Comparison of Different Disease-Specific Health-Related Quality of Life Measurements in Patients with Long-Term Noninvasive Ventilation by Toru Oga, Hiroyuki Taniguchi, Hideo Kita, Tomomasa Tsuboi, Keisuke Tomii, Morihide Ando, Eiji Kojima, Hiromi Tomioka, Yoshio Taguchi, Yusuke Kaji, Ryoji Maekura, Toru Hiraga, Naoki Sakai, Tomoki Kimura, Michiaki Mishima, Wolfram Windisch, Kazuo Chin

“…Two disease-specific questionnaires have been developed to assess health-related quality of life (HRQL) in patients with chronic respiratory failure: the Severe Respiratory Insufficiency (SRI) Questionnaire and the Maugeri Respiratory Failure (MRF) Questionnaire. We aimed to compare the characteristics of the SRI, MRF-26, and St. …”
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Lipoprotein-Associated Phospholipase A2 Mass Level Is Increased in Elderly Subjects with Type 2 Diabetes Mellitus by J. Fortunato, V. Bláha, J. Bis, J. Št’ásek, C. Andrýs, J. Vojáček, B. Jurašková, L. Sobotka, P. Polanský, M. Brtko

“…Lipoprotein-associated phospholipase A2 (Lp-PLA2) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA2 mass between them. …”
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Identification of Potential Vectors and Detection of Rift Valley Fever Virus in Mosquitoes Collected Before and During the 2022 Outbreak in Rwanda by Isidore Nsengimana, Emmanuel Hakizimana, Jackie Mupfasoni, Jean Nepomuscene Hakizimana, Augustino A. Chengula, Christopher J. Kasanga, Gillian Eastwood

“…Information on vector species with a role in RVFV eco-epidemiology in Rwanda is scarce. Here we sought to identify potential mosquito vectors of RVFV in Rwanda, their distribution and abundance, as well as their infection status. …”
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Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation by Ai-Li Xu, Zheng Shen, Shi-Hao Wang, Hai-Yun Luan, Yong Xu, Ze-Chun Kang, Zi-Qi Liao, Jie Liu, Xiao-Lei Duan, Wei-Hua Bian, Hui Sun, Xin Xie

“…These effects of DOX were partially alleviated by rAAV9 expressing shRNA-ATG5 and deteriorated by rAAV9-ATG5. We demonstrated that genetic ATG5 knockdown or autophagy inhibition by chemical inhibitors increased GATA4 protein expression, which was reduced by ATG5 overexpression or autophagy activator in vitro and in vivo, suggesting that ATG5-mediated autophagy promoted GATA4 degradation. …”
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Post-harvest conservation practices, related insect pests of stored pearl millet (Pennisetum glaucum (L) R. Br.), and their management in northern Benin by Tayé Obédatou Alagbe, Yeyinou Laura Estelle Loko, Innocent Djègbè, Julien Gandjala, Dieudonné Gavoedo, Manuele Tamò

“…In order to develop an integrated pest management strategy, we documented farmers’ post-harvest conservation practices, perceptions, and management of storage insect pests. …”
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Comparison of 1D and 3D volume measurement techniques in NF2-associated vestibular schwannoma monitoring by Isabel Gugel, Nuran Aboutaha, Bianca Pfluegler, Ulrike Ernemann, Martin Ulrich Schuhmann, Marcos Tatagiba, Florian Grimm

“…VS were clinically followed every 6 months with cranial, thin-sliced (< 3 mm) MRI. We retrospectively reviewed and used T1-weighted post-contrast enhanced (gadolinium) images for both SVA and linear measurements. 3D-SVA was performed manually or combined with semiautomated segmentation by using axial planes. …”
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Immune responses of cattle vaccinated by various routes with Mycobacterium bovis Bacillus Calmette-Guérin (BCG) by Mitchell V. Palmer, Soyoun Hwang, Carly Kanipe, Ellie J. Putz, Luis Guilherme Virgilio Fernandes, Anna Didkowska, Paola M. Boggiatto

