IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch by Maria Abreu, Marta Miranda, Mafalda Castro, Iolanda Fernandes, Renata Cabral, Ana Helena Santos, Sónia Fonseca, João Rodrigues, Magdalena Leander, Catarina Lau, Inês Freitas, Susana Coimbra, Alice Santos-Silva, Margarida Lima

“…Recent studies have highlighted the possible role of interleukins in nonhistaminergic itch. We investigated the role of IL-31 and IL-8 in CTCL, concerning disease severity and associated itch. …”
Get full text

Cross-protection against homo and heterologous influenza viruses via intranasal administration of an HA chimeric multiepitope nanoparticle vaccine by Yongqiang Zhao, Jia Liu, Chun Peng, Shuangshuang Guo, Bo Wang, Longping Chen, Yating Wang, Haiwen Tang, Liming Liu, Qi Pan, Shiren Li, Jingyu Wang, Dongni Yang, Enqi Du

“…Multiepitope vaccines combining multiple conserved epitopes can induce more robust and broader immune responses and provide a potential solution. Results Here, we demonstrated that an HA chimeric multiepitope nanoparticle vaccine, delivered intranasally conferred broad protection against challenges with various influenza viruses in mice. …”
Get full text

Deep Learning in Oral Hygiene: Automated Dental Plaque Detection via YOLO Frameworks and Quantification Using the O’Leary Index by Alfonso Ramírez-Pedraza, Sebastián Salazar-Colores, Crystel Cardenas-Valle, Juan Terven, José-Joel González-Barbosa, Francisco-Javier Ornelas-Rodriguez, Juan-Bautista Hurtado-Ramos, Raymundo Ramirez-Pedraza, Diana-Margarita Córdova-Esparza, Julio-Alejandro Romero-González

“…This study focuses on detecting three plaque stages—new, mature, and over-mature—using state-of-the-art YOLO architectures to enhance early intervention and reduce reliance on manual visual assessments. <b>Methods</b>: We compiled a dataset of 531 RGB images from 177 individuals, captured via multiple mobile devices. …”
Get full text

Modeling the impact of pandemic on the urban thermal environment over megacities in China: Spatiotemporal analysis from the perspective of heat anomaly variations by Jianfeng Gao, Qingyan Meng, Linlin Zhang, Xinli Hu, Die Hu, Jiangkang Qian

“…During the entire year, we found that although the pandemic significantly reduced surface urban heat island intensity during 5 % to 35 % of days, it did not change significantly throughout 2020. …”
Get full text

Knowledge translation strategies for policy and action focused on sexual, reproductive, maternal, newborn, child and adolescent health and well-being: a rapid scoping review by Etienne V Langlois, Leah Boulos, Lori Wozney, Janet A Curran, Helen Wong, Zulfiqar Bhutta, Robin Urquhart, Hwayeon Danielle Shin, Allyson J Gallant, Julia Kontak

“…Reported barriers to KT strategies included limited resources and time constraints, while enablers included stakeholder involvement throughout the KT process.Conclusion We identified a number of gaps among KT strategies for SRMNCAH policy and action, including limited focus on adolescent, sexual and reproductive health and rights and SRMNCAH financing strategies. …”
Get full text

Multifunctional Analysis of CD4+ T-Cell Response as Immune-Based Model for Tuberculosis Detection by Miriam Lichtner, Claudia Mascia, Ilaria Sauzullo, Fabio Mengoni, Serena Vita, Raffaella Marocco, Valeria Belvisi, Gianluca Russo, Vincenzo Vullo, Claudio M. Mastroianni

“…Mono- and multifunctional specific CD4+ and CD8+ T-cell responses were evaluated to improve the immune-based detection of active tuberculosis (TB) and latent infection (LTBI). We applied flow cytometry to investigate cytokines profile (IFN-γ, TNF-α, and IL-2) of T cells after stimulation with TB antigens in 28 TB-infected subjects (18 active TB and 10 LTBI) and 10 uninfected controls. …”
Get full text

