Transcriptome and chromatin accessibility landscape of ovarian development at different egg-laying stages in taihe black-bone silky fowls by Jingyi Zhang, Yong Cui, Jiming Ruan, Haiyan Zhu, Haiping Liang, Ji Cao, Qing Wei, Jianzhen Huang

“…Compared to the late laying period, several genes related to ovarian development and reproductive hormone secretion, including TDRD5, CCNO, CYP17A1, BMP15, and STAR, were upregulated during the peak egg-laying period. Additionally, we identified key transcription factors (TF) associated with different egg-laying periods. …”
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Enabling regulatory policy globally will promote realization of the potential of animal biotechnology by Eric Hallerman, Justin Bredlau, Luiz Sergio A. Camargo, Maria Lucia Zaidan Dagli, Margaret Karembu, Daniel Kovich, Anne Ndanu Muia, Mariana L. Murrone, Pedro Jesus Rocha-Salavarrieta, Rhodora Romero-Aldemita, Mark Tizard, Mark Walton, Diane Wray-Cahen

“…An international workshop on regulatory approaches for animal biotechnology was convened in 2022 with 27 countries represented. We synthesize here technical progress, development of regulatory policy, and strategies for engagement with diverse publics on animal biotechnology reported in the workshop. …”
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Analisis Efek Augmentasi Dataset dan Fine Tune pada Algoritma Pre-Trained Convolutional Neural Network (CNN) by Theopilus Bayu Sasongko, Haryoko Haryoko, Agit Amrullah

“…Abstract Today deep learning technology is often associated with reliable processes (methods) when we have large amounts of data. In deep learning CNN (Convolutional Neural Network) plays a very important role which is often used to analyze (classify or recognize) visual images. …”
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Integrated multiomics approach and pathological analyses provide new insights into hepatic injury and metabolic alterations in Saanen goats after dietary exposure to aflatoxin B1 by Donghua Su, Jing Peng, Jingjing Hao, Xi Wang, Peiqiang Yu, Shengli Li, Haitao Shi

“…The hepatocyte apoptosis rate was significantly increased after AFB1 exposure, and the western blotting results revealed that both the external apoptotic pathway and mitochondrial-mediated intrinsic apoptotic pathway might be involved in AFB1-induced hepatocyte apoptosis. We identified 251, 269, and 154 significant differentially expressed genes (DEG) and 340, 596, and 127 significant differential metabolites in comparisons between the control (CON; 0 μg/kg) and low-dose (LO; 50 μg/kg) groups, the CON and high-dose (HI; 500 μg/kg) groups, and the LO and HI groups, respectively. …”
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Ecosystem carbon stock variation along forest stand ages: insight from eastern coast mangrove ecosystem of India by Muktipada Panda, Bikash R. Dash, Sudam C. Sahu

“…This study aimed to estimate the forest structural attributes, biomass and total ecosystem carbon stock (TECS) of old natural (age > 50 years) and young planted (age ~ 20 years) mangrove forest stands at Bichitrapur Mangrove Reserve Forest in eastern coast of India. We also attempted to understand the interrelationship of structural attributes, biomass and soil properties in the mangrove forests. …”
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Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile A... by Keisuke Yoshikiyo, Hidehisa Shimizu, Edward G. Nagato, Satoshi Ishizuka, Tatsuyuki Yamamoto

“…These findings suggest that γ-CD may exacerbate liver injury and dyslipidemia caused by elevated gastrointestinal 12OH bile acid levels, whereas γ-CD–perilla oil inclusion complexes may ameliorate these effects by altering fatty acid metabolism. Furthermore, we recommend evaluating γ-CD safety in both healthy and pathological models and carefully selecting compounds co-ingested with γ-CD.…”
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Increasing trend of antimicrobial resistance among methicillin-resistant Staphylococcus aureus strains in Southwest Finland, 2007–2016: An analysis of shifting strain dynamics and... by Jaakko Silvola, Kirsi Gröndahl-Yli-Hannuksela, Tiina Hirvioja, Kaisu Rantakokko-Jalava, Mari Kanerva, Kari Auranen, Harri Marttila, Jenna Junnila, Jaana Vuopio

