L-shaped association of body mass index with prognosis in individuals with sepsis: a multicenter cohort study by Kunping Cui, Xiangnan Teng, Wei liu, Xiaoxiao Zhao, Shanling Xu, Lang Bai

“…The primary outcome was ICU mortality, and secondary outcomes were in-hospital and 28-day mortality. We performed the log-rank test to detect whether there is a difference in prognosis among different groups in two different cohorts. …”
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The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels by Xiong Weichen, Fan Huizhen, Zeng Qingye, Deng Zhenhui, Li Guanhui, Lu Wancheng, Zhang Bei, Lai Shian, Chen Xin, Xu Xueqing

“…Voltage-gated K+ (Kv) channels play a role in the cellular processes of various cancer cells, including lung cancer cells. We previously identified and reported a salivary protein from the Xenopsylla cheopis, FS48, which exhibited inhibitory activity against Kv1.1-1.3 channels when assayed in HEK 293T cells. …”
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Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men by Jéssica Guedes, Indira Pla, Aniel Sanchez, Gyorgy Marko-Varga, Gilberto Barbosa Domont, K Barbara Sahlin, Berk Hazir, Aleksander Giwercman, Fábio César Sousa Nogueira, Johan Malm, Yvonne Lundberg Giwercman

“…Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unclear and difficult to disentangle from that of androgens. In this study, we examined the metabolic changes induced by FSH and distinguished them from those caused by testosterone. …”
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The Shiism Dimension in Iran's Relations with Europe: The Example of Germany-France-United Kingdom by Orhan Karaoğlu

“…Especially in the 21st century, we see that religion has begun to affect international relations in various areas. …”
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Impact of periprocedural factors on revascularization success and good clinical outcomes in anterior circulation stroke patients treated with mechanical thrombectomy by M. Kurminas, A. Berūkštis, N. Misonis, A. E. Tamošiūnas, D. Jatužis

“…Materials and methods. We included 191 patients who were treated with mechanical thrombectomy (MTE) due to large vessel occlusion in the anterior circulation from January 2015 to November 2018 in Vilnius University Hospital Santaros Clinics. …”
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Advancements, Trends and Future Prospects of Lower Limb Prosthesis by Muhammad Asif, Mohsin Islam Tiwana, Umar Shahbaz Khan, Waqar Shahid Qureshi, Javaid Iqbal, Nasir Rashid, Noman Naseer

“…Quality of life, phantom limb pain, and psycho-social impact of prosthetic users have been summarized for different countries that are believed to attract the interest of the readers. We have also developed an open-source database “FAKH-50” for patents to emphasize the design trends and advancements in lower limb prostheses from 1970 to 2020. …”
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Burden of hospitalizations in newly diagnosed heart failure patients in Poland: real world population based study in years 2013–2019 by Przemysław Leszek, Daniel Waś, Kinga Bartolik, Kladiusz Witczak, Andrzej Kleinork, Bohdan Maruszewski, Katarzyna Brukało, Paulina Rolska‐Wójcik, Małgorzata Celińska‐Spodar, Tomasz Hryniewiecki, Marta Załęska‐Kocięcka

“…Abstract Aims We aim to report trends in unplanned hospitalizations among newly diagnosed heart failure patients with regard to hospitalizations types and their impact on outcomes. …”
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Crustacean Zooplankton Ingestion of Potentially Toxic <i>Microcystis</i>: In Situ Estimation Using <i>mcyE</i> Gene Gut Content Detection in a Large Temperate Eutrophic Lake by Helen Agasild, Margarita Esmeralda Gonzales Ferraz, Madli Saat, Priit Zingel, Kai Piirsoo, Kätlin Blank, Veljo Kisand, Tiina Nõges, Kristel Panksep

