Diagnostic Capability of Pattern Electroretinogram and Three Circumpapillary Retinal Nerve Fiber Layer Thickness Circle Diameter Scans in Glaucoma Suspects by Tirsi A, Tsai J, Abizadeh A, Kacaj D, Procyk O, Gliagias V, Leung N, Yang H, Park SC, Tello C

“…MagD showed the foremost diagnostic capability (AUC = 0.81), followed by Mag (AUC = 0.799) and MagD/Mag (AUC = 0.762).Conclusion: Global, superior, and inferior RNFLT in 3.5 and 4.1 mm diameters, and MagD performed best in discriminating GS from controls, suggesting that a larger scan of 4.1 mm may be equally useful in glaucoma diagnosis as the conventional 3.5 mm diameter. We recommend using PERG with OCT of 3.5 or 4.1 mm diameters for glaucoma suspect diagnosis.Keywords: glaucoma suspects, glaucoma, PERG, SD-OCT, RNFL…”
Get full text

Size distribution of extracellular vesicles in pretreatment ascites and plasma is correlated with primary treatment outcome in advanced high-grade serous carcinoma by Maruša Herzog, Ivan Verdenik, Borut Kobal, Katarina Černe

“…The correlations of the EV concentration and size distribution in ascites and plasma with treatment outcome, progression-free survival (PFS) and overall survival (OS) were analysed. We found a significant correlation between the EV size distribution in ascites and residual disease after primary cytoreductive surgery. …”
Get full text

Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation by Laura Kampe, Laura Kampe, Christian Melcher, Christian Melcher, Katrin Westphal, Katrin Westphal, Korbinian Brand, Niko Föger, Niko Föger, Kyeong-Hee Lee, Kyeong-Hee Lee

“…Employing adoptive transfer of different mature B cell subsets into lymphopenic Rag2-/- hosts, we here show that not only innate B cells – MZBs and B1a cells – but also adaptive FoBs were capable to differentiate into PCs and to produce IgM and class-switched IgA serum antibodies in a T cell-independent fashion during homeostatic proliferation. …”
Get full text

Artificial Liver Support Systems in Acute Liver Failure and Acute-on-Chronic Liver Failure: Systematic Review and Meta-Analysis by Robert S. Brown, Jr, MD, MPH, Robert A. Fisher, MD, FACS, TACC, Ram M. Subramanian, MD, MBA, Adam Griesemer, MD, Milene Fernandes, PharmD, MSc, William H. Thatcher, MS, Kathryn Stiede, BS, Michael Curtis, PhD

“…Eligible NBAL/BAL studies from PubMed/Embase searches were randomized controlled trials (RCTs) in adult patients with ALF/ACLF, greater than or equal to ten patients per group, reporting outcomes related to survival, adverse events, transplantation rate, and hepatic encephalopathy, and published in English from January 2000 to July 2023. Separately, we searched for studies evaluating W-ECLP in adult patients with ALF or ACLF published between January1990 and July 2023. …”
Get full text

Metal–Salen‐Incorporated conjugated microporous polymers as robust artificial leaves for solar‐driven reduction of atmospheric CO2 with H2O by Wei Wu, Zhaocen Dong, Mantao Chen, Waner Li, An Liao, Qing Liu, Yachao Zhang, Zhixin Zhou, Chao Zeng, Xuezhong Gong, Chunhui Dai

“…Abstract Exploration of efficient and stable photocatalysts to mimic natural leaves for the conversion of atmospheric CO2 into hydrocarbons utilizing solar light is very important but remains a major challenge. Herein, we report the design of four novel metal–salen‐incorporated conjugated microporous polymers as robust artificial leaves for photoreduction of atmospheric CO2 with gaseous water. …”
Get full text

Deleterious effects of thermal and water stresses on life history and physiology: a case study on woodlouse by Depeux, Charlotte, Branger, Angèle, Moulignier, Théo, Moreau, Jérôme, Lemaître, Jean-François, Dechaume-Moncharmont, François-Xavier, Laverre, Tiffany, Paulhac, Hélène, Gaillard, Jean-Michel, Beltran-Bech, Sophie

“…We tested independently the influences of increasing temperature and decreasing moisture on life history and physiological traits in the arthropod  Armadillidium vulgare. …”
Get full text

Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes by Yunus E. Dogan, Yunus E. Dogan, Yunus E. Dogan, Niharika Bala, Niharika Bala, Erika S. Galban, Erika S. Galban, Russell L. Lewis, Nancy D. Denslow, Sihong Song, Abdel A. Alli, Abdel A. Alli

