Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD by Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen

“…., immunoprecipitation (IP), RNA-IP, Immunofluorescence (IF)/fluorescence in situ hybridization (FISH), live cell imaging, live cell tracking of RNA using beacon, and mouse model study are used to elucidate a novel mechanism regulating dendritic spine transport of mRNAs in mammalian neurons. Results We demonstrate here that brief mGluR1 activation-mediated dephosphorylation of pFMRP (S499) results in the dissociation of FMRP from TDP-43 and handover of TDP-43/Rac1 mRNA complex from the dendritic transport track on microtubules to myosin V track on the spine actin filaments. …”
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Epidemics In The 21st Century: A Multifaceted Challenge by Shawana Sharif

“…The crucible of epidemics in the 21st century compels us to acknowledge the imperativeness of collective resilience and concerted efforts. As we navigate the uncharted territories of emerging infectious threats and persisting health challenges, the amalgamation of scientific innovation, proactive policy interventions, and unwavering global solidarity becomes indispensable. …”
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Transcriptome responses to Ralstonia solanacearum infection in tetraploid potato by Zhuo Chen, Shunwei Shao, Xi Zhu, Yu Zhang, Zhendong Lan, Hui Jin

“…Huashu No. 12, a tetraploid potato genotype, is highly resistant to R. solanacearum. We inoculate Huashu No. 12 and Longshu No. 7 (highly susceptible to R. solanacearum) with R. solanacearum to compare disease resistance in these two potato varieties. …”
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IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution by Carlos J. Ballester-Rosado, John T. Le, Trang T. Lam, Anne E. Anderson, James D. Frost, Jr., John W. Swann

“…In the TTX brain injury model of epileptic spasms, we undertook experiments to evaluate the impact of IGF-1 deficiencies on neocortical interneurons and their role in spasms. …”
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Cardiovascular Reactivity to Mental Stress and Adverse Cardiovascular Outcomes in Patients With Coronary Artery Disease by Kasra Moazzami, Samaah Sullivan, Maggie Wang, Alexis K. Okoh, Zakaria Almuwaqqat, Brad Pearce, Amit J. Shah, Yan V. Sun, Yi‐An Ko, Paolo Raggi, J. Douglas Bremner, Viola Vaccarino, Arshed A. Quyyumi

“…Background Acute psychological stress may induce physiological changes predisposing individuals to adverse health outcomes through hemodynamic and vascular effects. We studied the association between the aggregated stress‐induced changes in hemodynamic and vascular function tests with adverse cardiovascular outcomes in patients with coronary artery disease, after adjusting for sociodemographic and clinical factors. …”
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INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses by Jason Ho, Chelsie Macedo, Garrett Cyprus, Rajay Pandit, Anya Polovina, Nadja Kern, Abrahim Hussain, Sae Jeong Ahn, William Crago, Emily Rowell, Florian J Sulzmaier, John C Timmer, Brendan P Eckelman

“…Recent engineering efforts, including non-α IL-2 variants, have lowered the toxicity profile, but have yet to induce meaningful antitumor activity in a wider patient population.Methods We engineered INBRX-120, a CD8α-targeted Cisleukin™ molecule consisting of an affinity tuned IL-2 (IL2-x) connected to two high affinity CD8α-specific single domain antibodies via an effector-silenced Fc domain. …”
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Deep Learning-Based Fully Automatic Segmentation of the Paranasal Sinuses in Chronic Rhinosinusitis Patients Using Computed Tomographic Images by Yuhang Wang, Xiaolei Zhang, Weidong Du, Na Dai, Yi Lyv, Keying Wu, Yiyang Tian, Yuxin Jie, Yu Lin, Weipiao Kang

“…The study involved 242 Computed Tomography (CT) images of patients with CRSwNP, constructing a high-quality professional CRSwNP database for the training, validation, and testing of neural networks. We chose a custom 3D nnU-Net v2 network model because of its excellent performance in the field of 3D medical image segmentation, especially in automated training and accurate segmentation of complex structures. …”
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Presenting a Multi-objective Mathematical Model for Smart Grids Considering Load Response Programs by Mohammad Hossein Tahari-Mehrjardi, Aliyeh Kazemi, Hamed Shakouri Ganjavi

“…In the scope of this research, we focused on the former, which relies on real-time pricing. …”
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„... nenábožnost nynějšího věku ...“ Proměny zbožnosti ve druhé polovině 19. století očima katolických kněží by Hana Stoklasová

“…During the “long” 19th century, in these periodicals, we could find more than twenty contributions concerning this problem directly and a lot of other ones dealing with this topic marginally, especially in connection with pastoral work, teaching religion at schools, raising children and young people in families, churchgoing, confessing, Holy Communion and celebrating religious holidays. …”
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Digital Health Solutions for Cardiovascular Disease Prevention: Systematic Review by Yihan Qi, Emma Mohamad, Arina Anis Azlan, Chenglin Zhang, Yilian Ma, Anqi Wu

“…MethodsFollowing PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we conducted a comprehensive search in Web of Science, Scopus, and PubMed to identify original English-language studies published between January 2000 and May 2024 that examined primary or secondary CVD prevention through digital solutions. …”
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The prognostic role of vasculoendothelial growth factor A in patients with ST-segment elevation acute myocardial infarction during 6-months follow-up period by N.P. Kopytsya, I.M. Кutya, I.V. Rodionova, Ya.V. Hilova