“…While laboratory investigations have provided extensive knowledge on zooplankton and toxic cyanobacteria interactions, information on zooplankton feeding on toxin-producing cyanobacteria in natural water bodies remains scarce. In this study, we quantified <i>Microcystis</i>-specific <i>mcyE</i> synthase genes from the gut contents of various cladoceran and copepod taxa to assess the in situ crustacean community and taxon-specific ingestion of potentially toxic <i>Microcystis</i> in Lake Peipsi, a large eutrophic lake in Estonia, Northern Europe. …”
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Development of morphology-dependent nanoselenium carriers for enhancing biological activity and reducing plant stress by Jingyuan Wang, Ronggang Zhai, Yifan Ma, Haoyu Chen, Danyang Jing, Huaiyu Yang, Yi Wang

“…Owing to their small size, morphology and release modification properties, nanopesticides are considered promising alternative strategies for enhancing biological activity and minimizing pesticide losses. In this study, we used a colloidal self-assembly method to develop a morphology-stable, regularly rod-shaped nanoselenium pesticide carrier (NSer), which was further modified with chitosan. …”
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Minor Antigen Disparities Impede Induction of Long Lasting Chimerism and Tolerance through Bone Marrow Transplantation with Costimulation Blockade by Sinda Bigenzahn, Ines Pree, Christoph Klaus, Nina Pilat, Benedikt Mahr, Elisabeth Schwaiger, Patrick Nierlich, Friedrich Wrba, Thomas Wekerle

“…Mixed chimerism and tolerance can be successfully induced in rodents through allogeneic bone marrow transplantation (BMT) with costimulation blockade (CB), but varying success rates have been reported with distinct models and protocols. We therefore investigated the impact of minor antigen disparities on the induction of mixed chimerism and tolerance. …”
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Importance of early use of tolvaptan in hyponatremic acutely decompensated heart failure patients, a retrospective study by Rarsari Soerarso, Emir Yonas, Silfi Pauline Sirait, Dian Yaniarti Hasanah, Sunu Budhi Raharjo, Bambang Budi Siswanto, Maarten J. Cramer, Pim van der Harst, Marish I. F. J. Oerlemans

“…Fluid-overloaded heart failure patients are commonly treated with loop diuretics, acutely decompensated heart failure patients tend to be less responsive to conventional oral doses of a loop diuretic, while other different diuretics could work in different part of nephron circulation system. In this study, we aim to further examine the role of tolvaptan, a vasopressin receptor antagonist, in the treatment of hyponatremia secondary to acutely decompensated heart failure. …”
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Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study by Steffen Hartleif, Michael Schumm, Michaela Döring, Markus Mezger, Peter Lang, Marc H. Dahlke, Joachim Riethmüller, Alfred Königsrainer, Rupert Handgretinger, Silvio Nadalin, Ekkehard Sturm

“…Our secondary objective is to evaluate efficacy of MSC treatment as measured by the individual need for immunosuppression and the incidence of biopsy-proven acute rejection. We will perform detailed immune monitoring to investigate immunomodulatory effects. …”
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Perspectives on which health settings geriatricians should staff: a qualitative study of patients, care providers and health administrators by Eric Kai-Chung Wong, Andrea C. Tricco, Wanrudee Isaranuwatchai, David M. J. Naimark, Sharon E. Straus, Joanna E. M. Sale

“…The perspectives of knowledge users on staffing geriatricians in different healthcare settings are unknown. We aimed to understand the acceptability and feasibility (including barriers and facilitators) of implementing a geriatrician-led comprehensive geriatric assessment (CGA) in acute care, rehabilitation, and community clinic settings. …”
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Translation and Validation of the Sinhalese Version of the Brief Medication Questionnaire in Patients with Diabetes Mellitus by P. Ranasinghe, R. Jayawardena, P. Katulanda, G. R. Constantine, V. Ramanayake, P. Galappatthy

