Therapeutic drug monitoring and neutralizing anti-drug antibody detection to optimize TNF-alpha inhibitor treatment for uveitis by Howard C. Chen, Jenny Shunyakova, Amit K. Reddy, Srujay Pandiri, Lynn Hassman

“…Patients who have a suboptimal response to this treatment may suffer from recurrent inflammation and vision loss. Here, we investigated the use of therapeutic drug monitoring and neutralizing anti-drug antibody detection as a strategy to optimize tumor necrosis factor (TNF)-alpha inhibitor treatment in patients who have a suboptimal response to the initial dosing of adalimumab.MethodRetrospective cohort study performed in two tertiary referral uveitis services in the United States between 2015 to 2023. …”
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Changes in sexual activities and risky sexual behaviors during the COVID-19 pandemic: A systematic review by Alinaghi Seyed Seyed Ahmad, Karimi Amirali, Mirzapour Pegah, Qaderi Kowsar, Mohammadi Parsa, Salehi Mohammad Amin, Tantuoyir Marcarious M., Arjmand Ghazal, Shahmohamadi Elnaz, Mahalleh Mehrdad, Kianzad Shaghayegh, Pashaei Ava, Khodaei Sepideh, Afsahi Amir Masoud, Mehraeen Esmaeil

“…However, there is a lack of comprehensive systematic reviews in this field. We aimed to systematically review the changes in sexual activities and risky sexual behaviors during the COVID-19 pandemic. …”
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Giant pit craters on the modern seafloor above magma-induced hydrothermal vent complexes of Scotia Sea, offshore Antarctica by L. Somoza, K. M. Andreassen, A. Plaza-Faverola, T. Medialdea, J. Gafeira, F. J. González, G. R. Dickens

“…The concept mostly derives from studies of a few ancient sedimentary basins with numerous hydrothermal vent complexes (HTVCs) where craters appear to have formed across large areas of the seafloor at the same time, but good examples remain rare in strata younger than the Early Eocene. We present geophysical data documenting at least 150 large (km-scale) craters on the modern seafloor across ∼148,000 km2 of Scan Basin in the southern Scotia Sea, a remote region offshore Antarctica. …”
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Retrospective analysis of 300 microbial cell-free DNA sequencing results in routine blood stream infection diagnostics by Claudio Neidhöfer, Claudio Neidhöfer, Niklas Klein, Niklas Klein, Aylin Yürüktümen, Tessa Hattenhauer, Rebekka Mispelbaum, Christian Bode, Tobias A. W. Holderried, Achim Hoerauf, Marijo Parčina

“…Noscendo GmbH (Duisburg, Germany) has developed the CE/IVD pipeline DISQVER for clinical metagenomics testing based on cell-free DNA (cfDNA) from blood samples to address this issue.MethodsWe conducted a retrospective study to evaluate the diagnostic utility of this methodological setup in improving treatment decisions since it was introduced into our clinical setting. …”
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Atypical Metastases from Prostate Cancer: Alpha-Methylacyl-Coenzyme A Racemase (AMACR) as a Potential Molecular Target in Prostate-Specific Membrane Antigen-Negative Prostate Adeno... by Ilham Badrane, Angelo Castello, Matteo Brunelli, Corrado Cittanti, Sara Adamantiadis, Ilaria Bagni, Noemi Mindicini, Federica Lancia, Massimo Castellani, Licia Uccelli, Mirco Bartolomei, Luca Urso

“…In some cases, PCa patients may present atypical sites of metastases, with uncommon appearance at PET imaging with different radiotracers. We present the case of a patient with biochemical recurrence of PCa (ISUP Grade Group IV; PSA 4.7 ng/mL) showing atypical sites of metastases (the testis and multiple lung nodules) with absent PSMA expression and high [¹⁸F]FDG avidity. …”
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CD-1 mice females recognize male reproductive success via volatile organic compounds in urine by A. S. Khotskina, E. L. Zavjalov, E. P. Shnayder, L. A. Gerlinskaya, S. O. Maslennikova, D. V. Petrovskii, M. N. Baldin, A. L. Makas, V. M. Gruznov, M. L. Troshkov, M. P. Moshkin