“…Materials and methods. We studied 135 patients with STEMI, 109 (80.7 %) men, 26 (19.3 %) women, average age (59.21 ± 8.92) years. …”
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Retrospective Comparison of 27-Gauge and 25-Gauge Microincision Vitrectomy Surgery with Silicone Oil for the Treatment of Primary Rhegmatogenous Retinal Detachment by Jie Li, Bo Zhao, Sanmei Liu, Fang Li, Wentao Dong, Jie Zhong

“…Fifty-eight eyes underwent 25G MIVS and 34 eyes underwent 27G MIVS. We analyzed the characteristics of the patients, surgical time, main clinical outcomes, and rate of complications. …”
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Use of cannabis during pregnancy and birth outcomes in an Aboriginal birth cohort: a cross-sectional, population-based study by Deirdre Gartland, Stephanie J Brown, Karen Glover, Fiona K Mensah, Cathy Leane, Jane Yelland, Jackie Ah Kit, Deanna Stuart-Butler, Donna Weetra, Jonathan Newbury

“…The reasons for disparities are complex and multifactorial. We aimed to assess the extent to which adverse birth outcomes are associated with maternal cannabis use and exposure to stressful events and social health issues during pregnancy.Design/setting Cross-sectional, population-based survey of women giving birth to Aboriginal babies in South Australia, July 2011–June 2013. …”
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IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M by Fernando Botelho, Anisha Dubey, Ehab A. Ayaub, Rex Park, Ashley Yip, Allison Humbles, Roland Kolbeck, Carl D. Richards

“…Since OSM induces IL-33 expression, we here test the IL-33 function in OSM-mediated lung inflammation using IL-33-/- mice. …”
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Dietary quality and adherence to dietary recommendations in Chinese patients with chronic kidney disease by Wenwei Ouyang, Wenwei Ouyang, Bingjie Xiao, Huifen Chen, Lizhe Fu, Fang Tang, Gaetano Marrone, Xusheng Liu, Yifan Wu, Yifan Wu, Juan Jesús Carrero

“…ObjectivesThere is a lack of data regarding the quality of the diet and the adherence to dietary guidelines of patients with non-dialysis-dependent CKD (NDD-CKD) in China.Design and methodsSingle-center cross-sectional study of 261 patients with CKD stages 3–5, who responded to 3-day dietary records and undertook 24-h urine samples along with clinical, laboratory, and anthropometric assessments. We compared their food intake with Chinese recommendations for CKD patients, assessed dietary quality through the Chinese Healthy Eating Index (CHEI), and calculated the contribution to energy intake by processed foods according to the NOVA classification.ResultsAverage energy intake was 30 ± 9 Kcal/kg/d, and 65% consumed less energy than recommended. …”
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Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes by Chloe Wong, Jun Yan Ng, Yang Yie Sio, Fook Tim Chew

“…This systematic review and meta-analysis aims to summarise the genetic loci found to be associated with skin ageing phenotypes by published genome-wide association studies (GWAS) and candidate gene studies. We also evaluated the overall association of loci via meta-analysis and identified the association patterns to explore potential biological pathways contributing to skin ageing. …”
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Inhibition of histone deacetylase in Arabidopsis root calli promotes de novo shoot organogenesis by Qinwei Pan, Ruirui Huang, Qiong Xiao, Xuting Wu, Baoxia Jian, Yanan Xiang, Lijun Gan, Zongrang Liu, Yi Li, Tingting Gu, Huawei Liu, Huawei Liu

“…De novo organogenesis from somatic cells to the entire plant represents a remarkable biological phenomenon, but the underlying regulatory mechanism, particularly at the epigenetic level, remains obscure. In this work, we demonstrate the important role of histone deacetylases (HDACs) in shoot organogenesis. …”
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Concentrated Solar Power and Photovoltaic Systems: A New Approach to Boost Sustainable Energy for All (Se4all) in Rwanda by Noel Hagumimana, Jishi Zheng, Godwin Norense Osarumwense Asemota, Jean De Dieu Niyonteze, Walter Nsengiyumva, Aphrodis Nduwamungu, Samuel Bimenyimana

“…Firstly, this paper summarizes the present status of CSP and PV systems in Rwanda. Secondly, we conducted a technoeconomic analysis for CSP and PV systems by considering their strengths, weaknesses, opportunities, and threats (SWOT). …”
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Walking for transport and all-cause mortality: a prospective cohort study of Australian community-dwelling older adults by Rory Wolfe, Neville Owen, Ben Beck, Yang Chen, David W Dunstan, Alice Owen, Robyn L Woods, Danijela Gasevic, Joanne Ryan, Shivangi Shah, Carlene Britt

“…Background Walking for transport may prolong survival in younger and middle-aged adults; however, evidence for older adults is scarce. We examined a prospective relationship between transport-related walking and all-cause mortality among adults aged 70 years and over.Methods Community-dwelling, apparently healthy older adults (n=11 539; mean age 75.1 years, 53.1% females), participants of the ASPirin in Reducing Events in the Elderly Longitudinal Study of Older Persons, reported their frequency of transport-related walking (never, rarely/once a week, more than once a week or every day). …”
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Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning by Areti Batzikosta, Despina Moraitou, Paschalis Steiropoulos, Georgia Papantoniou, Georgios A. Kougioumtzis, Ioanna-Giannoula Katsouri, Maria Sofologi, Magda Tsolaki

“…Sleep duration was measured using actigraphy. <b>Results:</b> We identified significant differences in various ToM tasks’ performance between the groups, particularly in non-literal speech tasks and third-order ToM stories. …”
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