“…Similar to oral lyophilized BCG vaccinated animals, we did not observe any significant increases in the frequency of CD8 and γδ T cell proliferative and IFN-γ responses following SQ or oral liquid vaccinated animals. …”
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Modifiable factors for irritable bowel syndrome: evidence from Mendelian randomisation approach by Jinling Tang, Zhirong Yang, Shanshan Wu, Feng Sha, Tengfei Lin, Di Liu, Meiling Cao, Yiwen Jiang, Weijie Cao, Fuxiao Li

“…Background The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while accounting for the impact of unobserved confounders and coexisting disorders.Methods Genetic correlation and Mendelian randomisation (MR) analyses were integrated to identify potential modifiable factors and coexisting disorders linked to IBS. …”
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Effects of ultra-processed foods on the liver: insights from gut microbiome and metabolomics studies in rats by Liping Shi, Zhuoyuan Li, Xiaojun Ma, Junru Wang, Yueping Wu, Yongbin Zhu, Yanrong Wang, Yue Yang, Minxiu Luo, Jiangping Li, Xian Sun, Xian Sun, Shulan He, Shulan He

“…Nevertheless, there is limited empirical evidence regarding the impact of UPF, which are typical combination of processed foods, on liver health through alterations in gut microbiota and metabolic processes. We aim to examine the potential impact of UPF on liver health and to explore the role of gut microbiota and metabolites.MethodsThis study used Sprague–Dawley rats to mimic modern UPF diets for 90 days. …”
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Contrast quality control for segmentation task based on deep learning models—Application to stroke lesion in CT imaging by Juliette Moreau, Juliette Moreau, Laura Mechtouff, Laura Mechtouff, David Rousseau, Omer Faruk Eker, Omer Faruk Eker, Yves Berthezene, Yves Berthezene, Tae-Hee Cho, Tae-Hee Cho, Carole Frindel, Carole Frindel

“…Despite advances in acquisition technologies and segmentation architectures, one of the main challenges of subacute stroke lesion segmentation in computed tomography (CT) imaging is image contrast.MethodsTo address this issue, we propose a method to assess the contrast quality of an image dataset with a ML trained model for segmentation. …”
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The Regulatory Effect of Se-Cd Interaction on Tea Plants (<i>Camellia sinensis</i> (L.) O. Kuntze) Under Cadmium Stress by Yanyun Sun, Yueling Zhao, Hongyu Zhou, Faxing Li, Yuanyuan Wang, Xiao Du

“…This study utilized annual Fuding Dabaicha cuttings as the experimental subject, employing a nutrient solution cultivation technique to establish three distinct treatments: (1) CK: reference processing; (2) Cd: 20 mg/L CdSO₄ nutrient solution culture; (3) Cd + Se: 20 mg/L CdSO₄ + 1.5 mg/L Na₂SeO₃ nutrient solution culture. We measured and analyzed the electrolyte permeability, proline content, malondialdehyde (MDA) content, antioxidant-related indicators, photosynthesis-related indicators, Cd content in various organs, and transmission electron microscopy images depicting the distribution of Cd and Se elements within different organs of tea plants under these treatments after 30 days of processing, studying the regulatory role of selenium on the resistance mechanism of tea plants (<i>Camellia sinensis</i>) under cadmium stress. …”
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Genome‐Wide Analysis of the APETALA2/Ethylene‐Responsive Factor Gene Family in Carthamus tinctorius L. by Zheng‐Wei Tan, Dan‐Dan Lu, Yong‐Liang Yu, Lei Li, Lan‐Jie Xu, Wei Dong, Chun‐Ming Li, Qing Yang, Hui‐Zhen Liang

“…This study aimed to elucidate the roles of these transcription factors in plant growth, metabolic regulation, and environmental adaptation in safflower, providing foundational information and theoretical support for genetic improvement and stress resilience research in this crop. In this study, we identified and characterized the AP2/ERF family genes in safflower through a comprehensive genomic analysis. …”
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Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats by Elin Strand, Vegard Lysne, Mari Lausund Grinna, Pavol Bohov, Asbjørn Svardal, Ottar Nygård, Rolf K. Berge, Bodil Bjørndal

