Gallium Sulfide-Immobilized Optical Fiber-Based SPR Sensor for Detection of Brilliant Blue Food Adulteration by Nasih Hma Salah, Baljinder Kaur, Hogr M. Rasul, Yesudasu Vasimalla, Chella Santhosh, Ramachandran Balaji, S. R. Srither, Santosh Kumar

“…Surface plasmon resonance (SPR) biosensors provide a reliable, label-free method for highly sensitive detection of food adulterants. In this study, we present a novel gallium sulfide (GaS)-immobilized optical fiber SPR sensor designed for the rapid, real-time detection of BB synthetic dye. …”
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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tu... by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

“…The primary endpoint was all-cause death or new neurological event over the first 12 months after randomisation. We took a hybrid trial-design approach which aims to prove non-inferiority of placebo first but also allows claiming superiority of placebo in case dexamethasone causes substantial harm. …”
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Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults by Junping Liu, Zhaoyue Liu, Xinru Liu, Nan Wang, Lin Wu, Xiaoxue Xu, Wei Liu, Yajie Feng, Huanyu Zhang, Yue Zhou, Xinle Yin, Yaping Liu, Qunhong Wu, Ning Ning, Libo Liang

“…Methods Data from the National Health and Nutrition Examination Survey (NHANES) were employed, including 1,341 participants. We included participants with full details on OSAS, covariates, and 7 types of serum BFRs (PBDE28, PBDE47, PBDE99, PBDE100, PBDE153, PBB153, and PBDE209). …”
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Exploring healthcare workers’ immunisation behaviour towards COVID-19 vaccines through psychological patterns by Nour El Houda Benkaddour, Sara Ramdani, Hind Khalil, Asmae Lekfif, Naima Abda, Bouchra Oneib, Yassamine Bentata

“…Setting: Eastern region of Morocco. Methods: We conducted a descriptive and analytical cross-sectional study involving 221 healthcare professionals in the Eastern region of Morocco. …”
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Asthma and obesity increase inflammatory markers in children by Harshita Shailesh, Safa Noor, Lena Hayati, Antonisamy Belavendra, Nicholas Van Panhuys, Abdul Badi Abou-Samra, Stefan Worgall, Ibrahim Janahi, Ibrahim Janahi

“…However, the combined impact of these conditions on inflammatory mechanisms in children has not been studied extensively. To address this gap, we investigated the interaction effects of asthma and obesity on inflammation in children.MethodsThe multiplex and singleplex assays were used to measure the levels of circulating cytokines, including IL-2, IL-5, IL-10, IL-13, IL-17A, IL-22, IL-33, IFN-γ, TNF-α, and the adipokine leptin, in plasma. …”
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Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

“…Objectives Little is known about the prevalence of comorbidity rates in people with severe mental illness (SMI) in UK primary care. We calculated the prevalence of SMI by UK country, English region and deprivation quintile, antipsychotic and antidepressant medication prescription rates for people with SMI, and prevalence rates of common comorbidities in people with SMI compared with people without SMI.Design Retrospective cohort study from 2000 to 2012.Setting 627 general practices contributing to the Clinical Practice Research Datalink, a UK primary care database.Participants Each identified case (346 551) was matched for age, sex and general practice with 5 randomly selected control cases (1 732 755) with no diagnosis of SMI in each yearly time point.Outcome measures Prevalence rates were calculated for 16 conditions.Results SMI rates were highest in Scotland and in more deprived areas. …”
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Associations between Physical Exercise, Quality of Life, Psychological Symptoms and Treatment Side Effects in Early Breast Cancer by Leena Vehmanen, Johanna Mattson, Evangelos Karademas, Albino J. Oliveira-Maia, Berta Sousa, Ruth Pat-Horenczyk, Ketti Mazzocco, Panagiotis Simos, Fátima Cardoso, Greta Pettini, Chiara Marzorati, Eleni Kolokotroni, Georgios Stamatakos, Diana Frasquilho, Paula Poikonen-Saksela

