Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

“…The overlapped targets between AD and ISL were generated with Venny. Then we performed Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analyses on these common targets. …”
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ZINQ-L: a zero-inflated quantile approach for differential abundance analysis of longitudinal microbiome data by Shuai Li, Runzhe Li, John R. Lee, John R. Lee, Ni Zhao, Wodan Ling

“…In addition, the existing methods are mostly mean-based, unable to identify heterogeneous associations such as tail events or subgroup effects, which could be important biomedical signals.MethodsWe propose a zero-inflated quantile approach for longitudinal (ZINQ-L) microbiome differential abundance test. …”
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Delayed facial nerve decompression for severe refractory cases of Bell’s palsy: a 25-year experience by Ilyes Berania, Mohamed Awad, Issam Saliba, Jean-Jacques Dufour, Marc-Elie Nader

“…Abstract Background This study aims to assess the effectiveness of delayed facial nerve decompression for Bell’s palsy (BP). Methods We performed a retrospective case review of all patients having undergone facial nerve decompression for severe refractory BP between 1984 and 2009 at our tertiary referral center. …”
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GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia by Lai L, Wu H, Peng L, Zhang Z, Wu X, Zheng S, Su Z, Chu H

“…However, there have been no reports on its efficacy in treating limb ischemia through promoting angiogenesis.Materials and Methods: In this study, we prepared AST-loaded lignin nanoparticles (LNP/AST) with sustained-release functionality, which were mixed with GelMA hydrogel (GelMA@LNP/AST). …”
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Bariatric Surgery in Moderately Obese Patients: A Prospective Study by M. Cerci, M. I. Bellini, F. Russo, D. Benavoli, M. Capperucci, A. L. Gaspari, P. Gentileschi

“…The role of bariatric surgery in this context is currently debated, reserved for patients with comorbidity, as an alternative to conservative medical treatment. We describe our experience in moderately obese patients treated with bariatric surgery. …”
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Consumer Products Nerve Injuries Among Patients Products Presenting to United States Emergency Departments Between 2012 and 2021: A Nationwide Cohort by Ganga A, Mukhdomi T, Kim EJ, Ly E, Patel Y, Dankievitch KN, Kendall MC

“…Injuries often occur either due to activity (ie sports related injury) or due to consumer products such as stairs or bedframes. We investigated the incidence of consumer product-related nerve injuries (CPNIs) in patients who presented to the ED in the United States.Materials and Methods: The National Electronic Injury Surveillance System was queried to identify patients presenting to US EDs between 2012 and 2021 with CPNIs. …”
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Phylogeography and genetic diversity of Ulmus elongata (Ulmaceae), a Tertiary relict tree with extremely small populations (PSESP) by Yakun Wang, Xiankun Wang, Junyuan Wu, Jun Yang, Yanpei Liu, Peng Guo, Fude Shang, Nan Lin

“…Utilizing chloroplast genome datasets, we found that U. elongata exhibited remarkably low nucleotide diversity and gene flow (π = 0.00013, Nm = 0.03). …”
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High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT) by Yuxuan Ding, Yong Feng, Yangfan Ye, Jiayi Shen, Chang Guo, Xia He, Liangjun Zhu, Lijun Wang

“…Radiotherapy in combination with immune checkpoint inhibitors is one of promising therapies, and the choice of radiotherapy and immunotherapy modalities is also a hot issue.MethodsHere, we report on a Phase I trial treating nine patients with MSS CLRM using a combination of high and low dose radiotherapy and immune checkpoint inhibitors (ICIs).ResultsThe primary endpoint of the trial was the safety and tolerability of this combination treatment modality. …”
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Gender-specific dual effects of physical activity on depression and mortality: a nine-year cohort study in Chinese adults aged 45 and above by Dan Shan, Dan Shan, Meina Yang, Meina Yang, Kunyan Zhou, Kunyan Zhou

“…However, the effects of PA on depressed patients and potential gender-specific responses have not been fully elucidated. In this study, we aimed to investigate the role of PA on new-onset depression and ACM in Chinese adults aged 45 year and older, with particular emphasis on gender differences.MethodsThis was a longitudinal cohort study that took place over a nine-year period and featured 2,264 participants drawn from the China Health and Retirement Longitudinal Study (CHARLS). …”
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Global burden of neck pain and its gender and regional inequalities from 1990 - 2021: a comprehensive analysis from the Global Burden of Disease Study 2021 by Haifeng Wu, Yue Li, Congying Zou, Weidong Guo, Feng Han, Guoshun Huang, Lin Sun

“…For the first time, this study aims to provide the most recent estimates on the global burden of neck pain between 1990 and 2021 obtained from the 2021 global burden of disease (GBD) database, focusing on regional and gender inequalities. We also predict future trends, highlighting its increasing impact on public health. …”
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Cissus quadrangularis L. hexane extract infused glyoxal cross-linked chitosan-collagen scaffold elicits early osteoinduction by Praseetha R. Nair, P.S. Unnikrishnan, Sachin J. Shenoy, G.S. Sailaja