Reconsidering routine admission for children under age 3 undergoing partial tonsillectomy: a prospective study by Ameen Biadsee, Craig Nathanson, Or Dagan, Firas Kassem, Avishai Stahl, Tova Mishali, Yaniv Ebner, Brian Rotenberg

“…Mean age in the younger group was 25.7 ± 6.9 months, and 56.1 ± 20.1 months in the older group. In total we had 7 children with post-operative complications; 4 with fever, 3 with low intake. …”
Get full text

Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome by Wenhua Tao, Xiaoyun Dong, Guimei Kong, Penghua Fang, Xiaoli Huang, Ping Bo

“…Microarray technology and real-time reverse transcriptase-polymerase chain reaction analysis (RT-PCR) were taken to examine the miRNA expression profiles of T2DM patients with diarrhea-predominant irritable bowel syndrome (D-IBS) compared with patients with T2DM, patients with D-IBS, and control subjects. Results. We have found that 35 miRNAs were differentially expressed in T2DM with D-IBS, in which three representative miRNAs, hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b, were found to be significantly elevated in T2DM with D-IBS by RT-PCR. …”
Get full text

Exploring smallholder farmers’ access and participation in the Home Grown School Feeding Programme in selected counties of Kenya by Joyce Kamau, Collins Okoyo, Collins Okoyo, Tabitha Kanyui, Charles Mwandawiro, Samrat Singh, Lesley Drake

“…The uptake of the MPP for procurement of food by HGSFP schools and FBOs was embraced and promising and was rated as faster to use (76.8%) and more transparent in HGSFP procurement (44.6%).ConclusionThe study concluded that local procurement opportunities through FBOs were underutilized. We recommend more capacity-building support for SHFs and FBOs to increase their production and give them better opportunities to be key participants in the HGSFP market and other structured markets. …”
Get full text

Specific plasma metabolite profile in intestinal Behçet’s syndrome by Cheng-cheng Hou, Hua-fang Bao, Chun-hui She, Hua-yu Chen, Guan-xing Pan, Hua-ning Chen, Hong-bing Rui

“…Methods In this study, we performed a global untargeted metabolomics approach in plasma samples from 30 IBS patients and 20 healthy subjects. …”
Get full text

Observational research in epidemic settings: a roadmap to reform by Marc Lipsitch, Nicholas Evans, Alexandra L Phelan, Stephany N Duda, Annette Rid, Colin J Carlson, Jennifer B Rosen, Natalie E Dean, John Barugahare, Maya B Mathur, Emily E Ricotta, Fausto A Bustos Carrillo, Samuel Angelli-Nichols, Adia Benton, Emma Chang-Rabley, Lisa Federer, Mary-Margaret A Fill, Elizabeth C LeRoy, Natalie M Linton, Lauren Sauer, Sheena G Sullivan, Mackenzie Zendt

“…This paper opens with a discussion of how well-designed observational studies contribute to biomedical evidence and provides examples from across the clinical literature of how these methods generate hypotheses for future research and uncover otherwise unattainable insights by providing examples from across the clinical literature. Then, we present obstacles that remain in ensuring observational studies are optimally designed, conducted and communicated.…”
Get full text

Forensic Assessment of Alcohol Intoxication in Cases of Fatal Road Traffic Accidents in Lithuania by Beata Kirstukaitė, Akvilė Paškauskienė, Sigitas Chmieliauskas, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“…Materials and methods: A retrospective study of 136 road traffic accident victims was performed in State Forensic Medicine Service of Lithuania in the period of 2013 to 2023. We analyzed blood alcohol concentration (BAC) in relation to sex, age, road user type, place and time of the day at death. …”
Get full text

Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation by Xin Zhang, Jieling Li, Minyi Fu, Xijie Geng, Junjie Hu, Ke-Jing Tang, Pan Chen, Jianyong Zou, Xiaoman Liu, Bo Zeng

“…Mitochondrial dysfunction is implicated in the development of PAH, but the key mitochondrial functional alterations in the pathogenesis have yet to be elucidated. Methods We integrated three microarray datasets from the Gene Expression Omnibus (GEO), including 222 lung samples (164 PAH, 58 controls), for differential expression and functional enrichment analyses. …”
Get full text

