lncRNA HHIP-AS1 Promotes the Osteogenic Differentiation Potential and Inhibits the Migration Ability of Periodontal Ligament Stem Cells by Qianyi Qin, Haoqing Yang, Chen Zhang, Xiao Han, Jing Guo, Zhipeng Fan, Jie Guo

“…First, HHIP-AS1 expression was downregulated in PDLSCs under continuous compressive pressure. Then, we found that the alkaline phosphatase activity, in vitro mineralization, and expression levels of bone sialoprotein, osteocalcin, and osterix were increased in PDLSCs by HHIP-AS1. …”
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The Long-Term Change of Arrhythmias after Transcatheter Closure of Perimembranous Ventricular Septal Defects by Hongyan Zheng, Aiwen Lin, Li Wang, Yukai Xu, Zhiwei Zhang

“…To observe and analyze the long-term change of different types of arrhythmias after transcatheter closure of perimembranous ventricular septal defect (pmVSD). Methods. We retrospectively collected the data of patients who underwent pmVSD closure in our institution from March 2002 to December 2010. …”
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DADmax/NADmax Ratio: Criterion for the Production and Selection of Demolition Aggregates with Low-Water Absorption by Kamel Akroum, Bouzidi Mezghiche

“…Our objective was to produce DAs suitable for use in structural concrete and to develop a simple, economical, and safe technique to generate good-quality DAs. We designed an upstream intervention based on the measurement of water absorption as a quality indicator. …”
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Single nucleotide polymorphism rs110861313 in the intergenic region of chromosome 23 is associated with the development of leukosis in the Russian Black Pied cattle by R. B. Aitnazarov, E. V. Ignatieva, T. A. Agarkova, N. G. Dvoeglazov, N. A. Osipova, V. V. Khramtsov, N. S. Yudin

“…FOXM1 is expressed in immune cells and can potentially affect the expression of the neighboring genes (LY6G5B, GPANK1, ABHD16A, LY6G6F, LY6G6E, CSNK2B, ApoM). Thus, we found that SNP rs110861313 in the intergenic region of bovine chromosome 23 is associated with the development of leukemia following BLV infection in the Russian Black Pied cattle.…”
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Exome sequencing reveals IFT172 variants in patients with non-syndromic cholestatic liver disease. by Magdaléna Neřoldová, Elżbieta Ciara, Janka Slatinská, Soňa Fraňková, Petra Lišková, Radana Kotalová, Janka Globinovská, Markéta Šafaříková, Lucie Pfeiferová, Hana Zůnová, Lenka Mrázová, Viktor Stránecký, Alena Vrbacká, Ondřej Fabián, Eva Sticová, Daniela Skanderová, Jan Šperl, Marta Kalousová, Tomáš Zima, Milan Macek, Joanna Pawlowska, A S Knisely, Stanislav Kmoch, Milan Jirsa

“…<h4>Background and aim</h4>Gene defects contribute to the aetiology of intrahepatic cholestasis. We aimed to explore the outcome of whole-exome sequencing (WES) in a cohort of 51 patients with this diagnosis.…”
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Fruit Detection and Yield Mass Estimation from a UAV Based RGB Dense Cloud for an Apple Orchard by Marius Hobart, Michael Pflanz, Nikos Tsoulias, Cornelia Weltzien, Mia Kopetzky, Michael Schirrmann

“…Overall, coefficients of determination of 0.56 (for the 7.5 m altitude flight) and 0.76 (for the 10 m flights) were achieved. Therefore, we conclude that mapping at an altitude of 10 m performs better than 7.5 m, in the context of low-altitude UAV flights for the estimation of ripe apple parameters directly from 3D RGB dense point clouds.…”
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Inhibition of inflammatory cell infiltration by antagonistic peptides that specifically bind to CCR5 via regulation of the NF-kB signaling pathway in rats with colitis by Yang-Da Song, Yi-Hang Song, Si-Xue Liu, Hua-Rong Huang, Ying-Qiang Zhong

