Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells by Jingwei Liu, Jingwei Liu, Tong Shu, Yiheng Mu, Wanlin Zheng, Xiaohuan Lu, Xiaohuan Lu, Hong Tao, Hong Tao

“…This study aims to explore the molecular mechanisms of curdione and borneol in treating HPV infection.MethodsWe conducted a retrospective cohort analysis of medical records from a single-center study involving 205 HPV patients, focusing on the correlation between HPV clearance and co-infection with other pathogens, confirming the efficacy of Baofukang suppository. …”
Get full text

Clinical and Radiographic Outcomes of Gap Osteotomy Versus Dorsal Opening Wedge Osteotomy for Extra-Articular Distal Radius Malunion and Internal Fixation Using a Volar Locking Pla... by Suhas Sondur, MS (Ortho), Anil K. Bhat, MS (Ortho), DNB (Ortho), Shyamasunder Bhat N, MS (Ortho), DNB (Ortho)

“…This study evaluated the outcomes of gap versus dorsal opening wedge and locking plate fixation without bone grafts for distal radius malunions and the correlation between the osteotomy defect and the osteotomy’s distance from the articular surface with the union time. Methods: We retrospectively reviewed 62 patients who underwent corrective osteotomy between 2010 and 2021. …”
Get full text

Water scarcity in semi-arid California compromises perennial alfalfa’s high yield and carbon sinking potentials by Tianxin Wang, Kanishka Mallick, Joseph Verfaille, Daphne Szutu, Dennis Baldocchi

“…However, water scarcity in these regions poses increasing challenges to alfalfa’s yield and carbon sinking potential. In this study, we used long-term eddy covariance data (2017–2023) to assess the trade-off between yield potential and water availability via energy, water, and carbon dynamics at an irrigated alfalfa site in California. …”
Get full text

The Impact of Effective Vaccination on Clinical and Radiological Involvement in COVID-19 Patients by Coskun DOGAN, Deniz BILICI, Burcu ARPINAR YIGITBAS, Omer ZENGIN, Orhan ZOR, Oguzhan AKMAN, Ilyas KOCABAG, Gonul Seven YALCIN, Esra ERTAN YAZAR

“…Objective: We aimed to analyze clinical, radiological, and laboratory differences between vaccinated and unvaccinated patients admitted to hospital due to coronavirus disease-2019 (COVID-19) pneumonia. …”
Get full text

Effects of Electroacupuncture at Governor Vessel Acupoints on Neurotrophin-3 in Rats with Experimental Spinal Cord Injury by Yu-ping Mo, Hai-jiang Yao, Wei Lv, Liang-yu Song, Hong-tao Song, Xiao-chen Yuan, Ying-qiu Mao, Quan-kai Jing, Su-hua Shi, Zhi-gang Li

“…SCI was induced by a modified Allen’s weight-drop method. We investigated the response of EA at Dazhui (GV 14) and Mingmen (GV 4) acupoints to understand the effects and mechanisms of EA in neuroprotection and neuronal function recovery after SCI. …”
Get full text

Landslide Susceptibility Mapping Using Single Machine Learning Models: A Case Study from Pithoragarh District, India by Trinh Quoc Ngo, Nguyen Duc Dam, Nadhir Al-Ansari, Mahdis Amiri, Tran Van Phong, Indra Prakash, Hiep Van Le, Hanh Bich Thi Nguyen, Binh Thai Pham

“…Single, ensemble, and hybrid machine learning (ML) models have been used in landslide studies for better landslide susceptibility mapping and risk management. In the present study, we have used three single ML models, namely, linear discriminant analysis (LDA), logistic regression (LR), and radial basis function network (RBFN), for landslide susceptibility mapping at Pithoragarh district, as these models are easy to apply and so far they have not been used for landslide study in this area. …”
Get full text

Biomarkers for Diagnosis and Prediction of Outcomes in Contrast-Induced Nephropathy by Justor Banda, Raquel Duarte, Therese Dix-Peek, Caroline Dickens, Pravin Manga, Saraladevi Naicker