Impact of noninsulin-dependent diabetes mellitus (level of control) on sex hormone profile and erectile function by Abdullah A. Khawaji, Hossam S. El-Tholoth, Muath A. Albarakati, Bander A. Binjabaan, Abdulaziz Alzahrani, Abdulmajeed Althobity, Abdulmalik Almardawi, Khaled Bedaiwi, Mussa AlNuami

“…Methodology: A comparative study between two arms – relatively controlled and uncontrolled type 2 diabetic men. We considered a relatively controlled diabetes mellitus (DM), patient with glycated hemoglobin (HbA1c) of 7.9 mmol/L or less. …”
Get full text

Correlation of GLUT4, LEPR , and TNF-a with endometrial receptivity in women with polycystic ovarian syndrome-induced infertility by Yan Dong, Kong Wei, Yifei Li, Yan Liu, Lin Li, Yan Li

“…Background: To analyze the correlation of glucose transporter 4 (GLUT4), leptin receptor (LEPR), and tumour necrosis factor-a (TNF-a) with endometrial receptivity (ER) in patients with polycystic ovarian syndrome (PCOS)induced infertility to provide clinical evidence for future diagnosis and treatment of PCOS-induced infertility. Methods: We prospectively enrolled 109 study subjects admitted to The Second Hospital Affiliated of Shandong University of Traditional Chinese Medicine from June 2020 to August 2023, including 42 patients with PCOS-induced infertility (research group), 35 nonpregnant patients with simple PCOS (control group), and 32 nonpregnant healthy women (normal group). …”
Get full text

Characterization of Avocado (<i>Persea americana</i> Mill) Seed Extract from the Variety Semil 34 Cultivated in the Dominican Republic by Ramon Sanchez-Rosario, Luis Castillo, Alejandra Féliz-Jiménez, Sebastián Vargas, Ramón Pérez-Romero, Mónica Aquino, Maha T. Abutokaikah

“…This study aimed to explore the potential of Semil 34 avocado seed (AS) as a source of bioactive compounds with applications in the food industry. We conducted the chemical characterization of the seed extract, focusing on its total phenolic content, total flavonoids, and antioxidant capacity. …”
Get full text

Deep learning and hyperspectral features for seedling stage identification of barnyard grass in paddy field by Siqiao Tan, Qiang Xie, Wenshuai Zhu, Yangjun Deng, Lei Zhu, Xiaoqiao Yu, Zheming Yuan, Zheming Yuan, Yuan Chen, Yuan Chen

“…To explore the feasibility of hyperspectral identification of barnyard grass and rice in the seedling stage, we have pioneered the DeepBGS hyperspectral feature parsing framework. …”
Get full text

Understanding the use of the National Early Warning Score 2 in acute care settings: a realist review protocol by Nia Roberts, Geoff Wong, Michelle Treacy, Mandy Odell

“…Documents set in the paediatric, maternity and primary care settings will be excluded. (3) Selecting documents and quality appraisal. (4) Extracting and organising the data. (5) Synthesising the data. (6) Disseminating the findings. We will recruit a group of stakeholders comprised of experienced clinicians who use the NEWS2 as part of their clinical practice to provide feedback throughout the review. …”
Get full text

A Comprehensive Review on the Effects of Laser Photobiomodulation on Skeletal Muscle Fatigue in Spastic Patients by Sadi F. Stamborowski, Fernanda Púpio Silva Lima, Patrícia Sardinha Leonardo, Mário Oliveira Lima

“…To perform a literature review, we used the systematic review methodology for the literature search. …”
Get full text

Characterizing Tidal Marsh Inundation with Synthetic Aperture Radar, Radiometric Modeling, and In Situ Water Level Observations by Brian T. Lamb, Kyle C. McDonald, Maria A. Tzortziou, Derek S. Tesser

“…Accurate characterization of tidal marsh inundation dynamics is crucial for understanding these processes and ecosystem services. In this study, we developed remote sensing-based inundation classifications over a range of tidal stages for marshes of the Mid-Atlantic and Gulf of Mexico regions of the United States. …”
Get full text