“…To understand the implications of these changes to the management of MRSA, we sought to analyse the antimicrobial resistance (AMR) trends of MRSA in relation with patient characteristics. …”
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Herbicide resistance in Leptochloa chinensis (L.) Nees populations from different regions of Jiangsu Province, China: sensitivity differences and underlying mechanisms by Peng Xu, Ke Wang, Yawen Ju, Yousheng Fu, Axiu Zhu, Kaige Cao, Hongchun Wang

“…Furthermore, mutations in the ACCase gene were identified as a crucial mechanism for cyhalofop-butyl resistance. Specifically, we found ACCase mutations I1781L, W1999C, W2027C/L/S, I2041N, and D2078G in cyhalofop-butyl-resistant L. chinensis populations, among which, W1999C and W2027C accounted for a relatively high proportion, while I1781L, W2027L/S, I2041N, and D2078G were found in one population each. …”
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Residency training programs to support residents working in First Nations, Inuit, and Métis communities by Marghalara Rashid, Julie Nguyen, Wayne Clark, Jessica L. Foulds, Ida John, Ming-Ka Chan, Molly Whalen-Browne, Pamela Roach, Melanie Morris, Sarah Forgie

“…Equipping trainees to provide holistic care, immersing in and learning from First Nations, Inuit and/or Métis communities is essential for developing the next generation of clinicians and preceptors. We present educational recommendations for residency programs to optimize First Nations, Inuit and/or Métis health educational experiences and provide residents with skills to provide effective and culturally safe care.…”
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Is Rhodamine 123 an Appropriate Fluorescent Probe to Assess P-Glycoprotein Mediated Multidrug Resistance in Vinblastine-Resistant CHO Cells? by Jordi Pétriz, José Enrique O’Connor, Mercè Carmona, Joan García‐López

“…To study cellular drug resistance, we have obtained a CHO‐K1 derived cell line resistant to vinblastine by means of multistep selection. …”
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Translation, content validity and internal structure of the Brazilian version of the Adolescent Resilience Questionnaire (B-ARQ). by Genara Brum Gomes, Luisa Gatti-Reis, Matheus França Perazzo, Marisa Alves Araújo, Flávio Freitas Mattos, Deirdre Gartland, Saul Martins Paiva, Isabela Almeida Pordeus

“…One scale showed a ceiling effect (frequency higher than 15.0%), but we identified no critical floor effect. The B-ARQ-SV is a valid (in terms of content and structural validity) and reliable (in terms of internal consistency) measurement instrument to assess resilience in Brazilian adolescents.…”
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Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) and mortality among survivors of liver cirrhosis: a prospective cohort study by Danial Fotros, Azita Hekmatdoost, Fereshteh Pashayee-khamene, Sara Karimi, Saleheh Ahmadzadeh, Mehdi Saberifiroozi, Behzad Hatami, Zahra Yari

“…Abstract Background Cirrhosis is a medical condition marked by persistent liver damage, which leads to the development of fibrous tissue and compromised liver function. In the present study, we decided to investigate the possibility of a connection between the consumption of fermentable olig-, di-, monosaccharides, and polyols (FODMAPs) and mortality rates in cirrhotic patients by utilizing data obtained from a prospective cohort study. …”
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Antimicrobial Susceptibility of <i>Glaesserella parasuis</i> to Macrolides and Characterization of <i>erm</i>(T)-Carrying Mobile Elements on Chromosome by Peng Zhang, Changmin Li, Shuna Shang, Ting Huang, Junqi Liu, Qianwen Ge, Xiaoping Liao, Liangxing Fang, Yang Yu