“…Using a rapid headspace GC/MS analysis, we have found volatile organic compounds (VOCs) in male urine that correlated with female behavior. …”
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Association between serum uric acid levels and left ventricular hypertrophy based on electrocardiographic findings: a sex-specific analysis across cardiometabolic diseases by Anwar Ahmed Salim, Shin Kawasoe, Takuro Kubozono, Satoko Ojima, Satoshi Yamaguchi, Koji Higuchi, Yoshiyuki Ikeda, Hironori Miyahara, Koichi Tokushige, Mitsuru Ohishi

“…Abstract The association between serum uric acid (UA) levels and left ventricular hypertrophy (LVH) remains unclear. We aimed to investigate this association using electrocardiographic findings. …”
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An In-depth Investigation of the Primordial Cluster Pair ASCC 19 and ASCC 21 by Qingshun Hu, Yuting Li, Mingfeng Qin, Chenglong Lv, Yang Pan, Yangping Luo, Shuo Ma

“…Utilizing Gaia data from the literature, we report a new young (∼8.9 Myr) cluster pair, ASCC 19 and ASCC 21, located near the Orion star-forming complex. …”
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Soluble CD14 Enhances the Response of Periodontal Ligament Stem Cells to Toll-Like Receptor 2 Agonists by Christian Behm, Alice Blufstein, Johannes Gahn, Nazanin Noroozkhan, Andreas Moritz, Xiaohui Rausch-Fan, Oleh Andrukhov

“…Several studies also show that sCD14 enhances the responsiveness of different immune cells to TLR-2, but such effect in hPDLSCs has not been studied so far. In the present study, we investigated for the first time the potential effect of sCD14 on the hPDLSC response to two different TLR-2 agonists, in vitro. …”
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Prevalence, associated factors, management and outcomes of hypokalaemia in hospitalised patients at a South African tertiary centre by C Burton, M-Y Chothia, A Zemlin, S Lahri

“…To evaluate the prevalence, associated factors, management and risk factors for all-cause mortality in hospitalised adult patients with hypokalaemia at a tertiary centre in SA. Methods. We conducted a retrospective cohort study of all adult patients admitted with, or who developed, hypokalaemia during hospitalisation in 2019. …”
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The difference between young and older ducks: Amino acid, free fatty acid, nucleotide compositions and breast muscle proteome by Tiantian Gu, Mingcai Duan, Li Chen, Yong Tian, Wenwu Xu, Tao Zeng, Lizhi Lu

“…Proteomic approach was further performed to analyze the difference of breast muscle between young and older ducks in protein level. We found that 496 differentially expressed proteins (DEPs) were screened. …”
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The protoplast two-way fusions and fusant characteristics of Antrodia cinnamomea and Cordyceps militaris by Wei-Kuang Lai, Yang-Chang Wu, Tai-Sheng Yeh, Chun-Ren Hsieh, Yi-Hong Tsai, Chien-Kei Wei, Chi-Ying Li, Ying-Chen Lu, Fang-Rong Chang

“…On the other hand, when A. cinnamomea and C. militaris were treated with heat and UV oppositely using similar experiments, the fusion rate was (9.70 ± 0.68) × 10-5 fusants/mL, and the new fusants were abbreviated as Cm-Ac. We selected each of two best-growing fused colonies Ac-Cm-1, Ac-Cm-2, Cm-Ac-1, and Cm-Ac-2, together with parental A. cinnamomea and C. militaris, and studied their morphology, growth antagonism tests, and genetic relationships by 18S rRNA sequencing. …”
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Epidemiology, Disease Severity and Outcome of Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Viruses Coinfection Seen at Egypt Integrated Acute Respiratory Infection... by Manal Fahim, Wael H. Roshdy, Ola Deghedy, Reham Kamel, Amel Naguib, Shymaa Showky, Nancy Elguindy, Mohammad Abdel Fattah, Salma Afifi, Amira Mohsen, Amr Kandeel, Khaled Abdelghaffar

