Estimation of Abbreviated Cyclosporine A Area under the Concentration-Time Curve in Allogenic Stem Cell Transplantation after Oral Administration by Hanene ELjebari, Nadia Ben Fradj, Issam Salouage, Emna Gaies, Sameh Trabelsi, Nadia Jebabli, Mohamed Lakhal, Tarek Ben Othman, Anis Kouz

“…Optimal LSSs equations which limited to those utilizing three timed concentrations taken within 4 hours post-dose developed from ASCT recipient's patients yielded a low bias <5% ranged from 1.27% to 2.68% and good precision <15% ranged from 9.60% and 11.02%. We propose an LSS model with equation AUC0–12 h=0.82+2.766×𝐶2+3.409×𝐶4 for a practical reason. …”
Get full text

Knowledge, Attitudes, and Practices of HIV-Positive Adolescents Related to HIV/AIDS Prevention in Abidjan (Côte d’Ivoire) by Azagoh-Kouadio Richard, Yeboua Kossonou Roland, Yao Kouassi Christian, Kouassi-Kouadio Amenan Cécile, Aholi Jean Michel, Cissé Lacina, Asse Kouadio Vincent

“…The level of knowledge, attitude, and practice of HIV-positive adolescents regarding HIV/AIDS transmission is insufficient. We suggest setting up a therapeutic HIV/AIDS education program for these adolescents.…”
Get full text

Prediction of OCT contours of short-term response to anti-VEGF treatment for diabetic macular edema using generative adversarial networks by Xueying Yang, Fabao Xu, Han Yu, Zhongwen Li, Xuechen Yu, Zhiwen Li, Li Zhang, Jie Liu, Shaopeng Wang, Shaopeng Liu, Jiaming Hong, Jianqiao Li

“…Generative adversarial networks (GANs) have demonstrated remarkably in forecasting prognosis of diseases, yet their performance is still constrained by the limited availability of real-world data and suboptimal image quality, which subsequently impacts the model's outputs. We endeavor to employ preoperative images along with postoperative OCT contours annotated and extracted via LabelMe and OpenCV to train the model in generating postoperative contours of critical OCT structures instead of previous whole retinal morphology, considerably alleviating the difficulty of output phase and diminishing the requisite quantity of training datasets. …”
Get full text

Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus by Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin

“…The role of EETs in synaptic function in the central nervous system is still largely unknown. We found that pharmacological inhibition of sEH to stabilize endogenous EETs and exogenous 14,15-EET significantly increased the field excitatory postsynaptic potential (fEPSP) response in the CA1 area of the hippocampus, while additionally enhancing high-frequency stimulation- (HFS-) induced long-term potentiation (LTP) and forskolin- (FSK-) induced LTP. sEH inhibitor (sEHI) N-[1-(oxopropyl)-4-piperidinyl]-N’-[4-(trifluoromethoxy) phenyl)-urea (TPPU) and exogenous 14,15-EET increased HFS-LTP, which could be blocked by an N-methyl-D-aspartate (NMDA) receptor subunit NR2B antagonist. …”
Get full text

Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…In the metformin group, the adjusted HRs for the second (1.5–4 years) and third (≥4 years) tertiles of metformin treatment duration were 0.52 and 0.14, respectively, compared with the first tertile (<1.5 years). We also found significant trends of lower HRs (all p-value for trend <0.05) with increasing total and average doses. …”
Get full text

Novel application of an imageless robotic system in simultaneous unicompartmental knee arthroplasty and anterior cruciate ligament reconstruction by Joshua Yeuk Shun Tran, Rex Wang-Fung Mak, Kevin Ki-Wai Ho, Jonathan Patrick Ng, Cham Kit Wong, Gloria Yan-Ting Lam, Tsz Lung Choi, Michael Tim-Yun Ong, Patrick Shu-Hang Yung

“…The integration of robotic assistance offers enhanced precision in surgical procedures, addressing both medial compartment OA and ACL insufficiency in a single operation.We present a case involving a 47-year-old patient with medial compartment osteoarthritis and complete ACL rupture. …”
Get full text

The immunoregulatory effects of scoparone on immune-mediated inflammatory diseases by Feifei Qiu, Jingru Lin, Xiaofei Huang, Bin Yang, Weihui Lu, Weihui Lu, Zhenhua Dai, Zhenhua Dai