“…Macrolide resistance poses an urgent threat to their treatment, as macrolides are widely used for preventing and treating <i>G. parasuis</i> infections. Here, we determined the susceptibilities to five macrolides and characterized the genetic markers of macrolide resistance. …”
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Detection and subtyping of Blastocystis sp. in human and animal stool samples using high-resolution melting analysis by Ghodratollah Salehi Sangani, Ahmad Hosseini-Safa, Bibi Razieh Hosseini Farash, Pooria Salehi Sangani, Mehdi Zarean, Elham Moghaddas, Saeid Zoghdar Moghadam, Lida Jarahi, Ali Gholizadeh, Fariba Berenji

“…However, molecular diagnostics have become essential for the accurate detection and differentiation of Blastocystis subtypes Materials and methods We collected 730 stool samples from humans and domestic animals. …”
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Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver by Yuki Ito, Toshiki Nakamura, Yukie Yanagiba, Doni Hikmat Ramdhan, Nozomi Yamagishi, Hisao Naito, Michihiro Kamijima, Frank J. Gonzalez, Tamie Nakajima

“…However, species differences in the receptor functions between rodents and human make it difficult to precisely extrapolate their toxicity from animal studies to human. In this paper, we compared the species differences in the activation of mouse and human hepatic PPARα by these plasticizers using wild-type (mPPARα) and humanized PPARα (hPPARα) mice. …”
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The Effectiveness of Self-Expandable Metallic Stent Insertion in Treating Right-Sided Colonic Obstruction: A Comparison between SEMS and Decompression Tube Placement and an Investi... by Rintaro Moroi, Katsuya Endo, Ryo Ichikawa, Hiroshi Nagai, Hirohiko Shinkai, Tomoya Kimura, Fumitake Ishiyama, Kei Yaguchi, Shoichi Kayaba, Tooru Shimosegawa

“…Technical and clinical success, complications, and technical difficulties were analyzed. We compared the results between SEMS insertion and decompression tube placement in right colons and the outcomes of SEMS insertion between right- and left-sided colonic obstructions. …”
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Klasifikasi Ekspresi Wajah Menggunakan Covolutional Neural Network by Ahmad Taufiq Akbar, Shoffan Saifullah, Hari Prapcoyo

“…The data was processed using a CNN architecture comprising 3 convolutional layers, 2 subsampling layers, and 2 dense layers. We evaluated the model with 5-fold- and 10-fold cross-validation for robust performance estimation and hold-out techniques (70:30, 80:20, 85:15, and 90:10) for clear result comparison. …”
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A Comparison of Cooling Techniques to Treat Cardiac Arrest Patients with Hypothermia by Anna Finley Caulfield, Shylaja Rachabattula, Irina Eyngorn, Scott A. Hamilton, Rajalakshmi Kalimuthu, Amie W. Hsia, Maarten G. Lansberg, Chitra Venkatasubramanian, J. J. Baumann, Marion S. Buckwalter, Monisha A. Kumar, James S. Castle, Christine A. C. Wijman

“…Introduction. We sought to compare the performance of endovascular cooling to conventional surface cooling after cardiac arrest. …”
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Staphylococcus aureus induces mitophagy via the HDAC11/IL10 pathway to sustain intracellular survival by Yaji Yang, Haotian Zhou, Feilong Li, Yanhao Zhang, Jianye Yang, Yidong Shen, Ning Hu, Quanming Zou, Leilei Qin, Hao Zeng, Wei Huang

“…Results The findings demonstrated that IL10 promotes mitophagy to clear mitochondrial reactive oxygen species (mtROS), thereby enhancing the intracellular survival of S. aureus within macrophages. Additionally, we discovered that the transcriptional repressor of IL10, HDAC11, was significantly downregulated during S. aureus infection. …”
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Systemic Vascular Function Is Associated with Muscular Power in Older Adults by Kevin S. Heffernan, Angela Chalé, Cynthia Hau, Gregory J. Cloutier, Edward M. Phillips, Patrick Warner, Heather Nickerson, Kieran F. Reid, Jeffrey T. Kuvin, Roger A. Fielding

“…Age-associated loss of muscular strength and muscular power is a critical determinant of loss of physical function and progression to disability in older adults. In this study, we examined the association of systemic vascular function and measures of muscle strength and power in older adults. …”
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