Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis by Charlene Hawkins, Guzel Shaginurova, D. Auriel Shelton, Jose D. Herazo-Maya, Kyra A. Oswald-Richter, Joseph E. Rotsinger, Anjuli Young, Lindsay J. Celada, Naftali Kaminski, Carla Sevin, Wonder P. Drake

“…T cell exhaustion is defined by decreased cytokine production upon TCR activation, decreased proliferation, increased expression of inhibitory cell surface receptors, and increased susceptibility to apoptosis. We characterized sarcoidosis CD4+ T cell immune function in systemic and local environments among subjects undergoing disease progression compared to those experiencing disease resolution. …”
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Avolition Characterizes the Chronic Fatigue Experienced in Quiescent Inflammatory Bowel Disease by Tristan Gabriel-Segard, Margherita Boltri, Mathilde Barrau, Catherine Massoubre, Stéphane Paul, Xavier Roblin

“…Fatigue is a widespread complaint of patients suffering from inflammatory bowel disease (IBD), significantly impacting patients’ well-being, even during the quiescent stage of the disease. We here address the hypothesis that fatigue experienced by IBD patients is associated with motivational impairment. …”
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Enhancing laboratory education through collaborative online international learning: A case study between USA and UK students by Matthew Allan Jones, Pika Miklavc, MaryAnne Stewart

“…Further analysis based on participants international institution revealed significant differences in responses between the two participating cohorts, namely questions relating to cultural intelligence and their confidence of working with cultures unfamiliar to themselves.We are the first to report that implementation of laboratory-based COIL opportunities have significant potential in enhancing students' international, cultural and transferable competencies within laboratory and health education. …”
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Low body mass index as a predictor of sputum culture conversion and treatment outcomes among patients receiving treatment for multidrug-resistant tuberculosis in Lesotho by Lawrence Oyewusi, Chengbo Zeng, KJ Seung, Stephanie Mpinda, Mikanda Kunda, Carole D Mitnick, Makelele Kanu, Meseret Tamirat, Joalane Makaka, Mabatloung Mofolo, Refiloe Maime, Llang Maama, Ninza Senyo, Bamidele Oguntoyinbo, Lwayi Mayombo, Molly F Franke

“…Whether the relative importance of low BMI in predicting treatment outcomes differs by HIV status is unclear. Objectives We evaluated the association between low BMI and two dependent variables, sputum culture conversion and end-of-treatment outcome, among patients receiving treatment for MDR/RR-TB in Lesotho, a setting with a high prevalence of HIV infection. …”
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Hepatic arterial infusion chemotherapy combined with systemic therapy sequentially or simultaneously for advanced hepatocellular carcinoma by Yu-zhe Cao, Jia-yu Pan, Guang-lei Zheng, Chao An, Meng-Xuan Zuo

“…Propensity score matching (PSM; 1:1) was performed to eliminate possible confounder imbalances across cohorts. We used the Kaplan–Meier method and a log-rank test to compare the overall survival (OS) and progression-free survival (PFS) rates between the SI and SE groups. …”
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Effects of trimester-specific urinary aluminum concentrations on ultrasound measures of fetal growth and size at birth: A longitudinal cohort study in Chinese women by Haiying Chen, Wenjing Yan, Xueyan Wu, Yuanyuan Li

“…Besides, statistically significant interactions were detected between biparietal diameter (BPD) (Pinteraction = 0.007), head circumference (Pinteraction = 0.026) at 16 weeks’ gestation in the first trimester, BPD (Pinteraction = 0.015) at 24 weeks’ gestation in the second trimester, BPD (Pinteraction = 0.014) at 31 weeks’ gestation in the second trimester and BPD (Pinteraction = 0.035) at 37 weeks’ gestation in the third trimester and fetal sex, and the strength of the association between the level of Al exposure and BPD was significantly stronger in female fetuses than in male fetuses. Furthermore, we observed three distinct trajectories of trimester-specific Al concentrations during pregnancy. …”
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Sterol‐Targeted Laboratory Evolution Allows the Isolation of Thermotolerant and Respiratory‐Competent Clones of the Industrial Yeast Saccharomyces cerevisiae by Isabel‐Elena Sánchez‐Adriá, Jose A. Prieto, Gemma Sanmartín, Miguel Morard, Estéfani García‐Ríos, Francisco Estruch, Francisca Randez‐Gil