“…Materials and methods: Glyoxal cross-linked chitosan-collagen scaffold is prepared as per the procedure we have reported recently. A critical-size defect (6 mm diameter × 2 mm thickness) was made at the dorsal calvarium using a trephine burr. …”
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TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes by Wenrui Sun, Jianchao Zhang, Shuang Li, Wanrong Fu, Yangyang Liu, Mengduan Liu, Jianzeng Dong, Xiaoyan Zhao, Xiaowei Li

“…Methods In this study, we generated a TAB2 compound heterozygous knockout cell line in induced pluripotent stem cells (iPSCs) derived from a healthy individual using CRISPR/Cas9 technology. …”
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Combined real-time fMRI and real time fNIRS brain computer interface (BCI): Training of volitional wrist extension after stroke, a case series pilot study. by Avi K Matarasso, Jake D Rieke, Keith White, M Minhal Yusufali, Janis J Daly

“…<h4>Objective</h4>Pilot testing of real time functional magnetic resonance imaging (rt-fMRI) and real time functional near infrared spectroscopy (rt-fNIRS) as brain computer interface (BCI) neural feedback systems combined with motor learning for motor recovery in chronic severely impaired stroke survivors.<h4>Approach</h4>We enrolled a four-case series and administered three sequential rt-fMRI and ten rt-fNIRS neural feedback sessions interleaved with motor learning sessions. …”
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CO2 methanation over low-loaded Ni-M, Ru-M (M = Co, Mn) catalysts supported on CeO2 and SiC by Chopendra G. Wasnik, Maki Nakamura, Taiki Shimada, Hiroshi Machida, Koyo Norinaga

“…The present study investigated bimetallic catalysts with SiC, which is known for its exceptional thermal conductivity, and CeO2, which is characterized by its CO₂ affinity, as base materials. We incorporated Ni-M and Ru-M (M = Co and Mn) as the active metals, each loaded at 2 %. …”
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New insights into the salt-responsive regulation in eelgrass at transcriptional and post-transcriptional levels by Huan Zhao, Huan Zhao, Xu Dong, Xu Dong, Dazuo Yang, Dazuo Yang, Qingchao Ge, Qingchao Ge, Peng Lu, Peng Lu, Chang Liu, Chang Liu

“…By examining the transcriptional responses of homologous genes in eelgrass, rice, and maize, we identified several groups of genes that are conserved in their response to salt stress. …”
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An Exceptionally Powerful, Radiatively Driven Ultrafast Outflow in the Rapidly Accreting AGN RE J1034+396 by Chloe S. Taylor, Daniel R. Wilkins, Steven W. Allen

“…We report the analysis of ∼1 Ms of XMM-Newton observations of the rapidly accreting active galactic nucleus RE J1034+396. …”
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The impact of dietary patterns on gut microbiota for the primary and secondary prevention of cardiovascular disease: a systematic review by Junwen Yu, Yue Wu, Zheng Zhu, Hongzhou Lu

“…Our systematic review aimed to explore the effect of dietary patterns on gut microbiota composition and on risk factors for CVD in these populations. Methods We systematically searched seven databases, including PubMed/MEDLINE, MEDLINE (Ovid), Embase (Ovid), CINHAL (EBSCO), Web of Science, CNKI (Chinese), and Wanfang (Chinese), covering literature from inception to October 2024. …”
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Characteristics and Source-specific Health Risks of Ambient PM2.5-bound PAHs in an Urban City of Northern Taiwan by Yu-Chieh Ting, Chun-Hung Ku, Yu-Xuan Zou, Kai-Hsien Chi, Jhy-Charm Soo, Chin-Yu Hsu, Yu-Cheng Chen

“…Fifteen PAHs in PM2.5 were analyzed via gas chromatography tandem mass spectrometry (GC/MS-MS). We utilized a positive matrix factorization (PMF) model, diagnostic ratios, and potential source contribution function (PSCF) to identify the origins of PM2.5-bound PAHs. …”
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Hybrid Recommender System for Tourism Based on Big Data and AI: A Conceptual Framework by Khalid AL Fararni, Fouad Nafis, Badraddine Aghoutane, Ali Yahyaouy, Jamal Riffi, Abdelouahed Sabri

“…To assist tourists in trip planning and help them to find the information they are looking for, many recommender systems have been developed. In this article, we present an overview of the various recommendation approaches used in the field of tourism. …”
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Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses by J. P. van Wijngaarden, E. L. Doets, A. Szczecińska, O. W. Souverein, M. E. Duffy, C. Dullemeijer, A. E. J. M. Cavelaars, B. Pietruszka, P. van't Veer, A. Brzozowska, R. A. M. Dhonukshe-Rutten, C. P. G. M. de Groot

“…Meta-analysis of eight studies including 11511 people showed an increased fracture risk of 4% per μmol/L increase in homocysteine concentration (RR = 1.04, 95% CI = 1.02 to 1.07). We could not draw a conclusion regarding folate levels and fracture risk, as too few studies investigated this association. …”
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