“…IntroductionRecombinant alpha-1 antitrypsin (AAT) therapy has been shown to have beneficial effects to mitigate the progression of various diseases. Here, we hypothesized that administration of pharmaceutical-grade human AAT (hAAT) is effective in mitigating hypertension induced by salt-loading in juvenile mice by reducing the concentration of diacylglycerols (DAGs) and activity of protein kinase C (PKC) in the kidney.MethodsFour-week old 129Sv mice were salt-loaded to induce hypertension and then administered hAAT or vehicle.ResultsAdministration of hAAT was found to significantly reduce high blood pressure in both the active and inactive cycles of the 129Sv hypertensive mice. …”
Get full text

Prediction of implant failure risk due to periprosthetic femoral fracture after primary elective total hip arthroplasty: a simplified and validated model based on 154,519 total hip... by M. A. Alagha, Justin Cobb, Alexander D. Liddle, Henrik Malchau, Ola Rolfson, Maziar Mohaddes

“…Our study aimed to develop and validate predictive models of periprosthetic femoral fracture (PPFF) necessitating revision and reoperation after elective total hip arthroplasty (THA). Methods: We included 154,519 primary elective THAs from the Swedish Arthroplasty Register (SAR), encompassing 21 patient-, surgical-, and implant-specific features, for model derivation and validation in predicting 30-day, 60-day, 90-day, and one-year revision and reoperation due to PPFF. …”
Get full text

A LASSO-derived clinical score to predict severe acute kidney injury in the cardiac surgery recovery unit: a large retrospective cohort study using the MIMIC database by Qi Guo, Jingjing Huang, Yuewei Li, Hongwei Li, Jingfeng Wang, Yong Xie, Tucheng Huang, Wanbing He, Wenyu Lv, Jieping Huang, Yangxin Chen

“…Objectives We aimed to develop an effective tool for predicting severe acute kidney injury (AKI) in patients admitted to the cardiac surgery recovery unit (CSRU).Design A retrospective cohort study.Setting Data were extracted from the Medical Information Mart for Intensive Care (MIMIC)-III database, consisting of critically ill participants between 2001 and 2012 in the USA.Participants A total of 6271 patients admitted to the CSRU were enrolled from the MIMIC-III database.Primary and secondary outcome Stages 2–3 AKI.Result As identified by least absolute shrinkage and selection operator (LASSO) and logistic regression, risk factors for AKI included age, sex, weight, respiratory rate, systolic blood pressure, diastolic blood pressure, central venous pressure, urine output, partial pressure of oxygen, sedative use, furosemide use, atrial fibrillation, congestive heart failure and left heart catheterisation, all of which were used to establish a clinical score. …”
Get full text

Maternal smoking during infancy increases the risk of allergic diseases in children: a nationwide longitudinal survey in Japan by Kenji Shigehara, Naomi Matsumoto, Mitsuru Tsuge, Kazuhiro Uda, Yukie Saito, Masato Yashiro, Takashi Yorifuji, Masanori Ikeda, Hirokazu Tsukahara

“…Methods Using Japanese national longitudinal survey data (n = 38,444) for newborns born between May 10 and 24, 2010, we assessed parental smoking habits when their children were 6 months old and investigated the association with the development of allergic diseases until the age of 5.5 years. …”
Get full text

Allelic variants for Waxy genes in common wheat lines bred at the Lukyanenko National Grain Center by E. R. Davoyan, L. A. Bespalova, R. O. Davoyan, E. V. Agaeva, G. I. Bukreeva, Yu. S. Zubanova, D. S. Mikov, D. M. Boldakov

“…The presence of three null alleles (Wx-A1b + Wx-B1b + Wx-D1b), which corresponded to fully Wx wheat, was found in one line. We selected 37 lines that combined the presence of the Wx-B1e allele with the Wx-A1b and Wx-D1b null alleles. …”
Get full text

Bactericidal/Permeability-Increasing Protein (BPI), a Novel Antimicrobial Molecule in Human Breast Milk with Immune Potential by Alba Soledad Aquino-Domínguez, María de los Ángeles Romero-Tlalolini, Honorio Torres-Aguilar, Juan Carlos Rodríguez-Alba, Lucia Lourdes Martínez-Martínez, Francisco Javier Sánchez-Peña, María Teresa Hernández-Huerta, Jesús Elizarrarás-Rivas, Gabriela Tapia-Pastrana, Melisa Gómez-López, Elsa Cruz-Martínez, Uriel Eleazar Hernández-Corrales, Sergio Roberto Aguilar-Ruiz

“…Using BPI at concentrations typical of colostrum, we observed that it reduces the growth of two distinct <i>E. coli</i> strains, enhances the uptake of these bacteria by monocytes, and suppresses the secretion of the proinflammatory cytokine interleukin (IL)-8 in infected intestinal cells. …”
Get full text

Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume-to-Platelet Count Ratio as Biomarkers in Critically Ill and Inj... by Dragan Djordjevic, Goran Rondovic, Maja Surbatovic, Ivan Stanojevic, Ivo Udovicic, Tamara Andjelic, Snjezana Zeba, Snezana Milosavljevic, Nikola Stankovic, Dzihan Abazovic, Jasna Jevdjic, Danilo Vojvodic

