Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice by Shiyue Sun, Tongtong Yu, Joo Young Huh, Yujie Cai, Somy Yoon, Hafiz Muhammad Ahmad Javaid

“…Conclusions AGH treatment restored mitochondrial autophagy, reduced oxidative stress, apoptosis, and altered muscle fiber composition via the AKT/FOXO1 pathway, collectively improving muscle force in mdx mice. We propose AGH as a potential therapeutic strategy for DMD and related muscle disorders.…”
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Improving timing resolution of BGO for TOF-PET: a comparative analysis with and without deep learning by Francis Loignon-Houle, Nicolaus Kratochwil, Maxime Toussaint, Carsten Lowis, Gerard Ariño-Estrada, Antonio J. Gonzalez, Etiennette Auffray, Roger Lecomte

“…It remains to be explored how timing estimation methods utilizing one (LED), two (TWC), or multiple (CNN) waveform data points compare in CTR performance of BGO scintillators. Results In this work, we compare classical experimental timing estimation methods (LED, TWC) with a CNN-based method using the signals from BGO crystals read out by NUV-HD-MT SiPMs and high-frequency electronics. …”
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Impact of wave–current coupling on the bottom boundary layer in Bohai Bay by Siyu Liu, Siyu Liu, Guangxue Li, Xue Liu, Lulu Qiao, Nan Wang, Shidong Liu, Xiangdong Wang, Di Yu, Lei Zhang

“…Sediment resuspension primarily occurs within the bottom boundary layer (BBL) of water bodies, particularly in silty coastal environments, and helps form the fluid mud layer (FML). In this study, we report data on the water level, waves, currents, and suspended sediment concentration (SSC) collected from the Bohai Sea over one year, at a vertical resolution of 4 cm, by using the acoustic wave and current profiler, acoustic Doppler current profiler, and an acoustic backscattering system. …”
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The Impact of Lockdown on Air Quality in Pakistan during the COVID-19 Pandemic Inferred from the Multi-sensor Remote Sensed Data by Rehana Khan, Kanike Raghavendra Kumar, Tianliang Zhao

“…Abstract The present study utilized multi-sensory gridded and reanalysis data in conjunction with the meteorological variables to evaluate the impact of lockdown due to the Coronavirus disease of 2019 (COVID-19) pandemic on the changes of concentration of atmospheric pollutants in Pakistan. We focused on assessing the significant changes of pollutant concentrations during March–May for the years 2019 and 2020 utilizing the satellite datasets observed from the Moderate Resolution Imaging Spectroradiometer (MODIS), Ozone Monitoring Instrument (OMI), Atmospheric Infrared Sounder (AIRS), and Modern-Era Retrospective analysis for Research and Applications (MERRA-2) reanalysis data. …”
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Discrepancies in safety reporting for chronic back pain clinical trials: an observational study from ClinicalTrials.gov and publications by Nick Boyne, Alison Duke, Jack Rea, Adam Khan, Alec Young, Jared Van Vleet, Matt Vassar

“…This study aimed to quantify inconsistencies in AE reporting between ClinicalTrials.gov and corresponding randomized controlled trial (RCT) publications, emphasizing the importance of comprehensive safety reporting to improve clinical decision-making and patient care. Methods We retrospectively analyzed Phase 2–4 CBP RCTs registered on ClinicalTrials.gov from 2009 to 2023. …”
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SEGS-1 episomes generated during cassava mosaic disease enhance disease severity by Evangelista Chiunga, Evangelista Chiunga, Evangelista Chiunga, Catherine D. Aimone, Cyprian Rajabu, Mary M. Dallas, Joseph Ndunguru, José T. Ascencio-Ibáñez, Elijah M. Ateka, Linda Hanley-Bowdoin

“…A previous study showed that SEGS-1 (sequences enhancing geminivirus symptoms), which occur both in the cassava genome and as episomes during CMD, can increase CMD disease severity and overcome host resistance. In this report, we examined the effects of exogenously applied SEGS-1 on the incidence of CMB infection, symptom severity, and viral DNA copy number in five cassava cultivars that ranged from highly susceptible to highly resistant to CMD. …”
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Spatial and temporal characteristics and driving mechanisms of recreational ecosystem services supply-demand mismatch in rapidly urbanizing areas: Evidence from the Yangtze River D... by Ruien Tang, Guolin Hou, Yueyi Chen, Xiao Liu, Shaoying Chu, Li Li

