Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection by Matilde Otero-Losada, Hernán Gómez Llambí, Graciela Ottaviano, Gabriel Cao, Angélica Müller, Francisco Azzato, Giuseppe Ambrosio, José Milei

“…We report experimental evidence confirming renal histopathology, proinflammatory mediators, and oxidative metabolism induced by cola drinking. …”
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Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells by Angela P. Bastidas-Coral, Astrid D. Bakker, Behrouz Zandieh-Doulabi, Cornelis J. Kleverlaan, Nathalie Bravenboer, Tim Forouzanfar, Jenneke Klein-Nulend

“…The effect of pro- and anti-inflammatory cytokines on osteogenic differentiation of mesenchymal stem cells is controversial. Here, we investigated the effect of the proinflammatory cytokines TNF-α, IL-6, IL-8, and IL-17F and the anti-inflammatory cytokine IL-4 on proliferation and osteogenic differentiation of human adipose stem cells (hASCs). hASCs were treated with TNF-α, IL-6, IL-8, IL-17F, or IL-4 (10 ng/mL) for 72 h mimicking bone repair. …”
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Original Personalized Reconstruction Method for Certain Large Tumors of the Lower Lip (Not Including Oral Commissures) by Ovidiu Dan Grigorescu, Marius Irimie, Nadinne Roman, Roxana Steliana Miclaus, Maria-Cristina Cîmpeanu, Bogdan-Radu Necula, Christian-Gabriel Strempel, Simona Grigorescu, Marius Alexandru Moga, Dana Gabriela Festila

“…Unfortunately, the majority involve the use of both local and regional flaps, which either lack labial structure or disorganize the oral commissures as nodal oral function points. We set out to design a new reconstruction method that is not burdened by any of the above disadvantages, starting from the necessity to reconstruct large lower lip defects by exclusively using local and/or regional labial flaps belonging only to the healthy upper lip and the remaining structures of the lower lip after surgical tumor removal. …”
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Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis by Noelia Marquez Pete, Cristina Perez Ramirez, Maria del Mar Maldonado Montoro, Fernando Martinez Martinez, Fernando Fernández-Llimos, Antonio Sánchez Pozo, María del Carmen Ramirez Tortosa, Alberto Jiménez Morales

“…Conclusions VDR FokI gene polymorphism showed a trend for risk of RA, taking into account the variables of gender, age and tobacco use, and preventing false positives. Among our patients we found no influence of VDR BsmI, TaqI, ApaI and Cdx2 on the risk of developing RA. …”
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Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals by Alessandra Quercioli, Fabrizio Montecucco, Katia Galan, Osman Ratib, Pascale Roux-Lombard, Sabrina Pagano, François Mach, Thomas H. Schindler, Nicolas Vuilleumier

“…We aimed at determining whether anti-apolipoprotein (apo) A-1 IgG levels are independent predictors of coronary artery calcification (CAC) and coronary endothelial dysfunction in obese and nonobese subjects without cardiovascular disease. 48 nonobese and 43 obese subjects were included. …”
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Long time-series and high-frequency ecological evaluation of Henan section of the Yellow River by Jianzhong Guo, Daozhu Xu, Jian Xu, Ruoxin Zhu, Ning Li

“…To further elucidate the spatial-temporal distribution pattern, fluctuations, change trends, and future evolution trends of the ecological environment quality, we conducted coefficient of variation fluctuation analysis, Theil-Sen's slope estimation, Mann-Kendall test, and Hurst index calculation. …”
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Artificial neural network systems to predict the response to sintilimab in squamous-cell non-small-cell lung cancer based on data of ORIENT-3 study by Tongji Xie, Guangyu Fan, Le Tang, Puyuan Xing, Yuankai Shi