“…Introduction CC chemokine receptor 5 (CCR5) and the NF-kB signaling pathway play important roles in the pathophysiology of inflammatory bowel disease (IBD). Previously, we synthesized two peptides (GH and HY peptides) that specifically bind to the first and the second extracellular loops (ECL1 and ECL2, respectively) of CCR5 and preliminarily found an inhibitory effect of these peptides on colitis. …”
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Optimal Timing and Treatment Modalities of Arytenoid Dislocation and Subluxation: A Meta-Analysis by Andrea Frosolini, Valeria Caragli, Giulio Badin, Leonardo Franz, Patrizia Bartolotta, Andrea Lovato, Luca Vedovelli, Elisabetta Genovese, Cosimo de Filippis, Gino Marioni

“…To comprehensively cover the last 25 years, an updated literature search was conducted, screening PubMed, Scopus, and Cochrane databases. Review Methods: We included studies that reported treatment modalities and the time to treatment (TT) for AS/AD, with outcomes objectively evaluated. …”
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Impact of biological sex and gender-related factors on public engagement in protective health behaviours during the COVID-19 pandemic: cross-sectional analyses from a global survey by Simon L Bacon, Kim L Lavoie, Valeria Raparelli, Louise Pilote, Rubee Dev, Colleen M Norris

“…Objective Given the role of sociocultural gender in shaping human behaviours, the main objective of this study was to examine whether sex and gender-related factors were associated with the public’s adherence to COVID-19-recommended protective health behaviours.Design This was a retrospective analysis of the survey that captured data on people’s awareness, attitudes and behaviours as they relate to the COVID-19 policies.Setting Data from the International COVID-19 Awareness and Responses Evaluation survey collected between March 2020 and February 2021 from 175 countries.Participants Convenience sample around the world.Main outcome measures We examined the role of sex and gender-related factors in relation to non-adherence of protective health behaviours including: (1) hand washing; (2) mask wearing; and (3) physical distancing. …”
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LURAP1L-AS1 long noncoding RNA promotes breast cancer progression and associates with poor prognosis by Radhakrishnan Vishnubalaji, Dania Awata, Nehad M. Alajez

“…Through a custom siRNA library screen targeting TNBC-associated lncRNAs in MDA-MB-231 and BT-549 TNBC cell models, we identified LURAP1L-AS1 as a key modulator of TNBC progression. …”
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Satisfaction toward Quality of Care and Associated Factors among Patients Admitted to Gambella General Hospital, Gambella Region, Southwest Ethiopia by Natnael Animut, Temesgen Kabeta chala, Waju Beyene Salgedo, Muluneh Getachew Geredew, Bekalu Getachew

“…Occupation, signs and directions to follow, getting adequate information about treatment, providers’ attention, and understanding of specific needs and concerns of the patients were the significant factors. Thus, we would recommend that the hospital management should closely work together with health professionals, supportive staff, patients, and other concerned stakeholders to improve admitted patients’ satisfaction with the quality of care. …”
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Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? by Katarzyna Siennicka, Aleksandra Zolocinska, Karolina Stepien, Natalia Lubina-Dabrowska, Marzena Maciagowska, Ewa Zolocinska, Anna Slysz, Renata Piusinska-Macoch, Slawomir Mazur, Urszula Zdanowicz, Robert Smigielski, Adam Stepien, Zygmunt Pojda

“…Although mesenchymal stem cells are used in numerous clinical trials, the safety of their application is still a matter of concern. We have analysed the clinical results of the autologous adipose-derived stem cell treatment (stromal vascular fraction (SVF) containing adipose-derived stem cells, endothelial progenitors, and blood mononuclear cells) for orthopedic (cartilage, bone, tendon, or combined joint injuries) and neurologic (multiple sclerosis) diseases. …”
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Identification of core biomarkers for tuberculosis progression through bioinformatics analysis and in vitro research by Zhanpeng Chen, Qiong Wang, Quan Ma, Jinyun Chen, Xingxing Kong, Yuqin Zeng, Lanlan Liu, Shuihua Lu, Xiaomin Wang

“…Initially, a total of 1228 genes with altered expression patterns were identified through two-way analysis of variance (ANOVA). We define genes with a P-value less than 0.05 for the combined effect of infection and time on gene expression as those with altered expression patterns. …”
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Emergency Laparotomy in the Critically Ill: Futility at the Bedside by Niels D. Martin, Sagar P. Patel, Kristen Chreiman, Jose L. Pascual, Benjamin Braslow, Patrick M. Reilly, Lewis J. Kaplan