“…An increase in the number of patients with coinfection was recently reported. We studied epidemiology, severity, and outcome of patients with SARS-CoV-2/Flu coinfection seen at Egypt’s integrated acute respiratory infections surveillance to better describe disease impact and guide effective preventive measures. …”
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Effects of Different Microplastics on Methane Production and Microbial Community Structure in Anaerobic Digestion of Cattle Manure by Mengjiao Zhang, Congxu Zhao, Tian Yuan, Qing Wang, Qiuxian Zhang, Shuangdui Yan, Xiaohong Guo, Yanzhuan Cao, Hongyan Cheng

“…However, there is limited research on the effects of different types of MPs on the anaerobic digestion (AD) performance of livestock and poultry manure. Herein, we investigated the impact of four types of MPs (polyvinyl chloride (PVC), polypropylene (PP), polyethylene (PE), and polyhydroxyalkanoate (PHA)) on AD performance using cattle manure as a substrate. …”
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Mesenchymal Stromal Cells from Osteoarthritic Synovium Are a Distinct Population Compared to Their Bone-Marrow Counterparts regarding Surface Marker Distribution and Immunomodulati... by Sebastien Hagmann, Claudia Rimmele, Florin Bucur, Thomas Dreher, Felix Zeifang, Babak Moradi, Tobias Gotterbarm

“…Based on previous studies in an allogeneic T-cell coculture model, we aimed at further determining the role of synovial MSCs in OA pathogenesis. …”
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Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme by A. J. McCarthy, S. M. O’Reilly, J. Shanley, R. Geraghty, E. J. Ryan, G. Cullen, K. Sheahan

“…Our aim was to characterize the clinicopathological features of a series of SSL/Ps & TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps & TSAs. Methods. We identified all colorectal serrated polyps between 01/01/2004 and 31/05/2016, by searching the laboratory information system for all cases assigned a “serrated adenoma” SNOMED code. …”
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Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-bli... by Mandana Kashaki, Arash Mohazzab, Mohammad Radgoudarzi, Arash Bordbar, Sama Dabbagh

“…However, trials reported the association with unwanted effects. Thus, in this study, we assess another agent in the same family, Macitentan. …”
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Real-world clinical utility of Xpert MTB/RIF Ultra in the assessment of tuberculosis in a low-TB-incidence, high-resource setting by Robert C Free, Manish Pareek, Hemu Patel, Pranabashis Haldar, Jee Whang Kim, Richard Halliwell, Nelun Perera, Gerrit Woltmann, Alison Glimour-Caunt, Raman Verma

“…Background Tuberculosis (TB) diagnosis in the UK is impacted by delay and suboptimal culture-based microbiological confirmation rates due to the high prevalence of paucibacillary disease. We examine the real-world clinical utility of Xpert MTB/RIF Ultra (Xpert-Ultra) as a diagnostic test and biomarker of transmissible infection in a UK TB service.Methods Clinical specimens from suspected TB cases triple tested (smear microscopy, mycobacterial culture and Xpert-Ultra) at University Hospitals of Leicester NHS Trust (1 March 2018–28 February 2019) were retrospectively analysed. …”
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Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retro... by Ha Young Jo, Hyun Ji Jang, Chong Kun Cheon, Ju Young Yoon, Sukdong Yoo, Jung Hyun Lee, Jeong Eun Lee, Ye Jin Kim, Sejin Kim, Hyun-Ji Kim, Im Jeong Choi, Min Jung Kwak

“…Abstract Background This study aimed to compare the response to growth hormone (GH) therapy according to the presence of GH deficiency (GHD) in short-stature children born small for gestational age (SGA) in Korea and to present appropriate GH dose criteria. Methods We evaluated 27 children born SGA with short stature and GHD (GHD group) and 23 without GHD (non-GHD group) registered in the LG Growth Study. …”
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CONTRIBUTION TO THE GEOCHEMICAL STUDY OF KANZI AND MVUANGU PHOSPHATE ROCKS IN THE LEMBA OIL SUB-BASIN OF CENTRAL CONGO by Deko Oyema Bruno, Emmanuel Kazinguvu Atibu, Dan Mandjumba Yenor, Dominique Wetshondo Osomba, Loma Wonga Mathias, John Pote Wembonyama

“…Open to oil and mining exploration, we brought back phosphate rock samples from the field, which were analyzed by the Commissariat Général à l'Energie Atomique (CGEA) using the ED- XRF Xepos III spectrometer. …”
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