“…Using a targeted evolution strategy involving fluconazole (FCNZ), an inhibitor of the sterol biosynthesis pathway, and the immunosuppressant FK506, we aimed to enhance thermotolerance in an industrial baker's yeast population by modifying their sterol composition. …”
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HIDRA3: a deep-learning model for multipoint ensemble sea level forecasting in the presence of tide gauge sensor failures by M. Rus, M. Rus, H. Mihanović, M. Ličer, M. Ličer, M. Kristan

“…Furthermore, since the inference requires immediate past SSH measurements as input, forecasts cannot be made during temporary tide gauge failures. We address the aforementioned issues using a new architecture, HIDRA3, that considers observations from multiple locations, shares the geophysical encoder across the locations, and constructs a joint latent state that is decoded into forecasts at individual locations. …”
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Experience in the treatment of type C congenital esophageal atresia using a staged approach by Yong Zhao, Shihui Tan, An Wang, Shuangshuang Li, Junmin Liao, Dingding Wang, Kaiyun Hua, Yichao Gu, Yanan Zhang, Jinshi Huang

“…Abstract Background In select patients with type C esophageal atresia, primary anastomosis is not appropriate and a staged approach is required. We aim to summarize our experience in the management of type C EA using a staged approach. …”
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Implementing Internet-Delivered Cognitive Behavioral Therapy for Depression and Anxiety in Adults: Systematic Review by Daniel Duffy, Derek Richards, Garrett Hisler, Ladislav Timulak

“…A mixed methods systematic review using a convergent synthesis design was conducted to bring together evidence across this sparse literature consisting of divergent scientific article types to investigate the implementation of iCBT for depression and anxiety in adults. MethodsWe searched the PsycINFO, PsycArticles, MEDLINE, CINAHL Complete, and Embase databases for any published peer-reviewed scientific articles that report on the implementation of iCBT for depression or anxiety disorders in adults. …”
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Distribution of Tunisian beet wild relatives (Beta sp.) according to morphological characteristics and eco-geographical origin by Kaouther Ben Mahmoud, Najla Mezghani, Youssef Ouakrim, Neila Mezghani, Noura Jemai, Ahmed Jemmali

“…Climate change poses a significant threat to genetic reservoir in Tunisia. We evaluated the morphological diversity of ten populations of B. vulgaris subsp. maritima and five populations of B. macrocarpa growing in different Tunisian bioclimatic and ecological areas using a set of 9 quantitative and 14 qualitative traits to promote the preservation and exploration of this germplasm. …”
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Echocardiography evaluation of iatrogenic atrial septal defect after combined procedure of catheter ablation and left atrial appendage closure for atrial fibrillation by Yu Xin Su, Sai Nan Li, Nan Nan Liu, Ming Liang, Zu Lu Wang, Ping Zhang, Qi Zhang, Wei Wei Zhou

“…Abstract Using transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) to investigate the occurrence and related causes of iatrogenic atrial septal defect (iASD) after catheter ablation combined with left atrial appendage closure (LAAC) for atrial fibrillation (AF) and its impact on the right heart system. We retrospectively analyzed 330 patients that underwent combined procedure of catheter ablation for AF and LAAC at General Hospital of Northern Theater Command from January 2018 to March 2022. …”
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Eicosapentaenoic Acid Supplementation Changes Fatty Acid Composition and Corrects Endothelial Dysfunction in Hyperlipidemic Patients by Ken Yamakawa, Michio Shimabukuro, Namio Higa, Tomohiro Asahi, Kageyuki Ohba, Osamu Arasaki, Moritake Higa, Yoshito Oshiro, Hisashi Yoshida, Tohru Higa, Taro Saito, Shinichiro Ueda, Hiroaki Masuzaki, Masataka Sata