“…Serum creatinine is suboptimal as a biomarker in the early diagnosis of contrast-induced nephropathy (CIN). In this study, we investigated a panel of novel biomarkers in the early diagnosis of CIN and in assessing patient outcomes. …”
Get full text

Unveiling the role of melatonin‐related gene CSNK1D in osteoclastogenesis and its implications for osteoporosis treatment by Jiewen Zhang, Shaobo Wu, Fangze Xing, Ning Kong, Yiwei Zhao, Xudong Duan, Yiyang Li, Kunzheng Wang, Run Tian, Pei Yang

“…This study aimed to identify the relationship between melatonin‐related genes and OP through bioinformatics methods and to verify it experimentally.We analysed microarray data from the GSE35959 dataset, identifying differentially expressed genes in OP patients. …”
Get full text

Indications for Endoscopic Ultrasound-Guided Pancreatic Drainage: For Benign or Malignant Cases? by Daisuke Uchida, Hironari Kato, Yosuke Saragai, Saimon Takada, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Hiroyuki Okada

“…Endoscopic ultrasound-guided pancreatic drainage (EUS-PD) was developed as an alternative to a surgical approach after failed ERP; however, the indications for EUS-PD are unclear. In this study, we evaluated the outcomes of EUS-PD and established the indications for EUS-PD. …”
Get full text

The BASIDIN effector of the fungus Moniliophthora perniciosa promotes positive effects on the seed germination and seedlings development of Lactuca sativa by Keilane Silva Farias, Monaliza Macêdo Ferreira, Ivina Barbosa De Oliveira, Ronaldo José Durigan Dalio, Carlos Priminho Pirovani

“…Based on this premise, we tested the effect of the rBASIDIN effector regarding its ability to induce germination and physiological changes in lettuce seedlings through seed treatment. …”
Get full text

Descripción de la estructura familiar de una muestra de pacientes con hemofilia. Comparación Argentina-México / Description of a Sample of Hemophilia Patients’ Family Structures: A... by Maricela Osorio-Guzmán, Silvina Graña

“…For adaptability, on the other hand, 100% of the Mexican families presented a rigid structure. Discussion: We believe that to recover a healthy balance and improve family life quality, integrated and sustained psychological intervention is required. …”
Get full text

Common spine codes are reimbursed 13% less by Medicaid compared to Medicare, ranging from 46% to 160% by state by Adam P. Henderson, BS, M. Lane Moore, MD, MBA, Camryn S. Payne, BA, Jack M. Haglin, MD, MS, Joseph C. Brinkman, MD, Paul R. Van Schuyver, MD, Joshua S. Bingham, MD, Michael S. Chang, MD

“…Substantial variability between states and codes was also found for Medicaid, while little variability in Medicare rates existed. Conclusions: We found that Medicaid reimbursement to surgeons for 24 common spine surgeons was 13% less than Medicare on average. …”
Get full text

Risk factors for mediastinal lymph node metastasis and lung metastasis in papillary thyroid carcinoma patients: who benefits from preoperative computed tomography? by Yoko Omi, Juro Yanagida, Yusaku Yoshida, Kiyomi Horiuchi, Takahiro Okamoto

“…In papillary thyroid carcinoma (PTC) patients with mediastinal lymph nodes (LN) and lung metastases, adding preoperative computed tomography (CT) to ultrasound is useful for planning surgery. We identified risk factors (RFs) for mediastinal lymph node metastasis (MLNM) and lung metastasis in PTC patients. …”
Get full text

Vaccination with Enzymatically Cleaved GPI-Anchored Proteins from Schistosoma mansoni Induces Protection against Challenge Infection by Vicente P. Martins, Carina S. Pinheiro, Barbara C. P. Figueiredo, Natan R. G. Assis, Suellen B. Morais, Marcelo V. Caliari, Vasco Azevedo, William Castro-Borges, R. Alan Wilson, Sergio C. Oliveira

“…As the major interface between parasite and mammalian host, the tegument plays crucial roles in the establishment and further course of schistosomiasis. Herein, we evaluated the potential of a GPI fraction, containing representative molecules located on the outer surface of adult worms, as vaccine candidate. …”
Get full text

