Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model by Alaa AM. Osman, Dávid Laczkó, Máté Vágvölgyi, Adrienn Seres-Bokor, Anita Sztojkov-Ivanov, Kata Kira Kemény, Attila Hunyadi, Eszter Ducza

“…Based on our findings, we are supposed to show new preventive possibilities for overweight-induced chronic progressive diseases.…”
Get full text

Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands by Bárbara Marques, Diogo M. Engrácia, João Franco Machado, Jaime A. S. Coelho, Filipa Mendes, Tânia S. Morais

“…Results: In this study, we report the synthesis and characterization of two new ruthenium(II) complexes with the general formula [Ru(η⁵-C₅H₄CCH₃=R)(PPh₃)(bipy)][CF₃SO₃], where R represents a nicotinic acid derivative (NNHCO(py-3-yl)) (1) or an isoniazid derivative (NNHCO(py-4-yl)) (2). …”
Get full text

Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes by Manabu Midorikawa, Hiroaki Suzuki, Yasuhiro Suzuki, Kazuyoshi Yamauchi, Hiroyuki Sato, Kiyotaka Nemoto, Yoko Sugano, Hitoshi Iwasaki, Motohiro Sekiya, Shigeru Yatoh, Naoya Yahagi, Yasushi Hada, Tetsuaki Arai, Hitoshi Shimano

“…Aim. We investigated the relationship between cognitive function and olfactory and physical functions in middle-aged persons with and without type 2 diabetes (T2D) to examine the potential of olfactory and physical functions as biomarkers for early cognitive impairment. …”
Get full text

How much water vapour does the Tibetan Plateau release into the atmosphere? by C. Zheng, L. Jia, G. Hu, M. Menenti, M. Menenti, J. Timmermans

“…However, the performance of ET products over the TP has not been adequately assessed, and there is still considerable uncertainty in the magnitude and spatial variability in the water vapour released from the TP into the atmosphere. In this study, we evaluated 22 ET products in the TP against in situ observations and basin-scale water balance estimations. …”
Get full text

Metastatic Uterine Leiomyosarcoma in the Upper Buccal Gingiva Misdiagnosed as an Epulis by Andrea Cassoni, Valentina Terenzi, Davina Bartoli, Oriana Rajabtork Zadeh, Andrea Battisti, Mario Pagnoni, Davide Conte, Alessandro Lembo, Sandro Bosco, Francesco Alesini, Valentino Valentini

“…In case of metastases, surgical excision can be performed considering extent of disease, number and type of distant lesions, disease free interval from the initial diagnosis to the time of metastases, and expected life span. We illustrate a case of uterine LMS metastasis in the upper buccal gingiva that occurred during chemotherapy in a 63-year-old woman that underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy for a diagnosis of LMS staged as pT2bN0 and that developed lung metastases eight months after primary treatment. …”
Get full text

Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering by Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

“…Following a 30-day implantation period, we also evaluate histological parameters. The findings revealed that the incorporation of a 20 (μg/ml) dose of Insulin into Alg-Cs 3D-printed scaffolds significantly enhanced the expression of these markers, indicating improved chondrogenic potential for cartilage regeneration. …”
Get full text

Post-stroke outcome prediction based on lesion-derived features by Maedeh Khalilian, Olivier Godefroy, Martine Roussel, Amir Mousavi, Ardalan Aarabi

“…This study investigated whether simulated measures of network disruption, derived from structural lesions, could predict functional impairments in stroke patients. We extracted four lesion-derived feature sets: lesion masks, probabilistic structural disconnection maps (pSDMs), structural and indirectly estimated functional connectivity strengths between brain regions, and topological properties of functional and structural brain networks to predict motor, executive, and processing speed deficits in 340 S patients, employing PCA-based ridge regression with leave-one-out cross validation.The findings revealed that both structural disconnection map patterns and lesion masks were strong predictors of functional deficits. …”
Get full text

