“Unmasking the Uncommon”: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates [version 2; peer review:... by Anisha Maria Fernandes, Sinchana Bhat, Suchitra Shenoy M., Prajnha U.P.

“…It exhibits resistance to many commonly employed first-line antibiotics used to treat gram-negative pathogens. Herein, we present three cases of late-onset sepsis with multi-drug resistant (MDR) Elizabethkingia meningoseptica in high-risk neonates. …”
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Evaluation of a new human immunodeficiency virus antigen and antibody test using light-initiated chemiluminescent assay by Yijun Li, Fangfang Jin, Yunhui Li, Yan Li, Yajie Wang, Ximing Yang

“…ObjectivesThe goal of this study is to evaluate the analytical and clinical performance of a new human immunodeficiency virus antigen and antibody (HIV Ag/Ab) test using light-initiated chemiluminescent assay (LiCA®) and compare it with the well-established Architect® HIV Ag/Ab combo assay in a clinical setting.MethodsWe used banked samples and national reference controls to identify the ability to detect HIV Ag/Ab and different viral subtypes. …”
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Cognitive behavior therapy for academic burnout, procrastination, self-handicapping behavior, and test anxiety among adolescents: a randomized control trial by Khizra Khurshid, Rabia Mushtaq, Umara Rauf, Nida Anwar, Qasir Abbas, Sumayah Aljhani, Zoobia Ramzan, Mafia Shahzadi

“…After the baseline assessment, participants were involved in the treatment condition, and after 6–8 follow-up sessions, they were referred for the post-assessment. We used different assessment measures to assess the outcome, i.e. …”
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Fire-driven disruptions of global soil biochemical relationships by Guiyao Zhou, Nico Eisenhauer, Zhenggang Du, Manuel Esteban Lucas-Borja, Kaiyan Zhai, Miguel Berdugo, Huimin Duan, Han Wu, Shengen Liu, Daniel Revillini, Tadeo Sáez-Sandino, Hua Chai, Xuhui Zhou, Manuel Delgado-Baquerizo

“…Yet, how soil biogeochemistry and its environmental drivers respond to fire remain virtually unknown globally. Here, we integrate experimental observations and random forest model, and reveal significant divergence in the responses of soil biogeochemical attributes to fire, including soil carbon (C), nitrogen (N), and phosphorus (P) contents worldwide. …”
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The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome by Jin Ye, Hui Liu, Gehua Zhang, Peng Li, Zhiyuan Wang, Shaotong Huang, Qintai Yang, Yuan Li

“…Twenty-three patients were classified into mild to moderate group and 21 cases were classified into severe group according to the severity of OSAS. We detected the frequencies of Th17 and Treg and related serum cytokines secretion and expressions of key transcription factors. …”
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Trends in clinical encounters and management for infertility among women attending Australian general practice: a national longitudinal study using MedicineInsight, 2011 to 2021 by Alice R Rumbold, Michael Davies, Danielle Mazza, Jacqueline Boyle, Vivienne Moore, Renae C Fernandez, Luke E Grzeskowiak

“…Univariable logistic regression analyses compared the likelihood of women having a documented clinical encounter related to infertility and receiving selected management actions based on individual characteristics. We also examined practice-level variation in the proportion receiving selected management for infertility by stratifying proportions based on practice site.Results A total of 2 552 339 women had one or more clinical encounters with their general practitioner (GP) between January 2011 and December 2021, of which 27 671 (1.1%) had a clinical encounter related to infertility management. …”
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Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study by Hongwei Wang, Fangying Tian, Caizheng Yang, Xinyu Cui, Yongxia Ding, Ming Zhao, Xueyu Wang, Shanshan Ge

“…It has been suggested that Hp infection affects the development of MetS in the host, but the causal relationship between the two has not been confirmed. Methods We conducted a two-sample Mendelian randomization study to investigate the causal effect of Hp infection with MetS and its components. …”
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The association of lifestyle with cardiovascular and all-cause mortality based on machine learning: a prospective study from the NHANES by Xinghong Guo, Mingze Ma, Lipei Zhao, Jian Wu, Yan Lin, Fengyi Fei, Clifford Silver Tarimo, Saiyi Wang, Jingyi Zhang, Xinya Cheng, Beizhu Ye

“…As age increases, the effects of dietary scores and sedentary time on mortality risk become more pronounced, while the influence of physical activity tends to diminish. Conclusion We develop a ML model based on lifestyle behaviors to predict all-cause and cardiovascular mortality. …”
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Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids by Annabell Reinhold, Annegret Glasow, Sandra Nürnberger, Annett Weimann, Lucie Telemann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz

“…A combination therapy (IR+PDT) could be beneficial for BCa treatment. Purpose: For PDT, we used the near-infrared photosensitizer tetrahydroporphyrin-tetratosylate (THPTS) showing high therapeutic efficacy. …”
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Prediction of Reproductive Outcomes of Intracytoplasmic Sperm Injection Cycles Using a Multivariate Scoring System by Ahmed Abuelsoud Abden, Momen Ahmed Kamel, Ahmed Nabil Fetih, Ali Haroun Yousef

“…For each woman included in the study, Younis multivariate score was calculated. Then, we correlate the different reproductive outcomes with score levels to validate the score predictability. …”
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Temporally enhanced RSEI and nighttime lights reveal long-term ecological changes and effective protection in China’s inaugural national parks by Chunhui Wen, Tengfei Long, Guojin He, Weili Jiao, Wei Jiang