“…Accurately measuring adherence is the primary step in improving adherence. We translated and validated the Sinhalese version of the Brief Medication Questionnaire (BMQ) in patients with diabetes. …”
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Timeline of cognitive impairments after radiotherapy for head and neck cancer: A review by K. Wickborn, C.W.J. van der Weijden, E.F.J. de Vries, T.W.H. Meijer, M.C.A. Kramer, J.M. Spikman, A.M. Buunk, A. van der Hoorn

“…Currently, there is a lack of comprehensive information on the timeline of cognitive impairments following radiotherapy for head and neck cancer (HNC). To address this gap, we conducted a literature review on cognitive impairments observed after radiotherapy for HNC. …”
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“You wished the ground would open and swallow you up”: Expert opinions on shame, the collective, and other cultural considerations for suicide prevention among Asian American and P... by Evan R. Polzer, Carly M. Rohs, Christe’An D. Iglesias, Joseph Mignogna, Lauren S. Krishnamurti, Ryan Holliday, Lindsey L. Monteith

“…Knowledge is limited regarding suicide prevention considerations for clinicians working with AAPI Veterans, yet culturally responsive strategies tend to be most effective. To address this gap, we sought to elucidate subject matter experts’ perspectives regarding suicide prevention considerations for AAPI Veterans. …”
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Prevalence and factors associated with uptake of pre-exposure prophylaxis amongst women vulnerable to HIV who received HIV antibodies in Antibody Mediated Prevention HVTN703/HPTN08... by Bernard Ngara, Bekezela Siziba, Nyaradzo Mavis Mgodi, Tariro Dianah Chawana, Miria Chitukuta, Pamela Grace Mukwekwerere, Muchaneta Bhondai-Mhuri, Zvavahera Mike Chirenje, Felix Godwin Sivukile Mhlanga

“…Challenges faced in accessing PrEP included those related to the health facility, transport problems and stigma.Conclusion The majority (85%) of former AMP participants were not on PrEP at the time of questionnaire administration. We observed poor uptake of PrEP post-study exit among participants who had received risk reduction counselling through study duration. …”
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Leaf reflectance and physiological attributes monitoring differentiate rice cultivars under drought-stress and non-stress conditions by Kossi Lorimpo Adjah, Maxwell Darko Asante, Michael Frei, Aboubacar Toure, Mawuli Aziadekey, Linbo Wu, Andriele Wairich, Daniel Dzorkpe Gamenyah, Shailesh Yadav

“…To achieve these objectives, we screened 14 rice genotypes under drought-stress and non-stress conditions in the greenhouse. …”
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Transcription Factor E2F-1 Is Upregulated in Human Gastric Cancer Tissues and Its Overexpression Suppresses Gastric Tumor Cell Proliferation by Qiang Xiao, Lei Li, Yubo Xie, Ning Tan, Changqing Wang, Junyi Xu, Keyi Xia, Kevin Gardner, Qingdi Q. Li

“…To better understand the involvement of E2F-1 in the development and progression of gastric tumors, we investigated the mutation and expression of E2F-1 in human gastric cancer tissues and the effect of E2F-1 overexpression on the proliferation of gastric carcinoma cells. …”
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Measurement of Capsaicinoids in Chiltepin Hot Pepper: A Comparison Study between Spectrophotometric Method and High Performance Liquid Chromatography Analysis by Alberto González-Zamora, Erick Sierra-Campos, Rebeca Pérez-Morales, Cirilo Vázquez-Vázquez, Miguel A. Gallegos-Robles, José D. López-Martínez, José L. García-Hernández

“…The absorbance of the diluted samples was read on a spectrophotometer at 215–300 nm and monitored at 280 nm. We report herein the comparison between traditional UV assays and HPLC-DAD methods for the determination of the molar absorptivity coefficient of capsaicin (ε280=3,410 and ε280=3,720 M−1 cm−1) and dihydrocapsaicin (ε280=4,175 and ε280=4,350 M−1 cm−1), respectively. …”
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