“…In the absence of a preoperative diagnosis, abdominal exploration may be offered despite desperate circumstances. We hypothesize that (1) abdominal exploration for such patients is associated with a high mortality and (2) commonly obtained physiologic measures at laparotomy anticipate mortality. …”
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Predicting risk on cardiovascular or cerebrovascular disease based on a physical activity cohort: Results from APAC study by Juan Zhao, Ye Yu, Xiaolan Zhu, Yuling Xie, Songwei Ai, H. Immo Lehmann, Xuan Deng, Feifei Hu, Guoping Li, Yong Zhou, Junjie Xiao

“…Using the Kailuan physical activity cohorts from Asymptomatic Polyvascular Abnormalities in Community (APAC) study, we developed a 9‐year cardiovascular or cerebrovascular disease (CVD) risk prediction equation. …”
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Can verbal autopsies be used on a national scale? Key findings and lessons from South Africa's national cause-of-death validation study by Monique Maqungo, Nadine Nannan, Beatrice Nojilana, Erin Nichols, Diane Morof, Mireille Cheyip, Chalapati Rao, Carl Lombard, Jessica Price, Kathleen Kahn, Lorna J. Martin, Francois Bezuidenhout, Ria Laubscher, Chodziwadziwa Kabudula, Tracy Glass, Oluwatoyin Awotiwon, Nesbert Zinyakatira, Noluntu Funani, Jané Joubert, Debbie Bradshaw, Pamela Groenewald

“…Objective To describe the challenges and successes of collecting a national sample of verbal autopsy interviews in South Africa to obtain the cause of death profile in 2017/18. Methods We recruited next of kin from 27 randomly selected sub-districts (10.5%) across South Africa between September 2017 and April 2018. …”
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Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury by Ji Cheol Shin, Keung Nyun Kim, Jeehyun Yoo, Il-Sun Kim, Seokhwan Yun, Hyejin Lee, Kwangsoo Jung, Kyujin Hwang, Miri Kim, Il-Shin Lee, Jeong Eun Shin, Kook In Park

“…In a phase I/IIa open-label and nonrandomized controlled clinical trial, we sought to assess the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) transplanted into the injured cord after traumatic cervical spinal cord injury (SCI). …”
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Biomechanical Effects of Different Spacing Distributions Between the Cemented Superior Boundary and Surgical Vertebral Superior Endplates After Percutaneous Vertebroplasty for Oste... by Xiao Meng, Chengqiang Zhou, Yifeng Liao, Haibin Zhou, Hua Li, Jiayuan Liu, Xuebin Tang, Yunqing Wang

“…Results In this paper, we found that the Von Mises stress of the L1 vertebrae was the smallest when the spacing between the upper boundary of the bone cement and the vertebral body's upper endplates was 0 mm. …”
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Variability and Source Characterization of Regional PM of Two Urban Areas Dominated by Biomass Burning and Anthropogenic Emission by Christian Mark G. Salvador, Jhon Robin dR. Yee, Iara Chantrelle V. Coronel, Angel T. Bautista, Raymond J. Sugcang, Mark Anthony M. Lavapiez, Rey Y. Capangpangan, Preciosa Corazon B. Pabroa

“…Abstract Identifying the sources and formation pathways of particulate matter (PM) and its components is important to determine the impact of atmospheric aerosols on human health and the warming of the global atmosphere. Here, we characterized the variability of the eleven-year concentration and the origin of PM2.5 in two urban regions (Metro Manila and Boracay) in the Philippines, a country in South East Asia (SEA) with high local anthropogenic emissions and frequently impacted by transboundary pollution. …”
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Positron Emission Tomography—Computer Tomography Scan Used as a Monitoring Tool Following Cellular Therapy in Cerebral Palsy and Mental Retardation—A Case Report by Alok Sharma, Hemangi Sane, Amruta Paranjape, Nandini Gokulchandran, Pooja Kulkarni, Anjana Nagrajan, Prerna Badhe

“…Even after lifelong medical and therapeutic management there are residual deficits which affect the quality of life of the patients and their families. We examined a maximally rehabilitated, 20 year old male suffering from CP and Mental Retardation (MR). …”
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