Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices by Asmaa M. Zahran, Helal F. Hetta, Zeinab Albadry M. Zahran, Alaa Rashad, Amal Rayan, Dalia O. Mohamed, Zeinab Ahmed Abd Elhameed, Salah M. Khallaf, Gaber El-Saber Batiha, Yasir Waheed, Khalid Muhammad, Hanaa Nafady-Hego

“…The current study is aimed at providing the predictive and prognostic role of Mo-MDSCs in advanced non-small-cell lung cancer (NSCLC) in relation to different hematologic indices. Methods. We recruited 40 cases of advanced NSCLC, stages III and IV, aged>18–<70 years old, and eligible to receive chemotherapy with or without radiotherapy, along with 20 healthy controls of comparable age and sex; after diagnosis and staging of patients, blood samples were collected for flow cytometric detection of Mo-MDSCs. …”
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Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia by Shasha Wu, Tailian Xue, Yilin Li, Weikang Chen, Yan Ren

“…Methods In this study, we recruited 26 EOS patients and 27 healthy controls (HCs), and microarray data were collected. …”
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Higher Long‐Term Visit‐to‐Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population by Xinyu Zhao, Ying Hui, Jing Li, Xian‐Quan Shi, Shuohua Chen, Han Lv, Shouling Wu, Zhenchang Wang

“…ABSTRACT Long‐term visit‐to‐visit blood pressure (BP) variability is linked to various diseases, but its impact on cerebral small vessel disease (cSVD) burden, and its features remains uncertain. We analyzed 1284 participants from the Kailuan cohort (2006–2022). …”
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Cost-Benefit Analysis of Genetic Testing as a Prenatal Diagnostic Tool for Thalassemia: A Single-Center Study From Central Thailand by Malasai K, Jittikoon J, Udomsinprasert W, Talungchit P, Youngkong S, Sangroongruangsri S, Mahasirimongkol S, Chaikledkaew U

“…Kwandao Malasai,1,2 Jiraphun Jittikoon,3 Wanvisa Udomsinprasert,3 Pattarawalai Talungchit,4,5 Sitaporn Youngkong,5,6 Sermsiri Sangroongruangsri,6 Surakameth Mahasirimongkol,7 Usa Chaikledkaew5,6 1Social, Economic and Administrative Pharmacy (SEAP) Graduate Program, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Social Pharmacy Research Unit, Faculty of Pharmacy, Mahasarakham University, Maha Sarakham, Thailand; 3Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 4Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 5Mahidol University Health Technology Assessment (MUHTA) Graduate Program, Mahidol University, Bangkok, Thailand; 6Social and Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 7Information and Communication Technology Center, Office of the Permanent Secretary, Ministry of Public Health, Nonthaburi, ThailandCorrespondence: Usa Chaikledkaew, Social and Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhaya Road, Rachathewi, Phayathai, Bangkok, 10400, Thailand, Email usa.chi@mahidol.ac.thPurpose: This study aimed to evaluate the costs and benefits of genetic testing, specifically mutation analysis and prenatal diagnostic testing, for the confirmation of thalassemia in at-risk pregnancies in Thailand, providing crucial insights to inform public health policy decision-making.Patients and Methods: We analyzed the costs and benefits of following standard screening guidelines, which included a sequence of tests such as mean corpuscular volume (MCV)/mean corpuscular hemoglobin (MCH) with dichlorophenol indophenol precipitation (DCIP), hemoglobin (Hb) typing, genetic testing, and amniocentesis. …”
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W poszukiwaniu nowych funkcji słuchu muzycznego by Alicja Kozłowska-Lewna

“…Udowodniono, że amuzji towarzyszą: zaburzenia motoryczno-czuciowe, zaburzenia pamięci, zaburzenia organiczne (mniejsza ilość substancji szarej, mniejsza ilość substancji białej, słabsza sieć połączeń synaptycznych, słabsza sieć połączeń między półkulami, słabiej rozwinięta kora słuchowa). We współczesnych badaniach nad słuchem absolutnym coraz częściej zwraca się uwagę na związek tej zdolności z plastycznością mózgu oraz towarzyszącymi mu umiejętnościami poznawczymi. …”
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Universality of universal health coverage: A scoping review. by Aklilu Endalamaw, Charles F Gilks, Fentie Ambaw, Yibeltal Assefa

“…There is dearth of evidence about the extent of the universality of UHC in terms of types of health services, its integrated definition (dimensions) and tracer indicators utilized in the measurement of UHC. Therefore, we mapped the existing literature to assess universality of UHC and summarize the challenges towards UHC.…”
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Dynamic changes in soil erosion and challenges to grain productivity in the black soil region of Northeast China by Jiawang Zhang, Ming Wang, Kai Liu, Zhan’ao Zhao