A Cross-Sectional Comparative Study of the Performance of the Widal Test and the Typhidot Immunoassay for Typhoid Fever Diagnosis in the West Region of Cameroon by Karimo Ousenu, Innocent Mbulli Ali, Leonard Fonkeng Sama, Marcel Nsangou Ndam, Thibau Florant Tchouangueu, Christopher Bonglavnyuy Tume

“…The diagnosis of typhoid fever based on the Widal slide agglutination test remains a major hurdle in developing countries due to varied perceptions of the value of the Widal test in determining clinical decision-making. We undertook a study to evaluate the diagnostic performance of the Widal test and the Typhidot immunoassay in patients suspected of having typhoid fever in the Menoua division, West Region of Cameroon. …”
Get full text

TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers by Kimberly J. Briggs, Kevin M. Cottrell, Matthew R. Tonini, Alice Tsai, Minjie Zhang, Douglas A. Whittington, Wenhai Zhang, Steven A. Lombardo, Satoshi Yoda, Erik W. Wilker, Samuel R. Meier, Yi Yu, Teng Teng, Alan Huang, John P. Maxwell

“…MTA is a negative regulator of PRMT5 that accumulates as a result of MTAP deletion. In this study, we demonstrate that TNG908 selectively binds the PRMT5·MTA complex driving selective inhibition of PRMT5 in MTAP-null cancers, a mechanism that creates a large therapeutic index relative to first generation PRMT5 inhibitors that have alternative binding mechanisms that are not tumor-selective. …”
Get full text

The pattern of genetic diversity of different breeds of pigs based on microsatellite analysis by V. R. Kharzinova, N. A. Zinovieva

“…One of the main tasks of genetics and animal breeding is the assessment of genetic diversity and the study of genetic relationships between different breeds and populations using molecular genetic analysis methods. We analysed the polymorphism of microsatellites and the information on the state of genetic diversity and the population structure of local breeds in Russia: the Kemerovo, the Berkshire, the Liven, the Mangalitsa, and the Civilian; in the Republic of Belarus: the Large White and the Black-and-White; and in Ukraine: the White Steppe, as well as commercial breeds of imported origin of domestic reproduction: the Large White, the Landrace, and the Duroc. …”
Get full text

Impact of Polystyrene Microplastics on Soil Properties, Microbial Diversity and <i>Solanum lycopersicum</i> L. Growth in Meadow Soils by Shuming Liu, Yan Suo, Jinghuizi Wang, Binglin Chen, Kaili Wang, Xiaoyu Yang, Yaokun Zhu, Jiaxing Zhang, Mengchu Lu, Yunqing Liu

“…Using 16S rRNA sequencing and molecular ecological network techniques, we found that PS-MPs altered the structure and function of the rhizosphere microbial community associated with <i>S. lycopersicum</i> L. …”
Get full text

High Antennal Expression of <i>CYP6K1</i> and <i>CYP4V2</i> Participate in the Recognition of Alarm Pheromones by <i>Solenopsis invicta</i> Buren by Xinyi Jiang, Jiacheng Shen, Peng Lin, Youming Hou

“…To understand whether the highly expressed CYPs in the antennae play an olfactory function in <i>Solenopsis invicta</i> worker, in this study, we find six highly expressed antennal CYPs from the transcriptome of <i>S. invicta</i>. …”
Get full text

Medical students’ attitudes toward AI in education: perception, effectiveness, and its credibility by Abdul Sami, Fateema Tanveer, Khadeejah Sajwani, Nafeesa Kiran, Muhammad Ahsan Javed, Dilber Uzun Ozsahin, Khalid Muhammad, Yasir Waheed

“…AI tools are helping students learn medical concepts by cutting down on study-time, providing accurate answers, and ultimately improving study outcomes. We recommend developing dedicated AI tools for medical education and their formal integration into medical curricula, along with appropriate regulatory oversight to ensure AI can enhance human abilities rather than acting as a replacement for humans.…”
Get full text