Phα1β interaction with the Kv11.1 potassium channel in HEK293 cells transfected with the human ERG channel by João B. Calixto, Adara Aurea dos Santos, Juliano Ferreira, Alessandra Hubner Souza, Célio José de Castro Junior, Marcus Vinicius Gomez

“…Methods: To assess hERG potassium channel inhibition, we utilized the FLIPR® Potassium Assay, a commercially available kit. …”
Get full text

Yoruba Epistemology, Art, Language and the Universe of Meanings: A Meta-Analysis by Michael O. Afolayan

“…The attempt provides the data in which we are able to draw conclusions on a variety of issues: One, it highlights the futility of translation of a cultural theme at any level; two, it speaks to the frustration inherent in the imposition of one language over the art and culture of another; and three, it demonstrates the need for a cultural understanding between the originator of a text and the translator as precluding any reasonable translation and/or interpretation of the text. …”
Get full text

High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells by Hong Feng, Junling Gu, Fang Gou, Wei Huang, Chenlin Gao, Guo Chen, Yang Long, Xueqin Zhou, Maojun Yang, Shuang Liu, Shishi Lü, Qiaoyan Luo, Yong Xu

“…This study observed the expression of NLRP3 inflammasome signaling stimulated by high glucose, lipopolysaccharide, and reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine in glomerular mesangial cells, aiming to elucidate the mechanism by which the NLRP3 inflammasome signaling pathway may contribute to diabetic nephropathy. We found that the expression of thioredoxin-interacting protein (TXNIP), NLRP3, and IL-1β was observed by immunohistochemistry in vivo. …”
Get full text

Knowledge, attitude, and reasons for non-uptake of human papilloma virus vaccination among nursing students by Soni Chauhan, Surya Kant Tiwari, Vishal Dubey, Pragya Tripathi, Priyanka Pandey, Anuj Singh, Narendra Pal Singh Choudhary

“…The Human papillomavirus (HPV) vaccination, a vital preventive measure, has suboptimal uptake among nursing students. We aimed to assess the level of knowledge, attitudes, willingness, and reasons for non-uptake of HPV vaccination among nursing students. …”
Get full text

Influence of gestational weight gain on baby’s birth weight in Addis Ababa, Central Ethiopia: a follow-up study by Andrew Hayen, Yadeta Dessie, Maralyn Foureur, Fekede Asefa, Allison Cummins

“…Data were collected using a structured questionnaire and medical record reviews. We conducted a multivariable linear regression analysis to determine the independent effect of gestational weight on birth weight.Results Of the 395 women enrolled in the study, the participants’ pregnancy outcome was available for 329 (83.3%). …”
Get full text

Development of a cell-penetrating peptide-based nanocomplex for long-term delivery of intact mitochondrial DNA into epithelial cells by Kyrie Wilson, Charles Holjencin, Hwaran Lee, Balasubramaniam Annamalai, Masaaki Ishii, Jeremy L. Gilbert, Andrew Jakymiw, Bärbel Rohrer

“…Gene therapy approaches for mitochondrial DNA (mtDNA)-associated damage/diseases have thus far been limited, and despite advancements in single gene therapy for mtDNA mutations and progress in mitochondrial transplantation, no method exists for restoring the entire mtDNA molecule in a clinically translatable manner. Here, we present for the first time a strategy to deliver an exogenous, fully intact, and healthy mtDNA template into cells to correct endogenous mtDNA mutations and deletions, with the potential to be developed into an efficient pan-therapy for inherited and/or acquired mtDNA disorders. …”
Get full text

Metabolites induced by citrus tristeza virus and ‘Candidatus Liberibacter asiaticus’ influence the feeding behavior of Diaphorina citri: an electrical penetration graph and LC–MS/M... by Jingtian Zhang, Fengchun Xia, Yuhe Li, Yangyang Liu, Fengnian Wu, Xiaoling Deng, Meirong Xu

“…L. asiaticus, CLas) and citrus tristeza virus (CTV). We recently found that both CLas and CTV could be acquired and retained by the Asian citrus psyllid Diaphorina citri. …”
Get full text