“…Abstract Background Existing biomarkers and models for predicting response to programmed cell death protein 1 monoclonal antibody in advanced squamous-cell non-small cell lung cancer (sqNSCLC) did not have enough accuracy. We used data from the ORIENT-3 study to construct artificial neural network (ANN) systems to predict the response to sintilimab for sqNSCLC. …”
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Identifying the barriers and facilitators to culturally responsive HIV and PrEP screening for racial, ethnic, sexual, and gender minoritized patients: A scoping review protocol. by Julia Xavier, Maranda C Ward, Patrick G Corr, Nikhil Kalita, Paige McDonald

“…The limitations of this study include the analysis restrictions of a scoping review and the timeframe of this review. We anticipate that this study's findings will interest PCPs, public health professionals, community activists, patient populations, and researchers interested in culturally responsive care. …”
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Effect of Propionic Acid on Diabetes-Induced Impairment of Unfolded Protein Response Signaling and Astrocyte/Microglia Crosstalk in Rat Ventromedial Nucleus of the Hypothalamus by Larysa V. Natrus, Yulia S. Osadchuk, Olha O. Lisakovska, Dmytro O. Labudzinskyi, Yulia G. Klys, Yuri B. Chaikovsky

“…Western blotting, RT-PCR, transmission electron microscopy, and immunohistochemical staining were performed. Results. We found T2DM-associated enlargement of ER cisterns, while drug administration slightly improved VMH ultrastructural signs of damage. …”
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Shrimp White Spot Viral Infections Are Attenuated by Organic Acids by Regulating the Expression of HO-1 Oxygenase and β-1,3-Glucan-Binding Protein by Ioan Pet, Igori Balta, Nicolae Corcionivoschi, Tiberiu Iancu, Ducu Stef, Lavinia Stef, Iuliana Cretescu

“…With this exploratory study we aimed to test, both in vitro and in vivo, the efficacy of an organic acid mixture (Aq) against WSSV infections in shrimp. …”
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Pathologically altered articular cartilage attracts intense chondrocyte invasion into the extracellular matrix: in vitro pilot study by Victoria A. Shestakova, Ilya D. Klabukov, Ilya V. Kolobaev, Longfeng Rao, Dmitry A. Atiakshin, Michael A. Ignatyuk, Mikhail E. Krasheninnikov, Bagavdin G. Ahmedov, Sergey A. Ivanov, Peter V. Shegay, Andrey D. Kaprin, Denis S. Baranovskii

“…Biochemical analysis was performed to determine the glycosaminoglycan (GAG) and DNA content of the cartilage using dimethylmethylene blue and CyQuant Cell Proliferation Assay Kit. Results We seeded healthy and inflamed cartilage with nasal chondrocytes and found that the cells actively invade mainly pathologically altered cartilage. …”
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Understanding the Spectrum of Mild Clinical Outcomes and Novel Findings in Arterial Tortuosity Syndrome Among Qatari Patients: Implications of SLC2A10 Mutation by Muhammed Riyas K. Rahmath, Haytham Ibrahim, Muhammad Faiyaz-Ul-Haque, Zafar Nawaz, Ahmad Zitoun, Ahmed Hussein, Ahmed Sadek, Ayman El-Menyar, Reema Kamal, Hassan Al-Thani, Gulab Sher

“…The syndrome’s full clinical spectrum and course remain incompletely understood. <b>Methods</b>: We sought to review the medical records of Qatari patients who had ATS. …”
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Prognosis conferred by molecular features of appendix-derived Pseudomyxoma Peritonei by Ruiqing Ma, Guojun Li, Yingjiang Ye, Lei Liang, Chong Wang, Haipeng Zhou, Pu Zhang, Lubiao An, Guanjun Shi, Qian Chen, Hongbin Xu, Zhidong Gao

“…Introduction: Pseudomyxoma Peritonei (PMP) is an extremely rare disease characterized by progressive accumulation of mucinous ascites and implants in the peritoneum. We investigated the prognostic value for response to cytoreductive surgery (CRS) or hyperthermic intraperitoneal chemotherapy (HIPEC) and dissected potential beneficial targeted therapy utilizing genomic characteristics. …”
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Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Opti... by Magdalena Kuzma-Kozakiewicz, Andrzej Marchel, Anna Kaminska, Malgorzata Gawel, Jan Sznajder, Anna Figiel-Dabrowska, Arkadiusz Nowak, Edyta Maj, Natalia Ewa Krzesniak, Bartlomiej H. Noszczyk, Krystyna Domanska-Janik, Anna Sarnowska

