Age of Insomnia Onset Correlates with a Reversal of Default Mode Network and Supplementary Motor Cortex Connectivity by Emiliano Santarnecchi, Chiara Del Bianco, Isabella Sicilia, Davide Momi, Giorgio Di Lorenzo, Salvatore Ferrone, Giulia Sprugnoli, Simone Rossi, Alessandro Rossi

“…This might lead to alterations in brain connectivity patterns as those captured by functional connectivity fMRI analysis, leading to potential insight about primary insomnia (PI) pathophysiology as well as the impact of long-term exposure to sleep deprivation. We investigated changes of voxel-wise connectivity patterns in a sample of 17 drug-naïve PI patients and 17 age-gender matched healthy controls, as well as the relationship between brain connectivity and age of onset, illness duration, and severity. …”
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Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology by Robin Christ, Devon Siemes, Shuo Zhao, Lars Widera, Philippa Spangenberg, Julia Lill, Stephanie Thiebes, Jenny Bottek, Lars Borgards, Andreia G. Pinho, Nuno A. Silva, Susana Monteiro, Selina K. Jorch, Matthias Gunzer, Bente Siebels, Hannah Voss, Hartmut Schlüter, Olga Shevchuk, Jianxu Chen, Daniel R. Engel

“…Abstract Infection with enterohemorrhagic E. coli (EHEC) causes severe changes in the brain leading to angiopathy, encephalopathy and microglial activation. In this study, we investigated the role of tumour necrosis factor alpha (TNF-α) for microglial activation and brain pathology using a preclinical mouse model of EHEC infection. …”
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Enhancing PDAC therapy: Decitabine-olaparib synergy targets KRAS-dependent tumors by Giorgia Anastasio, Michela Felaco, Alessia Lamolinara, Francesco del Pizzo, Elisa Cacciagrano, Carla Mottini, Margherita Mutarelli, Francesca Di Modugno, Manuela Iezzi, Luca Cardone

“…Previous research indicates that dKRAS-PDAC cells are sensitive to decitabine (DEC), an FDA-approved drug for hematological cancers, though its use in solid tumors is limited by side effects. We discovered that low-dose DEC combined with the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib (OLA) enhances antitumor activity in dKRAS-PDAC. …”
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Measurement of Circulating 1,25-Dihydroxyvitamin D: Comparison of an Automated Method with a Liquid Chromatography Tandem Mass Spectrometry Method by Armin Zittermann, Jana B. Ernst, Tobias Becker, Jens Dreier, Cornelius Knabbe, Jan F. Gummert, Joachim Kuhn

“…In 129 clinical samples, we compared a new automated assay with a commercially available liquid chromatography tandem mass spectrometry (LC-MS/MS) kit. …”
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Tinnitus Suppression with Electrical Stimulation at the Most Basal Contact of the Cochlear Implant Electrode as a Model for Round Window Stimulation by Kiana Kheirkhah, Valerie Van Kelecom, Marc Leblans, Joost van Dinther, Glynnis De Greve, Erwin Offeciers, Andrzej Zarowsk

“…Conclusion: In 8 of the 10 included patients, we were able to obtain complete or almost complete tinnitus suppression with electrical stimulation at only 1 most basal electrode contact. …”
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Genes related to neural tube defects and glioblastoma by Rui Cao, Yurong Liu, Kaixin Wei, Ning Jin, Yuxiang Liang, Ruifang Ao, Weiwei Pan, Xiang Wang, Xiuwei Wang, Li Zhang, Jun Xie

“…To obtain genes related to both NTDs and GBM, as well as small molecule drugs with potential clinical application value. We performed bioinformatics analysis on transcriptome sequencing data of retinoic acid (RA)-induced NTDs mice, human NTDs samples and GBM samples. …”
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Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis by Weiquan Huang, Libin Liao, Qian Liu, Rongchao Ma, Xuan He, Xuan He, Xiaoqiong Du, Dujuan Sha, Dujuan Sha, Dujuan Sha, Dujuan Sha