“…Taking the Yangtze River Delta Urban Agglomeration in China as an example, this study first builds an updated supply indicator system based on the four dimensions and examines the supply, demand, and matching of RES in the region with the help of heterogeneous data from multiple sources. We also examine the spatio-temporal processes and spatial spillover effects of supply–demand matching, as well as the nonlinearity and spatial non-stationarity of the role of the driving factors. …”
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FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss by Lijun Li, Renjin Lin, Yang Xu, Lingdi Li, Zhijun Pan, Jian Huang

“…Transplanting genetically engineered MSCs has been acknowledged as a highly promising therapy for osteoporosis. We utilized a random walk-based technique to discern genes associated with ossification. …”
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Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma by Kazuhito Oba, Yuko Chiba, Yoko Matsuda, Takeshi Kumakawa, Rie Aoyama, Miho Akahoshi, Seiji Hashimoto, Aya Tachibana, Koichi Toyoshima, Remi Kodera, Kenji Toyoshima, Yoshiaki Tamura, Takashi Nagata, Yuto Yamazaki, Hironobu Sasano, Atsushi Araki

“…However, the adrenocorticotrophic hormone stimulation test was positive; considering the possibility of slight aldosterone overproduction from the right adrenal gland, the administration of spironolactone was started. Herein, we report a rare case of RCC in conjunction with PA histologically associated with MNs.…”
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Possible Usefulness of Gadolinium-Enhanced Brain MRI for Evaluating Risk of Perioperative Hemorrhage: A Case of Infective Endocarditis by Chikahiko Koeda, Atsushi Tashiro, Tomohiro Takahashi, Masanobu Niiyama, Ryohei Sakamoto, Takumi Kimura, Yoshihiro Morino, Katsutoshi Terui, Ryoichi Tanaka, Kunihiro Yoshioka, Hajime Kin, Hitoshi Okabayashi, Motoyuki Nakamura

“…Based on clinical episodes of subarachnoid hemorrhage after admission, it was judged that she was not a good candidate for urgent open heart surgery, and it was decided to treat her with conservative medical therapy for the acute phase. We explored the optimum timing for surgery by employing gadolinium (Gd) contrast medium-enhanced magnetic resonance imaging (MRI) T2* weighted image (black dots) due to her high risk of perioperative cerebral hemorrhage. …”
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HEDDI-Net: heterogeneous network embedding for drug-disease association prediction and drug repurposing, with application to Alzheimer’s disease by Yin-Yuan Su, Hsuan-Cheng Huang, Yu-Ting Lin, Yi-Fang Chuang, Sheh-Yi Sheu, Chen-Ching Lin

“…Methods To address the limitations of traditional methods, we developed HEDDI-Net, a heterogeneous embedding architecture designed to accurately detect drug-disease associations while preserving the interpretability of biological mechanisms. …”
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Increased Expression of Visfatin in Monocytes and Macrophages in Male Acute Myocardial Infarction Patients by Cheng-An Chiu, Teng-Hung Yu, Wei-Chin Hung, Li-Fen Lu, Fu-Mei Chung, I-Ting Tsai, Chih-Ying Yang, Chia-Chang Hsu, Yung-Chuan Lu, Jer-Yiing Houng, Yau-Jiunn Lee, Chao-Ping Wang

“…We demonstrated that visfatin expressed in monocytes and neutrophils and increased their reactivity in male acute ST-segment elevation myocardial infarction patients. …”
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Air Pollution Levels Related to Peak Expiratory Flow Rates among Adult Asthmatics in Lampang, Thailand by Wanwisa Chujit, Phongtape Wiwatanadate, Athavudh Deesomchok, Khajornsak Sopajaree, Kamal Eldeirawi, Ying I. Tsai