“…We investigated the effects of purified eicosapentaenoic acid (EPA) on vascular endothelial function and free fatty acid composition in Japanese hyperlipidemic subjects. …”
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Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy by Leandro Mamone, Daniel Sáenz, Pablo Vallecorsa, Alcira Batlle, Adriana Casas, Gabriela Di Venosa

“…C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.…”
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The development and validation testing of a comprehensive frailty assessment in women with breast cancer by Sheng-Miauh Huang, Ling-Ming Tseng, Chi-Cheng Huang, Pei-Ju Lien, Su-Chen Fang, Yinhui Hong

“…Methods A descriptive and explorative study design was used. We collected the data through systematic literature and modified Delphi method. …”
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Profiles and predictors of access to human and veterinary healthcare in multispecies households by Jennifer W. Applebaum, Courtney Dunn, Shelby E. McDonald, Kaylinn Escobar, Erin K. King, Rosalie Corona, Megan K. Mueller

“…Using Latent Class Analysis, a person-centered analytic approach, we identified five subgroups of pet owners in a diverse national sample (n = 750), each characterized by unique patterns of perceived access and actual usage of both human and veterinary healthcare. …”
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What motivates West African cocoa farmers to value trees? Taking the 4 W approach to the heart of the field by Marie Ruth Dago, Irié Casimir Zo‐Bi, Isaac Kouamé Konan, Aimé Kouadio Kouassi, Stéphane Guei, Patrick Jagoret, Anny Estelle N'Guessan, Elsa Sanial, Chloé Tankam, Soulemane Traoré, Bruno Hérault

“…Drawing from a sample of 150 farmers responsible for the management of 12,096 trees, we quantified the motivations of farmers for 10 material and immaterial uses of trees and used a Bayesian modelling framework to explore the relative importance of the 4 W framework in explaining general motivations, specific to each use, as well as the varying levels of specialization in tree management strategies among farmers. …”
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Normothermic Crystalloid Polarizing Cardioplegia Improves Systolic and Diastolic Function in a Porcine Model of Cardiopulmonary Bypass by David Santer, Stefan Heber, Anne-Margarethe Kramer, Judith Radloff, Katharina Heissl, Attila Kiss, David J. Chambers, Seth Hallström, Bruno K. Podesser

“…Background/Objectives: Previously, we showed that blood-based polarizing cardioplegia exerted beneficial cardioprotection during hypothermic ischemia; however, these positive effects of blood-based polarizing cardioplegia were reduced during normothermic ischemia compared to blood-based hyperkalemic (depolarizing) cardioplegia. …”
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Prediction of Cisplatin‐Induced Acute Kidney Injury Using an Interpretable Machine Learning Model and Electronic Medical Record Information by Kaori Ambe, Yuka Aoki, Miho Murashima, Chiharu Wachino, Yuto Deki, Masaya Ieda, Masahiro Kondo, Yoko Furukawa‐Hibi, Kazunori Kimura, Takayuki Hamano, Masahiro Tohkin

“…ABSTRACT Predicting cisplatin‐induced acute kidney injury (Cis‐AKI) before its onset is important. We aimed to develop a predictive model for Cis‐AKI using patient clinical information based on an interpretable machine learning algorithm. …”
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The role of gut microbiota in disease management: Ayurvedic perspectives on metabolic diseases and health by Bhawana Jangra, Shreyanshi Kulshreshtha, Alok Goyal, Sanjay M. Jachak

“…Exploring their phytoconstituents and Ayurvedic formulations, we uncover their role in nurturing gut microbiota and combating various gut disorders. …”
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