Сomparative analysis of wild and cultivated Lathyrus L. spp. according to their primary and secondary metabolite contents by A. E. Solovyeva, T. V. Shelenga, А. L. Shavarda, M. O. Burlyaeva

“…In view of the above,  our goal was to analyze organic  acids, free amino  acids and secondary metabolites in green biomass  of Lathyrus to facilitate comprehensive assessment of its forage  and  pharmacological value. We analyzed 32 accessions  of Lathyrus sativus L., L. tuberosus L., L. sylvestris L., L. vernus (L.) …”
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AutoMEX: Streamlining material extrusion with AI agents powered by large language models and knowledge graphs by Haolin Fan, Junlin Huang, Jilong Xu, Yifei Zhou, Jerry Ying Hsi Fuh, Wen Feng Lu, Bingbing Li

“…Despite its affordability, adaptability, and user-friendliness advantages, MEX faces challenges in scaling for mass production due to limited process automation and fragmented domain knowledge, leaving gaps in end-to-end workflow integration. We propose AutoMEX, an innovative framework that integrates large language models (LLMs) as artificial intelligence (AI) agents to automate the MEX process to address these limitations. …”
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Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer by Renee Vermeij, Toos Daemen, Geertruida H. de Bock, Pauline de Graeff, Ninke Leffers, Annechien Lambeck, Klaske A. ten Hoor, Harry Hollema, Ate G. J. van der Zee, Hans W. Nijman

“…Immunotherapeutic treatment using a cocktail of antigens has been proposed as a “universal” vaccine strategy. We determined the expression of tumor antigens in the context of MHC class I expression in 270 primary tumor samples using tissue microarray. …”
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Insight into the codon usage patterns and adaptation of Tembusu Virus by Fucheng Guo, Huiming Tan, Jinjin Yang, Rumin Jia, Ruichen Wang, Lie Wu, Fengzhi Pan, Kai Kang, Weitian Xie, Youquan Li, Kewei Fan

“…Since its emergence in 2010, Tembusu virus (TMUV) has rapidly spread across poultry populations in Asia, leading to substantial economic losses in these areas. Here, we investigate the codon usage patterns (CUPs) underlying TMUV's adaptation and evolutionary dynamics within host environments. …”
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Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits by Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

“…Taking advantage of zebrafish’s embryonic development that solely relys on yolk usage until 5 days post fertilization, we demonstrated that microglia proliferation and activation in the hypothalamus is independent from food intake. …”
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HCV and HIV co-infection among people who inject drugs in Vietnam by Vu Toan THINH, Li LI, Dréan MATTHIEU, Van Dinh HOA, Nguyen Huu ANH, Le Minh GIANG

“…The prevalence of HCV mono-infection and HIV/HCV co-infection was 22.59% and 39.1%, respectively. We found that engaging in methadone maintenance treatment (MMT) was positively associated with HCV mono-infection (aOR = 2.38, 95% Confidential Interval [CI] 1.07 to 5.28) and with at least either HIV or HCV infection (aOR = 2.22, 95% CI 1.08 to 4.56). …”
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A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs by Valeria Bettinsoli, Gloria Melzi, Angelica Crea, Lorenzo Degli Esposti, Michele Iafisco, Daniele Catalucci, Paolo Ciana, Emanuela Corsini

“…Beyond efficacy, addressing safety concerns—particularly those specific to this class of drugs—is crucial. Here, we propose an in vitro approach to screen for potential adverse off-target effects of NA-based drugs. …”
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Feasibility and Safety of Field-Based Physical Fitness Tests: A Systematic Review by Carolina Cruz-León, Pablo Expósito-Carrillo, Sandra Sánchez-Parente, José Jiménez-Iglesias, Milkana Borges-Cosic, Magdalena Cuenca-Garcia, José Castro-Piñero

“…Three evidence levels were constructed (strong, moderate and limited or inconclusive evidence) according to the number of studies and the consistency of the findings. Results We identified a total of 19 (14 of high quality) and 13 (11 high quality) original studies examining the feasibility and safety of field-based physical fitness tests, respectively. …”
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Fipronil prevents transmission of Lyme disease spirochetes by Radek Šíma, Adéla Palusová, Tereza Hatalová, Luise Robbertse, Petra Berková, Martin Moos, Petr Kopáček, Veronika Urbanová, Jan Perner, Ala Tabor

“…This study investigated the acaricidal efficacy of fipronil against Ixodes ricinus ticks and its potential to block Borrelia afzelii transmission. Initially, we employed the ex vivo membrane blood-feeding system to assess the dose–response acaricidal activity of ivermectin, fipronil and its metabolite fipronil sulfone, when supplemented in the blood meal throughout tick feeding. …”
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Analyzing special needs reports for children: sociodemographic trends, diagnoses, and support areas over five years (2019–2024) by Semih Canpolat, Mehmet Emin Parlak, Esra Kurt Canpolat, Erdogan Oz

“…Through harnessing these reports, we can make significant progress in identifying and supporting children with special needs, ultimately enhancing their quality of life. …”
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The new HFA/ICOS risk assessment tool to identify patients with chronic myeloid leukaemia at high risk of cardiotoxicity by Daniela Di Lisi, Cristina Madaudo, Giulia Alagna, Marco Santoro, Ludovico Rossetto, Sergio Siragusa, Giuseppina Novo

“…HFA/ICOS risk stratification tool was significantly more sensitive than SCORE (P < 0.01) in identifying patients at higher risk of cardiovascular toxicity. In addition, we did not find AEs in patients pretreated with aspirin. …”
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Immunotherapy in metastatic renal cell carcinoma: Insights from a Dutch nationwide cohort by Hilin Yildirim, Anke Richters, Adriaan D. Bins, Arnoud W. Postema, Maureen J.B. Aarts, Martijn G.H. van Oijen, Patricia J. Zondervan, Katja K.H. Aben