“…Identifying and understanding modifiable factors for the well-being of cancer patients is critical in survivorship research. We studied variables associated with the exercise habits of breast cancer patients and investigated if the achievement of exercise recommendations was associated with enhanced quality of life and/or psychological well-being. …”
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Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based rand... by Natalie Walker, Amanda Calder, Joanne Barnes, George Laking, Varsha Parag, Chris Bullen

“…Abstract Background Combining short-acting nicotine replacement therapy with varenicline increases smoking cessation rates compared with varenicline alone, but not all people tolerate these medications or find them helpful. We aim to investigate the therapeutic potential of an analogous combination, by evaluating the effectiveness, safety, and acceptability of combining nicotine salt e-cigarettes with cytisine, compared to nicotine salt e-cigarettes or cytisine only, on smoking abstinence at six months. …”
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Identification and Verification of Novel Biomarkers Involving Rheumatoid Arthritis with Multimachine Learning Algorithms: An In Silicon and In Vivo Study by Fucun Liu, Juelan Ye, Shouli Wang, Yang Li, Yuhang Yang, Jianru Xiao, Aimin Jiang, Xuhua Lu, Yunli Zhu

“…However, due to the heterogeneity among RA patients, there are still no robust diagnostic and therapeutic biomarkers for the diagnosis and treatment of RA. Methods. We retrieved RA-related and pan-cancer information datasets from the Gene Expression Omnibus and The Cancer Genome Atlas databases, respectively. …”
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Exploring the utility of different bulking agents for speeding up the composting process of household kitchen waste by Sania Mussa, Muhammad Farhan, Shoaib Ahmad, Khadija Zahra, Amina Kanwal, Qaiser Farid Khan, Muhammad Afzaal, Abdul Wahid, Pallab K. Sarker, Mohamed A. El-Sheikh, Shafaqat Ali

“…This study is designed to achieve a zero-waste concept and to convert HKW. We optimized the type and size of three different bulking agents to speed up the composting process. …”
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Proximal bronchiolar adenoma with malignant transformation to invasive mucinous adenocarcinoma with 4 years follow-up: a case report and literature review by Yuan-Hui Yang, Ke Yin, Jia-Qi Xu, Xiao-Ying Xu, Jun-Lei Zhang, Ji-Xuan Liu, Xin-Zhi Feng, Xiao-Yan Lin, Xiao-Yan Lin

“…In frozen sections, basal cells are difficult to identify under the microscope, which makes it difficult to distinguish from mucinous adenocarcinoma, especially when BA malignancies transform into invasive mucinous adenocarcinoma (IMA), which can only be distinguished by histomorphological criteria, greatly increasing the difficulty of diagnosis.Case summaryIn this paper, we present a case study of a 59-year-old man whose chest computed tomography (CT) revealed a progressively enlarging, high-density nodule over a four-year period in the outer basal segment of the right lower lobe. …”
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Master Robotic Net by Vladimir Lipunov, Victor Kornilov, Evgeny Gorbovskoy, Nikolaj Shatskij, Dmitry Kuvshinov, Nataly Tyurina, Alexander Belinski, Alexander Krylov, Pavel Balanutsa, Vadim Chazov, Artem Kuznetsov, Petr Kortunov, Anatoly Sankovich, Andrey Tlatov, A. Parkhomenko, Vadim Krushinsky, Ivan Zalozhnyh, A. Popov, Taisia Kopytova, Kirill Ivanov, Sergey Yazev, Vladimir Yurkov

“…All MASTER telescopes can be guided by alerts, and we plan to observe prompt optical emission from gamma-ray bursts synchronously in several filters and in several polarization planes.…”
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Modulating the coordination environment of cobalt porphyrins for enhanced electrochemical nitrite reduction to ammonia by Jingwei Han, Hai Sun, Fengkun Tian, Wenwen Zhang, Zonghang Zhang, Ping She, Jun‐Sheng Qin, Heng Rao