“…By calculating water and wind erosion modulus between 1991 and 2020, we investigated the temporal trend, spatial aggregation, and driving and interacting factors in subregion. …”
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Association of iron status indicators with thyroid hormone concentrations during pregnancy: a systematic review and meta-analysis by Mohammadamin Parsaei, Mohadese Dashtkoohi, Elahe Amirkhalili, Mohammadreza Chashmyazdan, Tim I. M. Korevaar, Tim I. M. Korevaar, Pantea Nazeri

“…This review examines the relationship between various indicators of maternal iron status and thyroid function during pregnancy.MethodsWe conducted a systematic search in MEDLINE/PubMed, Web of Science, Embase, Scopus, and the Cochrane Library for studies published up to 2023. …”
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Validation of a Novel Immunoline Assay for Patient Stratification according to Virulence of the Infecting Helicobacter pylori Strain and Eradication Status by Luca Formichella, Laura Romberg, Hannelore Meyer, Christian Bolz, Michael Vieth, Michael Geppert, Gereon Göttner, Christina Nölting, Wolfgang Schepp, Arne Schneider, Kurt Ulm, Petra Wolf, Ingrid Lisanne Holster, Ernst J. Kuipers, Bernd Birkner, Erwin Soutschek, Markus Gerhard

“…The presence of H. pylori virulence factors, such as CagA and VacA, has been associated with disease development, but assessment of virulence factor presence requires gastric biopsies. Here, we evaluate the H. pylori recomLine test for risk stratification of infected patients by comparing the test score and immune recognition of type I or type II strains defined by the virulence factors CagA, VacA, GroEL, UreA, HcpC, and gGT with patient’s disease status according to histology. …”
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Is the benefit of sequential 5-fluorouracil and daylight photodynamic therapy versus daylight photodynamic therapy alone sustained over time? – 12-month follow-up of a randomized c... by Stine Regin Wiegell, Gabriella Fredman, Flemming Andersen, Peter Bjerring, Uwe Paasch, Merete Haedersdal

“…Background: Since recurrences and new AKs commonly are observed after treatment long-term effects of field-directed therapies for AKs are crucial. Thus, we evaluated the 6- and 12-month efficacy and satisfaction of sequential topical 5-fluorouracil (5-FU) and daylight PDT (dPDT) with dPDT alone. …”
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Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer by Angelica Nogueira Rodrigues, Andreza Karine de Barros Almeida Souto, Diocésio Alves Pinto de Andrade, Larissa Müller Gomes, Sandra Satie Koide, Renata de Godoy e Silva, Bruno Batista de Souza, Juliana Doblas Massaro, Andréia Cristina de Melo, Andrea Morais Borges, Camila Giro, Carlos Augusto Vasconcelos de Andrade, Cesar Martins da Costa, Daniel Luiz Gimenes, Eduardo Caminha Bandeira de Mello, Fernanda Cesar de Oliveira, Frederico Müller de Toledo Lima, Gabriel Lima Lopes, Gustavo de Oliveira Bretas, Gustavo Guerra Jacob, Herika Lucia da Costa Silva, Juliana Ferrari Notaro, Lara Ladislau Alves, Marcos Veloso Moitinho, Mirian Cristina da Silva, Roberto Abramoff, Thais Amaral da Cunha Rauber, Rodrigo Dienstmann, Fernanda Christtanini Koyama

“…In this scenario, access to a validated diagnostic HRD test can optimize treatment selection and increase the effectiveness of the intervention.ObjectiveTo technically validate an in-house next-generation sequencing (NGS)-based HRD test, QIAseq Custom Panel (QIAGEN), by comparing it with the reference assay, MyChoice CDx® Plus HRD (Myriad Genetics), which is used in routine care.MethodsThis is a prospective cohort study conducted at the Oncoclínicas Precision Medicine (OCPM) laboratory using samples from patients with advanced or relapsed platinum-sensitive ovarian cancer eligible for HRD testing in a diagnostic clinical setting at Oncoclínicas and Co. We assessed the performance of the in-house test (GS Focus HRD) using Cohen’s kappa statistic to measure agreement with the gold standard assay (MyChoice® HRD Plus CDx) in HRD status classification, along with other accuracy metrics.ResultsIn total, 41 samples were analyzed (20 HRD-positive, 19 HRD-negative, and 2 inconclusive results with the MyChoice® HRD Plus CDx assay). …”
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LEGAL FRAMEWORK OF ENVIRONMENTAL LAW FOR AGRICULTURAL PRODUCTION IN POLAND by Monika Król

“…Okres harmonizacji polskiego ustawodawstwa z prawem EU oraz pierwsze lata członkostwa Polski we Wspólnocie przyniosły bardzo dynamiczny rozwój regulacji prawnej odnoszącej się do ochrony środowiska w działalności rolniczej. …”
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Facility capacity and provider knowledge for cholera surveillance and diarrhoea case management in cholera hotspots in the Democratic Republic of Congo – a mixed-methods study by Mattias Schedwin, Aurélie Bisumba Furaha, Kelly Elimian, Carina King, Espoir Bwenge Malembaka, Marc K Yambayamba, Thorkild Tylleskär, Tobias Alfvén, Simone E Carter, Placide Welo Okitayemba, Mala Ali Mapatano, Helena Hildenwall