“…Targeted therapy with tyrosine kinase inhibitors (TKIs) was the standard of care for metastatic renal cell carcinoma (mRCC) until recently, when new first-line combinations with immuno-oncology (IO) agents were approved. We evaluated IO uptake in both first-line and later-line treatment in routine clinical practice in the Netherlands. …”
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C-IVAL: A Longitudinal Study of Knowledge Retention and Technology Acceptance in Collaborative Virtual Reality-Based Medical Education by Mohammed Kadri, Fatima-Ezzahra Boubakri, Gwo-Jen Hwang, Fatima Zahra Kaghat, Ahmed Azough, Khalid Alaoui Zidani

“…This longitudinal study examined Collaborative Immersive Virtual Anatomy Laboratory (C-IVAL), an innovative VR platform designed to enhance traditional anatomy learning through integrated collaborative features, immersive technology, and serious game elements. We conducted an experimental study with 65 medical students to evaluate their knowledge acquisition and technology acceptance compared to its non-collaborative predecessor, the Immersive Virtual Anatomy Laboratory (IVAL). …”
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Role of radiologists in the diagnosis and management of adrenal disorders by Sota Oguro, Hiromitsu Tannai, Hideki Ota, Kazumasa Seiji, Hiroki Kamada, Yoshitaka Toyama, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Fumitoshi Satoh, Sadayoshi Ito, Tetsuhiro Tanaka, Hideki Katagiri, Kei Takase

“…This paper details the technical aspects of AVS, emphasizing catheterization techniques, anatomical considerations, and the importance of preprocedural imaging for successful sampling. Furthermore, we explore segmental adrenal venous sampling (SAVS), a more refined technique that samples specific adrenal tributary veins, offering enhanced diagnostic accuracy, particularly for microadenomas or challenging cases that may be missed with conventional AVS. …”
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Targeted sequencing analysis pipeline for species identification of human pathogenic fungi using long-read nanopore sequencing by Nattapong Langsiri, Navaporn Worasilchai, Laszlo Irinyi, Piroon Jenjaroenpun, Thidathip Wongsurawat, Janet Jennifer Luangsa-ard, Wieland Meyer, Ariya Chindamporn

“…The nanopore-based technology is now one of the most promising long-read sequencing technologies on the market as it has the potential to sequence the full-length ITS region in a single read. In this study, we established a workflow for species identification using the sequences of the entire ITS region generated by nanopore sequencing of both pure yeast isolates and mocked mixed species reads generated with different scenarios. …”
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Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a M... by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz

“…Recently, nonclassical RAS components have been implicated in the pathogenesis of hypertension and myocardial dysfunction; however, their cardiac functions are still controversial. We evaluated if the nonclassical RAS signaling pathways, directed by angiotensin III and angiotensin-(1-7), are involved in the cardioprotective effect of fenofibrate during ischemia in MetS rats. …”
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The Effect of Combination Therapy with Rituximab and Intravenous Immunoglobulin on the Progression of Chronic Antibody Mediated Rejection in Renal Transplant Recipients by Gun Hee An, Jintak Yun, Yu Ah Hong, Marina Khvan, Byung Ha Chung, Bum Soon Choi, Cheol Whee Park, Yeong Jin Choi, Yong-Soo Kim, Chul Woo Yang

“…The treatment for chronic active antibody-mediated rejection (CAMR) remains controversial. We investigated the efficacy of rituximab (RTX) and intravenous immunoglobulin (IVIg) for CAMR. …”
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Impact of obesity, overweight and underweight on life expectancy and lifetime medical expenditures: the Ohsaki Cohort Study by Shinichi Kuriyama, Miyuki Kawado, Shuji Hashimoto, Ichiro Tsuji, Atsushi Hozawa, Toshimasa Sone, Masato Nagai, Masako Kakizaki, Kaori Ohmori-Matsuda

“…However, in view of their shorter life expectancy, it is unclear whether obese people have higher lifetime medical expenditure. We examined the association between body mass index, life expectancy and lifetime medical expenditure.Design Prospective cohort study using individual data from the Ohsaki Cohort Study.Setting Miyagi Prefecture, northeastern Japan.Participants The 41 965 participants aged 40–79 years.Primary and secondary outcome measures The life expectancy and lifetime medical expenditure aged from 40 years.Results In spite of their shorter life expectancy, obese participants might require higher medical expenditure than normal weight participants. …”
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CENPN contributes to pancreatic carcinoma progression through the MDM2-mediated p53 signaling pathway by Ming Xu, Jie Tang, Qiong Sun, Jing Meng, Guoyu Chen, Yunli Chang, Yao Yao, Jieru Ji, Hao Luo, Lingling Chen, Minxue Lu, Weiwei Shi

“…Introduction We undertook an in-depth investigation of the data pertaining to pancreatic adenocarcinoma (PAAD) to identify potential targets for the development of precision therapies. …”
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Ex Vivo Expansion of Murine MSC Impairs Transcription Factor-Induced Differentiation into Pancreatic β-Cells by Dario Gerace, Rosetta Martiniello-Wilks, Rosaline Habib, Binhai Ren, Najah Therese Nassif, Bronwyn Anne O’Brien, Ann Margaret Simpson

“…To overcome the aforementioned limitation of current therapies, we assessed the utility of ex vivo expanded bone marrow-derived murine MSCs for their persistence in immune-competent and immune-deficient animal models and their ability to differentiate into surrogate β-cells. …”
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