“…Additionally, the average daily PEFR was positively associated with the average daily concentration of NO2 (lag 4), with a coefficient of 0.15, but negatively associated with that of SO2, with a coefficient of −0.47. We also observed a negative relationship between the average daily PEFR and NO2 max (lag 2), with a coefficient of −0.05, but a positive one between the former and O3 max (lag 3), with a coefficient of 0.06. …”
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Tear metabolomics reveals novel potential biomarkers in epithelial herpes simplex keratitis by Jinyu Zhang, Zhenning Wu, Yangqi Zhang, Kaili Wu, Xiaoyi Li, Shiyou Zhou

“…This study aims to identify biomarkers for HSK through tear metabolomics analysis between HSK and healthy individuals. Methods We conducted a cross-sectional study enrolling 33 participants. …”
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Balancing on carbon storage and ecological security in urban areas: The case of Dongguan city, China by Xinyi Wang, Fenzhen Su, Fengqin Yan, Vincent Lyne, Yikun Cui, Bin He, Rong Fan

“…Current and future national urban policies must therefore enhance carbon sink functions of ecosystems while maintaining spatial ecological structure networks. Here, we assessed current policies against future scenarios using systems thinking and land-use change simulation coupled to carbon-storage accounting. …”
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Abnormal Default-Mode Network Homogeneity in Melancholic and Nonmelancholic Major Depressive Disorder at Rest by Meiqi Yan, Xilong Cui, Feng Liu, Huabing Li, Renzhi Huang, Yanqing Tang, Jindong Chen, Jingping Zhao, Guangrong Xie, Wenbin Guo

“…Melancholic depression has been assumed as a severe type of major depressive disorder (MDD). We aimed to explore if there were some distinctive alterations in melancholic MDD and whether the alterations could be used to discriminate the melancholic MDD and nonmelancholic MDD. …”
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Characteristics of US hospitals using extraordinary collections actions against patients for unpaid medical bills: a cross-sectional study by Dominique Vervoort, Farah Hashim, Sanuri Hennayake, Christi M Walsh, Chen Dun, Joseph Giuseppe Paturzo, Indrani G Das, Emily A Stewart, Jonathan A Teinor, Morissa A Schochet, Allyson Keslar, Ge Bai, Martin Makary

“…Objective This study aims to characterise and evaluate the largest 100 hospitals in the USA that have adopted aggressive collection tactics to pursue patients with unpaid medical bills, such as lawsuits, wage garnishments and liens.Design Cross-sectional study.Setting We examined state and county court record systems to measure the magnitude and prevalence of these practices at the largest 100 hospitals in the UA between 1 January 2018 and 31 July 2020.Main outcomes measures The main outcome of this study was the number of lawsuits, wage garnishments and liens. …”
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Toward High-order Solar Corona Simulations: A High-order Hyperbolized Poisson Approach for Magnetic Field Initialization by Rayan Dhib, Firas Ben Ameur, Vatsalya Sharma, Andrea Lani, Stefaan Poedts

“…By hyperbolizing the elliptic Poisson equation into a set of hyperbolic equations, we develop an efficient and robust high-order PFSS solver. …”
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Comprehensiveness of Large Language Models in Patient Queries on Gingival and Endodontic Health by Qian Zhang, Zhengyu Wu, Jinlin Song, Shuicai Luo, Zhaowu Chai

“…Aim: Given the increasing interest in using large language models (LLMs) for self-diagnosis, this study aimed to evaluate the comprehensiveness of two prominent LLMs, ChatGPT-3.5 and ChatGPT-4, in addressing common queries related to gingival and endodontic health across different language contexts and query types. Methods: We assembled a set of 33 common real-life questions related to gingival and endodontic healthcare, including 17 common-sense questions and 16 expert questions. …”
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Auditory Phenotype of a Novel Missense Variant in the CEACAM16 Gene in a Large Russian Family With Autosomal Dominant Nonsyndromic Hearing Loss by Tatiana G. Markova, Natalia N. Alekseeva, Oxana P. Ryzhkova, Olga L. Shatokhina, Anna A. Orlova, Viktoriia V. Zabnenkova, Olga S. Groznova, Olesya V. Sagaydak, Svetlana S. Chibisova, Alexander V. Polyakov, George A. Tavartkiladze

“…Hearing loss slowly progresses with age in each person and is similar to age-related hearing loss. We have detected the novel likely pathogenic variant с.419С>T (p.…”
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