“…NLR and MPV were very good independent predictors of lethal outcome. For the first time, we demonstrate that nature of bacteremia influences MPV/PC, MLR, and PLR. …”
Get full text

The association of individual cognition and social environment of smoking with autonomy over tobacco: A survey from rural China by Jiaoyan Li, Yimei Zhu, Zhihong Zhang, Deyu Cai, Huinan Han, Jing Liang, Fang Wang, Beizhu Ye, Yuan Liang

“…Methods Data were collected from 1389 participants, aged ≥15 years, by face-toface interviews from June 2018 to November 2019 in central China. We assessed autonomy over tobacco using the Autonomy Over Smoking Scale (AUTOS), including Withdrawal Symptoms (WS), Psychological Dependence (PD) and Cueinduced Cravings (CC), and examined factors of individual cognition and social environment, as well as covariates, including demographic characteristics, health status, and smoking behavior. …”
Get full text

Rotation symmetry mismatch and interlayer hybridization in MoS2-black phosphorus van der Waals heterostructures by Zailan Zhang, Alberto Zobelli, Chaofeng Gao, Yingchun Cheng, Jiuxiang Zhang, Jonathan Caillaux, Lipeng Qiu, Songlin Li, Mattia Cattelan, Viktor Kandyba, Alexei Barinov, Mustapha Zaghrioui, Azzedine Bendounan, Jean-Pascal Rueff, Weiyan Qi, Luca Perfetti, Evangelos Papalazarou, Marino Marsi, Zhesheng Chen

“…In addition, the creation of flat bands at the valence band maximum (VBM) of TMDs is still an open challenge. In this work, we investigate the electronic structure of monolayer MoS2-black phosphorus heterojunctions with a combined experimental and theoretical approach. …”
Get full text

Difference of clinical characteristics in patients with reinfection and primary infection variants of SARS-CoV-2: a retrospective study in China by Chao-Chao Qiu, Xiao-Qing Lin, Qiang Zhang, Ya-Long Chen, Xiao-Qiao Su, Ming-Ying Zhang, Le-Fei Zhu, Zhi-Ruo Lin, Fang Cheng, Shang-Ren Xie, Ji-Chan Shi, Xian-Gao Jiang

“…Abstract Background The number of patients experiencing re-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is progressively increasing. In this study, we aimed to explore the differences in clinical characteristics between patients with primary infection and those with re-infection of SARS-CoV-2. …”
Get full text

Children with autoimmune hepatitis receiving standard-of-care therapy demonstrate long-term obesity and linear growth delay by Or Steg Saban, Shannon M. Vandriel, Syeda Aiman Fatima, Celine Bourdon, Amrita Mundh, Vicky L. Ng, Simon C. Ling, Robert H.J. Bandsma, Binita M. Kamath

“…Standard-of-care therapy in children with autoimmune hepatitis (AIH) includes induction with prednisone 1–2 mg/kg daily with gradual weaning of the dose. We aimed to test the hypothesis that children with AIH receiving standard-of-care treatment have altered growth trajectories. …”
Get full text

The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages by Duaa Abuarqoub, Nouf N. Mahmoud, Rand Zaza, Rana Abu-Dahab, Enam A. Khalil, Dima A. Sabbah

“…For GNR treatment groups, IL-1β, TNF-α, and IL-12p70 were significantly decreased (p<0.00005, p<0.05, p<0.00005). Conclusion. We can conclude that our nanocomplex is a potent effector that prevents tumoral progression by activating three main immunological strategies: switching the surface expression profile of the activated macrophages into a proinflammatory M1-like phenotype, downregulating the expression of proinflammatory cytokines, and upregulating the expression level of anti-inflammatory cytokines.…”
Get full text

A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virus by Min Lin, Yifan Yin, Xiaomeng Zhao, Chen Wang, Xueqing Zhu, Letao Zhan, Li Chen, Siling Wang, Xue Lin, Jun Zhang, Ningshao Xia, Zizheng Zheng

“…These vaccines employ the pre-fusion F (pre-F) protein as the immunogen. In this study, we explored an mRNA vaccine based on a modified pre-F protein called LC2DM-lipid nanoparticle (LC2DM-LNP). …”
Get full text

Cerebellum abnormalities in vascular mild cognitive impairment with depression symptom patients: A multimodal magnetic resonance imaging study by Yirong Chen, Liling Chen, Liyu Hu, Jianjun Wang, Jinhuan Zhang, Hanqing Lyu, Jinping Xu, Jianxiang Chen, Haibo Yu

“…Objective: This study aimed to investigates the gray matter volume and functional alterations in the cerebellum of svMCI patients, with and without depression symptoms, and their correlation with cognitive and depressive symptoms. Methods: We enrolled 16 svMCI patients with depression symptoms (svMCI+D), 15 without (svMCI-D), and 12 normal controls (NC). …”
Get full text