zn metamaterials and assessed their mechanical properties through simulations and compression tests. …”
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Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis by Liming Liu, Cuiqing Zhao, Ying Yang, Xiaoxia Kong, Tuo Shao, Li Ren, Xinyu Zhuang, Baishuang Yin, Gerald Dryden, Craig McClain, Weimin Luan, Wenke Feng

“…Fibroblast growth factor 21 (FGF21) is an important endocrine metabolic regulator with emerging beneficial roles in lipid homeostasis. We investigated the impact of FGF21 in experimental colitis-induced epididymal white adipose tissue (eWAT) lipolysis. …”
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Serum 25(OH)D Level and Parathyroid Hormone in Chinese Adult Population: A Cross-Sectional Study in Guiyang Urban Community from Southeast of China by Zhang Qiao, Shi Li-xing, Peng Nian-chun, Xu Shu-jing, Zhang Miao, Li Hong, Zhuang Hui-jun, Gong Ming-xian, Zhang Song, Wang Rui, Hu Ying, Zhang Jing-lu, Chen Shuang

“…Design and Participants. We conducted a cross-sectional evaluation in the General Community in Guiyang by cluster sampling method. …”
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E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases by Li Zhu, Yong-Ping Liu, Yuan-Wang, Bo-Xuan Sun, Yu-Ting Huang, Ji-Kai Zhao, Jian-Feng Liu, Li-Ming Yu, Hui-Shan Wang

“…This review synthesizes recent findings regarding the physiological and pathophysiological roles of SYVN1, offering new insights into potential strategies for the prevention and treatment of human diseases, as well as suggesting avenues for future drug development. In this Review, we summarize the latest findings regarding the physiological and pathophysiological roles of SYVN1, elucidating the mechanisms by which SYVN1 can regulate the progression of various diseases in humans. …”
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Digital Information Exchange Between the Public and Researchers in Health Studies: Scoping Review by Nazli Soltani, Thilo Dietz, Doris Ochterbeck, Jens Dierkes, Katja Restel, Lara Christianson, Karina Karolina De Santis, Hajo Zeeb

“…Exchange content included health information or data with the aim to inform, recruit, link, or gather innovative research ideas from participants in health studies. We identified 7 facilitators and 9 barriers to digital information exchange. …”
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Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice by Jing Ye, Ling Liu, Qingwei Ji, Ying Huang, Ying Shi, Lei Shi, Jianfang Liu, Menglong Wang, Yao Xu, Huimin Jiang, Zhen Wang, Yingzhong Lin, Jun Wan

“…Recent evidence has demonstrated that it plays a role in cardiovascular diseases. In the recent study, we investigate whether IL-22 is involved in cardiac hypertrophy. …”
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Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses by Liping Liu, Jiayu Zhao, Zichao Huang, Yudi Xu, Hongyu Chen, Ruirui Qiao, Wantong Song, Zhaohui Tang, Thomas P. Davis, Xuesi Chen

“…However, current nanocarriers are restricted by difficulties in the systematic spatial coordinative transport of antigens, which greatly hampers the immune response efficacy of nanovaccines. Herein, we designed a mannan-decorated stimulator of the interferon genes (STING)-activating vaccine carrier for spatial coordinative stimulation of antigen-specific immune responses and elicitation of robust antitumor immunity. …”
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Associations of Serum Cystatin C, DNAm Cystatin C, Renal Function, and Mortality in U.S. Adults by Yu-Wei Fang, Wei-Chung Huang, Chikang Wang, Chien-Yu Lin

“…This study aimed to examine the associations between serum cystatin C, DNAmCystatinC, renal function, and their joint and independent relationships with mortality in U.S. adults. We analyzed data from 1642 participants aged 50 and older from the National Health and Nutrition Examination Survey (NHANES) 1999–2002, linked to mortality information from the National Center for Health Statistics (NCHS), with follow-up through 2019. …”
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Differences in Characteristics of Peripartum Patients Who Did and Did Not Require an Upgrade to the Intensive Care Unit: A Propensity Score Matching Study by Jennifer A. Walker, Jerry M. Yang, Saad Pirzada, Manahel Zahid, Samantha Asuncion, Amanda Tuchler, Gillian Cooper, Allison Lankford, Emad Elsamadicy, Quincy K. Tran

“…<i>Results:</i> From 1855 peripartum patients, we analyzed 37 control and 34 upgrade patients. …”
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Therapeutic Efficacy of Intranasal <i>N</i>-Acetyl-L-Cysteine with Cell-Penetrating Peptide-Modified Polymer Micelles on Neuropathic Pain in Partial Sciatic Nerve Ligation Mice by Hiroshi Nango, Ai Takahashi, Naoto Suzuki, Takumi Kurano, Saia Sakamoto, Taiki Nagatomo, Toyofumi Suzuki, Takanori Kanazawa, Yasuhiro Kosuge, Hiroko Miyagishi

“…<b>Background/Objectives</b>: We previously demonstrated that the intranasal administration of cell-penetrating Tat peptide-modified carrier, PEG-PCL-Tat, improves drug delivery to the central nervous system. …”
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Preoperative anxiety and its impact on surgical outcomes: A systematic review and meta-analysis by Mohamed A. Shebl, Eman Toraih, Menna Shebl, Ahmed Mosaad Tolba, Parisa Ahmed, Harshdeep Singh Banga, Mohab Orz, Mahmoud Tammam, Keroles Saadalla, Mohamed Elsayed, Mennatallah Kamal, Mohamed Abdulla, Ahmed Ibrahim Eldessouky, Yousef Tarek Moustafa, Omar Ahmed Mohamed, Hani Aiash

“…Objective: This meta-analysis aimed to synthesize current evidence on the impact of preoperative anxiety on various surgical outcomes, including anesthetic and analgesic requirements, delirium, recovery times, and pain. Methods: We conducted a comprehensive literature search and meta-analysis of studies examining the relationship between preoperative anxiety and surgical outcomes. …”
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Effects of the Paediatric Regulation funding on the development of off-patent medicines in children by Lucia Ruggieri, Silvia Torretta, Viviana Giannuzzi, Alessandra Natale, Mariagrazia Felisi, Adriana Ceci, Adriana Ceci, Fedele Bonifazi

“…This study analysed the effects of funds provided under the Seventh Framework Programme for Research (FP7-FRP), issued by the European Commission from 2007 to 2013 according to the European Paediatric Regulation, in terms of new paediatric marketing authorisations (MAs) including paediatric Use Marketing Authorisations (PUMAs). Additionally, we investigated which funded projects included repurposing initiatives.MethodsData was collected on paediatric Investigation Plans (PIPs), new MAs, and MAs variations from the EMA website, national medicine registers, and final project reports. …”
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