“…., but also provides a comprehensive summary of its therapeutic effects on hepatic diseases, including non-alcoholic steatohepatitis, fulminant hepatic failure and hepatic fibrosis. In this review, we also include the broad impacts of SCO on intracellular signaling pathways, such as TLR4/Myd88/NFκB, TGFβR/Smad3, Nrf2/P38, JAK2/STAT3 and JNK/Sab/SHP-1 etc. …”
Get full text

Best practice portals in health promotion and disease prevention: approaches, definitions, and intervention evaluation criteria by Maria Piotrowicz, Małgorzata Gajewska, Katarzyna Lewtak, Katarzyna Lewtak, Ewa Urban, Anna Rutyna, Aneta Nitsch-Osuch

“…., Selection of the issue addressed by the practice, Description of a particular element of the practice, Theoretical foundation, or Evaluation/Effectiveness. However, we identified both similarities and differences in the adopted terms (names of criteria) and their definitions. …”
Get full text

Network pharmacology-based screening of the active ingredients and mechanisms of Cymbaria daurica against diabetes mellitus by Ruyu Shi, Dongxue Chen, Mingyue Ji, Baochang Zhou, Ziyan Zhang, Chunhong Zhang, Minhui Li

“…Based on data mining techniques involving topological parameters, gene ontology, and pathway enrichment, we established a compound-target, protein-protein interaction, and target-pathway network to identify central targets and pathways. …”
Get full text

Experimental prosopis management practices and grassland restoration in three Eastern African countries by René Eschen, Ketema Bekele, Yohana Jumanne, Staline Kibet, Fernadis Makale, John Richard Mbwambo, Berhanu Megersa, Mahamood Mijay, Francis Moyo, Linus Munishi, Mickfanaka Mwihomeke, Winnie Nunda, Moses Nyangito, Arne Witt, Urs Schaffner

“…In Eastern Africa, prosopis (Prosopis julifora) has invaded large areas of savanna and grassland, thereby affecting, among other things, fodder and water for livestock, access to dry season grazing lands and ultimately pastoral livelihoods. We tested three prosopis treatments (manual uprooting and cut stump and basal bark herbicide application) in combination with three incremental restoration interventions (divots, divots + mulching, divots + mulching + grass seed sowing). …”
Get full text

Effect of High, Medium, and Low Molecular Weight Hyaluronan on Inflammation and Oxidative Stress in an In Vitro Model of Human Nasal Epithelial Cells by Giusy Daniela Albano, Anna Bonanno, Luca Cavalieri, Eleonora Ingrassia, Caterina Di Sano, Liboria Siena, Loredana Riccobono, Rosalia Gagliardo, Mirella Profita

“…The aim of this study was to investigate the pro- or anti-inflammatory biologic function of HA at different molecular weight in an in vitro model of nasal inflammation IL-17A mediated. We evaluated the ERK1/2 and IκBα phosphorylation, NF-κB signal pathway activation, ROS production, IL-8 and NOX-4 protein, and mRNA levels, in nasal epithelial cells RPMI 2650 stimulated with recombinant human (rh) IL-17A. …”
Get full text

Rapid Screening and Quantitative Determination of Illegal Phosphodiesterase Type 5 Inhibitors (PDE-5i) in Herbal Dietary Supplements by Thi Oanh Nguyen, Cao-Son Tran, Thi Thu Hang Do, Thi Minh Hoa Nguyen, Quang-Dong Bui, Cao-Tien Bui, Hong-Ngoc Nguyen, Thu-Hien Dang, Viet-Chien Dinh, Thi Anh Huong Nguyen, Thi Hong Hao Le

“…Liquid chromatography coupled with high-resolution mass spectrometry has become one of the most effective methods to identify and measure PDE-5i concentration. In this research, we focused on (i) developing and validating an effective screening and quantitation method for more than 53 PDE-5i in ingredients and supplementary products using LC-Q-Exactive after a simple sample extraction and (ii) assessing PDE-5i content in natural-based supplementary products available in Vietnam market. …”
Get full text

Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit by Arthur Kwizera, Mary Nabukenya, Agaba Peter, Lameck Semogerere, Emmanuel Ayebale, Catherine Katabira, Samuel Kizito, Cecilia Nantume, Ian Clarke, Jane Nakibuuka

“…There are no data from low-income country ICUs. We sought to identify clinical characteristics and survival outcomes among HIV patients in a low-income country ICU. …”
Get full text