“…This study conducted a meta-analysis to evaluate the potential of various blood biomarkers associated with neuronal function as indicators of VCI. We searched four major databases—PubMed, Embase, Web of Science, and the Cochrane Library—up to December 31, 2023, for research on blood biomarkers for VCI. …”
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Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer by Zhe Chen, Gaoming Wang, Nan Wang, Jiangjiang Liu, Yu Yao, Haitao Ma, Haitao Ma, Jing Luo, Kai Xie

“…Among these, 5,302 FPLC patients developed SPLC within 5 years of their initial diagnosis. We employed the Fine-Gray competitive risk model, Cox proportional hazards model, and restricted mean survival time analysis to assess the effects of FPLC radiotherapy and chemotherapy on SPLC risk and survival differences.ResultsThe competitive risk model indicated that FPLC radiotherapy and chemotherapy did not significantly change the risk of developing SPLC. …”
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Accounting for differences between crops and regions reduces estimates of nitrate leaching from nitrogen-fertilized soils by Yan Wang, Yihong Liu, Longlong Xia, Hiroko Akiyama, Xinli Chen, Ji Chen, Yunying Fang, Tony Vancov, Yongfu Li, YuanZhi Yao, Dianming Wu, Bing Yu, Scott X. Chang, Yanjiang Cai

“…However, substantial uncertainties and variabilities in NO3 − leaching factors (LFs) among regions or crops impede accurate assessments of NO3 − leaching. Here we synthesize 2500 field observations worldwide and show that LFs vary by an order of magnitude across regions and crops, primarily driven by hydroclimatic and edaphic conditions rather than N fertilizer management. …”
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Evolution of local heterogeneity towards flat free energy landscape: Optimization of piezoelectric response in PNN-PZ-PT at morphotropic phase boundary by Shubham Modgil, Varun Kamboj, Mukul Kumar, Arun Kumar Singh, Shobhna Dhiman, Gyaneshwar Sharma, OP Thakur, Sanjeev Kumar

“…To enhance piezoelectric response, we adopt rare earth Sm3+ doping into ternary based morphotropic phase boundary 0.55Pb(Ni1/3Nb2/3)O3–0.135PbZrO3–0.315PbTiO3 samples. …”
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Evaluation of different sesame varieties cultivated under saline conditions in the southwestern coastal region of Bangladesh by Md Shihab Uddine Khan, Md Moshiur Rahman, Arup Ratan Basak, Prodipto Bishnu Angon, Sadia Afroz Ritu, Milon Kobir, Md Riazul Islam

“…The salty portions of the country have much lower agricultural yields, cropping intensities, and productivity than the rest of the country. In this paper, we compared the variations of yield performance and salinity torelance between modern and local sesame varieties to select the best-performing varieties under saline conditions in the southwestern coastal region of Bangladesh. …”
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TMBocelot: an omnibus statistical control model optimizing the TMB thresholds with systematic measurement errors by Xin Lai, Shaoliang Wang, Xuanping Zhang, Xiaoyan Zhu, Yuqian Liu, Zhili Chang, Zhili Chang, Xiaonan Wang, Xiaonan Wang, Yang Shao, Yang Shao, Jiayin Wang, Yixuan Wang

“…Given the unavoidable errors with current technologies, it is essential to adopt modeling methods to determine the optimal TMB-positive threshold. Therefore, we proposed a universal framework, TMBocelot, which accounts for pairwise measurement errors in clinical data to stabilize the determination of hierarchical thresholds. …”
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Kontemplacja mistyczna w ujęciu św. Jana od Krzyża by Jerzy Wiesław Gogola

“…Jana od Krzyża obserwujemy praktykę modlitwy aż do śmierci we wszystkich jej formach, włącznie z modlitwą ustną. …”
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A review of metabolic calorimetric applications in plant stress, waste management, and diagnostics by Michael Bayode, Ifeoluwaposi Ogundana, Oluwatosin Ogundare, Elizabeth Awodire, Patience Abbah, Israel Onifade, Adeola Adeyolanu, Stephen Okunade, Samuel Ogboye, Michael Elabiyi