“…However, designing and controlling the coordination environment of molecular catalysts is crucial for studying the mechanism of NO2−RR and catalyst design. Herein, we develop a molecular platform of cobalt porphyrin with three coordination microenvironments (Co‐N3X1, X = N, O, S). …”
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Combined effects of co-exposure to microcystin-LR and polystyrene microplastics on growth, brain pathology and thyroid hormone homeostasis in adult zebrafish by Wang Lin, Ling Liao, Ling Ling, Huimin Luo, Ying Jiang, Xinru Li, Yilong Yao, Pinhong Yang

“…In the MCLR-only treatment groups, we observed mild brain tissue damage characterized by glial scarring and hyperemia. …”
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Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages by Hiroki Yamazaki, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, Yusuke Nakatsu, Takako Kikuchi, Sunao Kaneko, Hirotoshi Tanaka, Tomoichiro Asano

“…In this study, using adipocytes and macrophages, we focused on the in vitro effects of SHBG on inflammation as well as lipid metabolism. …”
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Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation by Yiling Han, Qiangwang Geng, Aimeng Dong, Menglu Jiang, Jingyi Ma, Wulian Song, Pan Fan, Yuanyuan Li, Jiawen Gao, Fenghua Zhang, Jinsong Leng, Huiping Yuan

“…Although it is known that in implanted medical devices, microscale modification of the implant surface can modulate cell behavior and reduce the incidence of fibrosis, in the field of ophthalmic implants, especially the modification and effects of hydrogel micropatterns have rarely been reported. Here, we designed the patterned gelatin/acrylamide double network hydrogel and developed an innovative GDD with micropattern to suppress inflammatory and fibroblast activation after GDD implantation. …”
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An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers by Xiaoliang Qi, Yajing Xiang, Ying Li, Jiajia Wang, Yuxi Chen, Yulong Lan, Jinsong Liu, Jianliang Shen

“…However, their efficacy frequently faces obstacles due to uncontrolled premature activation and spatiotemporal distribution differences under physiological circumstances. Herein, we present an endogenous ATP-activated prodrug system (termed ISD3) consisting of nanoparticles (indole-3-acetic acid/zeolitic imidazolate framework-8@polydopamine@platinum, IZPP) embedded in a silk fibroin-based hydrogel, aimed at treating multidrug-resistant (MDR) bacteria-infected pressure ulcers. …”
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Vitamin D supplementation during intensive care unit stay is associated with improved outcomes in critically Ill patients with sepsis: a cohort study by Caifeng Li, Ke Zhao, Qian Ren, Lin Chen, Ying Zhang, Guolin Wang, Keliang Xie

“…However, whether vitamin D supplementation would improve their prognosis remains uncertain.MethodsWe conducted a retrospective cohort study using data from MIMIC-IV database, a publicly available database containing clinical information on patients admitted to the ICU at Beth Israel Deaconess Medical Center (BIDMC) from 2008 to 2019. …”
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Paraplegia due to Thoracic Mobile Schwannoma after Myelography by Akira Honda, Yoichi Iizuka, Tokue Mieda, Hiroyuki Sonoda, Sho Ishiwata, Yohei Kakuta, Daisuke Tsunoda, Eiji Takasawa, Tsuyoshi Tajika, Hiromi Koshi, Hirotaka Chikuda

“…Spinal mobile tumors are very rare. We herein report a case of paraplegia caused by migration and incarceration of thoracic mobile schwannoma after myelography. …”
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Moxibustion for Herpes Zoster and Postherpetic Neuralgia: A Meta-Analysis by Yuanen Huang, Jingping Wu, Hongbin Cheng, Yanling Liu

“…From a total of 1957 identified studies, 31 were included in analysis (N = 2334 cases). 31 RCTs contained the experimental sample of 1185 cases and the control sample of 1149 cases reported efficiency of different moxibustions in the treatment of herpes zoster, statistical heterogeneity inspection without heterogeneity. So, we used the fixed-effects model, merge effect quantity OR = 3.89 (95% CI: 2.88∼5.25), Z = 8.86, and it suggested sample merger analysis was statistically significant. …”
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