Perceived wildfire risk and past experiences with wildfire smoke influence public support for prescribed burning in the western conterminous United States by Christopher J Rogers, Celeste Beck, Rima Habre, Jo Kay Ghosh

“…In weighted logistic regression models, we evaluated associations between predictor variables (past experiences with smoke, wildfire risk perception) and support for prescribed burns in general or near a respondent’s neighborhood, adjusting for age, race/ethnicity, gender, education, household income, and wildland urban interface status. …”
Get full text

Nurses' Sleep Quality and Its Influencing Factors During the First Explosive COVID‐19 Outbreak in Zhejiang, China, After the Relaxation of Epidemic Prevention and Control Measures:... by Lifen Lu, Di Sheng, Yaling Zhu, Xiaowei Xia, Guanghui Chen, Jiali Liang, Xiulan Shen, Gui Zheng

“…The participants were recruited using convenience sampling, and the survey was distributed via the WeChat platform. The survey included a general information form; the Self‐Rating Scale of Sleep (SRSS); the Depression, Anxiety, and Stress Scale‐21 (DASS‐21); the Perceived Social Support Scale (PSSS); and the Brief Resilience Scale (BRS). …”
Get full text

Wind Field Retrieval From Co-Polarized SAR Imagery Without External Wind Direction Assistance by Xianen Wei, Jinsong Chong, Yawei Zhao, Lijie Diao, Xuan Jin

“…Four cases were initially conducted to demonstrate the effectiveness of the proposed method in both downwind and upwind scenarios. Furthermore, we compared wind field retrieved from 54 co-polarized SAR images with European Center for Medium-Range Weather Forecasts (ECMWF), ASCAT, and buoy data. …”
Get full text

Home-based strength and balance exercises for fall prevention among older individuals of advanced age: a randomized controlled single-blind study by Jian Zhou, Bo Liu, Jian-fang Xu, Fu-bai-hui Wang, Hui Ye, Jin-Ping Duan, Xin-wen Cui

“…The test group (n=63) performed strength and balance exercises facilitated by sports video training (≥ 3 sessions a week, ≥ 30 minutes per session), while the control group (n=61) maintained their daily routines. We conducted a comprehensive geriatric assessment (self-care ability, muscle strength, mobility, cognition, and psychological status) at baseline and 12 months later and dynamic posture mapping for balance and gait.Results The test group had a decreased risk of falls compared to the control group (25.4%vs.44.3%, respectively; RR = 0.747; 95% CI: 0.551–0.975; p = 0.027). …”
Get full text

Tear film lipid layer thickness and blink dynamics in patients with blepharospasm by Ji-Sun Paik, Min Jeong Kwon, Ga Hee Nam, Kyungdo Han, Woong-Joo Whang, Ho Sik Hwang, Suk-Woo Yang, Hyun-Seung Kim, Kyung Sun Na, Won-Kyung Cho

“…Abstract Background This study investigates the effect of botulinum toxin A on lipid layer thickness (LLT) and blink dynamics in patients with benign essential blepharospasm (BEB) compared to dry eye disease (DED) patients. Methods We reviewed the medical records of patients with dry eye disease (DED) and BEB treated with botulinum toxin A (BoT A) injections. …”
Get full text

Prevalence of mortality caused by injuries at Livingstone University Hospital, Zambia. A retrospective cross-sectional study. by Lukundo Siame, Malan Malumani, Chiyeñu O R Kaseya, Sergiy Ivashchenko, Leah Nombwende, Sepiso K Masenga, Benson M Hamooya, Michelo Haluuma Miyoba

“…Therefore, our aim was to estimate the proportion of deaths caused by injuries at Livingstone University Teaching Hospital, a tertiary hospital located in Zambia's southern province.<h4>Methods</h4>We conducted a retrospective cross-sectional study from June 22, 2020, to June 22, 2021, among 956 individuals from 1 month old (29 days of age) to 100 years. …”
Get full text

GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma by Shujie Wang, Tongjia Zhang, Yue Zhou, Zitao Jiao, Kejia Lu, Xinyi Liu, Wei Jiang, Zhe Yang, Hui Li, Xiaowei Zhang

“…However, as secreted proteins, the role of their extracellular secretions in HCC progression remains unclear. Here, we demonstrated that the expression of extracellular GP73 was positively correlated with extracellular PKM2. …”
Get full text