A rare intersection: squamous cell carcinoma of the tonsil and the anti-TIF1 syndrome masquerade by Manush Sondhi, Megan Lear, Saleha Dar, Madiha Tariq

“…Specific autoantibodies, including anti-TIF1 (Transcription Intermediary Factor 1), have been linked to this risk. We present a case of dermatomyositis in a male patient positive for anti-TIF1 antibodies, subsequently diagnosed with squamous cell carcinoma of the tonsil, a novel association not previously documented. …”
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Alginate-based encapsulation of porcine placenta extract: Preparation, enteric sustained release, biological activities, and stability by Anukul Taweechaipaisankul, Nutthanit Thumrongsiri, Walailuk Chonniyom, Paweena Dana, Prattana Tanyapanyachon, Monthira Rattanatayarom, Wannapa Chinchoosak, Nattika Saengkrit

“…Here, alginate microbeads containing porcine placenta extracts (pPEs) were developed by the ionotropic gelation method under various conditions, and many of their properties were tested. We found that placenta tissues prepared by freeze-drying could provide a great yield of protein derivatives and possessed 50.37 % anti-oxidative activity. …”
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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tu... by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

“…The primary endpoint was all-cause death or new neurological event over the first 12 months after randomisation. We took a hybrid trial-design approach which aims to prove non-inferiority of placebo first but also allows claiming superiority of placebo in case dexamethasone causes substantial harm. …”
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Low-Protein Diet Supplemented with Keto Acids Is Associated with Suppression of Small-Solute Peritoneal Transport Rate in Peritoneal Dialysis Patients by Na Jiang, Jiaqi Qian, Aiwu Lin, Wei Fang, Weiming Zhang, Liou Cao, Qin Wang, Zhaohui Ni, Qiang Yao

“…Objective. We investigate whether low-protein diet would show benefits in suppressing peritoneal transport rate in peritoneal dialysis (PD) patients. …”
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The performance of a machine learning model in predicting accelerometer-derived walking speed by Aleksej Logacjov, Tonje Pedersen Ludvigsen, Kerstin Bach, Atle Kongsvold, Mats Flaaten, Tom Ivar Lund Nilsen, Paul Jarle Mork

“…A measuring wheel with a speedometer along with video recording were used to define and record consecutive 5-min periods with the three walking speeds and jogging during conditions resembling free-living. In addition, we included a 5-min period with gradual increase and decrease in walking speed from slow to brisk and vice versa. …”
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Drivers of Palliative Care and Hospice Use Among Patients With Advanced Lung Cancer by Megan C. Edmonds, Melissa Mazor, Mayuri Jain, Lihua Li, Marsha Augustin, José Morillo, Olivia S. Allen, Amina Avril, Juan P. Wisnivesky, Cardinale B. Smith

“…Patients were surveyed about their knowledge of palliative care and hospice and their beliefs regarding medical mistrust, lung cancer care, palliative care and hospice. We used univariate and multivariable logistic regression analyses to examine the association between mistrust, knowledge and beliefs among the entire cohort and minority (Black and Hispanic) and non‐minority patients on utilization of palliative care consultation and hospice care use. …”
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Rancang Bangun Protokol Perutean SDGR+R pada Vehicular AD-HOC Network Berbasis Arah by Eliyah Acantha Manapa, Sri Wahjuni, Shelvie Nidya Neyman

“…In SDGR + R, the addition of route base directions uses multicast. Next, we compare the performance between SDGR and SDGR+R. …”
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Anti-GAPDH Autoantibody Is Associated with Increased Disease Activity and Intracranial Pressure in Systemic Lupus Erythematosus by Jingjing Sun, Xue Li, Haotian Zhou, Xiaoyun Liu, Jingjing Jia, Qizhi Xie, Sijia Peng, Xiaolin Sun, Qingwen Wang, Li Yi

“…However, the clinical relevance of the anti-GAPDH autoantibodies in patients with SLE is still elusive. In this study, we sought to determine the serum levels of the anti-GAPDH autoantibodies in patients with SLE to investigate the clinical significance of the anti-GAPDH autoantibodies in SLE. …”
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NKX6.3 modulation of mitotic dynamics and genomic stability in gastric carcinogenesis by Jung Hwan Yoon, Jeong-Kyu Kim, Jung Woo Eun, Hassan Ashktorab, Duane T. Smoot, Suk Woo Nam, Won Sang Park

“…The transcription factor NKX6.3 has emerged as a potential regulator of these processes in gastric epithelial cells, prompting an investigation into its role in gastric cancer development. Methods We employed a combination of in vitro and in vivo techniques to elucidate the impact of NKX6.3 depletion on mitotic dynamics and genomic stability in gastric epithelial cells. …”
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Otolith annulus validation and population dynamics of dark sleeper Odontobutis potamophila: insights for sustainable fisheries management by Miao Xiang, Miao Xiang, Haoran Liu, Haoran Liu, Haoran Liu, Bo Li, Hongxi Guo, Chuankun Zhu, Man Wang, Man Wang, Jie Wang, Jie Wang, Songguang Xie, Songguang Xie, Lei Zhang, Lei Zhang

“…In this study, we assessed the growth patterns and population characteristics of the Odontobutis potamophila in Nansi Lake to inform evidence-based management recommendations for the sustainable development of fisheries in the region. …”
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High quality genome assembly of the brown hare (Lepus europaeus) with chromosome-level scaffolding by Michell, Craig, Collins, Joanna, Laine, Pia K., Fekete, Zsófia, Tapanainen, Riikka, Wood, Jonathan M. D., Goffart, Steffi, Pohjoismäki, Jaakko L. O.