“…Moreover, both PPARα and PPARγ activation lowered plasma TAG and phospholipids, most likely through effects on liver and adipose tissue, respectively. In future studies we aim to reveal whether similar patterns can be found through diet-induced activation of specific pathways.…”
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Perbandingan Aplikasi Algoritma Kernel K-Means pada Graf Bipartit dan K-Means pada Matriks Dokumen- Istilah dalam Dataset Penelitian Covid-19 RISTEKBRIN by Budi Nugroho

“…The kernel matrix value that represents the similarity score between documents is used as input for the kernel k-means clustering algorithm, which provides the results of mapping research topics. As comparison, we applied original k-means algorithm on the document-term matrix of the dataset. …”
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Effect of Kind and Dosage of Enrichment Materials on the Nutritional Quality of Rotifers Especially n3-HUFA by Muhammad Agus Suprayudi

“…Rotifer enriched with EPA-TAG has a more complete of essential fatty acid profile compared to other enrichment materials due to their contained both of EPA and DHA. We conclude that rotifer enriched with EPA-TAG as enrichment material showed the best nutritional quality of rotifers from the stand point of essential fatty acid. …”
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Wnt signaling as a translational target in rheumatoid and psoriatic arthritis by Gloria Riitano, Francesca Spinelli, Valeria Manganelli, Daniela Caissutti, Antonella Capozzi, Cristina Garufi, Tina Garofalo, Roberta Misasi, Maurizio Sorice, Fabrizio Conti, Agostina Longo, Cristiano Alessandri

“…Recent evidence described the involvement of the Wnt pathway in the pathogenesis of these diseases. Thus, we aimed to analyze some components of Wnt signaling, i.e. …”
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Are noise and air pollution related to the incidence of dementia? A cohort study in London, England by Derek G Cook, Frank J Kelly, Iain M Carey, H Ross Anderson, David P Strachan, Richard W Atkinson, Sean D Beevers, David Dajnak, John Gulliver

“…Associations were more consistent for Alzheimer’s disease than vascular dementia.Conclusions We have found evidence of a positive association between residential levels of air pollution across London and being diagnosed with dementia, which is unexplained by known confounding factors.…”
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THE SOLANUM TUBEROSUM KNOWLEDGE BASE: THE SECTION ON MOLECULAR-GENETIC REGULATION OF METABOLIC PATHWAYS by T. V. Ivanisenko, O. V. Saik, P. S. Demenkov, V. K. Khlestkin, E. K. Khlestkina, N A. Kolchanov, V. А. Ivanisenko

“…However, in the literature, there is no data on the application of intellectual methods of automatic knowledge extraction from publications on agricultural crops, such as potato. Previously we have developed a pilot version of the SOLANUM TUBEROSUM knowledge base. …”
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Indoor and Ambient Air Pollution in Chennai, India during COVID-19 Lockdown: An Affordable Sensors Study by Naveen Puttaswamy, V. Sreekanth, Ajay Pillarisetti, Adithi R. Upadhya, Sudhakar Saidam, Balachandar Veerappan, Krishnendu Mukhopadhyay, Sankar Sambandam, Ronak Sutaria, Kalpana Balakrishnan

“…Due to COVID-19 related lockdowns, some TAPHE-2 activities were delayed; however, continuous indoor and outdoor air quality data were collected in and around Chennai, India. We report here the impact of graded COVID-19 lockdown on indoor particulate matter (PM2.5 and PM10) levels based on calibrated data from affordable real-time PM sensors called atmos™ and ambient PM levels from publicly available regulatory monitors. …”
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Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation by Donghyun Kang, Jeeyeon Lee, Geunho Yook, Sehan Jeong, Jungkwon Shin, Mi-Sung Kim, Yi-Jun Kim, Hyeryeon Jung, Jinsung Ahn, Tae Woo Kim, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Won Ho Yang, Yong-ho Lee, Jin Won Cho, Eugene C. Yi, Chanhee Kang, Jin-Hong Kim

“…Abstract UDP-GlcNAc serves as a building block for glycosaminoglycan (GAG) chains in cartilage proteoglycans and simultaneously acts as a substrate for O-GlcNAcylation. Here, we show that transporters for UDP-GlcNAc to the endoplasmic reticulum (ER) and Golgi are significantly downregulated in osteoarthritic cartilage, leading to increased cytosolic UDP-GlcNAc and O-GlcNAcylation in chondrocytes. …”
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