“… The majority of metabolic activities occur in adiabatic environments; carbon uptake in soils serves as a signal for thermal heat fluxes, and plants can spontaneously generate heat during metabolic processes. We discuss calorimetric studies that use basic chemical approaches, such as isothermal microcalorimetry (IMC) and differential scanning calorimetry (DSC), to investigate plant responses to abiotic and biotic stresses, vegetative growth, seed germination rate, and micropropagation viability. …”
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Microstructural modifications in bitumens rejuvenated by oil from pyrolysis of waste tires by Michela Alfe, Valentina Gargiulo, Giovanna Ruoppolo, Francesco Cammarota, Pietro Calandra, Cesare Oliviero Rossi, Valeria Loise, Michele Porto, Roberto Di Capua, Paolino Caputo

“…Instead of being landfilled, aged asphalts can be reused in new pavements after pretreatment with specific additives to restore their original properties.MethodsBy considering conscious utilization of natural resources, we propose using the condensable fraction (oil) obtained from the pyrolysis of waste tires (WTs) as the agent to rejuvenate aged bitumen. …”
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Oral Plaque from Type 2 Diabetic Patients Reduces the Clonogenic Capacity of Dental Pulp-Derived Mesenchymal Stem Cells by Antonella Bordin, Francesca Pagano, Eleonora Scaccia, Matteo Saccucci, Iole Vozza, Noemi Incerti, Antonella Polimeni, Elena Cavarretta, Isotta Chimenti, Elena De Falco

“…However, to what extent the biology of the progenitor pool is affected has still to be elucidated. In this short report, we aimed to explore the biological effects of oral plaque derived from T2D patients with PD in comparison to non-diabetic patients with PD. …”
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Protective effect of brain and muscle arnt-like protein-1 against ethanol-induced ferroptosis by activating Nrf2 in mice liver and HepG2 cells by Yanan Zhao, Ranran Zhang, Ziheng Chen, Ziyi Wang, Shuang Guan, Jing Lu

“…Ferroptosis is a newly recognized form of regulated cell death caused by the iron-dependent accumulation of lipid peroxidation. Here we showed that the circadian clock protein BMAL1 in hepatocytes is both necessary and sufficient to protect against ALD by mitigating ferroptosis. …”
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The effect of molecular structure of chlorin photosensitizers on photo-bleaching of 1,3-diphenylisobenzofuran—the possible evidence of iodine reactive species formation by Kustov, Andrey, Morshnev, Philipp, Kukushkina, Natal’ya, Krestyaninov, Mikhail, Smirnova, Nataliya, Berezin, Dmitry, Kokurina, Galina, Belykh, Dmitry

“…In this short communication, we focus on the ability of chlorin e$_{6}$ photosensitizers (PSs) with one, two or three cationic groups to generate singlet oxygen species ($^{1}$O$_{2}$) in an apolar model medium, viz. 1-octanol (OctOH). …”
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Chemical constituents, biological functions and pharmacological effects for comprehensive utilization of Eucommia ulmoides Oliver by Yi-Fan Xing, Dong He, Yi Wang, Wen Zeng, Chong Zhang, Yuan Lu, Nan Su, Yan-Hua Kong, Xin-Hui Xing

“…In order to improve the comprehensive utilization efficiency of E. ulmoides Oliv., in this review, we summarized the varieties and contents of main active compounds, biological functions and pharmacological effects in different parts of E. ulmoides Oliv. …”
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Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker by Ni M, Peng W, Wang X, Li J

“…However, the molecular mechanisms by which aging causes UC remain unclear. In this study, we explored the role of aging-related genes (ARGs) in UC pathogenesis and diagnosis prediction.Methods: Gene expression data were obtained from four independent datasets (GSE75214, GSE87466, GSE94648, and GSE169568) in the GEO database, and ARGs were derived from multiple public databases. …”
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