Randomized Comparison of Terumo® Coated Slender™ versus Terumo® Noncoated Traditional Sheath during Radial Angiography or Percutaneous Coronary Intervention by Birthe Sindberg, Christel Gry Aagren Nielsen, Marianne Hestbjerg Poulsen, Martin Bøhme Rasmussen, Steen Carstensen, Troels Thim, Lars Jakobsen, Jacob Thorsted Sørensen, Benedicte Haastrup, Hanne Maare Søndergaard, Michael Mæng, Christian Juhl Terkelsen

“…Radial artery occlusion (RAO) following the procedure is also a potential risk. We evaluate whether the design of the sheath has any impact on these variables. …”
Get full text

New Evidence for <i>Cotinus coggygria</i> Scop. Extracts Application in Gastrointestinal Ailments by Dejan Stojković, Nina Dragičević, Marija Ivanov, Nevena Gajović, Milena Jurišević, Ivan Jovanović, Marina Tomović, Jelena Živković

“…Background/Objectives: <i>Cotinus coggygria</i> Scop. is traditionally used for treatment of various gastrointestinal ailments. In this study, we investigated the phytochemical profile and biological activities of leaves, bark and flowers extracts of <i>C. coggygria.…”
Get full text

Dutch Validation of the Self-Evaluation of Negative Symptoms Scale (SNS) by Tim van Brouwershaven, Anika Poppe, Gerdina Hendrika Maria Pijnenborg, André Aleman, Nynke Boonstra, Shiral Gangadin, Sonia Dollfus, Wim Veling, Stynke Castelein, Jan Alexander de Vos, Edith Liemburg, PHAMOUS-researchers, Lisette van der Meer

“…Self-rating scales, like the Self-Evaluation of Negative Symptoms (SNS), could complement observer ratings by adding information from the patient’s perspective. Here, we aim to evaluate the psychometric properties of the Dutch translation of the SNS and the relationship between the SNS and functional outcomes. …”
Get full text

Codeveloping a community-based, peer-led psychosocial support intervention to reduce stigma and depression among people with tuberculosis and their households in Indonesia: a mixed... by Ahmad Fuady, Mariska Anindhita, Matsna Hanifah, Arieska Malia Novia Putri, Artasya Karnasih, Feranindhya Agiananda, Finny Fitry Yani, Marinda Asiah Nuril Haya, Trevino Aristaskus Pakasi, Tom Wingfield

“…This study aimed to engage with multisectoral stakeholders in Indonesia to co-develop a peer-led, community-based psychosocial intervention that is replicable, acceptable, and sustainable. We used a participatory action design and engaged key national, multisectoral stakeholders to ensure that the intervention co-design was relevant and appropriate to the TB health system and the sociocultural context of Indonesia. …”
Get full text

Impact of Low PM2.5 Exposure on Asthma Admission: Age-Specific Differences and Evidence from a Low-Pollution Environment in China by Xiaolong Fan, Chen Yang, Jinsheng Chen, Yuping Chen, Gaojie Chen, Ziyi Lin, Zecong Li, Yanting Chen, Liqian Yin, Lingling Xu, Naian Xiao

“…Using a time-stratified case-crossover study design, we examined the association between PM2.5 concentration and asthma admissions from January 2019 to November 2021. …”
Get full text

MiR-125b-5p ameliorates ox-LDL-induced vascular endothelial cell dysfunction by negatively regulating TNFSF4/TLR4/NF-κB signaling by Wenshuai He, Limin Zhao, Pengfei Wang, Maojia Ren, Yunfei Han

“…Results Our investigation revealed that exposure to ox-LDL led to a downregulation in miR-125b-5p, while upregulating the expression of tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4), TLR4, p-p65 and p-IkBa in HUVECs in a dose-dependent manner. We confirmed TNFSF4 as a direct target of miR-125b-5p. …”
Get full text