“…Objective Describe facility capacity and provider knowledge for case management of diarrhoea and cholera surveillance in cholera hotspots in the Democratic Republic of Congo (DRC) among health facilities, drug shops, and traditional health practitioners. Methods We conducted a sequential exploratory mixed-method study, using focus group discussions, facility audits, and provider knowledge questionnaires during September and October 2022 in North Kivu and Tanganyika provinces, Eastern DRC. …”
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Novel Algorithm for Surgical Management of Cervical Ossification of Posterior Longitudinal Ligament: A Retrospective Cohort Study With 2‐Year Follow‐Up by Zhuyun Cai, Hui Kang, Lei Quan, Yilong Ren, Meng Fang, Yixuan Tan, Haochen Zhang, Xuhui Zhou, Jun Ma

“…Through this analysis, we obtained on their clinical outcomes and complications. …”
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Preliminary Results of the Adoption and Application of the Integrated Comprehensive Care Bundle Care Program When Treating Patients with Chronic Obstructive Pulmonary Disease by Jason R. Guertin, James M. Bowen, Carolyn Gosse, Gord Blackhouse, Daria J. O’Reilly, Emanuel Baltaga, Gerard Cox, Donna Johnson, Brandi Le Blanc, Jane Loncke, Stewart Pugsley, Ravi Sivakumaran, Laura Wheatley, Kevin Smith, Jean-Eric Tarride

“…The aim of this analysis was to evaluate the performance of the ICC program within patients admitted with chronic pulmonary obstructive disease (COPD). Methods. We conducted a retrospective observational cohort study comparing ICC patients to non-ICC patients admitted to St. …”
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A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery by Elina E. Mansurova, Andrey A. Maslennikov, Anna P. Lyubina, Alexandra D. Voloshina, Irek R. Nizameev, Marsil K. Kadirov, Anzhela A. Mikhailova, Polina V. Mikshina, Albina Y. Ziganshina, Igor S. Antipin

“…This approach will ensure timely delivery of the antidote and minimize side effects associated with uncontrolled drug release. Here, we describe the creation of a new smart system that serves as a carrier for delivering an antidote (i.e., atropine) and functions as a synthetic esterase to hydrolyze acetylcholine. …”
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Dual-functional passivation on highly-efficient air-processed FAPbI₃ perovskite solar cells fabricated under high humidity without auxiliary equipment by Bo-Tau Liu, His-Sheng Su, I-Ru Chen, Rong-Ho Lee, Yi-Fang Su, Kai-Ting Sun, Shoaib Siddique

“…To date, few studies have reported a strategy for fabricating highly efficient FAPbI3 perovskite solar cells (PSCs) under humid conditions. In this study, we are the first to demonstrate the fabrication of FAPbI3 PSCs using a one-step solution deposition method in a relative humidity of 70 % without the need for auxiliary processes or equipment, achieved through the addition of a highly volatile solvent and the incorporation of methacrylic acid (MAA) into the perovskite layer. …”
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International expert consensus on micronutrient supplement use during the early life course by Irene Cetin, Roland Devlieger, Erika Isolauri, Rima Obeid, Francesca Parisi, Stefan Pilz, Lenie van Rossem, Maternal Nutrition Delphi Study Group, Régine Steegers-Theunissen

“…This Delphi study aimed to investigate the level of expert consensus on maternal nutrition and micronutrient needs during preconception, pregnancy and lactation. Methods We conducted a two-round web-based Delphi survey on various topics including general approaches to diet and supplement use, and existing guidelines. …”
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How does the concentration of spatial allocation of urban construction land across cities affect carbon emission intensity in China? by Hui Yang, Cheng Chen, Jingye Li, Min Li, Stefan Sieber, Kaisheng Long

“…To bridge this knowledge gap, we investigated the impact of CSA on CEI in 282 cities in China by using multi-source panel data (e.g., urban carbon emissions data, construction land area data, and socio-economic data) from 2005 to 2020 and applying econometric models: fixed effect model, mediating effect model, and spatial Durbin model. …”
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An organic matter database (OMD): consolidating global residue data from agriculture, fisheries, forestry and related industries by G. Weldesemayat Sileshi, G. Weldesemayat Sileshi, E. Barrios, J. Lehmann, J. Lehmann, F. N. Tubiello

“…Due to the lack of a uniform methodology, conversion coefficients and data on competing uses across countries, it was difficult to accurately estimate the quantities of all agricultural, fishery and forestry residues and by-products. Therefore, we strongly recommend investment in the inventory of agricultural, fishery and forestry residues as well as by-products and wastes at the national and sub-national levels for use in a circular bio-economy.…”
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