“…They combine clinical, neurophysiological, and functional assessment together with monitoring of the cytokine level. Here, we describe a pilot study on transplantation of autologous adipose-derived regenerative cells (ADRC) into the spinal cord of the patients with ALS and monitoring of the results in accordance with the current recommendations. …”
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High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor by Jie Hu, Weihao Lin, Liyang Shao, Chenlong Xue, Fang Zhao, Dongrui Xiao, Yang Ran, Yue Meng, Panpan He, Zhiguang Yu, Jinna Chen, Perry Ping Shum

“…To accurately distinguish the signal response caused by trace markers, the high demodulation resolution of the sensor is necessary. In this paper, we propose a dual-wavelength fiber laser sensing system enhanced with microwave photonics demodulation technology to achieve high-resolution tumor marker detection. …”
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An Analysis of the Vocational-Educational Problematics for Substantiating Production Specialist Competencies by V. E. Steinberg, L. V. Vakhidova, E. M. Gabitova

“…As a research methodology, a causal approach was used, specifically implemented in the form of a multi-dimensional matrix informing a stage-by-stage analysis, which links the need for qualified personnel (experts, who have necessary competencies) with the pedagogical conditions for their preparation (formation of necessary competencies in students).Results and scientific novelty. We present a recommendation for the organisational and content-based improvement of specialist education in terms of key SVE tasks and factors. …”
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mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections by Lijun Fang, Huaijun Tu, Wei Guo, Shixuan Wang, Ting Xue, Fei Yang, Xiaoyan Zhang, Yazhi Yang, Qian Wan, Zhexin Shi, Xulong Zhan, Jian Li

“…When compared to WT mice, we found higher mortality, greater numbers of bacteria, decreased expression of coactivators in monocytes, increased numbers of Tregs, and decreased numbers of effector T cells in TSC1 KO mice. …”
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Demographic disparities in access to COVID-19 clinical trial sites across the United States: a geospatial analysis by Raphael Cuomo, Tiana McMann, Qing Xu, Zhuoran Li, Joshua Yang, Julie Hsieh, Christine Lee, Milena Lolic, Richardae Araojo, Tim Mackey

“…Ensuring people from diverse backgrounds have the ability to participate in clinical trials is key to advancing health equity. We sought to analyze the spatial variability in locations of COVID-19 trials sites and to test associations with demographic correlates. …”
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Noninvasive prenatal diagnosis (NIPD) of non-syndromic hearing loss (NSHL) for singleton and twin pregnancies in the first trimester by Huanyun Li, Shaojun Li, Zhenhua Zhao, Lingrong Kong, Xinyu Fu, Jingqi Zhu, Jun Feng, Weiqin Tang, Di Wu, Xiangdong Kong

“…However, previous research is limited to the second trimester and the application in twin pregnancies is blank. Here we provide a novel algorithmic approach to assess singleton and twin pregnancies in the first trimester. …”
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Microbial keratitis in Southern Malawi: a microbiological pilot study by Timothy Neal, Dean Everett, Stephen B Kaye, Alistair Darby, Moira Gandiwa, Shaffi Mdala, Caroline E Corless, Rose Herbert, Nicholas A V Beare, Tobi F Somerville, Thokozani Zungu, Malcolm J Horsburgh, Petros C Kayange

“…Objective Microbial keratitis (MK) is a significant cause of blindness in sub-Saharan Africa. We investigated the feasibility of using a novel corneal impression membrane (CIM) for obtaining and processing samples by culture, PCR and whole-genome sequencing (WGS) in patients presenting with suspected MK in Malawi.Methods and analysis Samples were collected from patients presenting with suspected MK using a 12 mm diameter polytetrafluoroethylene CIM disc. …”
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