“…It also examines changes in human activities within and surrounding these parks using nighttime light (NTL) remote sensing data. We used Sen + MK trend analysis, climate factor removal analysis, and geographical detectors to explore the driving forces behind ecological environment quality changes and compare the effectiveness of ecological protection measures across different NPs. …”
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Adipose tissue-derived microRNA-450a-5p induces type 2 diabetes mellitus by downregulating DUSP10 by Jiaojiao Zhu, Yanting Hou, Wei Yu, Jingzhou Wang, Xiaolong Chu, Xueting Zhang, Huai Pang, Dingling Ma, Yihan Tang, Menghuan Li, Chenggang Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…In obesity, microRNA levels have been implicated in glucose metabolism disorders and T2DM, although many aspects remain unresolved. Here, we confirmed that visceral adipose tissue and serum microRNA-450a-5p content increased under obesity and T2DM, and it was significantly positively associated with fasting blood glucose, triglycerides, cholesterol, low-density lipoproteins-cholesterol levels of the subjects. …”
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Characterization of a Complex Mixture of Immunomodulator Peptides Obtained from Autologous Urine by Alberto Fragoso, Mérida Pedraza-Jiménez, Laura Espinoza-González, María Luisa Ceja-Mendoza, Hugo Sánchez-Mercado, Gloria Robles-Pérez, Julio Granados, Emilio Medina-Rivero

“…In this sense, it is expected to have the same molecular weight range although the profile of peptide abundance is different. Here, we characterized the peptide profile of three extracts of an immunomodulator obtained from the urine of different volunteers suffering from three different diseases (i.e., allergic rhinitis, rheumatoid arthritis, and chronic rhinopharyngitis), using size exclusion chromatography (SEC) and mass spectrometry (MS). …”
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Patient-Controlled Analgesia (PCA): Intravenous Administration (IV-PCA) versus Oral Administration (Oral-PCA) by Using a Novel Device (PCoA® Acute) for Hospitalized Patients with A... by Stefan Wirz, Stefanie Seidensticker, Ronit Shtrichman

“…Oral-PCA is a safe and beneficial alternative to intravenous (IV) PCA. We have developed a novel Oral-PCA device, which enables self-administration of solid pills to the patient’s mouth. …”
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Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis by Fatemeh B. Rassouli, Maryam M. Matin, Maryam M. Matin, Farzin Hadizadeh, Farzin Hadizadeh, Masoud Nejabat, Hossein Allahverdizadeh, Hamidreza Jamali, Shahin Gharedaghi, Halimeh Hassanzadeh

“…Due to the urgent demand for potent anti-metastatic agents, we aimed to determine the effects of sunitinib and novel analogs on the metastatic behavior of human CRC cells in hypoxic condition for the first time.MethodsFor in silico analyses, pathogenic targets of metastatic CRC were identified, PPI network was constructed and KEGG pathway enrichment analysis was conducted. …”
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Your brain on art, nature, and meditation: a pilot neuroimaging study by Beatrix Krause-Sorio, Sergio Becerra, Prabha Siddarth, Stacey Simmons, Taylor Kuhn, Helen Lavretsky

“…In a pilot functional magnetic resonance (fMRI) study, we explored the effect of watching digital art or nature videos compared to contemplating the universal connectedness (also known as transcendental meditation). …”
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Association between sleep disorders and subsequent heart failure by Jamschid Sedighi, Mark Luedde, Julia Gaensbacher-Kunzendorf, Hans-Joerg Hippe, Pascal Bauer, Birgit Assmus, Samuel Sossalla, Karel Kostev

“…Objective: The purpose of this study was to investigate whether sleep disorders are associated with an increased risk of developing HF. Methods: We conducted a retrospective cohort study using data from 1,293 general practices across Germany sourced from the IQVIA Disease Analyzer database. …”
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Assessment of Fish Species Biodiversity in the Yong River Basin Based on Environmental DNA Metabarcoding by Shengming Deng, Bai-an Lin, Yan Luo, Xiaolong Dang, Chengdan Ma, Yongcan Zhou, Xiang Zhang, Yang Zhang, Ning Xu, Shousong Jiang, Jiana Li, Jianlong Li

“…In this study, environmental DNA (eDNA) metabarcoding was employed to assess fish species biodiversity across five river sections of the Yong River basin in October 2022. Additionally, we checked the results against fishing gear (drift gillnets and ground cages) surveys and historical records. …”
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Rationale and Design of the First Double-Blind, Placebo-Controlled Trial with Allogeneic Adipose Tissue-Derived Stromal Cell Therapy in Patients with Ischemic Heart Failure: A Phas... by Jens Kastrup, Morten Schou, Ida Gustafsson, Olav W. Nielsen, Rasmus Møgelvang, Klaus F. Kofoed, Charlotte Kragelund, Jens Dahlgaard Hove, Andreas Fabricius-Bjerre, Merete Heitman, Mandana Haack-Sørensen, Lisbeth Drozd Lund, Ellen Mønsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Annette Ekblond

“…Ischemic heart failure (IHF) has a poor prognosis in spite of optimal therapy. We have established a new allogeneic Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors. …”
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Fecal Microbiota Transplantation as Therapy for Treatment of Active Ulcerative Colitis: A Systematic Review and Meta-Analysis by Xiaolei Liu, Yan Li, Kaichun Wu, Yongquan Shi, Min Chen

“…A systematic review and meta-analysis was conducted to evaluate the efficacy and safety of FMT for treatment of active UC. Methods. We searched Cochrane, Medline, Web of Science, and Embase from inception to February 2020. …”
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