“…We present here a high-quality genome assembly of the brown hare (Lepus europaeus Pallas), based on a fibroblast cell line of a male specimen from Liperi, Eastern Finland. …”
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Association of valproate use and hippocampal atrophy in idiopathic generalized epilepsy by Xiang Huang, Yingying Zhang, Qiuxing Lin, Kailing Huang, Yuming Li, Peiwen Liu, Danyang Cao, Wenhao Li, Wei Li, Xiuli Li, Qiyong Gong, Dong Zhou, Dongmei An

“…Objective: Recent studies revealed the effect of valproate (VPA) on brain structural changes in idiopathic generalized epilepsy (IGE). We aimed to investigate the volume of the entire hippocampus and subfields in patients with IGE, and explored their associations with VPA use. …”
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Metabolic reprogramming in cancer: Mechanisms and therapeutics by Shiqi Nong, Xiaoyue Han, Yu Xiang, Yuran Qian, Yuhao Wei, Tingyue Zhang, Keyue Tian, Kai Shen, Jing Yang, Xuelei Ma

“…Therefore, understanding how multiple metabolic pathways in cancer cells change can provide a reference for the development of new therapies for tumor treatment. Here, we systemically reviewed the metabolic changes and their alteration factors, together with the current tumor regulation treatments and other possible treatments that are still under investigation. …”
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Faktor Yang Mempengaruhi Kepatuhan Berobat Pasien Yang Diterapi Dengan Tamoxifen Setelah Operasi Kanker Payudara by Arif Budiman, Daan Khambri, Hafni Bachtiar

“…Analysis univariat, bivariat and multivariat performed by using SPSS version 18.00.Results. Of the 61 patients we found 9 patients not adherent tamoxifen therapy, the results bivariant a significant association between adherence to the age, level of education, familyIncome, availability of health insurance and medical care (p<0.05). …”
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Effect of Trandolapril on Regression of Retinopathy in Hypertensive Patients with Type 2 Diabetes: A Prespecified Analysis of the Benedict Trial by Piero Ruggenenti, Ilian Iliev, Marco Filipponi, Stefano Tadini, Annalisa Perna, Maria Ganeva, Bogdan Ene-Iordache, Paolo Cravedi, Roberto Trevisan, Antonio Bossi, Giuseppe Remuzzi

“…The effect of angiotensin converting enzyme inhibitors (ACEi) on regression of retinopathy in type 2 diabetics is still ill defined. Methods. We compared the incidence of retinopathy regression in 90 hypertensive type 2 diabetics randomized to at least 3-year blinded ACEi with trandolapril (2 mg/day) or non-ACEi therapy who had preproliferative or proliferative retinopathy at baseline. …”
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Deep learning of noncontrast CT for fast prediction of hemorrhagic transformation of acute ischemic stroke: a multicenter study by Huanhuan Ren, Haojie Song, Shaoguo Cui, Hua Xiong, Bangyuan Long, Yongmei Li

“…Abstract Background Hemorrhagic transformation (HT) is a complication of reperfusion therapy following acute ischemic stroke (AIS). We aimed to develop and validate a model for predicting HT and its subtypes with poor prognosis—parenchymal hemorrhage (PH), including PH-1 (hematoma within infarcted tissue, occupying < 30%) and PH-2 (hematoma occupying ≥ 30% of the infarcted tissue)—in AIS patients following intravenous thrombolysis (IVT) based on noncontrast computed tomography (NCCT) and clinical data. …”
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Machine learning validation of the AVAS classification compared to ultrasound mapping in a multicentre study by Katerina Lawrie, Petr Waldauf, Peter Balaz, Radoslav Bortel, Ricardo Lacerda, Emma Aitken, Krzysztof Letachowicz, Mario D’Oria, Vittorio Di Maso, Pavel Stasko, Antonio Gomes, Joana Fontainhas, Matej Pekar, Alena Srdelic, VAVASC Study Group, Stephen O’Neill

“…Demographics, risk factors, vessels parameters, types of predicted and created VA (pVA, cVA) were collected. We modelled pVA and cVA using the Random Forest algorithm. …”
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Participation in a pre-registration student interprofessional education (IPE) society: influence on subsequent professional practice by Christine Hirsch, Emily Audet, Emily Audet, Ekrahh Dawood, Freya Beardmore, Nafeesa Hussain, Wing Chi Wong, Robert J. Barry, Sharon Buckley

“…To inform institutional decisions about establishing and maintaining a student IPE society, we have investigated the perceptions of early career health professionals who were KASE members during their pre-registration training.MethodsKASE alumni working as early career health professionals were invited to participate in the study. …”
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Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11 by Benjamin J. Ravenhill, Marisa Oliveira, George Wood, Ying Di, Joanne Kite, Xinyue Wang, Colin T.R. Davies, Yongxu Lu, Robin Antrobus, Gill Elliott, Nerea Irigoyen, David J. Hughes, Paul A. Lyons, Betty Chung, Georg H.H. Borner, Michael P. Weekes

“…To comprehensively identify signaling factors, we analyzed protein relocalization on a global scale during viral infection. cAMP-responsive element-binding protein (CREB)-regulated transcription coactivators 2 and 3 (CRTC2/3) exhibited early cytoplasmic-to-nuclear translocation upon infection with multiple viruses in diverse cell types. …”
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Characteristics That Predict Psoriatic Arthritis by the Classification Criteria for Psoriatic Arthritis in Patients With Juvenile Idiopathic Arthritis 18 Years After Disease Onset by Agnes Szentpetery, Mia Glerup, Kristiina Aalto, Ellen D. Arnstad, Anders Fasth, Troels Herlin, Charlotte Myrup, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Veronika Gjertsen Rypdal, Lillemor Berntson

“…Patients were classified according to the International League of Associations for Rheumatology (ILAR) criteria at baseline, and we applied ILAR and CASPAR criteria at 18 years. …”
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